Detailed information for compound 1812843

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 521.497 | Formula: C25H22F3N9O
  • H donors: 1 H acceptors: 6 LogP: 4.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN1CCN(CC1)c1nc(nc(n1)Oc1ncnc2c1cccc2)Nc1ccc(c(c1)C(F)(F)F)C#N
  • InChi: 1S/C25H22F3N9O/c1-2-36-9-11-37(12-10-36)23-33-22(32-17-8-7-16(14-29)19(13-17)25(26,27)28)34-24(35-23)38-21-18-5-3-4-6-20(18)30-15-31-21/h3-8,13,15H,2,9-12H2,1H3,(H,32,33,34,35)
  • InChiKey: NBWRKVXXAJVOED-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major calcium motive p-type ATPase, putative 0.007 0.0717 0.104
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0078 0.0821 0.0801
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0088 0.0948 0.1438
Schistosoma mansoni hypothetical protein 0.0138 0.161 0.2403
Echinococcus multilocularis para nitrobenzyl esterase 0.0034 0.0234 0.0212
Trypanosoma cruzi cation-transporting ATPase, putative 0.0028 0.0156 0.0227
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0088 0.0948 0.1512
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0112 0.0091
Schistosoma mansoni smad 0.0025 0.012 0.0147
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0315 0.0294
Loa Loa (eye worm) MH2 domain-containing protein 0.0367 0.4611 0.4616
Brugia malayi Membrane calcium atpase protein 3 0.007 0.0717 0.0701
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.1053 0.1771
Plasmodium falciparum copper-transporting ATPase 0.0028 0.0156 0.0174
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0111 0.0097
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0111 0.0134
Plasmodium falciparum calcium-transporting ATPase 0.007 0.0717 0.1127
Entamoeba histolytica vacuolar sorting protein-associating protein 4A (VPS4), putative 0.0025 0.0125 0.012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0229 0.0483
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0809 0.133
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0204 0.247 0.2453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0387 0.0365
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0054 0.0000040997
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.2412 0.3617
Toxoplasma gondii P-type ATPase4, putative 0.0088 0.0948 0.1512
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0948 0.0905
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0088 0.0948 0.2473
Schistosoma mansoni regulator of G protein signaling 0.004 0.0315 0.0444
Giardia lamblia Topoisomerase II 0.0025 0.0125 0.0196
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0018 0.0022 0.0035
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.007 0.0717 0.1051
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0204 0.247 0.2472
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0223 0.034
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0443 0.0711
Onchocerca volvulus 0.0034 0.0234 0.0182
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0132 0.1532 0.1513
Schistosoma mansoni hypothetical protein 0.052 0.6632 1
Echinococcus granulosus GPCR family 2 0.0064 0.0633 0.0612
Echinococcus granulosus acetylcholinesterase 0.0199 0.2412 0.2396
Echinococcus multilocularis nervana 2 0.0132 0.1532 0.1513
Trypanosoma cruzi katanin, putative 0.0025 0.0125 0.0173
Toxoplasma gondii cell division protein CDC48AP 0.0295 0.3668 0.5851
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1083 0.1656
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.0234 0.0222
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0223 0.0203
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.1053 0.1034
Schistosoma mansoni smad1 5 8 and 0.0025 0.012 0.0147
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0088 0.0948 0.1565
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0467 0.5936 1
Echinococcus granulosus katanin p60 ATPase containing subunit A1 0.0025 0.0125 0.0103
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0493 0.6269 0.6261
Brugia malayi Carboxylesterase family protein 0.0034 0.0234 0.0214
Schistosoma mansoni smad1 5 8 and 0.0025 0.012 0.0147
Echinococcus granulosus Smad4 0.0025 0.012 0.0098
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0265
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0633 0.0612
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0223 0.034
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0493 0.6269 0.9452
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.007 0.0717 0.1834
Brugia malayi regulator of G-protein signaling egl-10 0.0049 0.0431 0.0413
Plasmodium vivax P-type ATPase4, putative 0.0088 0.0948 0.1593
Chlamydia trachomatis metal transport ATPase 0.0028 0.0156 0.5854
Leishmania major DNA polymerase eta, putative 0.005 0.0443 0.0569
Brugia malayi ImpB/MucB/SamB family protein 0.0104 0.1153 0.1142
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0295 0.3668 0.5851
Mycobacterium tuberculosis Probable reductase 0.0219 0.267 0.7159
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0387 0.0337
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0132 0.1532 0.2284
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0387 0.0365
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0028 0.0156 0.0283
Brugia malayi Carboxylesterase family protein 0.0199 0.2412 0.2414
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0502 0.0761
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0229 0.0207
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0182
Echinococcus multilocularis geminin 0.052 0.6632 0.6624
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0111 0.0097
Schistosoma mansoni hypothetical protein 0.0064 0.0633 0.0925
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0111 0.0097
Trichomonas vaginalis cation-transporting ATPase, putative 0.0056 0.0527 0.0761
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0821 0.1305
