TDR Targets

Basic information

Technical information

TDR Targets ID: 257310
Name: 2-imidazol-1-yl-1-[2-[(4-methoxyphenoxy)methy l]-1,3-thiazolidin-3-yl]ethanone
MW: 333.405 | Formula: C16H19N3O3S
H donors: 0 H acceptors: 2 LogP: 1.87 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)OCC1SCCN1C(=O)Cn1cncc1
InChi: 1S/C16H19N3O3S/c1-21-13-2-4-14(5-3-13)22-11-16-19(8-9-23-16)15(20)10-18-7-6-17-12-18/h2-7,12,16H,8-11H2,1H3
InChiKey: NFVMEWLXJNWRCV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-imidazol-1-yl-1-[2-[(4-methoxyphenoxy)methyl]thiazolidin-3-yl]ethanone
2-(1-imidazolyl)-1-[2-[(4-methoxyphenoxy)methyl]-3-thiazolidinyl]ethanone
121277-05-2
2-((4-Methoxyphenoxy)methyl)-3-(2-imidazolylacetyl)-1,3-thiazolidine
3-(1H-Imidazol-1-ylacetyl)-2-((4-methoxyphenoxy)methyl)thiazolidine
Thiazolidine, 3-(1H-imidazol-1-ylacetyl)-2-((4-methoxyphenoxy)methyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0035	0.0703	0.0703
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0035	0.0687	0.1907
Loa Loa (eye worm)	beta-tubulin	0.0019	0.01	0.01
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0035	0.0687	0.1907
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0035	0.0687	0.1907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0287	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0035	0.0703	0.0609
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Entamoeba histolytica	tubulin alpha chain, putative	0.0035	0.0703	0.1958
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0035	0.0687	0.0593
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0035	0.0687	0.0593
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.3181	1
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0035	0.0687	0.0593
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Echinococcus granulosus	Tubulin alpha 1 chain	0.0035	0.0703	0.0609
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0287	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0035	0.0703	0.1958
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Loa Loa (eye worm)	BEN-1 protein	0.0019	0.01	0.01
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0035	0.0687	0.0687
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus granulosus	tubulin alpha chain	0.0035	0.0703	0.0609
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0035	0.0687	0.0593
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Echinococcus granulosus	peroxisome assembly protein 26	0.0035	0.0703	0.0609
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0035	0.0703	0.1958
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0305	0.0305
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0687	0.1907
Echinococcus granulosus	tubulin alpha chain	0.0035	0.0703	0.0609
Plasmodium vivax	phosphodiesterase gamma, putative	0.0035	0.0687	0.1907
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0035	0.0687	0.0593
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	tubulin beta-1 chain	0.0019	0.01	0.01
Echinococcus granulosus	tubulin alpha 1C chain	0.0035	0.0703	0.0609
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Leishmania major	prefoldin subunit, putative	0.0102	0.3181	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0035	0.0687	0.0593
Brugia malayi	KE2 family protein	0.0102	0.3181	0.3579
Leishmania major	hypothetical protein, conserved	0.0035	0.0687	0.1907
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Echinococcus granulosus	Tubulin alpha 1 chain	0.0035	0.0703	0.0609
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0687	0.1907
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Loa Loa (eye worm)	BEN-1 protein	0.0019	0.01	0.01
Loa Loa (eye worm)	tubulin beta-4 chain	0.0019	0.01	0.01
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	tubulin alpha 3 chain	0.0035	0.0703	0.0609
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Trypanosoma brucei	alpha tubulin	0.0035	0.0703	0.1958
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0035	0.0687	0.1907
Trypanosoma cruzi	prefoldin subunit, putative	0.0102	0.3181	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0035	0.0687	0.0593
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Schistosoma mansoni	tubulin subunit alpha	0.0035	0.0703	0.0609
Plasmodium vivax	prefoldin subunit 6, putative	0.0102	0.3181	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0687	0.1907
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus granulosus	tubulin alpha chain	0.0035	0.0703	0.0609
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0027	0.0398	0.0398
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0027	0.0398	0.0967
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0035	0.0687	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0687	0.0687
Brugia malayi	tubulin alpha-2 chain	0.0035	0.0703	0.0701
