TDR Targets

Basic information

Technical information

TDR Targets ID: 285247
Name: 1-methyl-2-nitrobenzimidazole
MW: 177.16 | Formula: C8H7N3O2
H donors: 0 H acceptors: 3 LogP: 1.6 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1nc2c(n1C)cccc2
InChi: 1S/C8H7N3O2/c1-10-7-5-3-2-4-6(7)9-8(10)11(12)13/h2-5H,1H3
InChiKey: YGVJTZIZVPQREL-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

1-methyl-2-nitro-benzimidazole
5709-68-2
Benzimidazole, 1-methyl-2-nitro-
1-N-Methyl-2-nitrobenzimidazole
BRN 0958504
1-methyl-2-nitro-1H-benzimidazole
1H-benzimidazole, 1-methyl-2-nitro-
InChI=1/C8H7N3O2/c1-10-7-5-3-2-4-6(7)9-8(10)11(12)13/h2-5H,1H
CCRIS 3258

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nervana 2	0.032	0.8063	0.8063
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.032	0.8063	0.8063
Brugia malayi	E1-E2 ATPase family protein	0.0067	0.1518	0.2872
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0213	0.5284	0.5283
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.0067	0.1518	0.2259
Echinococcus granulosus	GPCR family 2	0.0015	0.0175	0.0172
Plasmodium falciparum	phospholipid-transporting ATPase, putative	0.0025	0.0419	0.0476
Brugia malayi	calcium ATPase	0.0093	0.2184	0.4133
Schistosoma mansoni	ATPase	0.0213	0.5284	0.5254
Trypanosoma brucei	cation-transporting ATPase, putative	0.0067	0.1518	0.2627
Leishmania major	aminophospholipid translocase, putative	0.0025	0.0419	0.0476
Onchocerca volvulus		0.0028	0.0498	0.0104
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0042	0.088	0.0877
Echinococcus multilocularis	phosphoserine phosphatase	0.0042	0.088	0.0877
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.017	0.4185	0.4148
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0176	0.0173
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.017	0.4185	0.4148
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0175	0.0172
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Echinococcus multilocularis	phospholipid transporting ATPase IA	0.0025	0.0419	0.0416
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0213	0.5284	0.5254
Schistosoma mansoni	patched 1	0.0041	0.0836	0.0778
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.032	0.8063	0.8063
Echinococcus multilocularis	cation transporting atpase worm	0.0067	0.1518	0.1515
Plasmodium vivax	cation transporting ATPase, putative	0.0067	0.1518	0.2627
Echinococcus multilocularis	nervana 2	0.032	0.8063	0.8063
Toxoplasma gondii	P-type ATPase PMA1	0.0135	0.3283	0.6082
Schistosoma mansoni	type V p-type atpase isoform	0.0067	0.1518	0.1464
Giardia lamblia	Phospholipid-transporting ATPase IA, putative	0.0067	0.1518	0.2259
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0067	0.1518	0.2259
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0093	0.2184	0.3628
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Leishmania major	calcium-transporting ATPase, putative	0.017	0.4185	0.7849
Mycobacterium tuberculosis	Probable metal cation transporter ATPase P-type CtpE	0.0067	0.1518	0.4014
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0836	0.0834
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1026	0.127
Schistosoma mansoni	hypothetical protein	0.0164	0.4014	0.3976
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0213	0.5284	1
Trypanosoma cruzi	plasma-membrane proton-efflux P-type ATPase, putative	0.0093	0.2184	0.3931
Brugia malayi	hypothetical protein	0.0016	0.0187	0.0355
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.2764	0.3425
Onchocerca volvulus		0.0146	0.3556	0.4104
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.3296	0.3294
Brugia malayi	CHE-14 protein	0.0041	0.0836	0.1583
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.017	0.4185	0.7741
Schistosoma mansoni	hypothetical protein	0.0039	0.0798	0.074
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0213	0.5284	1
Onchocerca volvulus		0.0213	0.5284	0.6365
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.0067	0.1518	0.2259
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.012	0.2881	0.5452
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.017	0.4185	0.4148
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0042	0.088	0.1378
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0067	0.1518	0.1515
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0632	0.0781
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0213	0.5284	1
Brugia malayi	Sodium/potassium-transporting ATPase alpha-3 chain, putative	0.0093	0.2184	0.4133
Echinococcus granulosus	copper transporting ATPase 1	0.0067	0.1518	0.1515
Leishmania major	P-type H -ATPase, putative	0.0135	0.3283	0.6082
Trypanosoma cruzi	proton motive ATPase 1, putative	0.0042	0.088	0.1378
Echinococcus multilocularis	nervana 2	0.032	0.8063	0.8063
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0145	0.3519	0.666
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0411	0.046
Toxoplasma gondii	Copper-exporting ATPase	0.0025	0.0419	0.0476
Loa Loa (eye worm)	phospholipid-transporting ATPase ID	0.0025	0.0419	0.0516