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0182
Loa Loa (eye worm) RGS-3 protein 0.004 0.0315 0.0265
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0054 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0315 0.0294
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0112 0.1267 0.1257
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0315 0.0294
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0111 0.015
Echinococcus multilocularis transcription factor eb 0.0112 0.1267 0.1248
Echinococcus multilocularis nervana 2 0.0132 0.1532 0.1513
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.007 0.0717 0.1834
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0038 0.0296 0.0463
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0088 0.0948 0.1519
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Brugia malayi Carboxylesterase family protein 0.0034 0.0234 0.0214
Brugia malayi MH2 domain containing protein 0.0025 0.012 0.0098
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.032 0.03
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0493 0.6269 1
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0028 0.0156 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0315 0.0421
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0229 0.0281
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0821 0.2124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0387 0.0552
Echinococcus multilocularis nervana 2 0.0132 0.1532 0.1513
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0182
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0111 0.0097
Loa Loa (eye worm) calcium ATPase 0.005 0.0443 0.0394
Entamoeba histolytica hypothetical protein 0.011 0.1244 0.2022
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0054 0.0054
Trypanosoma cruzi P-type H+-ATPase, putative 0.0038 0.0296 0.0463
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0088 0.0948 0.1436
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0229 0.0208
Trypanosoma brucei P-type H+-ATPase, putative 0.0056 0.0527 0.0804
Leishmania major katanin, putative,serine peptidase, Clan SJ, family S16, putative 0.0025 0.0125 0.0024
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0018 0.0022 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0821 0.1352
Leishmania major trypanothione reductase 0.0096 0.1053 0.1618
Echinococcus multilocularis calcium transporting atpase 0.007 0.0717 0.0696
Loa Loa (eye worm) fidgetin protein 0.0025 0.0125 0.0072
Schistosoma mansoni axis inhibition protein axin 0.004 0.0315 0.0444
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.006 0.0577 0.053
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0088 0.0948 0.0928
Brugia malayi glutathione reductase 0.0096 0.1053 0.1041
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0809 0.1283
Schistosoma mansoni cation-transporting ATPase 0.0028 0.0156 0.0203
Schistosoma mansoni hypothetical protein 0.0025 0.0125 0.0155
Echinococcus multilocularis vacuolar protein sorting associated protein 4A 0.0025 0.0125 0.0103
Trypanosoma cruzi katanin, putative 0.0025 0.0125 0.0173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0349
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0028 0.0156 0.0164
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0112 0.126 0.1222
Schistosoma mansoni transcription factor LCR-F1 0.011 0.1244 0.1848
Trypanosoma brucei calcium-translocating P-type ATPase 0.007 0.0717 0.1127
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0182
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0182
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0633 0.0587
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0104
Trypanosoma brucei polo-like protein kinase 0.0098 0.1083 0.1749
Echinococcus granulosus axis inhibition protein axin 0.004 0.0315 0.0294
Brugia malayi DKFZp564C0469 protein 0.002 0.0054 0.0032
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0088 0.0948 0.2473
Leishmania major calcium-translocating P-type ATPase 0.0088 0.0948 0.1436
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0223 0.0202
Leishmania major DNA polymerase kappa, putative 0.0078 0.0821 0.122
Echinococcus multilocularis dna polymerase kappa 0.0078 0.0821 0.0801
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0493 0.6269 0.6261
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0315 0.0294
Loa Loa (eye worm) hypothetical protein 0.012 0.1364 0.1327
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.006 0.0577 0.1198
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0315 0.0294
Loa Loa (eye worm) glutathione reductase 0.0096 0.1053 0.1012
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1083 0.1656
Echinococcus granulosus dna polymerase eta 0.0104 0.1153 0.1133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0633 0.0612
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0028 0.0156 0.0283
Schistosoma mansoni hypothetical protein 0.0035 0.0248 0.0341
Trypanosoma brucei unspecified product 0.0054 0.0502 0.0761
Loa Loa (eye worm) Smad1 0.0025 0.012 0.0066
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0229 0.0281
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0431 0.041
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Loa Loa (eye worm) VCP protein 0.0204 0.247 0.2448
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0229 0.0365
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0132 0.1532 0.2284
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.007 0.0717 0.1051
Echinococcus granulosus nervana 2 0.0132 0.1532 0.1513
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0038 0.0024
Schistosoma mansoni Smad4 0.0025 0.012 0.0147
Trypanosoma brucei DNA polymerase eta, putative 0.0104 0.1153 0.1869
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0223 0.0193
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0315 0.0294
