Detailed information for compound 343560

Basic information

Technical information
  • TDR Targets ID: 343560
  • Name: 2-N-(5-chloro-2-methylphenyl)-5-methyl-7-N-ph enethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2,7- diamine
  • MW: 392.885 | Formula: C21H21ClN6
  • H donors: 2 H acceptors: 3 LogP: 5.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Nc1nn2c(n1)nc(cc2NCCc1ccccc1)C)C
  • InChi: 1S/C21H21ClN6/c1-14-8-9-17(22)13-18(14)25-20-26-21-24-15(2)12-19(28(21)27-20)23-11-10-16-6-4-3-5-7-16/h3-9,12-13,23H,10-11H2,1-2H3,(H,25,27)
  • InChiKey: NHRHUJASDVKCES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N2-(5-chloro-2-methyl-phenyl)-5-methyl-N7-phenethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2,7-diamine
  • N2-(5-chloro-2-methylphenyl)-5-methyl-N7-phenethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2,7-diamine
  • [2-(5-chloro-2-methyl-anilino)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-phenethyl-amine
  • N-(5-chloro-2-methylphenyl)-5-methyl-N'-(2-phenylethyl)-[1,2,4]triazolo[5,1-b]pyrimidine-2,7-diamine
  • N-(5-chloro-2-methyl-phenyl)-5-methyl-N'-(2-phenylethyl)-[1,2,4]triazolo[5,1-b]pyrimidine-2,7-diamine
  • [2-[(5-chloro-2-methyl-phenyl)amino]-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-yl]-(2-phenylethyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis voltage gated potassium channel 0.0007 0.0007 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0013 0.0013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0055 0.0196 0.0173
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0018 0.0018
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0019 0.0002
Echinococcus multilocularis bloom syndrome protein 0.002 0.0058 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0111
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Brugia malayi Pre-SET motif family protein 0.0238 0.0908 0.0908
Leishmania major farnesyl pyrophosphate synthase 0.2567 1 1
Echinococcus multilocularis transfer RNA-Gly 0.0007 0.0007 0.0007
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0121 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0154 0.0154
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0018 0.0018
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.2567 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0019 0.0002
Echinococcus granulosus dnaJ subfamily B 0.0409 0.1578 0.1578
Schistosoma mansoni hypothetical protein 0.0164 0.0619 0.0619
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0058 0.0052
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0018 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.0018
Onchocerca volvulus 0.0036 0.0121 0.1011
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0055 0.0196 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0154 0.0154
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0018
Schistosoma mansoni ap endonuclease 0.0055 0.0196 0.0196
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0594 0.0594
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0116 0.0111
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0111
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2567 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0121 0.0121
Schistosoma mansoni trans-prenyltransferase 0.0706 0.2737 0.2737
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0013 0.0013
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0031 0.0011
Echinococcus multilocularis Ankyrin 0.0014 0.0036 0.0036
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0007 0.0007 0.0007
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Schistosoma mansoni hypothetical protein 0.0021 0.0063 0.0063
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0948 0.3679 0.3679
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0121 0.0121
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0594 0.0594
Onchocerca volvulus 0.0011 0.0023 0.0054
Brugia malayi follicle stimulating hormone receptor 0.0235 0.0897 0.0897
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0121 0.0121
Echinococcus granulosus bloom syndrome protein 0.002 0.0058 0.0058
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0121 0.0098
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0154 0.0154
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0018 0.0018
Trichomonas vaginalis Phospholipase C precursor, putative 0.0011 0.0023 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0083 0.0304 0.0304
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0055 0.0196 0.0196
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.2567 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0154 0.0154
Loa Loa (eye worm) histone methyltransferase 0.001 0.0019 0.0019
Brugia malayi Death domain containing protein 0.0014 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0018 0.0018
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0031 0.0011
Schistosoma mansoni DNA helicase recq5 0.002 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.0097
Treponema pallidum octaprenyl-diphosphate synthase 0.0948 0.3679 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0948 0.3679 0.3679
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0196 0.0173
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0706 0.2737 0.2737
Onchocerca volvulus 0.0091 0.0335 0.3115
Schistosoma mansoni farnesyl pyrophosphate synthase 0.2567 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0058 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0018 0.0018
Leishmania major polyprenyl synthase, putative 0.0948 0.3679 0.3664
Echinococcus multilocularis potassium voltage gated channel protein 0.0087 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0031 0.0124
Loa Loa (eye worm) voltage-gated potassium channel 0.0007 0.0007 0.0007
Toxoplasma gondii exonuclease III APE 0.0055 0.0196 0.0178
Brugia malayi CCR4 0.0011 0.0023 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.0038
Onchocerca volvulus 0.0011 0.0023 0.0054
Loa Loa (eye worm) RecQ helicase 0.002 0.0058 0.0058
Schistosoma mansoni carbon catabolite repressor protein 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0018 0.0018
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Brugia malayi ecdysteroid receptor 0.001 0.0018 0.0018
Brugia malayi nuclear hormone receptor 0.001 0.0018 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0121 0.0098
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0063 0.0063
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0196 0.0191
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0121 0.0098
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0023 0.0023