Toxoplasma gondii	P-type ATPase of unknown pump specificity (type V) protein	0.0025	0.0419	0.0476
Plasmodium vivax	calcium-transporting ATPase, putative	0.0213	0.5284	1
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0213	0.5284	0.5283
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0924	0.0921
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0176	0.0332
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Echinococcus multilocularis	nervana 2	0.032	0.8063	0.8063
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.017	0.4185	0.7741
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0213	0.5284	1
Leishmania major	calcium-translocating P-type ATPase	0.0213	0.5284	1
Giardia lamblia	Copper-transporting P-type ATPase	0.0067	0.1518	0.2259
Onchocerca volvulus		0.032	0.8063	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0411	0.046
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0498	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1546	0.1914
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0077	0.1782	0.3145
Leishmania major	phospholipid-transporting ATPase 1-like protein	0.0025	0.0419	0.0476
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Trypanosoma brucei	phospholipid-transporting ATPase 1-like protein, putative	0.0025	0.0419	0.0476
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.2241	0.424
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0175	0.0172
Echinococcus multilocularis	calcium transporting atpase	0.017	0.4185	0.4184
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0836	0.0858
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0213	0.5284	0.5283
Schistosoma mansoni	hypothetical protein	0.0015	0.0175	0.0112
Plasmodium falciparum	guanylyl cyclase	0.0025	0.0419	0.0476
Mycobacterium tuberculosis	Probable cation transporter P-type ATPase D CtpD	0.0067	0.1518	0.4014
Echinococcus granulosus	nervana 2	0.032	0.8063	0.8063
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0175	0.0172
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0213	0.5284	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0498	0.0943
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0042	0.088	0.1378
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0102	0.242	0.458
Brugia malayi	hypothetical protein	0.0146	0.3556	0.673
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0176	0.0173
Schistosoma mansoni	hypothetical protein	0.0015	0.0175	0.0112
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0175	0.0331
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.032	0.8063	0.8051
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.017	0.4185	0.7849
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0836	0.1034
Loa Loa (eye worm)	E1-E2 ATPase	0.0135	0.3283	0.4069
Trypanosoma cruzi	phospholipid-transporting ATPase 1-like protein, putative	0.0025	0.0419	0.0476
Toxoplasma gondii	P-type ATPase4, putative	0.0213	0.5284	1
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0176	0.0332
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.032	0.8063	0.8063
Echinococcus multilocularis	protein patched	0.0041	0.0836	0.0834
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.012	0.2881	0.5061
Schistosoma mansoni	hypothetical protein	0.0039	0.0798	0.074
Echinococcus multilocularis	expressed conserved protein	0.0089	0.2091	0.2089
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.017	0.4185	0.4148
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0213	0.5284	1
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0067	0.1518	0.1515
Trypanosoma brucei	calcium-transporting ATPase, putative	0.0025	0.0419	0.0476
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0145	0.3519	0.4362
Schistosoma mansoni	cation-transporting atpase worm	0.0067	0.1518	0.1464
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0176	0.0173
Loa Loa (eye worm)	calcium ATPase	0.0025	0.0419	0.0516
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0836	0.0834
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0176	0.0173
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.2279	0.2229
Trypanosoma brucei	phospholipid-translocating ATPase, putative	0.0025	0.0419	0.0476
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0067	0.1518	0.1515
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0213	0.5284	0.6552
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.017	0.4185	0.4184
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1518	0.1879
Trypanosoma brucei	calcium-transporting ATPase, putative	0.0102	0.242	0.4394
Echinococcus multilocularis	dnaJ subfamily B	0.0395	1	1
Toxoplasma gondii	proton ATPase, putative	0.0025	0.0419	0.0476
Loa Loa (eye worm)	sodium potassium adenosine triphosphatase	0.0093	0.2184	0.2706
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.017	0.4185	0.4148
Plasmodium vivax	copper-transporting ATPase, putative	0.0067	0.1518	0.2627
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.012	0.2881	0.5061
Trypanosoma brucei	P-type H+-ATPase, putative	0.0135	0.3283	0.6082