Trypanosoma cruzi katanin-like protein, putative 0.0025 0.0125 0.0173
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0088 0.0948 0.1512
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0132 0.1532 0.1513
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1519
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.012 0.0066
Loa Loa (eye worm) carboxylesterase 0.0034 0.0234 0.0182
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0028 0.0156 0.0283
Schistosoma mansoni na+/k+ atpase alpha subunit 0.007 0.0717 0.1051
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.032 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0502 0.0761
Giardia lamblia SKD1 protein 0.0025 0.0125 0.0196
Plasmodium vivax cell division cycle ATPase, putative 0.0178 0.2137 0.3597
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0038 0.0296 0.0277
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0112 0.0091
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0028 0.0156 0.0227
Onchocerca volvulus 0.0034 0.0234 0.0182
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0028 0.0156 0.0249
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0028 0.0156 0.0203
Loa Loa (eye worm) hypothetical protein 0.0028 0.0162 0.011
Plasmodium vivax glutathione reductase, putative 0.0096 0.1053 0.1771
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0229 0.0365
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0111 0.0177
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0028 0.0156 0.0134
Echinococcus granulosus cation transporting ATPase 13A1 0.0028 0.0156 0.0134
Trichomonas vaginalis AAA ATPase, putative 0.0025 0.0125 0.0114
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1083 0.1042
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0028 0.0156 0.0283
Giardia lamblia Copper-transporting P-type ATPase 0.0028 0.0156 0.0283
Trypanosoma brucei unspecified product 0.0054 0.0502 0.0761
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.007 0.0717 0.0696
Plasmodium falciparum thioredoxin reductase 0.0033 0.0229 0.0297
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1083 0.1071
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0467 0.5936 1
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0028 0.0156 0.0283
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.012 0.0098
Plasmodium vivax calcium-transporting ATPase, putative 0.0088 0.0948 0.1593
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0315 0.0444
Echinococcus granulosus BC026374 protein S09 family 0.0034 0.0234 0.0212
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0821 0.1352
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0229 0.0312
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.0234 0.0222
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0223 0.0172
Trypanosoma brucei vesicular transport protein (CDC48 homologue), putative 0.0025 0.0125 0.012
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0049 0.0431 0.0382
Brugia malayi polk-prov protein 0.0024 0.0111 0.009
Loa Loa (eye worm) carboxylesterase 0.0199 0.2412 0.2389
Giardia lamblia AAA family ATPase 0.0295 0.3668 1
Brugia malayi hypothetical protein 0.002 0.0054 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0387 0.0552
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0229 0.0297
Giardia lamblia Kinase, PLK 0.0098 0.1083 0.2847
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0229 0.0297
Entamoeba histolytica ATPase, Vps4 oligomerisation domain containing protein 0.0025 0.0125 0.012
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0028 0.0156 0.0174
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1083 0.1656
Entamoeba histolytica hypothetical protein 0.004 0.0315 0.0445
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0028 0.0156 0.0283
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0054 0.0000043321
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0034 0.0234 0.029
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.005 0.0443 0.0661
Brugia malayi hypothetical protein 0.0034 0.0234 0.0214
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0315 0.0444
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0248 0.0226
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.007 0.0717 0.0696
Trypanosoma brucei calcium-transporting ATPase, putative 0.0042 0.0346 0.0496
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.007 0.0717 0.1175
Echinococcus granulosus transcription factor eb 0.0112 0.1267 0.1248
Brugia malayi ATPase, AAA family protein 0.0025 0.0125 0.0104
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0111 0.0177
Schistosoma mansoni topbp1 0.002 0.0054 0.0048
Echinococcus granulosus cation transporting atpase worm 0.0028 0.0156 0.0134
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0265
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0229 0.0381
Echinococcus multilocularis carboxylesterase 5A 0.0199 0.2412 0.2396
Brugia malayi N-terminal motif family protein 0.0179 0.2141 0.214
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0223 0.0202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.2453 0.2454
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1438
Loa Loa (eye worm) hypothetical protein 0.0049 0.0431 0.0382
Echinococcus granulosus acetylcholinesterase 0.0199 0.2412 0.2396
Echinococcus granulosus geminin 0.052 0.6632 0.6624
Toxoplasma gondii katanin-like family protein 0.0025 0.0125 0.0199
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.267 0.7159
Brugia malayi isocitrate dehydrogenase 0.0033 0.0223 0.0203
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0223 0.0372
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.007 0.0717 0.1051
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0248 0.0226
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0116 0.1323 0.2041
