Detailed information for compound 370697

Basic information

Technical information
  • TDR Targets ID: 370697
  • Name: N-(cyclohexylmethyl)-2-[(1R,2S)-2-(1H-imidazo l-5-yl)cyclopropyl]ethanamine
  • MW: 247.379 | Formula: C15H25N3
  • H donors: 2 H acceptors: 1 LogP: 2.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)CNCC[C@H]1C[C@@H]1c1c[nH]cn1
  • InChi: 1S/C15H25N3/c1-2-4-12(5-3-1)9-16-7-6-13-8-14(13)15-10-17-11-18-15/h10-14,16H,1-9H2,(H,17,18)/t13-,14-/m0/s1
  • InChiKey: NESASFDNMLPZIR-KBPBESRZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • cyclohexylmethyl-[2-[(1R,2S)-2-(1H-imidazol-5-yl)cyclopropyl]ethyl]amine
  • N-(cyclohexylmethyl)-2-[(1R,2S)-2-(3H-imidazol-4-yl)cyclopropyl]ethanamine
  • cyclohexylmethyl-[2-[(1R,2S)-2-(3H-imidazol-4-yl)cyclopropyl]ethyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H4 Starlite/ChEMBL References
Homo sapiens histamine receptor H1 Starlite/ChEMBL References
Homo sapiens histamine receptor H2 Starlite/ChEMBL References
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein histamine receptor H2 397 aa 333 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0077 0.0445 0.0445
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Trypanosoma brucei cysteine peptidase C (CPC) 0.0504 0.3712 0.8729
Echinococcus multilocularis c src tyrosine kinase 0.0045 0.0197 0.0197
Plasmodium vivax unspecified product 0.0314 0.2257 0.5207
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0635 0.0635
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Echinococcus granulosus tyrosine kinase 0.0083 0.049 0.049
Toxoplasma gondii alpha-tubulin I, putative 0.0094 0.0578 0.0587
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0308 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Entamoeba histolytica cysteine proteinase 2 0.0314 0.2257 0.5307
Schistosoma mansoni tensin-related 0.0019 0.0004 0.0004
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0136 0.0896 0.0968
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0149 0.0149
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.0004 0.0004
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.0578 0.0578
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0308 1
Echinococcus granulosus SH2 domain containing protein 7 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0136 0.0896 0.0896
Echinococcus multilocularis N chimaerin 0.0019 0.0004 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Brugia malayi SH2 domain containing protein 0.0019 0.0004 0.0004
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Trichomonas vaginalis tubulin epsilon chain, putative 0.0077 0.0445 0.1046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0308 1
Trypanosoma cruzi cysteine peptidase, putative 0.0575 0.4252 0.4252
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Loa Loa (eye worm) tubulin alpha chain 0.0094 0.0578 0.0578
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0896 0.0896
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0094 0.0576 0.0576
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0048 0.0048
Loa Loa (eye worm) beta-tubulin 0.0077 0.0445 0.0445
Brugia malayi beta-tubulin, identical 0.0077 0.0445 0.0445
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1121 0.8432 0.8432
Brugia malayi Cathepsin L-like precursor 0.0397 0.2892 0.2892
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Trypanosoma brucei zeta tubulin 0.0303 0.2172 0.5108
Trichomonas vaginalis tubulin gamma chain, putative 0.0077 0.0445 0.1046
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Onchocerca volvulus Cathepsin L homolog 0.0136 0.0896 0.2107
Giardia lamblia Hypothetical protein 0.0136 0.0896 0.0968
Trypanosoma brucei alpha tubulin 0.0094 0.0578 0.1359
Trypanosoma cruzi cysteine peptidase, putative 0.0575 0.4252 0.4252
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Schistosoma mansoni tubulin subunit alpha 0.0094 0.0578 0.0578
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus granulosus expressed conserved protein 0.0019 0.0004 0.0004
Echinococcus granulosus tubulin subunit beta 0.0077 0.0445 0.0445
Mycobacterium ulcerans methionine aminopeptidase 0.0042 0.0175 0.3916
Brugia malayi bZIP transcription factor family protein 0.0082 0.0482 0.0482
Plasmodium falciparum serine repeat antigen 3 0.0136 0.0896 0.1939
Entamoeba histolytica cysteine proteinase, putative 0.0314 0.2257 0.5307
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0045 0.0197 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0314 0.2257 0.5307
Loa Loa (eye worm) hypothetical protein 0.008 0.0465 0.0465
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Loa Loa (eye worm) hypothetical protein 0.0136 0.0896 0.0896
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1326 1 1
Onchocerca volvulus Cathepsin F homolog 0.0575 0.4252 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0136 0.0899 0.0899
Echinococcus granulosus tyrosine protein kinase shark 0.0026 0.0052 0.0052
Giardia lamblia Cathepsin L precursor 0.0136 0.0896 0.0968
Plasmodium vivax calcium-dependent protein kinase, putative 0.0094 0.0576 0.1171
Trichomonas vaginalis tubulin, putative 0.0032 0.0098 0.0231
Echinococcus multilocularis musashi 0.0026 0.0056 0.0056
Giardia lamblia Cathepsin B precursor 0.0504 0.3712 0.4343
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0042 0.0175 0.3916
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0136 0.0899 0.0899
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0102 0.0635 0.0635
Giardia lamblia Gamma tubulin 0.0089 0.0534 0.0534