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0025	0.0305	0.0667
Plasmodium falciparum	alpha tubulin 1	0.0035	0.0703	0.1958
Echinococcus multilocularis	tubulin alpha 1C chain	0.0035	0.0703	0.0609
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Trypanosoma brucei	alpha tubulin	0.0035	0.0703	0.1958
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0035	0.0687	0.0593
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0035	0.0703	0.1958
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0687	0.1907
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Plasmodium falciparum	alpha tubulin 2	0.0035	0.0703	0.1958
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.0703	0.0609
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0287	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.0703	0.1958
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0035	0.0687	0.0593
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0025	0.0305	0.0305
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus granulosus	alpha tubulin	0.0035	0.0703	0.0609
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0035	0.0687	0.0593
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma cruzi	alpha tubulin, putative	0.0035	0.0703	0.1958
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0035	0.0687	0.1907
Brugia malayi	Tubulin alpha-2 chain	0.0035	0.0703	0.0701
Loa Loa (eye worm)	tubulin beta-2A chain	0.0019	0.01	0.01
Echinococcus multilocularis	tubulin alpha 3 chain	0.0035	0.0703	0.0609
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0687	0.0687
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Echinococcus multilocularis	tubulin subunit TubB	0.0035	0.0703	0.0609
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	tubulin alpha 2	0.0027	0.0398	0.0398
Echinococcus granulosus	tubulin alpha chain	0.0035	0.0703	0.0609
Trypanosoma cruzi	prefoldin subunit, putative	0.0102	0.3181	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0035	0.0687	0.0593
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0035	0.0687	0.0593
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0035	0.0687	0.0593
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0035	0.0687	0.0682
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0287	1	1
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Brugia malayi	alpha-tubulin	0.0035	0.0703	0.0701
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.0703	0.0609
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0035	0.0687	0.1907
Toxoplasma gondii	alpha-tubulin I, putative	0.0035	0.0703	0.0609
Giardia lamblia	Hypothetical protein	0.0035	0.0687	0.0593
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0252	0.8709	0.8696
Plasmodium falciparum	phosphodiesterase delta, putative	0.0035	0.0687	0.1907
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0287	1	1
Brugia malayi	tubulin alpha chain - mouse	0.0035	0.0703	0.0701
Echinococcus granulosus	tubulin alpha chain	0.0035	0.0703	0.0609
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus granulosus	Tubulin alpha 1 chain	0.0035	0.0703	0.0609
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Schistosoma mansoni	alpha tubulin	0.0035	0.0703	0.0609
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0035	0.0687	0.0682
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0687	0.1907
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.0703	0.1958
Giardia lamblia	Hypothetical protein	0.0102	0.3181	0.3113
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0035	0.0687	0.0593
Loa Loa (eye worm)	alpha-tubulin	0.0035	0.0703	0.0703
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	PDE1B protein	0.0035	0.0687	0.0687
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0035	0.0687	0.0682
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	hypothetical protein	0.0035	0.0703	0.0609
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0035	0.0687	0.1907
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0035	0.0687	0.0682
Loa Loa (eye worm)	tubulin gamma chain	0.0019	0.01	0.01
Loa Loa (eye worm)	alpha-tubulin	0.0035	0.0703	0.0703
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0287	1	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0687	0.0687
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0687	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0398	0.0398
Trypanosoma brucei	alpha tubulin	0.0035	0.0703	0.1958
Loa Loa (eye worm)	tubulin beta chain	0.0019	0.01	0.01
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0035	0.0687	0.1907
Toxoplasma gondii	prefoldin subunit 6, putative	0.0102	0.3181	0.3113
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0035	0.0703	0.0609
Schistosoma mansoni	alpha tubulin	0.0035	0.0703	0.0609
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0687	0.1907