Schistosoma mansoni	atpase class VI type 11c	0.0042	0.088	0.0822
Schistosoma mansoni	cation-transporting ATPase	0.0067	0.1518	0.1464
Schistosoma mansoni	hypothetical protein	0.0039	0.0798	0.074
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0067	0.1518	0.2259
Mycobacterium tuberculosis	Probable metal cation transporter P-type ATPase CtpV	0.0067	0.1518	0.4014
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0632	0.1197
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0924	0.0866
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0145	0.3519	1
Trypanosoma brucei	calcium-translocating P-type ATPase	0.017	0.4185	0.7849
Schistosoma mansoni	transmemberane protein	0.032	0.8063	0.8051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0924	0.0921
Plasmodium falciparum	calcium-transporting ATPase	0.017	0.4185	0.7849
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0175	0.0172
Echinococcus granulosus	cpg binding protein	0.0029	0.0539	0.0537
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0924	0.0866
Plasmodium falciparum	cation transporting ATPase, putative	0.0025	0.0419	0.0476
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0093	0.2184	0.3931
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.032	0.8063	0.8063
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0135	0.3283	0.5887
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.017	0.4185	0.792
Brugia malayi	Membrane calcium atpase protein 3	0.017	0.4185	0.792
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Echinococcus granulosus	cation transporting ATPase 13A3	0.0067	0.1518	0.1515
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0836	0.0834
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.2241	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2184	0.2706
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0924	0.0921
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0176	0.0113
Trypanosoma cruzi	copper-transporting ATPase, putative	0.0042	0.088	0.1378
Plasmodium falciparum	copper-transporting ATPase	0.0067	0.1518	0.2627
Brugia malayi	Potential phospholipid-transporting ATPase IA	0.0025	0.0419	0.0793
Schistosoma mansoni	hypothetical protein	0.0395	1	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.242	0.2999
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0175	0.0214
Trypanosoma cruzi	phospholipid-transporting ATPase 1-like protein, putative	0.0025	0.0419	0.0476
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0213	0.5284	1
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0093	0.2184	0.3931
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0213	0.5284	1
Brugia malayi	calcium ATPase	0.0077	0.1782	0.3373
Trypanosoma cruzi	cation-transporting ATPase, putative	0.0067	0.1518	0.2627
Echinococcus granulosus	cation transporting ATPase 13A1	0.0067	0.1518	0.1515
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0213	0.5284	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0924	0.1142
Mycobacterium tuberculosis	Cation transporter P-type ATPase a CtpA	0.0067	0.1518	0.4014
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.032	0.8063	0.8063
Echinococcus granulosus	calcium transporting atpase	0.017	0.4185	0.4184
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0067	0.1518	0.1515
Echinococcus multilocularis	phosphoserine phosphatase	0.0042	0.088	0.0877
Echinococcus multilocularis	phosphoserine phosphatase	0.0042	0.088	0.0877
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0479
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0067	0.1518	0.2627
Plasmodium vivax	P-type ATPase, putative	0.0025	0.0419	0.0476
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0924	0.0921
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0213	0.5284	0.5283
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0176	0.0214
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0924	0.0866
Leishmania major	P-type H -ATPase, putative	0.0135	0.3283	0.6082
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0067	0.1518	0.2259
Leishmania major	proton motive ATPase, putative	0.0067	0.1518	0.2627
Plasmodium vivax	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0025	0.0419	0.0476
Leishmania major	hypothetical protein, conserved	0.0024	0.0411	0.046
Toxoplasma gondii	cation-transporting ATPase, putative	0.0025	0.0419	0.0476
Trypanosoma brucei	P-type H+-ATPase, putative	0.0135	0.3283	0.6082
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0102	0.242	0.2999
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0411	0.046
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0213	0.5284	1
Echinococcus granulosus	Na:K ATPase alpha subunit	0.017	0.4185	0.4184
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.032	0.8063	0.8063
Loa Loa (eye worm)	calcium ATPase	0.012	0.2881	0.3571
Schistosoma mansoni	phospholipid-transporting atpase 1 (aminophospholipid flippase 1)	0.0025	0.0419	0.0358
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0135	0.3283	0.6082