Trypanosoma brucei metalloprotease, putative 0.0025 0.0125 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.267 0.7159
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1519
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0229 0.0207
Trypanosoma brucei katanin, putative 0.0025 0.0125 0.012
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0315 0.0421
Schistosoma mansoni transmemberane protein 0.0132 0.1532 0.2284
Echinococcus granulosus replication factor c subunit 1 0.002 0.0054 0.0032
Schistosoma mansoni z-protein (S1r protein) 0.0049 0.0431 0.0619
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0132 0.1532 0.2284
Onchocerca volvulus 0.0771 0.9925 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.0104 0.0082
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0054 0.0054
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0315 0.0294
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0223 0.0191
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.1053 0.1034
Echinococcus granulosus Na:K ATPase alpha subunit 0.007 0.0717 0.0696
Trypanosoma cruzi katanin-like protein, putative 0.0025 0.0125 0.0173
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0182
Echinococcus granulosus nervana 2 0.0132 0.1532 0.1513
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0229 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0199 0.2412 0.2389
Toxoplasma gondii cation-transporting atpase family protein 0.0018 0.0022 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0431 0.0606
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0431 0.041
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.2992 0.8074
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.007 0.0717 0.0701
Schistosoma mansoni hypothetical protein 0.0064 0.0633 0.0925
Schistosoma mansoni BC026374 protein (S09 family) 0.0034 0.0234 0.0321
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0234 0.0321
Mycobacterium ulcerans ATPase 0.0295 0.3668 1
Onchocerca volvulus 0.0034 0.0234 0.0182
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0132 0.1532 0.2284
Brugia malayi hypothetical protein 0.005 0.0448 0.043
Echinococcus multilocularis nervana 2 0.0132 0.1532 0.1513
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0078 0.0821 0.0801
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0809 0.1359
Trypanosoma brucei katanin, putative 0.0025 0.0125 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1083 0.1605
Toxoplasma gondii P-type ATPase PMA1 0.0056 0.0527 0.0841
Trypanosoma brucei unspecified product 0.0078 0.0821 0.1305
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0054 0.0086
Echinococcus multilocularis cation transporting ATPase 13A1 0.0028 0.0156 0.0134
Schistosoma mansoni cation-transporting atpase worm 0.0028 0.0156 0.0203
Echinococcus multilocularis katanin p60 ATPase containing subunit A1 0.0025 0.0125 0.0103
Plasmodium falciparum vacuolar protein sorting-associated protein 4 0.0025 0.0125 0.012
Trypanosoma cruzi katanin, putative 0.0025 0.0125 0.0173
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0229 0.0349
Brugia malayi MH1 domain containing protein 0.0025 0.012 0.0098
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.2992 0.8074
Brugia malayi PXA domain containing protein 0.004 0.0315 0.0296
Schistosoma mansoni type V p-type atpase isoform 0.0028 0.0156 0.0203
Echinococcus multilocularis dna polymerase eta 0.0104 0.1153 0.1133
Schistosoma mansoni regulator of G protein signaling 0.0049 0.0431 0.0619
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.011 0.1244 0.1848
Brugia malayi Thioredoxin reductase 0.0096 0.1053 0.1041
Giardia lamblia DNA damage repair protein 0.0024 0.0111 0.0158
Plasmodium falciparum glutathione reductase 0.0033 0.0229 0.0297
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.267 0.7159
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0821 0.1894
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0809 0.129
Entamoeba histolytica hypothetical protein 0.011 0.1244 0.2022
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0054 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0315 0.0421
Loa Loa (eye worm) carboxylesterase 0.0034 0.0234 0.0182
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0088 0.0948 0.0928
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1083 0.1656
Mycobacterium ulcerans carboxylesterase, LipT 0.0034 0.0234 0.0498
Echinococcus granulosus dna polymerase kappa 0.0078 0.0821 0.0801
Echinococcus multilocularis copper transporting ATPase 1 0.0028 0.0156 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1083 0.1656
Entamoeba histolytica hypothetical protein 0.004 0.0315 0.0445
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0088 0.0948 0.1565
Schistosoma mansoni gliotactin 0.0034 0.0234 0.0321
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0296
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0315 0.0294
Schistosoma mansoni regulator of G protein signaling 0.004 0.0315 0.0444
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.007 0.0717 0.1051
Trypanosoma cruzi katanin, putative 0.0025 0.0125 0.0173
Brugia malayi calcium ATPase 0.0032 0.0212 0.0191
Brugia malayi hypothetical protein 0.0771 0.9925 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.012 0.0098
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.2141 0.2115
Mycobacterium tuberculosis Putative conserved ATPase 0.0295 0.3668 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.0058
Treponema pallidum cation-transporting ATPase, P-type 0.0028 0.0156 0.6494
Plasmodium falciparum glutathione reductase 0.0096 0.1053 0.1699
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1438
Plasmodium falciparum thioredoxin reductase 0.0096 0.1053 0.1699
Loa Loa (eye worm) hypothetical protein 0.0289 0.359 0.3583
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0034 0.0234 0.0212