Leishmania major hypothetical protein, conserved 0.0024 0.0075 0.0052
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0058 0.0058
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0087 0.0319 0.0319
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0018 0.0018
Brugia malayi steroid hormone receptor 0.001 0.0018 0.0018
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0706 0.2737 0.2737
Onchocerca volvulus Putative neutral sphingomyelinase 0.0011 0.0023 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0196 0.0191
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.2723
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0058 0.0034
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0058 0.0058
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.0056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0055 0.0196 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.0097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0361
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0706 0.2737 0.2737
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0121 0.0116
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0121 0.0098
Echinococcus multilocularis synaptojanin 1 0.0011 0.0023 0.0023
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2567 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Brugia malayi hypothetical protein 0.0024 0.0075 0.0075
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0023 0.0018
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0035 0.0035
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0025
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Loa Loa (eye worm) beta-lactamase 0.0036 0.0121 0.0121
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Trypanosoma brucei glucosidase, putative 0.0035 0.0116 0.0093
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0018 0.0018
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0023 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0108 0.0108
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0075 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0018 0.0018
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0011 0.0023 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0018 0.0018
Echinococcus multilocularis cpg binding protein 0.003 0.0099 0.0099
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.2723
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0031 0.0047
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.0056
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0019 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Schistosoma mansoni ap endonuclease 0.0055 0.0196 0.0196
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0115 0.0115
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0023 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0023 0.0006
Trypanosoma cruzi polyprenyl synthase, putative 0.0948 0.3679 0.3667
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0706 0.2737 0.2737
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0594 0.0594
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0058 0.0058
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0007 0.0007 0.0007
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0031 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0055 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0018 0.0018
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0023 0.0018
Trypanosoma brucei farnesyl pyrophosphate synthase 0.2567 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0115
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0023 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0018 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0018
Plasmodium vivax SET domain protein, putative 0.0035 0.0115 0.0097
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Conserved protein 0.0036 0.0121 0.0098
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0023
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.2567 1 1
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0011 0.0023 0.002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Schistosoma mansoni coup transcription factor 0.001 0.0018 0.0018
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0075
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0706 0.2737 0.2724
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0087 0.0319 0.0319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0055 0.0196 0.0177
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0706 0.2737 0.272
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0197 0.018
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0121 0.0121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.000000000032041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.0897 0.0897
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0023 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0018 0.0018
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0023 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0007 0.0007 0.0007
Echinococcus granulosus farnesyl pyrophosphate synthase 0.2567 1 1
Echinococcus multilocularis shaker cognate 0.0007 0.0007 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0116 0.0116
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0031 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.0052
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0706 0.2737 1
Echinococcus granulosus Ankyrin 0.0014 0.0036 0.0036
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0011 0.0023 0.0018
Echinococcus granulosus potassium voltage gated channel protein 0.0007 0.0007 0.0007
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0948 0.3679 0.3679
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0055 0.0196 0.0196
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0058 0.0058
Brugia malayi Protein kinase domain containing protein 0.0014 0.0035 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.0052
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0116 0.0111
Onchocerca volvulus 0.0035 0.0115 0.0954
Echinococcus granulosus voltage gated potassium channel 0.0007 0.0007 0.0007
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.002
Echinococcus multilocularis potassium voltage gated channel protein 0.0007 0.0007 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0018 0.0018
Schistosoma mansoni vesicular amine transporter 0.0007 0.0007 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0706 0.2737 0.2723
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0121 0.0121
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0023 0.0018
