Detailed information for compound 271437

Basic information

Technical information
  • TDR Targets ID: 271437
  • Name: 3-(4-methylsulfanylanilino)-4-phenylpyrrole-2 ,5-dione
  • MW: 310.37 | Formula: C17H14N2O2S
  • H donors: 2 H acceptors: 2 LogP: 3.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)NC1=C(C(=O)NC1=O)c1ccccc1
  • InChi: 1S/C17H14N2O2S/c1-22-13-9-7-12(8-10-13)18-15-14(16(20)19-17(15)21)11-5-3-2-4-6-11/h2-10H,1H3,(H2,18,19,20,21)
  • InChiKey: UOPHVMRUNRZBPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methylsulfanylanilino)-4-phenyl-pyrrole-2,5-dione
  • 3-[4-(methylthio)anilino]-4-phenylpyrrole-2,5-dione
  • 3-[(4-methylsulfanylphenyl)amino]-4-phenyl-pyrrole-2,5-dione
  • 3-[4-(methylthio)anilino]-4-phenyl-3-pyrroline-2,5-quinone
  • 3-[(4-methylsulfanylphenyl)amino]-4-phenylpyrrole-2,5-dione
  • 3-[[4-(methylthio)phenyl]amino]-4-phenylpyrrole-2,5-dione
  • 3-[[4-(methylthio)phenyl]amino]-4-phenyl-3-pyrroline-2,5-quinone
  • 4-arylmaleimide deriv. 6dd

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0052 0.0203
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.001 0.001
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0107 0.3498
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0048
Echinococcus multilocularis cysteine protease 0.0019 0.0059 0.0059
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0091 0.2258
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0091 0.1015
Echinococcus granulosus importin subunit beta 1 0.0033 0.0146 0.0146
Echinococcus granulosus ryanodine receptor 44f 0.0011 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.001 0.0093
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.001 0.0008
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Echinococcus multilocularis microtubule associated protein 2 0.1585 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.001 0.001
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0011 0.0009 0.0009
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0059 0.0059
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0009 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0059 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0305 1
Loa Loa (eye worm) calcium channel 0.0186 0.1119 0.513
Echinococcus multilocularis calcium activated potassium channel 0.0012 0.0012 0.0012
Entamoeba histolytica cysteine protease, putative 0.0019 0.0059 0.1945
Echinococcus granulosus sodium leak channel non selective protein 0.0011 0.0009 0.0009
Onchocerca volvulus 0.0019 0.0059 0.0617
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.0822 0.0822
Brugia malayi hypothetical protein 0.0141 0.0833 0.7442
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0302 0.2694
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0916 0.5755 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0009 0.0009
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0011 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.001 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0861 0.0861
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.001 0.0008
Echinococcus multilocularis sodium channel protein 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0059 0.0617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0019 0.0059 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Brugia malayi nuclear hormone receptor 0.0012 0.001 0.0093
Schistosoma mansoni importin beta-1 0.0033 0.0146 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.001 0.0093
Onchocerca volvulus Huntingtin homolog 0.0141 0.0833 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0305 0.1371
Echinococcus multilocularis transient receptor potential gamma protein 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0019 0.0619
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0011 0.0009 0.0009
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0052 0.1718
Echinococcus multilocularis conserved hypothetical protein 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0052 0.054
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0011 0.0009 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0091 0.2984
Entamoeba histolytica hypothetical protein 0.0027 0.0107 0.3498
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0146 0.1695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Echinococcus granulosus cathepsin l1 0.0013 0.0019 0.0019
Echinococcus granulosus TRP transient receptor potential channel 0.0011 0.0009 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.001 0.0093
Echinococcus granulosus short transient receptor potential channel 6 0.0011 0.0009 0.0009
Echinococcus multilocularis potassium large conductance calcium activated 0.0011 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel protein 0.0011 0.0009 0.0009
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.1119 0.1119
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0302 0.2694
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Onchocerca volvulus 0.0012 0.001 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0009 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.001 0.001
Echinococcus granulosus two pore calcium channel protein 1 0.0011 0.0009 0.0009
Brugia malayi cation channel family protein 0.0011 0.0009 0.0076
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.1119 0.1119
Echinococcus granulosus potassium large conductance calcium activated 0.0011 0.0009 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.001 0.0093
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0059 0.0531
Brugia malayi cathepsin L-like precursor 0.0013 0.0019 0.0169
Echinococcus granulosus tar DNA binding protein 0.0145 0.0861 0.0861
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus granulosus shaker cognate 0.0011 0.0009 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0139 0.0822 0.0822
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0059 0.1472
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0059 0.0617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus granulosus transient receptor potential cation channel 0.0011 0.0009 0.0009
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0009 0.0009
Echinococcus granulosus transient receptor potential cation channel 0.0011 0.0009 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0272 0.0272
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0235
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0305 0.1371
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Brugia malayi Cathepsin L-like precursor 0.0013 0.0019 0.0169
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0091 0.2258
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Brugia malayi Cathepsin L-like precursor 0.0013 0.0019 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.001 0.0093
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0009 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Brugia malayi ion channel NompC 0.0011 0.0009 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.001 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.1119 0.1119
Brugia malayi Cathepsin L-like precursor 0.0019 0.0059 0.0531
