Detailed information for compound 208080

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.239 | Formula: C17H15Cl2N5O2--
  • H donors: 1 H acceptors: 3 LogP: 4.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(NCc1ccco1)nc(n2)n1cncc1.[Cl-].[Cl-]
  • InChi: 1S/C17H15N5O2.2ClH/c1-23-12-4-5-15-14(9-12)16(19-10-13-3-2-8-24-13)21-17(20-15)22-7-6-18-11-22;;/h2-9,11H,10H2,1H3,(H,19,20,21);2*1H/p-2
  • InChiKey: GMBYFHZUUQFJIK-UHFFFAOYSA-L  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0139 0.0393 0.0692
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0027 0.0028
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0177 0.0167
Schistosoma mansoni cell polarity protein 0.0024 0.0013 0.0004
Brugia malayi hypothetical protein 0.004 0.0067 0.0101
Echinococcus granulosus adam 0.003 0.0032 0.0021
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0046 0.0087 0.0134
Schistosoma mansoni hypothetical protein 0.0028 0.0027 0.0028
Brugia malayi Melatonin receptor type 1A 0.0028 0.0027 0.0028
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0136 0.0382 0.0542
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0027 0.0048
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.1703 0.5536 1
Brugia malayi putative neuropeptide receptor 0.0028 0.0027 0.0028
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0136 0.0382 0.0542
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0027 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0128 0.0357 0.0706
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus granulosus integrin beta 2 0.0679 0.2169 0.216
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0027 0.0016
Schistosoma mansoni hypothetical protein 0.0028 0.0027 0.0028
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus granulosus orexin receptor type 2 0.0028 0.0027 0.0016
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0177 0.0301
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.01 0.0182
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1703 0.5536 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Brugia malayi Guanylate kinase family protein 0.0026 0.0021 0.0018
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0027 0.0016
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0042 0.0031
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Brugia malayi AKH receptor 0.0028 0.0027 0.0028
Mycobacterium ulcerans transcriptional regulator NrdR 0.0195 0.0576 0.1156
Schistosoma mansoni serine-type protease inhibitor 0.0437 0.1372 0.2464
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0128 0.0357 0.0706
Echinococcus granulosus sex peptide receptor 0.0028 0.0027 0.0016
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0027 0.0016
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0027 0.0016
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0104 0.019
Echinococcus granulosus neuropeptide receptor 0.0028 0.0027 0.0016
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.1508 0.4894 1
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0027 0.0048
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0027 0.0016
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0027 0.0048
Echinococcus granulosus fmrfamide receptor 0.0028 0.0027 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0128 0.0357 0.0706
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0027 0.0048
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0136 0.0382 0.0671
Schistosoma mansoni hypothetical protein 0.0028 0.0027 0.0028
Brugia malayi neuropeptide F receptor 0.0028 0.0027 0.0028
Brugia malayi Dopamine receptor protein 1 0.0028 0.0027 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3061 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0051 0.0104 0.0093
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.1703 0.5536 0.5531
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0058
Brugia malayi follicle stimulating hormone receptor 0.0028 0.0027 0.0028
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0042 0.0063
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0027 0.0016
Brugia malayi Dopamine receptor protein 2 0.0028 0.0027 0.0028
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.1703 0.5536 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0345 0.0682
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0027 0.0048
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0042 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0128 0.0357 0.0706
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0027 0.0048
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Brugia malayi G protein-coupled receptor 0.0028 0.0027 0.0028
Echinococcus granulosus g protein coupled receptor 0.0028 0.0027 0.0016
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0027 0.0016
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.0027 0.0016
Schistosoma mansoni amine GPCR 0.0028 0.0027 0.0028
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0139 0.0393 0.071
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0051 0.0104 0.0168
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0027 0.0016
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.1508 0.4894 1
Brugia malayi Cell death protein 3 precursor 0.0057 0.0123 0.0203
Brugia malayi EGF-like domain containing protein 0.003 0.0032 0.0038
Toxoplasma gondii hypothetical protein 0.0065 0.0148 0.0247
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0027 0.0016
Brugia malayi Serotonin receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis serotonin receptor 0.0028 0.0027 0.0016
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0136 0.0382 0.0542
Loa Loa (eye worm) proteasome subunit beta type 1 0.0051 0.0104 0.0188
Brugia malayi EGF-like domain containing protein 0.003 0.0032 0.0038
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0027 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0027 0.0016
Brugia malayi ORL1-like opioid receptor 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni amine GPCR 0.0028 0.0027 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Schistosoma mansoni amine GPCR 0.0028 0.0027 0.0028
Schistosoma mansoni biogenic amine receptor 0.0028 0.0027 0.0028
Brugia malayi sulfakinin receptor protein 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0139 0.0393 0.071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0128 0.0357 0.0706
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0051 0.0104 0.0168
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0128 0.0357 0.0706
Loa Loa (eye worm) hypothetical protein 0.0057 0.0123 0.0223
Brugia malayi proteasome subunit beta type 1 0.0051 0.0104 0.0168
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0196 0.0578 0.1026
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0027 0.0016
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0027 0.0048
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0177 0.034
Schistosoma mansoni neuropeptide receptor 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0058
Echinococcus multilocularis fibrillin 2 0.003 0.0032 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0067 0.0121
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.1703 0.5536 1
Onchocerca volvulus 0.004 0.0067 0.4144
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0027 0.0016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0027 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0196 0.0578 0.1026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Brugia malayi GnHR receptor homolog 0.0028 0.0027 0.0028
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Schistosoma mansoni hypothetical protein 0.004 0.0067 0.0101
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0012 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Plasmodium vivax proteasome subunit beta type-1, putative 0.0051 0.0104 0.0166