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.0004 0.0004
Loa Loa (eye worm) STAT protein 0.0019 0.0004 0.0004
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0042 0.0175 0.041
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0635 0.0635
Giardia lamblia Hypothetical protein 0.0136 0.0896 0.0968
Loa Loa (eye worm) tubulin alpha-2 chain 0.0094 0.0578 0.0578
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.049 0.049
Echinococcus multilocularis calcium dependent protein kinase 0.009 0.0547 0.0547
Brugia malayi SH2 domain containing protein 0.0019 0.0004 0.0004
Leishmania major epsilon tubulin, putative 0.0062 0.0332 0.0781
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0136 0.0896 0.2107
Loa Loa (eye worm) TK/ABL protein kinase 0.0852 0.6377 0.6377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Entamoeba histolytica tubulin family protein 0.0077 0.0445 0.1046
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0019 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0575 0.4252 0.4252
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0019 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Brugia malayi RhoGAP domain containing protein 0.0019 0.0004 0.0004
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0578 0.1359
Plasmodium vivax tubulin alpha chain, putative 0.0094 0.0578 0.1176
Loa Loa (eye worm) BEN-1 protein 0.0077 0.0445 0.0445
Schistosoma mansoni cathepsin F (C01 family) 0.0575 0.4252 0.4252
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Echinococcus granulosus signal transduction protein lnk realted 0.0019 0.0004 0.0004
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0136 0.0896 0.0896
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0896 0.2107
Onchocerca volvulus 0.0019 0.0004 0.0009
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0397 0.2892 0.2892
Giardia lamblia Cathepsin L precursor 0.0136 0.0896 0.0968
Echinococcus granulosus cathepsin L cysteine protease 0.0314 0.2257 0.2257
Loa Loa (eye worm) alpha-tubulin 0.0094 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0053
Echinococcus granulosus lamin 0.0026 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.2257 0.5307
Echinococcus granulosus SH2 domain containing adapter protein F 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0178 0.1215 0.1215
Echinococcus granulosus tubulin subunit TubB 0.0094 0.0578 0.0578
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0899 0.0899
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Echinococcus multilocularis NCK adaptor protein 0.0038 0.0149 0.0149
Entamoeba histolytica tubulin alpha-1 chain 0.0094 0.0578 0.1359
Giardia lamblia Cathepsin L precursor 0.0136 0.0896 0.0968
Leishmania major delta tubulin, putative 0.0031 0.0088 0.0208
Trichomonas vaginalis tubulin, putative 0.0032 0.0098 0.0231
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0094 0.0576 0.0576
Leishmania major hypothetical protein, conserved 0.0136 0.0899 0.2114
Loa Loa (eye worm) hypothetical protein 0.0064 0.0345 0.0345
Echinococcus multilocularis SH2 domain containing protein 7 0.0019 0.0004 0.0004
Brugia malayi PAS domain containing protein 0.0047 0.0218 0.0218
Brugia malayi cathepsin F-like cysteine proteinase 0.0178 0.1215 0.1215
Brugia malayi SH2 domain containing protein 0.0019 0.0004 0.0004
Brugia malayi Protein kinase domain containing protein 0.0026 0.0052 0.0052
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0578 0.0578
Brugia malayi tRNA modification GTPase TrmE family protein 0.0019 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Plasmodium falciparum phosphodiesterase gamma, putative 0.0136 0.0899 0.1946
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0504 0.3712 0.3712
Brugia malayi intermediate filament protein 0.0026 0.0056 0.0056
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0136 0.0896 0.1939
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0899 0.2114
Toxoplasma gondii beta-1 tubulin, putative 0.0077 0.0445 0.0427
Brugia malayi Tubulin gamma chain 0.0089 0.0534 0.0534
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0019 0.0004 0.0004
Brugia malayi Tubulin alpha-2 chain 0.0094 0.0578 0.0578
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0482 0.0482
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0314 0.2257 0.2257
Giardia lamblia Beta tubulin 0.0077 0.0445 0.0427
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Echinococcus granulosus cathepsin L 0.0136 0.0896 0.0896
Entamoeba histolytica hypothetical protein 0.0136 0.0896 0.2107
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0102 0.0635 0.0635
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1121 0.8432 1
Trypanosoma cruzi zeta tubulin, putative 0.0303 0.2172 0.2172
Entamoeba histolytica cysteine protease, putative 0.0136 0.0896 0.2107
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0019 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0102 0.0635 0.0635
Onchocerca volvulus 0.0019 0.0004 0.0009
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0094 0.0576 0.0584
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0852 0.6377 0.6377
Echinococcus granulosus single minded 2 0.0035 0.0124 0.0124
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus multilocularis cathepsin b 0.1326 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0149 0.0149
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Trichomonas vaginalis tubulin, putative 0.0057 0.029 0.0683
Trichomonas vaginalis tubulin epsilon chain, putative 0.0094 0.0578 0.1359
Loa Loa (eye worm) hypothetical protein 0.0136 0.0899 0.0899