Echinococcus granulosus death domain containing protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0031 0.0025
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0116 0.0116
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0018 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0018 0.0018
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.004
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0007 0.0007 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0196 0.0178
Entamoeba histolytica recQ family DNA helicase 0.001 0.0019 0.0006
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.0006
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0116 0.0116
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0263 0.0263
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Onchocerca volvulus 0.0036 0.0121 0.1011
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0035 0.0035
Echinococcus multilocularis potassium voltage gated channel protein 0.0007 0.0007 0.0007
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0011 0.0023 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0018 0.0018
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0035 0.0035
Mycobacterium tuberculosis Conserved protein 0.0036 0.0121 0.0098
Echinococcus granulosus shaker cognate 0.0007 0.0007 0.0007
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.0034
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2567 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0092 0.0092
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Schistosoma mansoni nuclear hormone receptor 0.001 0.0018 0.0018
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0115 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0115 0.0115
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Echinococcus granulosus FTZ F1 alpha 0.001 0.0018 0.0018
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0121 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0121 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0154 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0121 0.0098
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0023 0.0023
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0063 0.0045
Brugia malayi beta-lactamase family protein 0.0036 0.0121 0.0121
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0023 0.0004
Onchocerca volvulus 0.0271 0.1036 1
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0035
Brugia malayi Pre-SET motif family protein 0.0035 0.0115 0.0115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0023 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.0029 0.0092 0.0092
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0706 0.2737 0.272
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0706 0.2737 0.5
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.2567 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0055 0.0196 0.0482
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0018 0.0018
Schistosoma mansoni netrin receptor unc5 0.0014 0.0035 0.0035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.000000000032041
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0063 0.0045
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.2567 1 1
Schistosoma mansoni hypothetical protein 0.0409 0.1578 0.1578
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.0102
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0031 0.0007
Schistosoma mansoni synaptojanin 0.0011 0.0023 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0223 0.0223
Brugia malayi beta-lactamase 0.0036 0.0121 0.0121
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0948 0.3679 0.3679
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0011 0.0023 0.0004
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0023 0.0023
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0706 0.2737 0.2648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0154 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0319 0.0319
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.0018
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0058 0.0058
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.0018
Schistosoma mansoni alpha glucosidase 0.0035 0.0116 0.0116
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0706 0.2737 1
Plasmodium vivax exodeoxyribonuclease III, putative 0.0011 0.0023 0.0006
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0011 0.0023 0.0004
Onchocerca volvulus 0.0029 0.0092 0.0728
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0023 0.0023
Leishmania major hypothetical protein, conserved 0.0021 0.0063 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0075 0.0052
Leishmania major solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.272
Treponema pallidum hypothetical protein 0.0011 0.0023 0.0011
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0063 0.0063
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0018 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.1578 0.1578
Toxoplasma gondii ABC1 family protein 0.0036 0.0121 0.0103
Mycobacterium tuberculosis Conserved protein 0.0036 0.0121 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0154 0.0154
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0706 0.2737 0.272
Brugia malayi hypothetical protein 0.0016 0.0041 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0013 0.0013
Brugia malayi Uncoordinated protein 44 0.0014 0.0035 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0121 0.0121
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0706 0.2737 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0018 0.0018
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0063 0.004
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0018 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Brugia malayi nuclear receptor NHR-88 0.001 0.0018 0.0018
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0007 0.0007 0.0007
Echinococcus granulosus synaptojanin 1 0.0011 0.0023 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0036 0.0121 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Schistosoma mansoni neutral sphingomyelinase 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Schistosoma mansoni nocturnin 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0018 0.0018
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0011 0.0023 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Brugia malayi Protein kinase domain containing protein 0.0021 0.0063 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0013 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0121 0.0116
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2567 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0706 0.2737 1