Echinococcus granulosus allatostatin A receptor 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.1703 0.5536 1
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0051 0.0104 0.0093
Echinococcus multilocularis disks large 3 0.0024 0.0013 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.0375 0.0658
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0042 0.0063
Loa Loa (eye worm) rad51 0.0023 0.0011 0.002
Echinococcus multilocularis GPCR, family 2 0.0062 0.0139 0.0128
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0177 0.0166
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0051 0.0104 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0027 0.0028
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus multilocularis serotonin receptor 0.0028 0.0027 0.0016
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0027 0.0016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0027 0.0016
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0027 0.0016
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0046 0.0087 0.0152
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0139 0.0128
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.1703 0.5536 1
Echinococcus granulosus fibrillin 2 0.003 0.0032 0.0021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0177 0.0166
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0012 0.0002
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0177 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0027 0.0016
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0136 0.0382 0.0671
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0046 0.0087 0.0152
Echinococcus granulosus disks large 3 0.0024 0.0013 0.0002
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0542 0.1718 0.3494
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0136 0.0382 0.0371
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0139 0.0231
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0139 0.0128
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0027 0.0028
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Schistosoma mansoni hypothetical protein 0.0104 0.0279 0.0484
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0128 0.0357 0.0706
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0027 0.0048
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0136 0.0382 0.0671
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0027 0.0016
Schistosoma mansoni serine-type protease inhibitor 0.0437 0.1372 0.2464
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0027 0.0028
Giardia lamblia Proteasome subunit beta type 1 0.0051 0.0104 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0027 0.0016
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0027 0.0016
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0128 0.0357 0.0706
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0128 0.0357 0.0706
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Toxoplasma gondii hypothetical protein 0.0023 0.0012 0.0002
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0042 0.0031
Echinococcus granulosus fibrillin 1 0.003 0.0032 0.0021
Chlamydia trachomatis transcriptional repressor NrdR 0.0195 0.0576 0.0378
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0128 0.0357 0.0706
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0022 0.0009 0.0016
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0042 0.0056
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0067 0.0056
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0027 0.0016
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0136 0.0382 0.0671
Echinococcus granulosus g protein coupled receptor 0.0028 0.0027 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Toxoplasma gondii hypothetical protein 0.0023 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni neuropeptide receptor 0.0028 0.0027 0.0028
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0027 0.0016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Trypanosoma brucei proteasome beta 6 subunit 0.0051 0.0104 0.0032
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0027 0.0016
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0067 0.0056
Schistosoma mansoni histamine h1 receptor 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni hypothetical protein 0.0062 0.0139 0.0231
Mycobacterium leprae conserved hypothetical protein 0.0195 0.0576 0.1156
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0051 0.0104 0.0166
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0027 0.0016
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0027 0.0028
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0051 0.0104 0.0168
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0027 0.0016
Schistosoma mansoni hypothetical protein 0.0028 0.0027 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0148 0.0279
Schistosoma mansoni integrin beta subunit 0.054 0.1711 0.3076
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0139 0.0128
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0177 0.0167
Schistosoma mansoni hypothetical protein 0.0062 0.0139 0.0231
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0027 0.0028
Brugia malayi RE15519p 0.0028 0.0027 0.0028
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0128 0.0357 0.0706
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0177 0.0301
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0027 0.0016
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0128 0.0357 0.0706
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0136 0.0382 0.0671
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0027 0.0016
Echinococcus granulosus serotonin receptor 0.0028 0.0027 0.0016
Brugia malayi neuropeptide F receptor 0.0028 0.0027 0.0028
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.1508 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0058
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0027 0.0016
Echinococcus granulosus neuropeptide receptor 0.0028 0.0027 0.0016
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0042 0.0063
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0027 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0196 0.0578 0.1044
Schistosoma mansoni hypothetical protein 0.0134 0.0375 0.0658
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0128 0.0357 0.0706
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Echinococcus multilocularis somatostatin receptor 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Schistosoma mansoni amine GPCR 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0136 0.0382 0.069
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Brugia malayi G-protein coupled receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0128 0.0357 0.0706
Brugia malayi G-protein coupled receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0027 0.0048
Schistosoma mansoni opsin-like receptor 0.0028 0.0027 0.0028
Schistosoma mansoni neuropeptide receptor 0.0028 0.0027 0.0028
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0128 0.0357 0.0706
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.01 0.0161
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0136 0.0382 0.0671
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.0027 0.0048
Echinococcus multilocularis caspase 2 0.0057 0.0123 0.0112
Mycobacterium leprae putative cytochrome p450 0.0128 0.0357 0.0706
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0074 0.0177 0.0301
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0027 0.0016
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus multilocularis sex peptide receptor 0.0028 0.0027 0.0016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0027 0.0028
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0027 0.0028
Loa Loa (eye worm) integrin beta-2 0.0917 0.295 0.533