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0042 0.0175 0.041
Echinococcus granulosus tyrosine protein kinase Src64B 0.0102 0.0635 0.0635
Giardia lamblia Cathepsin B precursor 0.0136 0.0896 0.0968
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0575 0.4252 0.4252
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.0004 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0575 0.4252 1
Loa Loa (eye worm) cathepsin B 0.0504 0.3712 0.3712
Loa Loa (eye worm) hypothetical protein 0.0094 0.0576 0.0576
Echinococcus granulosus Tubulin beta 2C chain 0.0077 0.0445 0.0445
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Brugia malayi hypothetical protein 0.0019 0.0004 0.0004
Echinococcus granulosus suppressor of cytokine signaling 6 0.0019 0.0004 0.0004
Echinococcus granulosus tubulin alpha chain 0.0094 0.0578 0.0578
Echinococcus granulosus cysteine protease 0.0314 0.2257 0.2257
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0578 0.0578
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0578 0.0578
Echinococcus granulosus jun protein 0.0082 0.0482 0.0482
Echinococcus multilocularis beta tubulin 0.0077 0.0445 0.0445
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Schistosoma mansoni vav2 0.0019 0.0004 0.0004
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Onchocerca volvulus 0.0026 0.0052 0.0122
Loa Loa (eye worm) hypothetical protein 0.0575 0.4252 0.4252
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.0165 0.112 0.112
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1121 0.8432 0.8432
Brugia malayi Cell division protein ftsZ 0.0031 0.0088 0.0088
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.0578 0.0578
Brugia malayi Cathepsin L-like precursor 0.0397 0.2892 0.2892
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Loa Loa (eye worm) tubulin alpha 2 0.0064 0.0345 0.0345
Trichomonas vaginalis tubulin alpha chain, putative 0.0077 0.0445 0.1046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0397 0.2892 0.68
Echinococcus multilocularis hypothetical protein 0.0094 0.0578 0.0578
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Echinococcus multilocularis lamin 0.0026 0.0056 0.0056
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.0004 0.0004
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0136 0.0896 0.2107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0131 0.0131
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus granulosus tubulin alpha 3 chain 0.0094 0.0578 0.0578
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0131 0.0308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0098 0.0231
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0852 0.6377 0.6377
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0098 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0136 0.0896 0.2107
Echinococcus multilocularis cathepsin b 0.1326 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0077 0.0445 0.0445
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0635 0.0635
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0178 0.1215 0.1215
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0314 0.2257 0.2257
Onchocerca volvulus 0.0575 0.4252 1
Trypanosoma brucei alpha tubulin 0.0094 0.0578 0.1359
Echinococcus granulosus cathepsin l1 0.0397 0.2892 0.2892
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0131 0.0131
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Echinococcus multilocularis tyrosine protein kinase shark 0.0026 0.0052 0.0052
Echinococcus granulosus SH2 motif 0.0019 0.0004 0.0004
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0042 0.0175 0.0207
Schistosoma mansoni tubulin subunit beta 0.0077 0.0445 0.0445
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0064 0.0345 0.081
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0094 0.0576 0.0576
Schistosoma mansoni tubulin subunit beta 0.0077 0.0445 0.0445
Plasmodium vivax serine-repeat antigen (SERA) 0.0136 0.0896 0.1939
Plasmodium vivax tubulin alpha chain, putative 0.0094 0.0578 0.1176
Schistosoma mansoni nck2/grb4 0.0038 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Loa Loa (eye worm) hypothetical protein 0.012 0.077 0.077
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0136 0.0899 0.1946
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0136 0.0896 0.1939
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Brugia malayi Cathepsin L-like precursor 0.0575 0.4252 0.4252
Plasmodium vivax unspecified product 0.0136 0.0896 0.1939
Loa Loa (eye worm) TK protein kinase 0.0063 0.0341 0.0341
Echinococcus multilocularis tubulin alpha 1C chain 0.0094 0.0578 0.0578
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0131 0.0308
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Trypanosoma cruzi cysteine peptidase, putative 0.0178 0.1215 0.1215
Schistosoma mansoni tubulin subunit beta 0.0077 0.0445 0.0445
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0136 0.0896 0.0896
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0056 0.0056
Schistosoma mansoni SH2A 0.0019 0.0004 0.0004
Schistosoma mansoni tensin-related 0.0019 0.0004 0.0004
Plasmodium falciparum calcium-dependent protein kinase 1 0.0094 0.0576 0.1171
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0042 0.0175 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0504 0.3712 0.8729
Trypanosoma cruzi cruzipain precursor, putative 0.0178 0.1215 0.1215
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0136 0.0899 0.0899
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0136 0.0899 0.0899
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0019 0.0004 0.0009