Brugia malayi vesicle-fusing ATPase 0.0289 0.359 0.3603
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0821 0.1352
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0028 0.0156 0.0174
Echinococcus multilocularis neuroligin 0.0034 0.0234 0.0212
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0315 0.0421
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0111 0.0183
Schistosoma mansoni regulator of G protein signaling 0.004 0.0315 0.0444
Entamoeba histolytica hypothetical protein 0.011 0.1244 0.2022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0349
Echinococcus granulosus para nitrobenzyl esterase 0.0034 0.0234 0.0212
Entamoeba histolytica cdc48-like protein, putative 0.0467 0.5936 1
Trypanosoma cruzi katanin, putative 0.0025 0.0125 0.0173
Loa Loa (eye worm) hypothetical protein 0.0132 0.1532 0.1497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.1244 0.1224
Schistosoma mansoni axis inhibition protein axin 0.004 0.0315 0.0444
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0025 0.0125 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0111 0.015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0078 0.0821 0.122
Schistosoma mansoni smad1 5 8 and 0.0025 0.012 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0821 0.1305
Trypanosoma brucei vacuolar protein sorting-associated protein 4, putative 0.0025 0.0125 0.012
Trichomonas vaginalis skd/vacuolar sorting, putative 0.0025 0.0125 0.0114
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.007 0.0717 0.0696
Brugia malayi hypothetical protein 0.0077 0.0809 0.0794
Loa Loa (eye worm) hypothetical protein 0.0112 0.126 0.1222
Brugia malayi valosin containing protein 0.0289 0.359 0.3603
Brugia malayi MH2 domain containing protein 0.0367 0.4611 0.4634
Loa Loa (eye worm) hypothetical protein 0.0132 0.1532 0.1497
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0028 0.0156 0.0283
Schistosoma mansoni neuroligin 3 (S09 family) 0.0034 0.0234 0.0321
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0315 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0315 0.0421
Echinococcus multilocularis expressed protein 0.0777 1 1
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0088 0.0948 0.1519
Onchocerca volvulus 0.0088 0.0948 0.0905
Loa Loa (eye worm) hypothetical protein 0.0202 0.2453 0.243
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1083 0.1794
Brugia malayi topoisomerase 0.002 0.0054 0.0032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0315 0.0421
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0234 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.161 0.1604
Trypanosoma cruzi DNA polymerase eta, putative 0.0104 0.1153 0.1912
Schistosoma mansoni terminal deoxycytidyl transferase 0.0078 0.0821 0.1209
Mycobacterium ulcerans hypothetical protein 0.0024 0.0111 0.0158
Trichomonas vaginalis cation-transporting ATPase, putative 0.0088 0.0948 0.1438
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.032 0.0298
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1438
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0229 0.0381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0633 0.0612
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Trypanosoma brucei Valosin-containing protein 0.0467 0.5936 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0104 0.0082
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0182
Schistosoma mansoni ATPase 0.0088 0.0948 0.14
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.005 0.0443 0.0425
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.006 0.0577 0.1779
Trypanosoma cruzi vacuolar protein sorting-associated protein 4, putative 0.0025 0.0125 0.0173
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.006 0.0577 0.1446
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0349
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1438
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0315 0.0294
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0315 0.0294
Trypanosoma brucei P-type H+-ATPase, putative 0.0056 0.0527 0.0804
Brugia malayi fidgetin protein 0.0025 0.0125 0.0104
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0111 0.015
Leishmania major DNA polymerase eta, putative 0.0104 0.1153 0.1789
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.2453 0.2454
Leishmania major hypothetical protein, conserved 0.0077 0.0809 0.1198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.1244 0.1224
Brugia malayi PXA domain containing protein 0.004 0.0315 0.0296
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0315 0.0294
Loa Loa (eye worm) hypothetical protein 0.0179 0.2141 0.2115
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0229 0.0297
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0202
Loa Loa (eye worm) hypothetical protein 0.0077 0.0809 0.0765
Onchocerca volvulus 0.0132 0.1532 0.1497
Trypanosoma cruzi vacuolar transport protein 4A, putative 0.0025 0.0125 0.0173
Brugia malayi Smad1 0.0025 0.012 0.0098
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0229 0.0297
Loa Loa (eye worm) hypothetical protein 0.0038 0.0296 0.0245
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0042 0.0346 0.0327
Schistosoma mansoni DNA ligase IV 0.002 0.0054 0.0048
Schistosoma mansoni hypothetical protein 0.052 0.6632 1
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0431 0.041
Echinococcus granulosus copper transporting ATPase 1 0.0028 0.0156 0.0134
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0229 0.0483
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.007 0.0717 0.1175
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.1053 0.1744
Leishmania major P-type H -ATPase, putative 0.0056 0.0527 0.0714
Loa Loa (eye worm) hypothetical protein 0.0199 0.2412 0.2389
Loa Loa (eye worm) hypothetical protein 0.0138 0.161 0.1577
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0493 0.6269 0.6297