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.1508 0.4894 1
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0027 0.0016
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.1703 0.5536 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0195 0.0576 0.1156
Schistosoma mansoni adenoreceptor 0.0028 0.0027 0.0028
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0027 0.0028
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0027 0.0016
Schistosoma mansoni biogenic amine receptor 0.0028 0.0027 0.0028
Schistosoma mansoni opsin-like receptor 0.0028 0.0027 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni opsin-like receptor 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0136 0.0382 0.0542
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0027 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0027 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0128 0.0357 0.0706
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0027 0.0016
Brugia malayi EGF-like domain containing protein 0.003 0.0032 0.0038
Brugia malayi larval opioid receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis adam 0.003 0.0032 0.0021
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0027 0.0016
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Mycobacterium ulcerans oxidoreductase 0.0125 0.0345 0.0682
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0177 0.0301
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0027 0.0048
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0136 0.0382 0.0371
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0128 0.0357 0.0706
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0027 0.0028
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.0123 0.0203
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0027 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni amine GPCR 0.0028 0.0027 0.0028
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0128 0.0357 0.0706
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0027 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0148 0.0279
Echinococcus multilocularis protein jagged 2 0.003 0.0032 0.0021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0027 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0148 0.0279
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0128 0.0357 0.0706
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0128 0.0357 0.0706
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0051 0.0104 0.0168
Echinococcus multilocularis fibrillin 1 0.003 0.0032 0.0021
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.1703 0.5536 1
Schistosoma mansoni biogenic amine receptor 0.0028 0.0027 0.0028
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0463 0.1457 0.2616
Echinococcus granulosus g protein coupled receptor 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0062 0.0139 0.025
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0076
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0128 0.0357 0.0706
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0027 0.0028
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0027 0.0016
Echinococcus granulosus caspase 2 0.0057 0.0123 0.0112
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.1703 0.5536 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.01 0.0182
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0027 0.0028
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0051 0.0104 0.0168
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.0027 0.0016
Echinococcus granulosus hypothetical protein 0.0028 0.0027 0.0016
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0046 0.0087 0.0134
Echinococcus granulosus somatostatin receptor 0.0028 0.0027 0.0016
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.1703 0.5536 0.5531
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0027 0.0028
Brugia malayi EGF-like domain containing protein 0.003 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.1508 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus granulosus neuropeptide s receptor 0.0028 0.0027 0.0016
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.1703 0.5536 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0128 0.0357 0.0706
Echinococcus multilocularis integrin beta 2 0.0679 0.2169 0.216
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.0123 1
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0027 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0128 0.0357 0.0706
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0027 0.0016
Brugia malayi Serotonin receptor 0.0028 0.0027 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0027 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0027 0.0016
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0136 0.0382 0.0669
Schistosoma mansoni neuropeptide receptor 0.0028 0.0027 0.0028
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0128 0.0357 0.0706
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Brugia malayi Integrin beta pat-3 precursor 0.0917 0.295 0.532
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0027 0.0028
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0027 0.0028
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Echinococcus granulosus GPCR family 2 0.0062 0.0139 0.0128
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0139 0.0128
Brugia malayi Dopamine receptor 0.0028 0.0027 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0027 0.0016
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0196 0.0578 0.1044
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.0027 0.0016
Onchocerca volvulus 0.003 0.0032 0.0571
Schistosoma mansoni hypothetical protein 0.0062 0.0139 0.0231
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0027 0.0028
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0027 0.0028
Toxoplasma gondii hypothetical protein 0.003 0.0032 0.0038
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.003 0.0032 0.0043
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0027 0.0028
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0027 0.0016
Schistosoma mansoni hypothetical protein 0.0062 0.0139 0.0231
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0128 0.0357 0.0706
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0042 0.0056
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0177 0.034
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0136 0.0382 0.0669
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.1703 0.5536 1
Trypanosoma brucei RNA helicase, putative 0.0104 0.0279 0.0353
Schistosoma mansoni myosin xvIII 0.0028 0.0027 0.0028
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0027 0.0016
Brugia malayi ribonucleotide reductase 2 0.0136 0.0382 0.0671
Loa Loa (eye worm) hypothetical protein 0.0134 0.0375 0.0677
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0139 0.025
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0139 0.0231
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0136 0.0382 0.0757
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0128 0.0357 0.0706
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0048
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0027 0.0028
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0027 0.0016
Brugia malayi Kelch motif family protein 0.0139 0.0393 0.0692
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0177 0.034
Brugia malayi hypothetical protein 0.0028 0.0027 0.0028
Trichomonas vaginalis hypothetical protein 0.003 0.0032 0.0043
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0136 0.0382 0.0757

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.072 uM Inhibitory activity against phosphodiesterase 5 from human platelets ChEMBL. 7658441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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