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0136 0.0896 0.0968
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Plasmodium falciparum calcium-dependent protein kinase 5 0.0094 0.0576 0.1171
Echinococcus granulosus SHC transforming protein 3 0.0019 0.0004 0.0004
Plasmodium falciparum serine repeat antigen 7 0.0136 0.0896 0.1939
Loa Loa (eye worm) hypothetical protein 0.0094 0.0578 0.0578
Entamoeba histolytica protein kinase, putative 0.0023 0.0032 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0314 0.2257 0.5307
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0131 0.0131
Toxoplasma gondii methionine aminopeptidase 0.0042 0.0175 0.0103
Echinococcus granulosus lamin dm0 0.0026 0.0056 0.0056
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0094 0.0576 0.0576
Trypanosoma brucei tubulin gamma chain 0.0089 0.0534 0.1255
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1326 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0314 0.2257 0.2257
Trypanosoma cruzi cysteine protease, putative 0.0314 0.2257 0.2257
Trypanosoma brucei tubulin delta chain 0.0031 0.0088 0.0208
Toxoplasma gondii cathepsin B 0.0504 0.3712 0.4343
Echinococcus granulosus tubulin alpha 3 chain 0.0094 0.0578 0.0578
Onchocerca volvulus 0.0032 0.0098 0.0231
Schistosoma mansoni tubulin subunit alpha 0.0094 0.0578 0.0578
Echinococcus multilocularis signal transduction protein lnk realted 0.0019 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0063 0.0335 0.0787
Brugia malayi SH2 domain containing protein 0.0019 0.0004 0.0004
Trypanosoma cruzi tubulin delta chain 0.0031 0.0088 0.0088
Trypanosoma cruzi cysteine peptidase, putative 0.0314 0.2257 0.2257
Schistosoma mansoni protein kinase 0.0094 0.0576 0.0576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0077 0.0441 0.0441
Schistosoma mansoni hypothetical protein 0.0067 0.0365 0.0365
Onchocerca volvulus 0.0026 0.0052 0.0122
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0899 0.0899
Loa Loa (eye worm) tubulin alpha-3 chain 0.0063 0.0335 0.0335
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus granulosus NCK adaptor protein 0.0038 0.0149 0.0149
Giardia lamblia Cathepsin L-like protease 0.0136 0.0896 0.0968
Onchocerca volvulus 0.0026 0.0056 0.0132
Echinococcus multilocularis peroxisome assembly protein 26 0.0094 0.0578 0.0578
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0004 0.0004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0131 0.0131
Echinococcus multilocularis SH2 motif 0.0019 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0899 0.2114
Schistosoma mansoni cathepsin F (C01 family) 0.0397 0.2892 0.2892
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0131 0.0131
Schistosoma mansoni tubulin subunit epsilon 0.0062 0.0332 0.0332
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus granulosus c-Jun N-terminal kinases 0.095 0.7123 0.7123
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.0004 0.0004
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0042 0.0175 0.0175
Schistosoma mansoni tyrosine kinase 0.0045 0.0197 0.0197
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0094 0.0576 0.0576
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1326 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0136 0.0896 0.2107
Toxoplasma gondii methionine aminopeptidase 0.0042 0.0175 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0899 0.0899
Brugia malayi Cathepsin L-like precursor 0.0575 0.4252 0.4252
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0038 0.0149 0.0149
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0979 0.0979
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0136 0.0896 0.1939
Echinococcus granulosus tubulin epsilon chain 0.0062 0.0332 0.0332
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Trypanosoma brucei alpha tubulin, putative 0.0032 0.0098 0.0231
Giardia lamblia Beta tubulin 0.0077 0.0445 0.0427
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0038 0.0149 0.0149
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0136 0.0896 0.0968
Schistosoma mansoni alpha tubulin 0.0094 0.0578 0.0578
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Plasmodium falciparum serine repeat antigen 2 0.0136 0.0896 0.1939
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.0896 0.0896
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Entamoeba histolytica cysteine protease, putative 0.0136 0.0896 0.2107
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0136 0.0899 0.0899
Echinococcus granulosus intermediate filament protein 0.0026 0.0056 0.0056
Brugia malayi protein-tyrosine kinase 0.0083 0.049 0.049
Brugia malayi Tubulin beta chain 0.0031 0.0088 0.0088
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0575 0.4252 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Plasmodium vivax vivapain-2 0.0575 0.4252 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.0578 0.0578
Plasmodium vivax phosphodiesterase gamma, putative 0.0136 0.0899 0.1946
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0575 0.4252 0.4252
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Brugia malayi SH2 domain containing protein 0.0019 0.0004 0.0004
Plasmodium falciparum serine repeat antigen 8 0.0136 0.0896 0.1939
Echinococcus multilocularis tyrosine kinase 0.0026 0.0052 0.0052
Plasmodium vivax vivapain-1 0.0314 0.2257 0.5207
Entamoeba histolytica tubulin alpha chain, putative 0.0094 0.0578 0.1359
Echinococcus multilocularis tubulin beta 1 chain 0.0077 0.0445 0.0445
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0136 0.0896 0.0896
