Detailed information for compound 215007

Basic information

Technical information
  • TDR Targets ID: 215007
  • Name: [(2S)-2,3-dihydroxypropyl] (5Z,8Z,11Z,14Z)-ic osa-5,8,11,14-tetraenoate
  • MW: 378.545 | Formula: C23H38O4
  • H donors: 2 H acceptors: 3 LogP: 5.32 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC[C@H](CO)O
  • InChi: 1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-21-22(25)20-24/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-/t22-/m0/s1
  • InChiKey: DCPCOKIYJYGMDN-HUDVFFLJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid [(2S)-2,3-dihydroxypropyl] ester
  • (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • CHEBI:34071

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fatty acid amide hydrolase Starlite/ChEMBL References
Rattus norvegicus Cannabinoid CB2 receptor Starlite/ChEMBL References
Rattus norvegicus Cannabinoid CB1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus allatostatin A receptor Cannabinoid CB2 receptor   360 aa 363 aa 22.9 %
Loa Loa (eye worm) neuropeptide F receptor Cannabinoid CB2 receptor   360 aa 348 aa 24.7 %
Onchocerca volvulus Cannabinoid CB2 receptor   360 aa 330 aa 20.9 %
Schistosoma mansoni peptide (allatostatin)-like receptor Cannabinoid CB2 receptor   360 aa 323 aa 22.6 %
Schistosoma mansoni biogenic amine (5HT) receptor Cannabinoid CB2 receptor   360 aa 370 aa 23.5 %
Schistosoma mansoni opsin-like receptor Cannabinoid CB2 receptor   360 aa 314 aa 22.0 %
Onchocerca volvulus Cannabinoid CB2 receptor   360 aa 297 aa 21.9 %
Echinococcus granulosus neuropeptide receptor Cannabinoid CB2 receptor   360 aa 337 aa 24.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Cannabinoid CB2 receptor   360 aa 311 aa 20.6 %
Echinococcus multilocularis neuropeptide receptor Cannabinoid CB2 receptor   360 aa 299 aa 24.7 %
Leishmania major hypothetical protein, conserved fatty acid amide hydrolase 579 aa 471 aa 26.5 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Cannabinoid CB2 receptor   360 aa 360 aa 23.1 %
Onchocerca volvulus Cannabinoid CB2 receptor   360 aa 389 aa 21.1 %
Onchocerca volvulus Cannabinoid CB2 receptor   360 aa 327 aa 19.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Cannabinoid CB2 receptor   360 aa 370 aa 23.8 %
Onchocerca volvulus Phospholipase d-related homolog Cannabinoid CB2 receptor   360 aa 309 aa 23.3 %
Echinococcus multilocularis allatostatin A receptor Cannabinoid CB2 receptor   360 aa 342 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0091 0.6095
Loa Loa (eye worm) hypothetical protein 0.0089 0.003 0.003
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0302 0.0149 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Loa Loa (eye worm) hypothetical protein 0.0043 0.0004 0.0004
Trypanosoma cruzi serine peptidase, Clan SC, Family S9D 0.0302 0.0149 1
Onchocerca volvulus 0.0089 0.003 0.1819
Loa Loa (eye worm) ammd protein 0.0302 0.0149 0.0149
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0073 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0091 0.6095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0057 0.0057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0044 0.0044
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.0049 0.0049
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.003 0.2004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0006 0.0006
Onchocerca volvulus Glucosylceramidase homolog 0.0198 0.0091 0.6007
Mycobacterium tuberculosis Probable lipase/esterase LipN 0.0302 0.0149 1
Schistosoma mansoni hypothetical protein 0.0102 0.0037 0.0037
Loa Loa (eye worm) aryl-acylamidase 0.0302 0.0149 0.0149
Echinococcus multilocularis caspase 2 0.01 0.0036 0.0036
Plasmodium falciparum esterase, putative 0.0084 0.0027 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0302 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0231 0.0109 0.0109
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0006 0.0006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0119 0.0047 0.0047
Mycobacterium ulcerans hypothetical protein 0.0084 0.0027 0.1815
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Onchocerca volvulus 0.0089 0.003 0.1819
Schistosoma mansoni hypothetical protein 0.0047 0.0006 0.0006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0006 0.0006
Echinococcus multilocularis caspase 0.0137 0.0057 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0057 0.0057
Mycobacterium ulcerans lipase LipI 0.0302 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0006 0.0006
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.1814
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.0149 0.9996
Brugia malayi hypoxia-induced factor 1 0.0176 0.0079 0.5265
Trichomonas vaginalis Esterase, putative 0.0302 0.0149 0.9996
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0009 0.059
Brugia malayi hypothetical protein 0.0119 0.0047 0.3141
Mycobacterium ulcerans esterase LipO 0.0302 0.0149 1
Mycobacterium ulcerans lipase/esterase LipN 0.0302 0.0149 1
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0014 0.0014