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0088 0.0948 0.1519
Schistosoma mansoni serine/threonine protein kinase 0.004 0.032 0.045
Trypanosoma cruzi P-type H+-ATPase, putative 0.0056 0.0527 0.0854
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.267 0.7159
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0229 0.0297
Brugia malayi Carboxylesterase family protein 0.0199 0.2412 0.2414
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0229 0.0483
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0202
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0633 0.0617
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0229 0.0297
Brugia malayi Na,K-ATPase alpha subunit 0.0088 0.0948 0.0935
Echinococcus multilocularis acetylcholinesterase 0.0199 0.2412 0.2396
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0349
Leishmania major vacuolar protein sorting-associated protein 4 0.0025 0.0125 0.0024
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0018 0.0022 0.0035
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0315 0.0296
Entamoeba histolytica hypothetical protein 0.004 0.0315 0.0445
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0054 0.0000040997
Trichomonas vaginalis cation-transporting ATPase, putative 0.0088 0.0948 0.1438
Trichomonas vaginalis spastin, putative 0.0025 0.0125 0.0114
Leishmania major proton motive ATPase, putative 0.0028 0.0156 0.0078
Echinococcus granulosus carboxylesterase 5A 0.0199 0.2412 0.2396
Trichomonas vaginalis skd/vacuolar sorting, putative 0.0025 0.0125 0.0114
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1438
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.007 0.0717 0.1051
Onchocerca volvulus 0.0132 0.1532 0.1497
Trichomonas vaginalis AAA ATPase, putative 0.0025 0.0125 0.0114
Schistosoma mansoni ATPase 0.0088 0.0948 0.14
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0042 0.0346 0.0547
Schistosoma mansoni serine/threonine protein kinase 0.004 0.032 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0229 0.0349
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0132 0.1532 0.1513
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0028 0.0156 0.0135
Leishmania major calcium-transporting ATPase, putative 0.007 0.0717 0.104
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.007 0.0717 0.0696
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0028 0.0156 0.0164
Trypanosoma cruzi Valosin-containing protein, putative 0.0467 0.5936 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0088 0.0948 0.1519
Schistosoma mansoni kinase 0.005 0.0448 0.0644
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0028 0.0156 0.0174
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.2992 0.8074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0104
Trypanosoma cruzi metalloprotease, putative 0.0025 0.0125 0.0173
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.007 0.0717 0.1066
Toxoplasma gondii thioredoxin reductase 0.0096 0.1053 0.168
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.012 0.0098
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0088 0.0948 0.0928
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0315 0.0265
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0032 0.0212 0.0321
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1083 0.1669
Trypanosoma brucei katanin, putative 0.0025 0.0125 0.012
Echinococcus multilocularis BC026374 protein (S09 family) 0.0034 0.0234 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0111 0.0097
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.032 0.0298
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.007 0.0717 0.0696
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0467 0.5936 0.8947
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0088 0.0948 0.1519
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1083 0.1042
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1083 0.1656
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.032 0.0269
Loa Loa (eye worm) hypothetical protein 0.0088 0.0948 0.0905
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.0821 0.1235
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0223 0.0288
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0234 0.0321
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0223 0.0202
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.267 0.7159
Trypanosoma brucei trypanothione reductase 0.0096 0.1053 0.1699
Giardia lamblia DINP protein human, muc B family 0.0078 0.0821 0.2124
Loa Loa (eye worm) hypothetical protein 0.0104 0.1153 0.1113
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0028 0.0156 0.0174
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0223 0.0288
Echinococcus multilocularis fidgetin protein 1 0.0025 0.0125 0.0103
Brugia malayi Carboxylesterase family protein 0.0034 0.0234 0.0214
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0431 0.0606
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0223 0.0288
Brugia malayi Carboxylesterase family protein 0.0034 0.0234 0.0214
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0315 0.0296
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0088 0.0948 0.1436
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.005 0.0443 0.0661
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0387 0.0365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0387 0.0365
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0132 0.1532 0.1513
Echinococcus granulosus smad 0.0025 0.012 0.0098
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.007 0.0717 0.1143
Brugia malayi hypothetical protein 0.004 0.0315 0.0296
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1083 0.1794
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0078 0.0821 0.1894
Entamoeba histolytica hypothetical protein 0.011 0.1244 0.2022