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0706 0.2737 0.2724
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0055 0.0196 0.0654
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0706 0.2737 0.272
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0115 0.0115
Giardia lamblia Farnesyl diphosphate synthase 0.2567 1 1
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.2567 1 1
Brugia malayi beta-lactamase family protein 0.0036 0.0121 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0115 0.0115
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0058 0.0058
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0011 0.0023 0.002
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0075 0.0057
Schistosoma mansoni synaptojanin 0.0011 0.0023 0.0023
Brugia malayi Polyprenyl synthetase family protein 0.0706 0.2737 0.2737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0018 0.0018
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0018
Onchocerca volvulus 0.0036 0.0121 0.1011
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0263 0.0263
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0087 0.0319 0.0319
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0881 0.086
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0319 0.0319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0948 0.3679 0.3679
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0115 0.0097
Trypanosoma cruzi polyprenyl synthase, putative 0.0948 0.3679 0.3667
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Trichomonas vaginalis set domain proteins, putative 0.0271 0.1036 0.1031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0018 0.0018
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.002
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0063 0.0063
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0706 0.2737 0.2648
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0023 0.0004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0121 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0018 0.0018
Loa Loa (eye worm) polyprenyl synthetase 0.2567 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0023 0.0023
Brugia malayi CXXC zinc finger family protein 0.0029 0.0092 0.0092
Entamoeba histolytica recQ family helicase, putative 0.002 0.0058 0.0146
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0011 0.0023 0.0023
Echinococcus granulosus geminin 0.0164 0.0619 0.0619
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.0058
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0058 0.0034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel protein 0.0087 0.0319 0.0319
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0023 0.0023
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0058 0.0034
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0055 0.0196 0.0173
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0121 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0018 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0055 0.0196 0.0173
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0011 0.0023 0.0004
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0594 0.0594
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0115 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0154 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0121 0.0098
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0706 0.2737 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0115 0.0115
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0706 0.2737 0.272
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0063 0.0044
Schistosoma mansoni cript-related 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0018 0.0018
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0023 0.0006
Echinococcus multilocularis geminin 0.0164 0.0619 0.0619
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.0034
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0018
Onchocerca volvulus 0.0021 0.0063 0.0441
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0025
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0023 0.0023
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.2567 1 1
Schistosoma mansoni hypothetical protein 0.0164 0.0619 0.0619
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0031
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0116 0.0116
Trichomonas vaginalis esterase, putative 0.0036 0.0121 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0121 0.0098
Schistosoma mansoni glutathione synthetase 0.0706 0.2737 0.2737
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0007
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0098
Echinococcus granulosus cpg binding protein 0.003 0.0099 0.0099
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0706 0.2737 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0007 0.0007 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0055 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.0018
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0023 0.0023
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0023 0.0006
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0036 0.0036
Loa Loa (eye worm) polyprenyl synthetase 0.0706 0.2737 0.2737
Schistosoma mansoni alpha-glucosidase 0.0135 0.0509 0.0509
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0035 0.0169
Schistosoma mansoni DNA helicase recq1 0.002 0.0058 0.0058
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0055 0.0196 0.0173
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0594 0.0594
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.2567 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0007
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0023 0.0023
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0011 0.0023 0.0004
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0058 0.0052
Echinococcus granulosus potassium voltage gated channel protein 0.0007 0.0007 0.0007
Brugia malayi Kringle domain containing protein 0.0021 0.0063 0.0063
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.0908 0.0908
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000032041
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0116 0.0093
Schistosoma mansoni alpha-glucosidase 0.0135 0.0509 0.0509
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0018 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 290 nM Inhibitory constant against thrombin ChEMBL. 16137886
Ki (binding) = 290 nM Inhibitory constant against thrombin ChEMBL. 16137886

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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