Echinococcus multilocularis beta tubulin 0.0077 0.0445 0.0445
Echinococcus multilocularis tubulin alpha 3 chain 0.0094 0.0578 0.0578
Leishmania major cysteine peptidase A (CPA) 0.0575 0.4252 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0131 0.0308
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Giardia lamblia Cathepsin B precursor 0.0504 0.3712 0.4343
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0136 0.0896 0.2107
Plasmodium falciparum serine repeat antigen 1 0.0136 0.0896 0.1939
Entamoeba histolytica cysteine protease, putative 0.0575 0.4252 1
Schistosoma mansoni tubulin subunit beta 0.0031 0.0088 0.0088
Echinococcus multilocularis cathepsin L 0.0314 0.2257 0.2257
Plasmodium falciparum tubulin epsilon chain, putative 0.0062 0.0332 0.0585
Brugia malayi Tubulin alpha-2 chain 0.0094 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0397 0.2892 0.2892
Brugia malayi Tubulin alpha chain 0.0094 0.0578 0.0578
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1121 0.8432 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0136 0.0896 0.2107
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0004
Schistosoma mansoni cathepsin C 0.0136 0.0896 0.0896
Brugia malayi Tubulin beta-1 chain 0.0077 0.0445 0.0445
Brugia malayi Protein kinase domain containing protein 0.0026 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Trichomonas vaginalis tubulin, putative 0.0077 0.0445 0.1046
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0094 0.0576 0.0576
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.0004 0.0004
Brugia malayi cytokine inducible SH2-containing protein 5 0.0019 0.0004 0.0004
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0578 0.1359
Echinococcus granulosus tyrosine protein kinase HCK 0.0063 0.0341 0.0341
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0004 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0575 0.4252 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0131 0.0131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0153 0.1026 0.1026
Loa Loa (eye worm) hypothetical protein 0.0136 0.0899 0.0899
Schistosoma mansoni tyrosine kinase 0.0026 0.0052 0.0052
Trypanosoma brucei alpha tubulin 0.0094 0.0578 0.1359
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0131 0.0131
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0042 0.0175 0.3916
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0131 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0308 0.0308
Loa Loa (eye worm) tubulin beta-1 chain 0.0077 0.0445 0.0445
Brugia malayi SH2 domain containing protein 0.0019 0.0004 0.0004
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0896 0.2107
Trypanosoma brucei epsilon tubulin 0.0062 0.0332 0.0781
Entamoeba histolytica cysteine protease, putative 0.0136 0.0896 0.2107
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0136 0.0899 0.0899
Schistosoma mansoni signal transduction protein lnk-related 0.0019 0.0004 0.0004
Onchocerca volvulus 0.0019 0.0004 0.0009
Onchocerca volvulus Cathepsin L homolog 0.0575 0.4252 1
Toxoplasma gondii cathepsin CPC2 0.0136 0.0896 0.0968
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Echinococcus multilocularis tyrosine protein kinase Srms 0.0083 0.049 0.049
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0042 0.0175 0.041
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0136 0.0899 0.2114
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0045 0.0197 0.0197
Echinococcus granulosus alpha tubulin 0.0094 0.0578 0.0578
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.0578 0.0578
Plasmodium vivax tubulin gamma chain, putative 0.0089 0.0534 0.1069
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0077 0.0445 0.0445
Trichomonas vaginalis tubulin epsilon chain, putative 0.0094 0.0578 0.1359
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0136 0.0899 0.0899
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0094 0.0576 0.1171
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0026 0.0052 0.0122
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0984 0.7388 0.7388
Loa Loa (eye worm) tubulin alpha chain 0.0094 0.0578 0.0578
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.1946
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0136 0.0899 0.1946
Onchocerca volvulus 0.0019 0.0004 0.0009
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0094 0.0576 0.1354
Brugia malayi Cathepsin L-like precursor 0.0575 0.4252 0.4252
Brugia malayi SH2 domain containing protein 0.0026 0.0052 0.0052
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.0332 0.0781
Entamoeba histolytica cysteine proteinase, putative 0.0397 0.2892 0.68
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Loa Loa (eye worm) SRC-1 0.0102 0.0635 0.0635
Trichomonas vaginalis tubulin beta chain, putative 0.0077 0.0445 0.1046
Loa Loa (eye worm) cysteine protease 0.0575 0.4252 0.4252
Echinococcus granulosus cathepsin b 0.1326 1 1
Onchocerca volvulus Huntingtin homolog 0.012 0.077 0.1811
Giardia lamblia Cysteine protease 0.0136 0.0896 0.0968
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0042 0.0175 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0131 0.0131
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0136 0.0896 0.2107
Echinococcus granulosus tubulin beta 1 chain 0.0077 0.0445 0.0445
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Trypanosoma brucei beta tubulin 0.0062 0.0332 0.0781
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Toxoplasma gondii beta-tubulin, putative 0.0077 0.0445 0.0427
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0042 0.0175 0.0207