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0431 0.041
Echinococcus granulosus vacuolar protein sorting associated protein 4A 0.0025 0.0125 0.0103
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0467 0.5936 1
Loa Loa (eye worm) ATPase 0.0025 0.0125 0.0072
Leishmania major P-type H -ATPase, putative 0.0056 0.0527 0.0714
Brugia malayi E1-E2 ATPase family protein 0.0056 0.0527 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0821 0.1305
Loa Loa (eye worm) hypothetical protein 0.0028 0.0162 0.011
Echinococcus multilocularis cation transporting atpase worm 0.0028 0.0156 0.0134
Loa Loa (eye worm) vps4b-prov protein 0.0025 0.0125 0.0072
Brugia malayi E1-E2 ATPase family protein 0.0028 0.0156 0.0135
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0034 0.0234 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.004 0.032 0.045
Loa Loa (eye worm) vesicle-fusing ATPase 0.0289 0.359 0.3583
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0315 0.0444
Brugia malayi MH2 domain containing protein 0.0025 0.012 0.0098
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0088 0.0948 0.0928
Schistosoma mansoni hypothetical protein 0.0064 0.0633 0.0925
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0229 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0034 0.0234 0.0222
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0025 0.0125 0.0024
Brugia malayi MH1 domain containing protein 0.0025 0.012 0.0098
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0809 0.1283
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0349
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0088 0.0948 0.1565
Entamoeba histolytica deoxycytidyl transferase, putative 0.0078 0.0821 0.1305
Loa Loa (eye worm) hypothetical protein 0.0771 0.9925 1
Schistosoma mansoni topbp1 0.002 0.0054 0.0048
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0132 0.1532 0.1513
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0821 0.1305
Trypanosoma cruzi P-type H+-ATPase, putative 0.0056 0.0527 0.0854
Giardia lamblia SKD1 protein 0.0025 0.0125 0.0196
Echinococcus granulosus axis inhibition protein axin 0.004 0.0315 0.0294
Brugia malayi hypothetical protein 0.011 0.1244 0.1233
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0387 0.0368
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0156 0.0164
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0204 0.247 0.3704
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0088 0.0948 0.1519
Onchocerca volvulus 0.0034 0.0234 0.0182
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0088 0.0948 0.0928
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1083 0.1063
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0229 0.0483
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0315 0.0296
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0229 0.0349
Brugia malayi SAP1 protein 0.0025 0.0125 0.0104
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0229 0.0202
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0116 0.1323 0.2041
Schistosoma mansoni regulator of G protein signaling 0.004 0.0315 0.0444
Leishmania major P-type ATPase, putative 0.007 0.0717 0.104
Echinococcus multilocularis Smad4 0.0025 0.012 0.0098
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0223 0.0202
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0028 0.0156 0.0164
Echinococcus granulosus fidgetin protein 1 0.0025 0.0125 0.0103
Loa Loa (eye worm) acetylcholinesterase 1 0.0199 0.2412 0.2389
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0809 0.1283
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0054 0.0032
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.0443 0.0706
Echinococcus multilocularis acetylcholinesterase 0.0199 0.2412 0.2396
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0038 0.0296 0.0472
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0223 0.0356
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0028 0.0156 0.0348
Onchocerca volvulus 0.0034 0.0234 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.016
Echinococcus granulosus cation transporting ATPase 13A3 0.0028 0.0156 0.0134
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1083 0.1063
Giardia lamblia Katanin 0.0025 0.0125 0.0196
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0633 0.0617
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.012 0.0147
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0078 0.0821 0.0778
Treponema pallidum DNA ligase (lig) 0.002 0.0054 0.1544
Trypanosoma brucei cation-transporting ATPase, putative 0.0028 0.0156 0.0174
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0132 0.1532 0.1513
Trypanosoma brucei katanin, putative 0.0025 0.0125 0.012
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0223 0.0202
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0088 0.0948 0.14
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0821 0.2124
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0132 0.1532 0.1513
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0028 0.0156 0.0227
Loa Loa (eye worm) hypothetical protein 0.0064 0.0633 0.0587
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0633 0.0612
Loa Loa (eye worm) RecQ helicase 0.0024 0.0104 0.005
Echinococcus granulosus nervana 2 0.0132 0.1532 0.1513
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0054 0.0032
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0104 0.008
Brugia malayi hypothetical protein 0.004 0.0315 0.0296
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.006 0.0577 0.056
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0223 0.0356
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0104 0.008
Echinococcus granulosus nibrin 0.002 0.0054 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0809 0.133
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0028 0.0156 0.0174
