Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0084 | 0.0056 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0525 | 0.096 | 0.0703 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0237 | 0.0369 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.14 | 0.2752 | 1 |
Brugia malayi | hypothetical protein | 0.0237 | 0.0369 | 0.1341 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0237 | 0.0369 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.4939 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0237 | 0.0369 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.14 | 0.2752 | 0.2752 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0277 | 0.0222 |
Echinococcus multilocularis | neuroligin | 0.0237 | 0.0369 | 0.0095 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Echinococcus granulosus | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0056 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0237 | 0.0369 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0237 | 0.0369 | 0.0095 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Mycobacterium leprae | Possible lipase LipU | 0.0084 | 0.0056 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0237 | 0.0369 | 0.0095 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0277 | 0.0222 |
Loa Loa (eye worm) | ammd protein | 0.0084 | 0.0056 | 0.0056 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0369 | 0.0369 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0084 | 0.0056 | 0.0056 |
Leishmania major | ecotin, putative | 0.0084 | 0.0056 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0525 | 0.096 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.14 | 0.2752 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0369 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.14 | 0.2752 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.4939 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0237 | 0.0369 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0237 | 0.0369 | 0.0095 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0237 | 0.0369 | 0.0095 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0084 | 0.0056 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.14 | 0.2752 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0237 | 0.0369 | 0.0095 |
Echinococcus granulosus | neuroligin | 0.0237 | 0.0369 | 0.0095 |
Echinococcus granulosus | carboxylesterase 5A | 0.14 | 0.2752 | 0.2546 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0525 | 0.096 | 0.0703 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Brugia malayi | Carboxylesterase family protein | 0.14 | 0.2752 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0369 | 0.0369 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0525 | 0.096 | 0.0703 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0369 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Brugia malayi | aryl-acylamidase | 0.0084 | 0.0056 | 0.0203 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.14 | 0.2752 | 0.2711 |
Echinococcus multilocularis | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 45 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 4652 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 4652 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
Selectivity (binding) | = 10 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 10 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.