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0578 0.0578
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0136 0.0899 0.0899
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0094 0.0576 0.0576
Echinococcus granulosus Tubulin beta 2C chain 0.0077 0.0445 0.0445
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0218 0.0218
Loa Loa (eye worm) tubulin alpha 2 0.0032 0.0101 0.0101
Brugia malayi fibroinase precursor 0.0136 0.0896 0.0896
Brugia malayi Tyrosine-protein kinase abl-1 0.0361 0.2615 0.2615
Brugia malayi Papain family cysteine protease containing protein 0.0575 0.4252 0.4252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.1215 0.1215
Echinococcus granulosus tyrosine protein kinase Blk 0.0083 0.049 0.049
Echinococcus granulosus tensin 0.0019 0.0004 0.0004
Onchocerca volvulus 0.0026 0.0052 0.0122
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0004 0.0004
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0578 0.0578
Giardia lamblia hypothetical protein 0.0136 0.0899 0.0971
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0094 0.0576 0.1171
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0102 0.0635 0.0635
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0575 0.4252 0.4252
Loa Loa (eye worm) tubulin alpha 2 0.0064 0.0345 0.0345
Onchocerca volvulus Cathepsin L homolog 0.0575 0.4252 1
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Brugia malayi Papain family cysteine protease containing protein 0.0314 0.2257 0.2257
Echinococcus granulosus tubulin alpha 0.0062 0.0332 0.0332
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0984 0.7388 0.7388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Echinococcus granulosus tubulin alpha 1C chain 0.0094 0.0578 0.0578
Loa Loa (eye worm) tubulin beta-2A chain 0.0077 0.0445 0.0445
Trichomonas vaginalis tubulin alpha chain, putative 0.0062 0.0332 0.0781
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.1946
Onchocerca volvulus 0.0397 0.2892 0.68
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0136 0.0899 0.2114
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0136 0.0896 0.2107
Giardia lamblia Cathepsin L precursor 0.0136 0.0896 0.0968
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0136 0.0896 0.0896
Schistosoma mansoni tensin 0.0019 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0899 0.0899
Loa Loa (eye worm) tubulin beta chain 0.0077 0.0445 0.0445
Echinococcus granulosus tyrosine protein kinase Srms 0.0026 0.0052 0.0052
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0136 0.0899 0.0899
Onchocerca volvulus 0.0019 0.0004 0.0009
Giardia lamblia Cysteine protease 0.0136 0.0896 0.0968
Entamoeba histolytica cysteine protease, putative 0.0136 0.0896 0.2107
Schistosoma mansoni tyrosine kinase 0.0026 0.0052 0.0052
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0004 0.0004
Brugia malayi tubulin alpha-2 chain 0.0094 0.0578 0.0578
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0308 0.0725
Plasmodium falciparum serine repeat antigen 4 0.0136 0.0896 0.1939
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0136 0.0896 0.1939
Plasmodium vivax vivapain-3 0.0314 0.2257 0.5207
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0578 0.1359
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0042 0.0175 0.0175
Brugia malayi cathepsin L-like precursor 0.0397 0.2892 0.2892
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0136 0.0899 0.0899
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0136 0.0896 0.0896
Onchocerca volvulus 0.0575 0.4252 1
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0899 0.2114
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0094 0.0576 0.0576
Onchocerca volvulus 0.0135 0.0886 0.2083
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0136 0.0899 0.0899
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1121 0.8432 0.8432
Entamoeba histolytica protein kinase, putative 0.0094 0.0576 0.1354
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0102 0.0635 0.0635
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0136 0.0899 0.0899
Trypanosoma cruzi zeta tubulin, putative 0.0303 0.2172 0.2172
Trypanosoma cruzi epsilon tubulin, putative 0.0062 0.0332 0.0332
Echinococcus multilocularis tensin 0.0019 0.0004 0.0004
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0136 0.0899 0.0899
Entamoeba histolytica cysteine proteinase, putative 0.0575 0.4252 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0899 0.0899
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0178 0.1215 0.1215
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0635 0.0635
Trypanosoma cruzi cysteine proteinase, putative 0.0314 0.2257 0.2257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0896 0.0896
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0504 0.3712 0.3712
Trypanosoma cruzi epsilon tubulin, putative 0.0062 0.0332 0.0332
Schistosoma mansoni tyrosine kinase 0.0833 0.6228 0.6228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Echinococcus multilocularis tubulin subunit beta 0.0077 0.0445 0.0445
Onchocerca volvulus 0.0026 0.0052 0.0122
Entamoeba histolytica tubulin family protein 0.0077 0.0445 0.1046
Echinococcus multilocularis c Jun NH2 terminal kinase 0.095 0.7123 0.7123
Trypanosoma cruzi major cysteine proteinase, putative 0.0136 0.0896 0.0896
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0308 0.0264
Loa Loa (eye worm) BEN-1 protein 0.0077 0.0445 0.0445
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Schistosoma mansoni tubulin subunit beta 0.0077 0.0445 0.0445