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.0009 0.0009
Echinococcus granulosus FTZ F1 alpha 0.0012 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0011 0.0009 0.0009
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0059 0.0235
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0011 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Brugia malayi isocitrate dehydrogenase 0.0018 0.0052 0.0469
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0011 0.0009 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.001 0.0093
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0011 0.0009 0.0009
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0091 0.0814
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0052 0.0052
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0011 0.0009 0.0009
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0052 0.13
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0404 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0052 0.0052
Brugia malayi Transient-receptor-potential like protein 0.0011 0.0009 0.0076
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0009 0.0076
Schistosoma mansoni calcium-activated potassium channel 0.0011 0.0009 0.0009
Echinococcus multilocularis short transient receptor potential channel 6 0.0011 0.0009 0.0009
Toxoplasma gondii cathepsin CPL 0.0019 0.0059 0.0625
Loa Loa (eye worm) hypothetical protein 0.0141 0.0833 0.3807
Leishmania major GTP-binding protein, putative 0.0024 0.0091 0.1015
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.1119 0.1119
Echinococcus multilocularis ryanodine receptor 44f 0.0011 0.0009 0.0009
Schistosoma mansoni transient receptor potential channel 0.0011 0.0009 0.0009
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0059 0.1945
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.001 0.0093
Loa Loa (eye worm) hypothetical protein 0.0039 0.0186 0.0821
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 0.0305 0.0305
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Plasmodium vivax importin-beta 2, putative 0.0033 0.0146 0.4796
Entamoeba histolytica Ran family GTPase 0.0024 0.0091 0.2984
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0861 0.0861
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0059 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0009 0.0009
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0052 0.054
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0.0305 0.3648
Leishmania major cathepsin L-like protease 0.0019 0.0059 0.0625
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0009 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0019 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0272 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.001 0.0008
Loa Loa (eye worm) ctsf protein 0.0019 0.0059 0.0235
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0059 0.0059
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0009 0.0279
Schistosoma mansoni voltage-gated ion channel 0.0011 0.0009 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0012 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0011 0.0009 0.0076
Brugia malayi Cathepsin L-like precursor 0.0019 0.0059 0.0531
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0139 0.0822 0.0822
Schistosoma mansoni ryanodine receptor related 0.0011 0.0009 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0009 0.0009
Plasmodium vivax vivapain-2 0.0019 0.0059 0.1945
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0059 0.1945
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0059 0.1945
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0011 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0073 0.0404 0.4854
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0048
Schistosoma mansoni voltage-dependent calcium channel 0.0011 0.0009 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.001 0.0022
Echinococcus granulosus voltage dependent calcium channel 0.0011 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.001 0.0093
Onchocerca volvulus 0.0019 0.0059 0.0617
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.001 0.0093
Leishmania major cathepsin L-like protease 0.0073 0.0404 0.4854
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0916 0.5755 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0272 0.0272
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0052 0.0052
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0304 0.7525
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.001 0.001
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0011 0.0009 0.0009
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.1119 0.1119
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0011 0.0009 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0052 0.0052
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0059 0.0059
Echinococcus granulosus transient receptor potential cation channel 0.0011 0.0009 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 0.0305 1
Leishmania major cathepsin L-like protease 0.0019 0.0059 0.0625
Brugia malayi olfactory channel protein osm-9 0.0011 0.0009 0.0076
Brugia malayi RNA binding protein 0.0145 0.0861 0.7689
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0011 0.0009 0.0076
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0011 0.0009 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0272 0.2425
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0048
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.0009 0.0009
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 0.0305 0.3648
Brugia malayi RNA recognition motif domain containing protein 0.0145 0.0861 0.7689
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0019 0.0169
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel protein 0.0011 0.0009 0.0009
Schistosoma mansoni transient receptor potential channel 0.0011 0.0009 0.0009
Echinococcus multilocularis two pore calcium channel protein 1 0.0011 0.0009 0.0009
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus granulosus cathepsin l1 0.0019 0.0059 0.0059
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0011 0.0009 0.0211
Loa Loa (eye worm) hypothetical protein 0.0141 0.0833 0.3807
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0011 0.0009 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0052 0.0052
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0011 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel protein 0.0011 0.0009 0.0009
Loa Loa (eye worm) cysteine protease 0.0019 0.0059 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Schistosoma mansoni microtubule-associated protein tau 0.1585 1 1
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0861 0.0861
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0009 0.0009
Echinococcus granulosus transient receptor potential cation channel 0.0011 0.0009 0.0009
Schistosoma mansoni ran 0.0024 0.0091 0.0091
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0011 0.0009 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.001 0.0093
Echinococcus multilocularis potassium voltage gated channel protein 0.0011 0.0009 0.0009