Echinococcus multilocularis	prefoldin subunit 6	0.0102	0.3181	0.3113
Plasmodium falciparum	prefoldin subunit 6, putative	0.0102	0.3181	1
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.0703	0.0609
Loa Loa (eye worm)	tubulin alpha chain	0.0035	0.0703	0.0703
Entamoeba histolytica	prefoldin subunit 6, putative	0.0102	0.3181	1
Loa Loa (eye worm)	tubulin alpha 2	0.0027	0.0398	0.0398
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0687	0.1907
Brugia malayi	Tubulin alpha-2 chain	0.0035	0.0703	0.0701
Echinococcus granulosus	tubulin subunit TubB	0.0035	0.0703	0.0609
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	tubulin alpha chain	0.0035	0.0703	0.0703
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0035	0.0687	0.1907
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0252	0.8709	0.8696
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Leishmania major	hypothetical protein, conserved	0.0035	0.0687	0.1907
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0252	0.8709	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0035	0.0703	0.1958
Giardia lamblia	Alpha-tubulin	0.0035	0.0703	0.0609
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0252	0.8709	0.8709
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Trypanosoma brucei	alpha tubulin	0.0035	0.0703	0.1958
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.0703	0.1958
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0035	0.0703	0.0609
Giardia lamblia	hypothetical protein	0.0035	0.0687	0.0593
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus granulosus	prefoldin subunit 6	0.0102	0.3181	0.3113
Plasmodium vivax	tubulin alpha chain, putative	0.0035	0.0703	0.1958
Entamoeba histolytica	tubulin alpha-1 chain	0.0035	0.0703	0.1958
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0035	0.0687	0.0593
Brugia malayi	Tubulin alpha chain	0.0035	0.0703	0.0701
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.0703	0.0609
Schistosoma mansoni	tubulin subunit alpha	0.0035	0.0703	0.0609
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0035	0.0687	0.0593
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0687	0.1907
Trypanosoma brucei	prefoldin subunit, putative	0.0102	0.3181	1
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0287	1	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0035	0.0687	0.0593
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.0703	0.1958
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0035	0.0687	0.0593
Schistosoma mansoni	hypothetical protein	0.0102	0.3181	0.3113
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.0703	0.1958
Echinococcus multilocularis	tubulin alpha 1C chain	0.0035	0.0703	0.0609
Giardia lamblia	Alpha-tubulin	0.0035	0.0703	0.0609
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0035	0.0687	0.0593
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0035	0.0687	0.0593
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.0703	0.0609
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0035	0.0687	0.0593
Schistosoma mansoni	alpha tubulin	0.0035	0.0703	0.0609
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0035	0.0703	0.0609
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.0703	0.1958
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0703	0.0703
Echinococcus granulosus	tubulin alpha 3 chain	0.0035	0.0703	0.0609
Toxoplasma gondii	alpha tubulin TUBA1	0.0035	0.0703	0.0609
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0687	0.0593
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0035	0.0687	0.0682
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0687	0.1907
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0035	0.0687	0.0593
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0035	0.0687	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3181	0.3181
Echinococcus granulosus	tubulin alpha 3 chain	0.0035	0.0703	0.0609
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0035	0.0687	0.0682
Echinococcus granulosus	tubulin alpha 1C chain	0.0035	0.0703	0.0609
Schistosoma mansoni	tubulin subunit alpha	0.0035	0.0703	0.0609
Leishmania major	alpha tubulin	0.0035	0.0703	0.1958
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0687	0.1907

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 48 mg kg-1	Antitussive activity by inhibition of irritant citric acid aerosol-induced coughing in guinea pig upon oral administration.	ChEMBL.	7853344
LD50 (ADMET)	> 1000 mg kg-1	Acute toxicity was determined in mice upon peroral administration	ChEMBL.	7853344
LD50 (ADMET)	> 1000 mg kg-1	Acute toxicity was determined in mice upon peroral administration	ChEMBL.	7853344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL148923
PubChem: 3078457

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 257310