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0136 0.0899 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0032 0.0098 0.0231
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0899 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0136 0.0899 0.0899
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0019 0.0004 0.0004
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Giardia lamblia Cathepsin B precursor 0.0136 0.0896 0.0968
Giardia lamblia Cathepsin B precursor 0.0136 0.0896 0.0968
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0094 0.0576 0.0576
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0038 0.0149 0.0149
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1121 0.8432 0.8432
Brugia malayi hypothetical protein 0.012 0.077 0.077
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0136 0.0899 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0397 0.2892 0.68
Entamoeba histolytica cysteine protease, putative 0.0136 0.0896 0.2107
Brugia malayi cathepsin Z-like cysteine proteinase 0.0136 0.0896 0.0896
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0124 0.1607
Echinococcus multilocularis SH2 motif 0.0019 0.0004 0.0004
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0899 0.2114
Loa Loa (eye worm) fibroinase 0.0575 0.4252 0.4252
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0042 0.0175 0.0103
Echinococcus granulosus tyrosine protein kinase Lyn 0.0106 0.0663 0.0663
Plasmodium falciparum tubulin gamma chain 0.0089 0.0534 0.1069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0896 0.2107
Echinococcus multilocularis tubulin alpha 1C chain 0.0094 0.0578 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0088 0.0208
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0136 0.0896 0.1939
Brugia malayi Protein kinase domain containing protein 0.0026 0.0052 0.0052
Echinococcus granulosus cathepsin L 0.0314 0.2257 0.2257
Leishmania major cAMP-specific phosphodiesterase, putative 0.0136 0.0899 0.2114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0308 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.1946
Loa Loa (eye worm) hypothetical protein 0.0136 0.0896 0.0896
Onchocerca volvulus Tyrosine kinase homolog 0.0143 0.0952 0.2238
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0064 0.0345 0.0345
Giardia lamblia Cysteine protease 0.0136 0.0896 0.0968
Schistosoma mansoni tyrosine kinase 0.0102 0.0635 0.0635
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0136 0.0899 0.0899
Giardia lamblia Cysteine protease 0.0136 0.0896 0.0968
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0004 0.0004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Echinococcus granulosus tubulin alpha chain 0.0094 0.0578 0.0578
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Plasmodium falciparum alpha tubulin 2 0.0094 0.0578 0.1176
Echinococcus granulosus cathepsin l1 0.0575 0.4252 0.4252
Schistosoma mansoni tensin 0.0019 0.0004 0.0004
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.0004 0.0004
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0042 0.0175 0.0207
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0575 0.4252 0.4252
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.1946
Echinococcus multilocularis cathepsin L cysteine protease 0.0575 0.4252 0.4252
Treponema pallidum methionine aminopeptidase (map) 0.0042 0.0175 1
Giardia lamblia Alpha-tubulin 0.0094 0.0578 0.0587
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0899 0.0899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Trypanosoma brucei beta tubulin 0.0077 0.0445 0.1046
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0131 0.0131
Brugia malayi hypothetical protein 0.0064 0.0347 0.0347
Echinococcus multilocularis Tubulin beta 2C chain 0.0077 0.0445 0.0445
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Echinococcus multilocularis cathepsin L cysteine protease 0.0575 0.4252 0.4252
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.0004 0.0004
Schistosoma mansoni single-minded 0.0047 0.0218 0.0218
Plasmodium falciparum cysteine proteinase falcipain 1 0.0314 0.2257 0.5207
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0578 0.1359
Onchocerca volvulus 0.0575 0.4252 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.0578 0.0578
Entamoeba histolytica cysteine proteinase 1, putative 0.0314 0.2257 0.5307
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0899 0.0899
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0575 0.4252 0.4252
Schistosoma mansoni tubulin subunit beta 0.0077 0.0445 0.0445
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0896 0.0896
Brugia malayi Cathepsin L-like precursor 0.0575 0.4252 0.4252
Schistosoma mansoni GTPase activating protein 0.0019 0.0004 0.0004
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0136 0.0899 0.2114
Schistosoma mansoni shc transforming protein 0.0019 0.0004 0.0004
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.0004 0.0004
Echinococcus granulosus tubulin alpha 1C chain 0.0094 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0052
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0136 0.0899 0.0899
Brugia malayi hypothetical protein 0.0159 0.1074 0.1074
Plasmodium vivax vivapain-2 0.0575 0.4252 1
Onchocerca volvulus 0.0026 0.0056 0.0132
Echinococcus multilocularis cysteine protease 0.0575 0.4252 0.4252
Toxoplasma gondii beta tubulin 0.0077 0.0445 0.0427
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Brugia malayi Cathepsin L-like cysteine proteinase 0.0397 0.2892 0.2892
Schistosoma mansoni lamin 0.0026 0.0056 0.0056
Echinococcus granulosus cathepsin L cysteine proteinase 0.0575 0.4252 0.4252