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0175	0.0331
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0175	0.0172
Toxoplasma gondii	E1-E2 ATPase subfamily protein	0.0093	0.2184	0.3931
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.017	0.4185	0.7849
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0213	0.5284	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1303	0.1247
Plasmodium falciparum	cation-transporting ATPase 1	0.0025	0.0419	0.0476
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0102	0.242	0.4394
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0213	0.5284	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0411	0.046
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0836	0.1034
Chlamydia trachomatis	metal transport ATPase	0.0067	0.1518	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1026	0.1942
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.0067	0.1518	0.2627
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0135	0.3283	0.6082
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.0067	0.1518	0.2872
Echinococcus multilocularis	phosphoserine phosphatase	0.0042	0.088	0.0877
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.032	0.8063	0.8063
Schistosoma mansoni	phosphoserine phosphatase	0.0042	0.088	0.0822
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.2764	0.3425
Trypanosoma brucei	copper-transporting ATPase-like protein, putative	0.0067	0.1518	0.2627
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1518	0.1879
Schistosoma mansoni	copper ABC transporter ATPase	0.0067	0.1518	0.1464
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0411	0.046
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0419	0.0516
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.017	0.4185	0.7849
Plasmodium falciparum	cation transporting P-ATPase	0.0025	0.0419	0.0476
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0067	0.1518	0.2627
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.017	0.4185	0.4184
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0175	0.0214
Schistosoma mansoni	hypothetical protein	0.0015	0.0175	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1782	0.2207
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.017	0.4185	0.7741
Schistosoma mansoni	type V p-type atpase isoform	0.0025	0.0419	0.0358
Trypanosoma brucei	phospholipid-translocating P-type ATPase (flippase), putative	0.0025	0.0419	0.0476
Treponema pallidum	cation-transporting ATPase, P-type	0.0067	0.1518	1
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.017	0.4185	0.4184
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.0067	0.1518	0.2872
Brugia malayi	hypothetical protein	0.0042	0.088	0.1665
Schistosoma mansoni	hypothetical protein	0.0039	0.0798	0.074
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2241	0.2776
Schistosoma mansoni	hypothetical protein	0.0015	0.0175	0.0112
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0213	0.5284	0.5283
Schistosoma mansoni	cation-transporting atpase worm	0.0025	0.0419	0.0358
Brugia malayi	E1-E2 ATPase family protein	0.0135	0.3283	0.6213
Leishmania major	phospholipid-translocating P-type ATPase (flippase), putative	0.0025	0.0419	0.0476
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0042	0.088	0.1378
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.017	0.4185	0.4184
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0145	0.3519	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1026	0.1942
Schistosoma mansoni	hypothetical protein	0.0164	0.4014	0.3976
Echinococcus granulosus	phospholipid transporting ATPase IF	0.0025	0.0419	0.0416
Echinococcus granulosus	nervana 2	0.032	0.8063	0.8063
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.3296	0.3294
Brugia malayi	MH2 domain containing protein	0.0115	0.2764	0.523
Echinococcus granulosus	phospholipid transporting atpase ih	0.0025	0.0419	0.0416
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.2241	0.2238
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.017	0.4185	0.7849
Echinococcus multilocularis	cpg binding protein	0.0029	0.0539	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0411	0.0506
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0213	0.5284	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.032	0.8063	0.8051
Brugia malayi	hypothetical protein	0.0024	0.0411	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1518	0.1879
Toxoplasma gondii	cation-transporting atpase family protein	0.0042	0.088	0.1378
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0213	0.5284	0.5283
Echinococcus multilocularis	phospholipid transporting atpase ih phospholipid transporting atpase if	0.0025	0.0419	0.0416
Brugia malayi	Na,K-ATPase alpha subunit	0.0213	0.5284	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.114	0.1888
Onchocerca volvulus		0.032	0.8063	1
Schistosoma mansoni	phospholipid-transporting atpase	0.0025	0.0419	0.0358
Echinococcus multilocularis	phosphoserine phosphatase	0.0042	0.088	0.0877
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0145	0.3519	0.5314
