Detailed information for compound 291158

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.504 | Formula: C22H24N2S
  • H donors: 1 H acceptors: 0 LogP: 5.57 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c([nH]3)Sc1ccccc1
  • InChi: 1S/C22H24N2S/c1-14-11-17-16-9-6-10-19-21(16)18(12-20(17)24(2)13-14)22(23-19)25-15-7-4-3-5-8-15/h3-10,14,17,20,23H,11-13H2,1-2H3/t14-,17-,20-/m1/s1
  • InChiKey: FVVUBLWTATZKEN-WIBUTAKZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.7 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 430 aa 30.5 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.9 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 446 aa 31.8 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D2 receptor   444 aa 438 aa 29.9 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 489 aa 24.5 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 493 aa 26.8 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 455 aa 29.5 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 417 aa 23.3 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.3 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 464 aa 27.4 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 28.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D2 receptor   444 aa 464 aa 29.3 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 479 aa 22.8 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.7 %
Echinococcus granulosus alpha 1A adrenergic receptor Dopamine D2 receptor   444 aa 466 aa 20.2 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D2 receptor   444 aa 432 aa 30.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutamate receptor kainate 0.054 0.0444 0.0415
Mycobacterium ulcerans membrane-bound esterase LipM 0.0195 0.0145 0.1818
Mycobacterium tuberculosis Probable esterase LipO 0.0195 0.0145 0.296
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0046 0.0343
Brugia malayi metabotropic glutamate receptor type 2 0.0069 0.0036 0.008
Mycobacterium ulcerans esterase LipC 0.0195 0.0145 0.1818
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0632 0.0524 0.5326
Echinococcus multilocularis receptor type guanylyl cyclase 0.0069 0.0036 0.0027
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0136 0.0093 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Brugia malayi Metabotropic glutamate receptor precursor. 0.0069 0.0036 0.008
Schistosoma mansoni metabotropic glutamate receptor 0.0069 0.0036 0.0005
Brugia malayi Guanylyl cyclase protein 23 0.0069 0.0036 0.008
Echinococcus multilocularis NMDA receptor 0.0309 0.0244 0.0236
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1139 0.0965 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0507 0.0416 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0179 0.0131 0.0123
Mycobacterium ulcerans esterase LipW 0.0195 0.0145 0.1818
Mycobacterium tuberculosis Probable carboxylesterase LipQ 0.0195 0.0145 0.296
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0069 0.0036 0.0027
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0054 0.0022 0.1504
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0309 0.0244 0.0236
Loa Loa (eye worm) hypothetical protein 0.038 0.0305 0.0275
Loa Loa (eye worm) carboxylesterase 0.0067 0.0034 0.0003
Brugia malayi Glutamate receptor 1 precursor 0.0746 0.0624 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0195 0.0145 0.1304
Loa Loa (eye worm) RGC/RGC protein kinase 0.0069 0.0036 0.0005
Mycobacterium ulcerans esterase LipO 0.0195 0.0145 0.1818
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0003
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.0131 0.01
Mycobacterium tuberculosis Possible esterase LipW 0.0195 0.0145 0.296
Schistosoma mansoni glutamate receptor NMDA 0.0366 0.0294 0.0264
Schistosoma mansoni glutamate receptor kainate 0.054 0.0444 0.0415
Mycobacterium tuberculosis Probable esterase/lipase LipF 0.0195 0.0145 0.296
Mycobacterium ulcerans lipase LipU 0.0195 0.0145 0.1818
Echinococcus granulosus dna polymerase kappa 0.0126 0.0085 0.0076
Schistosoma mansoni glutamate receptor NMDA 0.0436 0.0354 0.0324
Echinococcus granulosus carboxylesterase 5A 0.0067 0.0034 0.0026
Echinococcus granulosus glutamate receptor 4 0.038 0.0305 0.0297
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0195 0.0145 0.0114
Trichomonas vaginalis Esterase, putative 0.0195 0.0145 1
Trichomonas vaginalis Esterase, putative 0.0195 0.0145 1
Mycobacterium ulcerans hypothetical protein 0.0195 0.0145 0.1818
Loa Loa (eye worm) RGC/RGC protein kinase 0.0069 0.0036 0.0005
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0195 0.0145 1
Mycobacterium ulcerans acetyl hydrolase MbtJ 0.0195 0.0145 0.1818
Loa Loa (eye worm) glutamate receptor 1 0.0746 0.0624 0.0595
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0021 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0021 0.008
Echinococcus multilocularis dna polymerase kappa 0.0126 0.0085 0.0076
Loa Loa (eye worm) aryl-acylamidase 0.0195 0.0145 0.0114
Schistosoma mansoni hormone-sensitive lipase (S09 family) 1.1528 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0098 0.006 0.0407
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0031 0.0023
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Mycobacterium ulcerans esterase/lipase 0.0195 0.0145 0.1818
Brugia malayi Receptor family ligand binding region containing protein 0.0069 0.0036 0.008
Schistosoma mansoni glutamate receptor AMPA 0.0366 0.0294 0.0264
