Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TYRO3 protein tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | AXL receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | MER proto-oncogene, tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008957,Fibronectin, type III-like fold,domain-containing | Get druggable targets OG5_132328 | All targets in OG5_132328 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | ephrin receptor | 0.0018 | 0.2163 | 0.2684 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0018 | 0.2163 | 0.2163 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0017 | 0.194 | 0.2407 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0017 | 0.194 | 0.194 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0017 | 0.1982 | 0.1982 |
Echinococcus multilocularis | neuroglian | 0.0021 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0021 | 0.3922 | 0.6452 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0025 | 0.6078 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0021 | 0.3922 | 0.4866 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.194 | 0.2407 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.3922 | 0.4866 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0018 | 0.2163 | 0.2163 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0703 | 0.1156 |
Schistosoma mansoni | cell adhesion molecule | 0.0028 | 0.806 | 1 |
Brugia malayi | protein unc-22 | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Echinococcus granulosus | twitchin | 0.0015 | 0.0662 | 0.0662 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0017 | 0.194 | 0.194 |
Schistosoma mansoni | nephrin | 0.0028 | 0.8018 | 0.9949 |
Schistosoma mansoni | neuroglian | 0.0021 | 0.3922 | 0.4866 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | myosin-binding protein-related | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | titin | 0.0017 | 0.194 | 0.2407 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0019 | 0.2866 | 0.4715 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0019 | 0.2866 | 0.4715 |
Schistosoma mansoni | nephrin | 0.0021 | 0.3922 | 0.4866 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.3922 | 0.6452 |
Schistosoma mansoni | hemicentin | 0.0017 | 0.194 | 0.2407 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | titin | 0.0017 | 0.194 | 0.194 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0017 | 0.1982 | 0.1982 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | titin | 0.0017 | 0.194 | 0.194 |
Echinococcus granulosus | nephrin | 0.0017 | 0.194 | 0.194 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0021 | 0.3922 | 0.6452 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.6078 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | titin | 0.0017 | 0.194 | 0.194 |
Loa Loa (eye worm) | projectin | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.1982 | 0.326 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.3922 | 0.4866 |
Echinococcus granulosus | neuroglian | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0025 | 0.6078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.1982 | 0.326 |
Schistosoma mansoni | cell adhesion molecule | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | contactin | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0703 | 0.0703 |
Echinococcus multilocularis | neuroglian | 0.0015 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Echinococcus granulosus | neuroglian | 0.0015 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2643 | 0.4349 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2643 | 0.4349 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | titin | 0.0017 | 0.194 | 0.2407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 1.3 % | Oral bioavailability in mouse at 3 mg/kg | ChEMBL. | 24195762 |
IC50 (binding) | = 0.7 nM | Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
IC50 (binding) | = 28 nM | Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
IC50 (binding) | = 72 nM | Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.