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0009 0.0009
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0011 0.0009 0.0211
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.001 0.0093
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0059 0.0625
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0928 0.583 0.583
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus granulosus voltage dependent calcium channel 0.0186 0.1119 0.1119
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.0822 0.0822
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Loa Loa (eye worm) hypothetical protein 0.0057 0.0302 0.1353
Echinococcus multilocularis transfer RNA-Gly 0.0011 0.0009 0.0009
Brugia malayi nuclear receptor NHR-88 0.0012 0.001 0.0093
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0011 0.0009 0.0211
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0009 0.0009
Schistosoma mansoni ran 0.0024 0.0091 0.0091
Echinococcus granulosus protein kinase shaggy 0.0058 0.0305 0.0305
Leishmania major cathepsin L-like protease 0.0019 0.0059 0.0625
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0.0305 0.7568
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0404 1
Onchocerca volvulus 0.0058 0.0305 0.36
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0009 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0145 0.0861 0.3935
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0186 0.1119 0.1119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0011 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Loa Loa (eye worm) fibroinase 0.0019 0.0059 0.0235
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0059 0.1945
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0009 0.0009
Echinococcus granulosus GPCR family 2 0.0018 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0011 0.0009 0.0009
Onchocerca volvulus 0.0019 0.0059 0.0617
Echinococcus multilocularis tar DNA binding protein 0.0145 0.0861 0.0861
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0009 0.0076
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0052 0.0467
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0091 0.0091
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0146 0.3629
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0052 0.0052
Leishmania major cathepsin L-like protease 0.0073 0.0404 0.4854
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0107 0.3498
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0019 0.0619
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0059 0.0617
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0052 0.13
Brugia malayi voltage-dependent calcium channel 0.0011 0.0009 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.001 0.0008
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 0.0305 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0272 0.0272
Schistosoma mansoni vesicular amine transporter 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0146 0.0637
Schistosoma mansoni hypothetical protein 0.0352 0.2174 0.2174
Echinococcus granulosus voltage gated hydrogen channel 1 0.0011 0.0009 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0019 0.0019
Brugia malayi hypothetical protein 0.0011 0.0009 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0052 0.0052
Schistosoma mansoni transient receptor potential channel 4 0.0011 0.0009 0.0009
Brugia malayi intracellular kinase 0.0058 0.0305 0.2728
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.1119 0.1119
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.001 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0011 0.0009 0.0076
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0305 1
Echinococcus granulosus short transient receptor potential channel 6 0.0011 0.0009 0.0009
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0011 0.0009 0.0009
Loa Loa (eye worm) RNA binding protein 0.0145 0.0861 0.3935
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.001 0.0022
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0186 0.1119 0.1119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0272 0.0272
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0139 0.0822 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0059 0.0531
Echinococcus multilocularis protein kinase shaggy 0.0058 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0186 0.1119 0.513
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0059 0.0059
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0091 0.0091
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0052 0.0467
Echinococcus multilocularis potassium voltage gated channel protein 0.0011 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Echinococcus multilocularis cysteine protease 0.0019 0.0059 0.0059
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus granulosus calcium activated potassium channel 0.0012 0.0012 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0052 0.0202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0052 0.0052
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.0009 0.0009
Echinococcus granulosus transient receptor potential cation channel 0.0011 0.0009 0.0009
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0011 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.001 0.0093
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0011 0.0009 0.0076
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0009 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0052 0.13
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus multilocularis short transient receptor potential channel 6 0.0011 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Echinococcus granulosus snurportin 1 0.0352 0.2174 0.2174
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0009 0.0009
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.0009 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0059 0.0059
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0011 0.0009 0.0009
Plasmodium falciparum importin beta, putative 0.0033 0.0146 0.4796
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0039 0.0186 0.0186
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0011 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus granulosus sodium channel protein 0.0011 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0404 1
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0404 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0186 0.1119 0.1119
Brugia malayi Importin beta-1 subunit 0.0033 0.0146 0.1308
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0011 0.0009 0.0076
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0146 0.0146
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0305 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 0.0305 0.0305
Leishmania major cathepsin L-like protease 0.0019 0.0059 0.0625
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.2174 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.001 0.001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0091 0.0381
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus multilocularis GPCR, family 2 0.0018 0.0052 0.0052
