Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | choline kinase alpha | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | choline/ethanolamine kinase | choline kinase alpha | 457 aa | 474 aa | 22.1 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0327 | 0.6035 | 0.6035 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.6035 | 0.6035 |
Onchocerca volvulus | 0.0055 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0079 | 0.0533 | 0.0647 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0427 | 0.824 | 1 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0506 | 1 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0067 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0597 | 0.0597 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0506 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0427 | 0.824 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0327 | 0.6035 | 0.6035 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0506 | 1 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0067 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.6035 | 0.6035 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1274 | 0.1274 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0506 | 1 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.023 | 0.3869 | 0.3869 |
Onchocerca volvulus | 0.0055 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1369 | 0.1369 |
Echinococcus granulosus | integrin alpha 3 | 0.0114 | 0.1307 | 0.1307 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 0.6035 | 0.6035 |
Onchocerca volvulus | 0.0055 | 0 | 0.5 | |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0427 | 0.824 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 0.6035 | 0.6035 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0427 | 0.824 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0327 | 0.6035 | 0.6035 |
Loa Loa (eye worm) | carboxylesterase | 0.0327 | 0.6035 | 0.6035 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0506 | 1 | 0.5 |
Onchocerca volvulus | 0.0055 | 0 | 0.5 | |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0079 | 0.0533 | 0.0647 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0427 | 0.824 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0149 | 0.2079 | 0.2079 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0113 | 0.1274 | 0.1274 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0506 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.6035 | 0.6035 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.6035 | 0.6035 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0506 | 1 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0255 | 0.0255 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0506 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0327 | 0.6035 | 0.6035 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0153 | 0.2176 | 0.2642 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.6035 | 0.6035 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0506 | 1 | 0.5 |
Onchocerca volvulus | 0.0055 | 0 | 0.5 | |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0255 | 0.0255 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0506 | 1 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0506 | 1 | 0.5 |
Schistosoma mansoni | integrin alpha | 0.0149 | 0.2079 | 0.2079 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.6035 | 0.6035 |
Echinococcus multilocularis | integrin alpha 3 | 0.0114 | 0.1307 | 0.1307 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0506 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 60 nM | Inhibition of human recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (binding) | = 330 nM | Inhibition of human BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (binding) | = 0.026 uM | Inhibition of bovine AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (binding) | = 0.179 uM | Inhibition of equine BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (functional) | = 1.6 uM | Antiproliferative activity was determined using HT-29 human colon cancer cell line | ChEMBL. | 15481981 |
IC50 (functional) | = 1.6 uM | Antiproliferative activity was determined using HT-29 human colon cancer cell line | ChEMBL. | 15481981 |
IC50 (binding) | = 1.9 uM | Inhibitory activity against human choline kinase enzyme | ChEMBL. | 15481981 |
IC50 (binding) | = 1.9 uM | Inhibitory activity against human choline kinase enzyme | ChEMBL. | 15481981 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15481981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.