Echinococcus granulosus receptor type guanylyl cyclase 0.0069 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Trypanosoma cruzi extracellular receptor, putative 0.0069 0.0036 0.0145
Echinococcus multilocularis glutamate receptor 2 0.0815 0.0684 0.0676
Brugia malayi ImpB/MucB/SamB family protein 0.0098 0.006 0.0496
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0515 0.0423 0.0415
Leishmania major ecotin, putative 0.0195 0.0145 0.1304
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0609 0.0505 0.0497
Echinococcus multilocularis dna polymerase eta 0.0098 0.006 0.0052
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0195 0.0145 0.1304
Loa Loa (eye worm) hypothetical protein 0.038 0.0305 0.0275
Brugia malayi Carboxylesterase family protein 0.0067 0.0034 0.005
Loa Loa (eye worm) hypothetical protein 0.0082 0.0046 0.0015
Schistosoma mansoni hormone-sensitive lipase (S09 family) 1.1528 1 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0069 0.0036 0.0027
Echinococcus granulosus glutamate receptor 1 0.038 0.0305 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0021 0.008
Leishmania major DNA polymerase kappa, putative 0.0073 0.0038 0.0176
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0195 0.0145 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0034 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0098 0.006 0.0491
Echinococcus multilocularis carboxylesterase 5A 0.0067 0.0034 0.0026
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0073 0.0038 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0038 0.0262
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Echinococcus granulosus glutamate receptor subunit protein glur 0.0515 0.0423 0.0415
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0034 0.0026
Mycobacterium tuberculosis Putative acetyl hydrolase MbtJ 0.0195 0.0145 0.296
Loa Loa (eye worm) ammd protein 0.0195 0.0145 0.0114
Leishmania major hypothetical protein, conserved 0.0195 0.0145 0.1304
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Entamoeba histolytica hypothetical protein 0.0069 0.0036 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0609 0.0505 0.0497
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Echinococcus multilocularis glutamate receptor 2 0.068 0.0566 0.0558
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0034 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0145 1
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0077 0.0667
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Onchocerca volvulus 0.0195 0.0145 1
Giardia lamblia DINP protein human, muc B family 0.0073 0.0038 0.5
Loa Loa (eye worm) hypothetical protein 0.038 0.0305 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.0085 0.0665
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0046 0.0343
Loa Loa (eye worm) glutamate receptor 2 0.0366 0.0294 0.0264
Toxoplasma gondii hypothetical protein 0.0183 0.0134 0.928
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Echinococcus granulosus tyrosine kinase 0.0069 0.0036 0.0027
Mycobacterium tuberculosis Probable non lipolytic carboxylesterase NlhH 0.0195 0.0145 0.296
Echinococcus multilocularis nmda type glutamate receptor 0.0069 0.0036 0.0027
Echinococcus granulosus glutamate receptor 2 0.0815 0.0684 0.0676
Echinococcus granulosus glutamate receptor 2 0.068 0.0566 0.0558
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0309 0.0244 0.0236
Brugia malayi polk-prov protein 0.0082 0.0046 0.0259
Loa Loa (eye worm) hypothetical protein 1.1528 1 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0069 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0003
Schistosoma mansoni hypothetical protein 0.0136 0.0093 0.0062
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0309 0.0244 0.0236
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1139 0.0965 1
Schistosoma mansoni glutamate receptor AMPA 0.0366 0.0294 0.0264
Schistosoma mansoni hormone-sensitive lipase (S09 family) 1.1528 1 1
Mycobacterium tuberculosis Probable lipase LipH 0.0195 0.0145 0.296
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0069 0.0036 0.0005
Trypanosoma cruzi Alpha/beta hydrolase domain-containing protein 0.0195 0.0145 0.1304
Mycobacterium tuberculosis Probable lipase/esterase LipN 0.0195 0.0145 0.296
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0254 0.0196 0.1843
Echinococcus multilocularis hormone sensitive lipase 1.1528 1 1
Schistosoma mansoni DNA polymerase eta 0.0098 0.006 0.003
Mycobacterium tuberculosis Possible lipase LipU 0.0195 0.0145 0.296
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0069 0.0036 0.0027
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0609 0.0505 0.0497
Loa Loa (eye worm) RGC/RGC protein kinase 0.0069 0.0036 0.0005
Brugia malayi hypothetical protein 0.0069 0.0036 0.008
Echinococcus granulosus nmda type glutamate receptor 0.0136 0.0093 0.0085
Mycobacterium ulcerans lipase LipU 0.0195 0.0145 0.1818
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Schistosoma mansoni metabotropic glutamate receptor 0.0069 0.0036 0.0005
Loa Loa (eye worm) hypothetical protein 0.0098 0.006 0.003
Trypanosoma brucei unspecified product 0.0117 0.0077 0.0667
Treponema pallidum N-acetylphosphinothricin-tripetide-deacetylase 0.0195 0.0145 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0179 0.0131 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Schistosoma mansoni tyrosine kinase 0.0069 0.0036 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0309 0.0244 0.0236
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0179 0.0131 0.1689
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.0085 0.0747
