Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0144 | 0.4649 | 0.5 |
Echinococcus granulosus | geminin | 0.0188 | 0.6962 | 0.4322 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0144 | 0.4649 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0144 | 0.4649 | 0.4649 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0188 | 0.6943 | 0.4287 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0144 | 0.4649 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0144 | 0.4649 | 0.4649 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0144 | 0.4649 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.6962 | 0.4322 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0226 | 0.8927 | 0.8927 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0144 | 0.4649 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0144 | 0.4649 | 0.4649 |
Echinococcus multilocularis | geminin | 0.0188 | 0.6962 | 0.4322 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8927 | 0.8927 |
Loa Loa (eye worm) | alpha amylase | 0.0144 | 0.4649 | 0.4649 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.6962 | 0.4322 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0188 | 0.6943 | 0.4287 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12 nM | Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay | ChEMBL. | 24440478 |
IC50 (binding) | = 28 nM | Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay | ChEMBL. | 24440478 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.