Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein kinase shaggy | 0.0082 | 0.0978 | 0.1211 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0341 | 0.6472 | 0.8202 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0507 | 1 | 1 |
Mycobacterium ulcerans | chorismate synthase | 0.0204 | 0.3559 | 0.3256 |
Chlamydia trachomatis | chorismate synthase | 0.0204 | 0.3559 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0082 | 0.0978 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Echinococcus granulosus | protein kinase shaggy | 0.0082 | 0.0978 | 0.1211 |
Loa Loa (eye worm) | carboxylesterase | 0.0058 | 0.045 | 0.057 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0082 | 0.0978 | 0.1211 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0082 | 0.0978 | 0.1211 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0058 | 0.045 | 0.4459 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.6472 | 0.8202 |
Brugia malayi | Carboxylesterase family protein | 0.0341 | 0.6472 | 0.8196 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0041 | 0.009 | 0.0083 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0082 | 0.0978 | 0.1211 |
Plasmodium vivax | chorismate synthase | 0.0204 | 0.3559 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0058 | 0.045 | 0.054 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0101 | 0.1362 | 0.0956 |
Onchocerca volvulus | 0.0082 | 0.0978 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0082 | 0.0978 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0068 | 0.0679 | 0.0832 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | insulin receptor | 0.0041 | 0.009 | 0.0083 |
Echinococcus multilocularis | neuroligin | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0341 | 0.6472 | 0.8196 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0082 | 0.0978 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0068 | 0.0679 | 0.0832 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0082 | 0.0978 | 0.2695 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.0978 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | neuroligin | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0068 | 0.0679 | 0.0832 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0127 | 0.1932 | 0.2424 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0082 | 0.0978 | 0.2695 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0408 | 0.789 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.009 | 0.0083 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.0978 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0041 | 0.009 | 0.0083 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0507 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0058 | 0.045 | 0.054 |
Schistosoma mansoni | acetylcholinesterase | 0.0058 | 0.045 | 0.054 |
Brugia malayi | Carboxylesterase family protein | 0.0341 | 0.6472 | 0.8196 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0041 | 0.009 | 0.0114 |
Brugia malayi | intracellular kinase | 0.0082 | 0.0978 | 0.1211 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0507 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0408 | 0.789 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0127 | 0.1932 | 0.2448 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0082 | 0.0978 | 0.2695 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0341 | 0.6472 | 0.8196 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0058 | 0.045 | 0.054 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0978 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.009 | 0.0083 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0082 | 0.0978 | 0.1239 |
Echinococcus multilocularis | 0.0039 | 0.0063 | 0.0048 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0408 | 0.789 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0408 | 0.789 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.6472 | 0.8202 |
Trypanosoma brucei | protein kinase, putative | 0.0082 | 0.0978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | insulin receptor | 0.0041 | 0.009 | 0.0083 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Giardia lamblia | Kinase, CMGC GSK | 0.0082 | 0.0978 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0127 | 0.1932 | 0.2424 |
Loa Loa (eye worm) | carboxylesterase | 0.0058 | 0.045 | 0.057 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Plasmodium falciparum | chorismate synthase | 0.0204 | 0.3559 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Mycobacterium leprae | Isocitrate lyase | 0.0238 | 0.4276 | 0.3373 |
Loa Loa (eye worm) | carboxylesterase | 0.0341 | 0.6472 | 0.8202 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0978 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0127 | 0.1932 | 0.2424 |
Echinococcus granulosus | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.009 | 0.0083 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0408 | 0.789 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0058 | 0.045 | 0.054 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0679 | 0.0832 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0127 | 0.1932 | 0.2424 |
Schistosoma mansoni | gliotactin | 0.0058 | 0.045 | 0.054 |
Toxoplasma gondii | chorismate synthase, putative | 0.0204 | 0.3559 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0341 | 0.6472 | 0.8196 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0058 | 0.045 | 0.4459 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0082 | 0.0978 | 0.1239 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0679 | 0.0832 |
Brugia malayi | hypothetical protein | 0.0058 | 0.045 | 0.054 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.0978 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.