Echinococcus granulosus metabotropic glutamate receptor 2 0.0069 0.0036 0.0027
Echinococcus granulosus dna polymerase eta 0.0098 0.006 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0254 0.0196 0.1843
Brugia malayi aryl-acylamidase 0.0195 0.0145 0.1924
Schistosoma mansoni glutamate receptor kainate 0.0366 0.0294 0.0264
Echinococcus granulosus atrial natriuretic peptide receptor 0.0069 0.0036 0.0027
Mycobacterium ulcerans lipase LipH 0.0195 0.0145 0.1818
Brugia malayi Glutamate receptor 2 precursor 0.0746 0.0624 1
Leishmania major DNA polymerase eta, putative 0.0098 0.006 0.0407
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0609 0.0505 0.0497
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0609 0.0505 0.0497
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0366 0.0294 0.0286
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0136 0.0093 0.0085
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.0131 0.01
Echinococcus multilocularis glutamate receptor 4 0.038 0.0305 0.0297
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0069 0.0036 0.0005
Echinococcus granulosus acetylcholinesterase 0.0067 0.0034 0.0026
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0031 0.0023
Mycobacterium tuberculosis Probable acetyl-hydrolase/esterase LipR 0.0195 0.0145 0.296
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0254 0.0196 0.1843
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0632 0.0524 0.5367
Trypanosoma brucei Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0195 0.0145 0.138
Brugia malayi Protein kinase domain containing protein 0.0179 0.0131 0.1689
Brugia malayi Carboxylesterase family protein 0.0067 0.0034 0.005
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0815 0.0684 0.0676
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0069 0.0036 0.0005
Loa Loa (eye worm) glutamate receptor 0.0069 0.0036 0.0005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0254 0.0196 0.1914
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0073 0.0038 0.0176
Mycobacterium ulcerans lipase/esterase LipN 0.0195 0.0145 0.1818
Schistosoma mansoni ATP-binding cassette transporter 0.0366 0.0294 0.0264
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0179 0.0131 0.8726
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Loa Loa (eye worm) acetylcholinesterase 1 0.0067 0.0034 0.0003
Mycobacterium ulcerans hypothetical protein 0.0507 0.0416 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0815 0.0684 0.0676
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0632 0.0524 0.5326
Leishmania major mitochondrial DNA polymerase beta 0.1139 0.0965 1
Mycobacterium tuberculosis Probable esterase LipC 0.0195 0.0145 0.296
Leishmania major extracellular receptor, putative 0.0069 0.0036 0.0145
Echinococcus multilocularis nmda type glutamate receptor 0.0136 0.0093 0.0085
Echinococcus granulosus nmda type glutamate receptor 0.0069 0.0036 0.0027
Trichomonas vaginalis Esterase, putative 0.0195 0.0145 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.0085 0.0665
Echinococcus granulosus glutamate NMDA receptor subunit 0.0366 0.0294 0.0286
Brugia malayi Receptor family ligand binding region containing protein 0.0069 0.0036 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.0085 0.0665
Schistosoma mansoni protein kinase 0.0069 0.0036 0.0005
Mycobacterium ulcerans carboxylesterase LipQ 0.0195 0.0145 0.1818
Echinococcus multilocularis glutamate receptor 2 0.0746 0.0624 0.0616
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0609 0.0505 0.0497
Echinococcus granulosus acetylcholinesterase 0.0067 0.0034 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0126 0.0085 0.0747
Echinococcus multilocularis tyrosine kinase 0.0069 0.0036 0.0027
Mycobacterium leprae Possible lipase LipU 0.0195 0.0145 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0126 0.0085 0.0747
Loa Loa (eye worm) hypothetical protein 0.0069 0.0036 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1139 0.0965 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.0085 0.0665
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0131 0.01
Mycobacterium tuberculosis Probable esterase LipM 0.0195 0.0145 0.296
Mycobacterium ulcerans lipase LipI 0.0195 0.0145 0.1818
Trypanosoma cruzi serine peptidase, Clan SC, Family S9D 0.0195 0.0145 0.1304
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0195 0.0144 0.1299
Schistosoma mansoni tyrosine kinase 0.0069 0.0036 0.0005
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0069 0.0036 0.008

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = 106 % Percent change in serum prolactin in adult male Dawley rats after intraperitoneal administration. ChEMBL. 8096548
EDmin (functional) = 10 mg kg-1 Compound was tested for the Conditioned avoidance response (CAR) in rats ChEMBL. 8096548
EDmin (functional) = 20 mg kg-1 Conditioned avoidance response in rats after oral administration ChEMBL. 8096548
EDmin (functional) = 20 mg kg-1 Tested for the amphetamine induced stereotyped behavior in rats after oral administration ChEMBL. 8096548
IC50 (binding) = 0.18 uM Competition in vitro with the dopamine receptor D2 anatagonist [3H]-spiperone, for binding sites on calf caudate membranes. ChEMBL. 8096548
IC50 (binding) = 0.18 uM Competition in vitro with the dopamine receptor D2 anatagonist [3H]-spiperone, for binding sites on calf caudate membranes. ChEMBL. 8096548

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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