Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MER proto-oncogene, tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | AXL receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | TYRO3 protein tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008957,Fibronectin, type III-like fold,domain-containing | Get druggable targets OG5_132328 | All targets in OG5_132328 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fibronectin type III domain containing protein | 0.0025 | 0.6078 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus granulosus | neuroglian | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.3922 | 0.4866 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2643 | 0.4349 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2643 | 0.4349 |
Echinococcus granulosus | neuroglian | 0.0015 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Schistosoma mansoni | titin | 0.0017 | 0.194 | 0.2407 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | cell adhesion molecule | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.1982 | 0.326 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | neuroglian | 0.0015 | 0.0662 | 0.0662 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0703 | 0.0703 |
Echinococcus granulosus | contactin | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | hemicentin | 0.0017 | 0.194 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.3922 | 0.6452 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | titin | 0.0017 | 0.194 | 0.194 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0019 | 0.2866 | 0.4715 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | titin | 0.0017 | 0.194 | 0.2407 |
Schistosoma mansoni | nephrin | 0.0021 | 0.3922 | 0.4866 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0019 | 0.2866 | 0.4715 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.6078 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0021 | 0.3922 | 0.6452 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.1982 | 0.326 |
Loa Loa (eye worm) | projectin | 0.0017 | 0.194 | 0.3192 |
Echinococcus granulosus | titin | 0.0017 | 0.194 | 0.194 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | nephrin | 0.0017 | 0.194 | 0.194 |
Echinococcus multilocularis | titin | 0.0017 | 0.194 | 0.194 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0017 | 0.1982 | 0.1982 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0662 | 0.0662 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Brugia malayi | protein unc-22 | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | cell adhesion molecule | 0.0028 | 0.806 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | nephrin | 0.0028 | 0.8018 | 0.9949 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0017 | 0.194 | 0.194 |
Schistosoma mansoni | myosin-binding protein-related | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | neuroglian | 0.0021 | 0.3922 | 0.4866 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | cell adhesion molecule | 0.0017 | 0.194 | 0.2407 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0018 | 0.2163 | 0.2163 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0021 | 0.3922 | 0.3922 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0017 | 0.194 | 0.194 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | ephrin receptor | 0.0018 | 0.2163 | 0.2684 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0017 | 0.194 | 0.3192 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0018 | 0.2163 | 0.2163 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.3922 | 0.4866 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.194 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0703 | 0.1156 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.194 | 0.3192 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0021 | 0.3922 | 0.6452 |
Echinococcus multilocularis | neuroglian | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0017 | 0.1982 | 0.1982 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0021 | 0.3922 | 0.4866 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0025 | 0.6078 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.81 nM | Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
IC50 (binding) | = 21 nM | Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
IC50 (binding) | = 70 nM | Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.