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0009 0.0009
Trichomonas vaginalis ran, putative 0.0024 0.0091 0.2984
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0011 0.0009 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0272 0.0272
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.001 0.001
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0052 0.0469
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0186 0.1119 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0107 0.3498
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.0363 0.8997
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.001 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0139 0.0822 0.135
Echinococcus granulosus hypothetical protein 0.0011 0.0009 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.001 0.0093
Onchocerca volvulus 0.0013 0.0019 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0009
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0011 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0011 0.0009 0.0009
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0059 0.1945
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.001 0.0022
Entamoeba histolytica protein kinase, putative 0.0058 0.0305 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.001 0.001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0011 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0009 0.0009
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0011 0.0009 0.0211
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0011 0.0009 0.0076
Schistosoma mansoni two-pore calcium channel 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0059 0.1945
Brugia malayi RNA, U transporter 1 0.0094 0.0533 0.476
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.001 0.001
Brugia malayi ecdysteroid receptor 0.0012 0.001 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0302 0.1353
Echinococcus granulosus transient receptor potential gamma protein 0.0011 0.0009 0.0009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.001 0.001
Echinococcus multilocularis snurportin 1 0.0352 0.2174 0.2174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.0009 0.0009
Schistosoma mansoni voltage-gated cation channel 0.0186 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0861 0.0861
Plasmodium falciparum glycogen synthase kinase 3 0.0058 0.0305 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0052 0.054
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0009 0.0009
Echinococcus multilocularis shaker cognate 0.0011 0.0009 0.0009
Echinococcus multilocularis potassium voltage gated channel protein 0.0011 0.0009 0.0009
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0186 0.1119 0.1119
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.001 0.001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0011 0.0009 0.0076
Schistosoma mansoni coup transcription factor 0.0012 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.001 0.0093
Echinococcus granulosus potassium voltage gated channel protein 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0059 0.1945
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0011 0.0009 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.001 0.001
Leishmania major importin beta-1 subunit, putative 0.0027 0.0107 0.1208
Echinococcus multilocularis sodium leak channel non selective protein 0.0011 0.0009 0.0009
Echinococcus granulosus transient receptor potential cation channel 0.0011 0.0009 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.001 0.0008
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0404 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.001 0.001
Onchocerca volvulus 0.0019 0.0059 0.0617
Trypanosoma brucei protein kinase, putative 0.0058 0.0305 0.7568
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0861 0.0861
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0186 0.1664
Toxoplasma gondii aldehyde dehydrogenase 0.0139 0.0822 1
Echinococcus granulosus potassium voltage gated channel protein 0.0011 0.0009 0.0009
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0305 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0107 0.2647
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0091 0.2258
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.001 0.001
Onchocerca volvulus 0.0019 0.0059 0.0617
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0052 0.1718
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0272 0.1214
Schistosoma mansoni transient receptor potential channel 0.0011 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0052 0.13
Echinococcus multilocularis potassium voltage gated channel protein 0.0011 0.0009 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.001 0.001
Plasmodium vivax vivapain-2 0.0019 0.0059 0.1945
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0305 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0011 0.0009 0.0076
Echinococcus granulosus two pore calcium channel protein 2 0.0011 0.0009 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.001 0.001
Loa Loa (eye worm) TAR-binding protein 0.0145 0.0861 0.3935
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Schistosoma mansoni 60S ribosomal protein L21 0.0011 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0011 0.0009 0.0009
Brugia malayi TAR-binding protein 0.0145 0.0861 0.7689
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.001 0.0093
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0186 0.1119 0.1119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0272 0.0272
Leishmania major cathepsin L-like protease 0.0019 0.0059 0.0625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Onchocerca volvulus Huntingtin homolog 0.0141 0.0833 1
Brugia malayi cation channel family protein 0.0011 0.0009 0.0076
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0146 0.3629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0059 0.1945
Echinococcus multilocularis two pore calcium channel protein 2 0.0011 0.0009 0.0009
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0091 0.2984
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.0009 0.0009
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0011 0.0009 0.0076
Brugia malayi Cathepsin L-like precursor 0.0019 0.0059 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.001 0.0008
Brugia malayi Cathepsin L-like precursor 0.0019 0.0059 0.0531
Onchocerca volvulus 0.0019 0.0059 0.0617
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0059 0.0059
Onchocerca volvulus 0.0019 0.0059 0.0617
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Brugia malayi steroid hormone receptor 0.0012 0.001 0.0093

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 404 nM Inhibition of recombinant GSK3beta (unknown origin) ChEMBL. 18324764
IC50 (binding) = 404 nM Inhibition of recombinant GSK3beta (unknown origin) ChEMBL. 18324764
IC50 (binding) = 404 uM Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha ChEMBL. 11266159
IC50 (binding) = 404 uM Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha ChEMBL. 11266159

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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