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0063	0.006
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1546	0.1914
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0067	0.1518	0.2259
Plasmodium falciparum	E1-E2 ATPase, putative	0.0025	0.0419	0.0476
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.017	0.4185	0.4184
Echinococcus multilocularis	phospholipid transporting ATPase IF	0.0025	0.0419	0.0416
Plasmodium vivax	phospholipid-transporting ATPase, putative	0.0025	0.0419	0.0476
Trypanosoma cruzi	phospholipid-translocating ATPase, putative	0.0025	0.0419	0.0476
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.032	0.8063	0.8063
Schistosoma mansoni	hypothetical protein	0.0033	0.0632	0.0573
Leishmania major	P-type ATPase, putative	0.017	0.4185	0.7849
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.0067	0.1518	0.2259
Loa Loa (eye worm)	transbilayer Amphipath transporters family member	0.0025	0.0419	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0213	0.5284	0.6552
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0479
Echinococcus multilocularis	nervana 2	0.032	0.8063	0.8063
Echinococcus multilocularis	phosphoserine phosphatase	0.0042	0.088	0.0877
Echinococcus multilocularis	copper transporting ATPase 1	0.0067	0.1518	0.1515
Schistosoma mansoni	cation-transporting atpase fly	0.0025	0.0419	0.0358
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0063	0.006
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0213	0.5284	1
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0213	0.5284	1
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0213	0.5284	1
Brugia malayi	phospholipid-translocating P-type ATPase, flippase family protein	0.0025	0.0419	0.0793
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0213	0.5284	1
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0042	0.088	0.1378
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.017	0.4185	0.4148
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.032	0.8063	0.8051
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.032	0.8063	0.8051
Loa Loa (eye worm)	hypothetical protein	0.0213	0.5284	0.6552
Leishmania major	calcium motive p-type ATPase, putative	0.017	0.4185	0.7849
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0176	0.0173
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.0067	0.1518	0.2259
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0411	0.046
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0067	0.1518	0.2627
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1026	0.127
Plasmodium vivax	P-type ATPase4, putative	0.0213	0.5284	1
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0067	0.1518	0.1464
Trypanosoma cruzi	phospholipid-transporting ATPase-like protein, putative	0.0042	0.088	0.1378
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0213	0.5284	1
Echinococcus granulosus	phospholipid transporting ATPase IA	0.0025	0.0419	0.0416
Loa Loa (eye worm)	hypothetical protein	0.032	0.8063	1
Loa Loa (eye worm)	hypothetical protein	0.032	0.8063	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0924	0.1748
Echinococcus granulosus	nervana 2	0.032	0.8063	0.8063
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0411	0.046
Schistosoma mansoni	phospholipid-transporting atpase	0.0025	0.0419	0.0358
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0986	0.0983
Echinococcus granulosus	geminin	0.0164	0.4014	0.4013
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0042	0.088	0.0877
Schistosoma mansoni	phospholipid-transporting atpase	0.0025	0.0419	0.0358
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0176	0.0173
Schistosoma mansoni	ATPase	0.0213	0.5284	0.5254
Loa Loa (eye worm)	hypothetical protein	0.005	0.1074	0.1329
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.2241	0.3744
Trypanosoma brucei	phospholipid-transporting ATPase, putative	0.0025	0.0419	0.0476
Schistosoma mansoni	cation-transporting atpase worm	0.0067	0.1518	0.1464
Schistosoma mansoni	cpg binding protein	0.0028	0.0498	0.0438
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0213	0.5284	1
Echinococcus granulosus	cation transporting atpase worm	0.0067	0.1518	0.1515
Echinococcus multilocularis	geminin	0.0164	0.4014	0.4013
Echinococcus granulosus	expressed conserved protein	0.0089	0.2091	0.2089
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3556	0.4408
Leishmania major	cation-transporting ATPase, putative	0.0025	0.0419	0.0476
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0213	0.5284	1
Leishmania major	copper-transporting ATPase-like protein, putative	0.0067	0.1518	0.2627

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 2.54	Mutagenic activity of the compound was tested in an Ames test on S. typhimurium TA98; Activity is log of revertants/nmol	ChEMBL.	1995902
logP (ADMET)	= 1.58	Partition coefficient (logP)	ChEMBL.	1995902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL354305
PubChem: 145807

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 285247