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0004 0.027
Loa Loa (eye worm) hypothetical protein 0.0073 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0001 0.0001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0004 0.0004
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0004 0.027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1582 0.087 0.087
Brugia malayi Cell death protein 3 precursor 0.01 0.0036 0.2401
Brugia malayi amidase 0.0123 0.0049 0.3277
Schistosoma mansoni caspase-3 (C14 family) 0.0137 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0048 0.0007 0.0007
Schistosoma mansoni lipoxygenase 0.0114 0.0044 0.0044
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.003 0.2004
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0006 0.0415
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.003 0.2004
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0109 0.0109
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0009 0.059
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0009 0.059
Brugia malayi jmjC domain containing protein 0.0061 0.0014 0.0928
Loa Loa (eye worm) tyrosinase 1 0.0089 0.003 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0004 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0009 0.0589
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.1814
Mycobacterium ulcerans lipase LipH 0.0302 0.0149 1
Onchocerca volvulus Cell death protein 3 homolog 0.01 0.0036 0.2225
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.1814
Trichomonas vaginalis Esterase, putative 0.0302 0.0149 0.9996
Echinococcus granulosus acetylcholinesterase 0.0073 0.0021 0.0021
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0052 0.0009 0.0009
Onchocerca volvulus Huntingtin homolog 0.0119 0.0047 0.2983
Loa Loa (eye worm) hypothetical protein 0.0052 0.0009 0.0009
Onchocerca volvulus 0.0047 0.0006 0.0192
Echinococcus multilocularis GPCR, family 2 0.0047 0.0006 0.0006
Mycobacterium ulcerans lipase LipU 0.0302 0.0149 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0001 0.0001
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0137 0.0057 0.0057
Mycobacterium ulcerans hypothetical protein 0.0302 0.0149 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0047 0.0006 0.0006
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0052 0.0009 0.0589
Echinococcus multilocularis caspase 3 0.0085 0.0028 0.0028
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0049 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.0097 0.6496
Schistosoma mansoni hypothetical protein 0.0037 0.0001 0.0001
Brugia malayi ShTK domain containing protein 0.0089 0.003 0.2004
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0137 0.0057 0.0057
Mycobacterium tuberculosis Probable esterase LipO 0.0302 0.0149 1
Onchocerca volvulus Huntingtin homolog 0.0119 0.0047 0.2983
Mycobacterium tuberculosis Probable carboxylesterase LipQ 0.0302 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0064 0.0064
Trypanosoma cruzi metacaspase, putative 0.0052 0.0009 0.059
Treponema pallidum N-acetylphosphinothricin-tripetide-deacetylase 0.0302 0.0149 0.5
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.003 0.003
Trypanosoma brucei metacaspase 0.0052 0.0009 0.059
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.0021 0.0021
Brugia malayi aryl-acylamidase 0.0302 0.0149 0.9996
Schistosoma mansoni caspase-7 (C14 family) 0.0137 0.0057 0.0057
Brugia malayi hypothetical protein 0.0048 0.0007 0.0456
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0091 0.6095
Mycobacterium ulcerans carboxylesterase LipQ 0.0302 0.0149 1
Mycobacterium ulcerans esterase/lipase 0.0302 0.0149 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0057 0.0057
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0012 0.0012
Leishmania major metacaspase, putative 0.0052 0.0009 0.059
Mycobacterium tuberculosis Possible lipase LipU 0.0302 0.0149 1
Entamoeba histolytica hypothetical protein 0.0037 0.0001 0.0227
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0009 0.059
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0006 0.0006
Plasmodium vivax PST-A protein 0.0084 0.0027 1
Brugia malayi Carboxylesterase family protein 0.0073 0.0021 0.139
Echinococcus multilocularis caspase 8 0.0052 0.0009 0.0009
Mycobacterium ulcerans esterase LipC 0.0302 0.0149 1
Schistosoma mansoni hypothetical protein 0.0047 0.0006 0.0006
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.003 0.2004
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0003 0.0003
Onchocerca volvulus 0.0089 0.003 0.1819
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0004 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0057 0.0057
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.1814
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0049 0.0049
Schistosoma mansoni survival motor neuron protein 0.0047 0.0006 0.0006
Brugia malayi Carboxylesterase family protein 0.0073 0.0021 0.139
Brugia malayi hypothetical protein 0.0037 0.0001 0.0041