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0028 0.0156 0.0348
Echinococcus multilocularis cation transporting ATPase 13A3 0.0028 0.0156 0.0134
Schistosoma mansoni acetylcholinesterase 0.0034 0.0234 0.0321
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0223 0.0202
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0042 0.0346 0.0296
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.012 0.0098
Plasmodium vivax cation transporting ATPase, putative 0.0028 0.0156 0.0259
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0111 0.015
Echinococcus granulosus nervana 2 0.0132 0.1532 0.1513
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0104 0.0082
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0111 0.0097
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0219 0.267 0.8906
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0502 0.0761
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0028 0.0156 0.0135
Toxoplasma gondii cell division protein CDC48CY 0.0493 0.6269 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0821 0.1352
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.1053 0.1012
Brugia malayi calcium ATPase 0.0038 0.0296 0.0277
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1083 0.1656
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.1053 0.2555
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0088 0.0948 0.2473
Schistosoma mansoni hypothetical protein 0.0064 0.0633 0.0925
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.0821 0.1235
Echinococcus multilocularis nibrin 0.002 0.0054 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.0367 0.4611 0.4616
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0223 0.0304
Trypanosoma cruzi vesicular transport protein (CDC48 homologue), putative 0.0025 0.0125 0.0173
Schistosoma mansoni copper ABC transporter ATPase 0.0028 0.0156 0.0203
Schistosoma mansoni skd/vacuolar sorting 0.0025 0.0125 0.0155
Brugia malayi vps4b-prov protein 0.0025 0.0125 0.0104
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0054 0.0086
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0132 0.1532 0.1513
Echinococcus granulosus calcium transporting atpase 0.007 0.0717 0.0696
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.2992 1
Brugia malayi hypothetical protein 0.002 0.0054 0.0032
Schistosoma mansoni cation-transporting atpase worm 0.0028 0.0156 0.0203
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0066 0.002
Schistosoma mansoni DNA polymerase eta 0.0104 0.1153 0.1711
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0467 0.5936 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0229 0.0349
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0038 0.0296 0.0463
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0028 0.0156 0.0134
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0078 0.0821 0.1209
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1083 0.1749
Loa Loa (eye worm) E1-E2 ATPase 0.0056 0.0527 0.0479
Echinococcus multilocularis GPCR, family 2 0.0064 0.0633 0.0612
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0054 0.0000040997
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0387 0.0552
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0088 0.0948 0.0928
Leishmania major copper-transporting ATPase-like protein, putative 0.0028 0.0156 0.0078
Trichomonas vaginalis spcc417.12 protein, putative 0.0034 0.0234 0.029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.2453 0.243
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0111 0.0097
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0229 0.0206
Echinococcus granulosus neuroligin 0.0034 0.0234 0.0212
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0054 0.0054
Treponema pallidum NADH oxidase 0.0033 0.0229 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0088 0.0948 0.1438
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0111 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0315 0.0421
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0038 0.0296 0.0245
Echinococcus multilocularis smad 0.0025 0.012 0.0098
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0088 0.0948 0.0905
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0265
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0038 0.0296 0.0412
Plasmodium vivax copper-transporting ATPase, putative 0.0028 0.0156 0.0259
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0265
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0229 1
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0821 0.0807
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.012 0.0066
Trypanosoma brucei calcium motive p-type ATPase, putative 0.007 0.0717 0.1127

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 100 ug/ml by BACTEC MGIT method ChEMBL. No reference
Inhibition (functional) = 95 % Antimicrobial activity against Mycobacterium tuberculosis H37Rv by Lowenstein and Jensen method ChEMBL. No reference
IZ (functional) = 21 mm Antimicrobial activity against Candida albicans MTCC 183 by paper-disk diffusion method ChEMBL. No reference
IZ (functional) = 21 mm Antimicrobial activity against Escherichia coli MTCC 739 by paper disk diffusion method ChEMBL. No reference
MIC (functional) > 6.25 ug ml-1 Antimicrobial activity against Mycobacterium tuberculosis H37Rv by BACTEC MGIT method ChEMBL. No reference
MIC (functional) = 100 ug ml-1 Antimicrobial activity against Escherichia coli MTCC 739 by agar streak dilution method ChEMBL. No reference
MIC (functional) = 100 ug ml-1 Antimicrobial activity against Candida albicans MTCC 183 by agar streak dilution method ChEMBL. No reference
MIC (functional) = 500 ug ml-1 Antimicrobial activity against Mycobacterium tuberculosis H37Rv by Lowenstein and Jensen method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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