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0004 0.027
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.1814
Mycobacterium tuberculosis Putative acetyl hydrolase MbtJ 0.0302 0.0149 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0014 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0014 0.0014
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0009 0.059
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0004 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0057 0.379
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0007 0.0007
Mycobacterium ulcerans membrane-bound esterase LipM 0.0302 0.0149 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0004 0.0004
Mycobacterium tuberculosis Possible esterase LipW 0.0302 0.0149 1
Trypanosoma brucei Metacaspase-4 0.0052 0.0009 0.059
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0037 0.0001 0.0227
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0302 0.0149 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0004 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.0149 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0004 0.027
Echinococcus granulosus caspase 2 0.01 0.0036 0.0036
Schistosoma mansoni tyrosinase precursor 0.0089 0.003 0.003
Mycobacterium tuberculosis Probable non lipolytic carboxylesterase NlhH 0.0302 0.0149 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0007 0.0007
Trypanosoma brucei metacaspase MCA3 0.0052 0.0009 0.059
Mycobacterium tuberculosis Probable esterase LipC 0.0302 0.0149 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0009 0.0589
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0004 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0014 0.0014
Leishmania major ecotin, putative 0.0302 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0007 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0004 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0064 0.4252
Leishmania major hypothetical protein, conserved 0.0302 0.0149 1
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0037 0.2478
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0302 0.0149 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0027 0.1814
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.0027 0.1815
Schistosoma mansoni hormone-sensitive lipase (S09 family) 1.7812 1 1
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0302 0.0149 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0009 0.0589
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0003 0.0228
Loa Loa (eye worm) hypothetical protein 0.0123 0.0049 0.0049
Echinococcus multilocularis hormone sensitive lipase 1.7812 1 1
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0302 0.0149 1
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.0149 1
Trypanosoma brucei metacaspase 5, putative 0.0052 0.0009 0.059
Schistosoma mansoni single-minded 0.0057 0.0012 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0004 0.0004
Onchocerca volvulus 0.0302 0.0149 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.0027 1
Schistosoma mansoni caspase-7 (C14 family) 0.01 0.0036 0.0036
Echinococcus granulosus caspase 8 0.0052 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.01 0.0036 0.0036
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.003 0.2004
Echinococcus granulosus caspase 3 0.0085 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0027 0.1814
Brugia malayi hypothetical protein 0.0231 0.0109 0.7324
Trypanosoma brucei metacaspase MCA2 0.0052 0.0009 0.059
Mycobacterium ulcerans acetyl hydrolase MbtJ 0.0302 0.0149 1
Mycobacterium leprae Possible lipase LipU 0.0302 0.0149 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0057 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.0097 0.6496
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0064 0.4252
Trypanosoma cruzi monoglyceride lipase, putative 0.0084 0.0027 0.1815
Echinococcus granulosus caspase 0.0137 0.0057 0.0057
Onchocerca volvulus 0.0089 0.003 0.1819
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0009 0.0589
Mycobacterium ulcerans lipase LipU 0.0302 0.0149 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0006 0.0006
Trypanosoma cruzi metacaspase, putative 0.0052 0.0009 0.059
Leishmania major monoglyceride lipase, putative 0.0084 0.0027 0.1815
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0302 0.0149 0.0149
Echinococcus granulosus acetylcholinesterase 0.0073 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 1.7812 1 1
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0027 1
Mycobacterium tuberculosis Probable lipase LipH 0.0302 0.0149 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0057 0.0057
Echinococcus multilocularis acetylcholinesterase 0.0073 0.0021 0.0021
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0006 0.0419
Trypanosoma brucei Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0302 0.0149 1
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.0149 1
Brugia malayi jmjC domain containing protein 0.0061 0.0014 0.0928
Schistosoma mansoni hormone-sensitive lipase (S09 family) 1.7812 1 1
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0027 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0009 0.0589
Echinococcus granulosus single minded 2 0.0042 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0037 0.0001 0.0227
Loa Loa (eye worm) hypothetical protein 0.0089 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0009 0.0589
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.0149 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.0027 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0176 0.0079 0.0079
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0014 0.0014
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0109 0.0109
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0003 0.0227
Schistosoma mansoni hypothetical protein 0.0047 0.0006 0.0006
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Mycobacterium tuberculosis Probable acetyl-hydrolase/esterase LipR 0.0302 0.0149 1
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0091 0.6095
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0049 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0006 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0004 0.027
Mycobacterium ulcerans esterase LipW 0.0302 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.0087 0.0087
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0004 0.149
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0049 0.0049
Trypanosoma cruzi Alpha/beta hydrolase domain-containing protein 0.0302 0.0149 1
Brugia malayi PAS domain containing protein 0.0057 0.0012 0.0783
Trypanosoma cruzi metacaspase, putative 0.0052 0.0009 0.059
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.0149 1
Mycobacterium ulcerans lysophospholipase 0.0084 0.0027 0.1815
Echinococcus granulosus carboxylesterase 5A 0.0073 0.0021 0.0021
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0084 0.0027 0.1814
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.0027 0.1815
Schistosoma mansoni hormone-sensitive lipase (S09 family) 1.7812 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0091 0.6095
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Entamoeba histolytica hypothetical protein 0.0037 0.0001 0.0227
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0 0.5
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0004 0.027
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0091 0.6095
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589
Schistosoma mansoni lipoxygenase 0.008 0.0025 0.0025
Mycobacterium tuberculosis Probable esterase/lipase LipF 0.0302 0.0149 1
Echinococcus multilocularis acetylcholinesterase 0.0073 0.0021 0.0021
Mycobacterium tuberculosis Probable esterase LipM 0.0302 0.0149 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0102 0.0037 0.0037
Loa Loa (eye worm) carboxylesterase 0.0073 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0119 0.0047 0.0047
Brugia malayi hypothetical protein 0.0191 0.0087 0.5821
Echinococcus multilocularis carboxylesterase 5A 0.0073 0.0021 0.0021
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0027 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0004 0.0004
Schistosoma mansoni amidase 0.0123 0.0049 0.0049
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0004 0.0004
Loa Loa (eye worm) acetylcholinesterase 1 0.0073 0.0021 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0064 0.0064
Echinococcus granulosus GPCR family 2 0.0047 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0047 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0091 0.6095
Onchocerca volvulus 0.0048 0.0007 0.0234
Trypanosoma cruzi metacaspase, putative 0.0052 0.0009 0.059
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.0149 1
Schistosoma mansoni tyrosinase precursor 0.0089 0.003 0.003
Trichomonas vaginalis Esterase, putative 0.0302 0.0149 0.9996
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0009 0.0589

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 1000 nM Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSF ChEMBL. 12166944
Ki (binding) > 1000 nM Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 2 in the presence of PMSF ChEMBL. 12166944
Ki (binding) > 1000 nM Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSF ChEMBL. 12166944
Ki (binding) > 1000 nM Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 2 in the presence of PMSF ChEMBL. 12166944
Ki (binding) = 3 uM Inhibition of Fatty-acid amide hydrolase (FAAH) activity in human lymphoma U937 cell using [3H]-AEA as substrate in the 0-25 uM conc ChEMBL. 12166944
Ki (binding) = 3 uM Inhibition of Fatty-acid amide hydrolase (FAAH) activity in human lymphoma U937 cell using [3H]-AEA as substrate in the 0-25 uM conc ChEMBL. 12166944
Ki (binding) > 10 uM Inhibition of N-arachidonoylethanolamine transporter (AEA) activity in human lymphoma U937 cell using [3H]-AEA as substrate in the 0-1000 nM conc. ChEMBL. 12166944

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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