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0576 0.0576
Loa Loa (eye worm) methionine aminopeptidase type I 0.0042 0.0175 0.0175
Giardia lamblia Cathepsin B precursor 0.0136 0.0896 0.0968
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0136 0.0896 0.2107
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0031 0.0088 0.0208
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0004 0.0004
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0094 0.0578 0.1359
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Schistosoma mansoni hypothetical protein 0.005 0.0241 0.0241
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0094 0.0576 0.0584
Brugia malayi cathepsin L precursor 0.0136 0.0896 0.0896
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.0896 0.0896
Giardia lamblia Encystation-specific protease 0.0136 0.0896 0.0968
Echinococcus multilocularis geminin 0.0165 0.112 0.112
Echinococcus multilocularis 0.0019 0.0004 0.0004
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0004 0.0004
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.0332 0.0292
Trypanosoma cruzi tubulin delta chain 0.0031 0.0088 0.0088
Schistosoma mansoni cathepsin B (C01 family) 0.0136 0.0896 0.0896
Echinococcus multilocularis tubulin alpha 3 chain 0.0094 0.0578 0.0578
Echinococcus multilocularis SH2 motif 0.0019 0.0004 0.0004
Echinococcus granulosus beta tubulin 0.0077 0.0445 0.0445
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0136 0.0896 0.0896
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0136 0.0896 0.1939
Trichomonas vaginalis tubulin gamma chain, putative 0.0031 0.0088 0.0208
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0136 0.0899 0.0899
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1326 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0575 0.4252 1
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Entamoeba histolytica protein kinase, putative 0.0063 0.0341 0.0801
Brugia malayi cathepsin Z-like cysteine proteinase 0.0136 0.0896 0.0896
Trypanosoma brucei alpha tubulin 0.0094 0.0578 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0896 0.2107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0896 0.2107
Schistosoma mansoni protein kinase 0.0094 0.0576 0.0576
Echinococcus granulosus cathepsin b 0.1326 1 1
Leishmania major protein kinase, putative 0.0094 0.0576 0.1354
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Brugia malayi cathepsin L-like cysteine proteinase 0.0136 0.0896 0.0896
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0136 0.0899 0.0899
Entamoeba histolytica cysteine protease, putative 0.0136 0.0896 0.2107
Toxoplasma gondii preprocathepsin c precursor, putative 0.0136 0.0896 0.0968
Schistosoma mansoni cathepsin s 0.0178 0.1215 0.1215
Loa Loa (eye worm) PDE1B protein 0.0136 0.0899 0.0899
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0056 0.0056
Giardia lamblia Beta tubulin 0.0077 0.0445 0.0427
Echinococcus granulosus tyrosine protein kinase Src42A 0.0077 0.0441 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0984 0.7388 0.7388
Echinococcus granulosus calcium dependent protein kinase 0.009 0.0547 0.0547
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0136 0.0899 0.2114
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0899 0.2114
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0314 0.2257 0.2257
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus granulosus N chimaerin 0.0019 0.0004 0.0004
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0019 0.0004 0.0004
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0019 0.0004 0.0009
Brugia malayi Cathepsin L-like precursor 0.0575 0.4252 0.4252
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0136 0.0896 0.0896
Echinococcus multilocularis lamin dm0 0.0026 0.0056 0.0056
Brugia malayi alpha-tubulin 0.0094 0.0578 0.0578
Onchocerca volvulus 0.0026 0.0052 0.0122
Echinococcus granulosus tubulin gamma 1 chain 0.0089 0.0534 0.0534
Trypanosoma brucei beta tubulin 0.0077 0.0445 0.1046
Plasmodium falciparum phosphodiesterase delta, putative 0.0136 0.0899 0.1946
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0899 0.0899
Schistosoma mansoni cathepsin F (C01 family) 0.0575 0.4252 0.4252
Trypanosoma brucei zeta tubulin, putative 0.0303 0.2172 0.5108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Echinococcus granulosus Tubulin beta 2C chain 0.0077 0.0445 0.0445
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0042 0.0175 0.3916
Loa Loa (eye worm) hypothetical protein 0.1326 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.0004 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.0136 0.0896 0.0896
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0136 0.0899 0.0899
Plasmodium falciparum cysteine proteinase falcipain 3 0.0575 0.4252 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0136 0.0896 0.1939
Loa Loa (eye worm) TK protein kinase 0.0083 0.049 0.049
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Plasmodium falciparum alpha tubulin 1 0.0094 0.0578 0.1176
Brugia malayi Protein kinase domain containing protein 0.0026 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Loa Loa (eye worm) hypothetical protein 0.0063 0.0335 0.0335
Echinococcus granulosus tyrosine protein kinase Src42A 0.0102 0.0635 0.0635
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0045 0.0197 0.0197
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0131 0.0131
Plasmodium falciparum calcium-dependent protein kinase 4 0.0094 0.0576 0.1171
Echinococcus multilocularis cathepsin L 0.0136 0.0896 0.0896
Echinococcus granulosus peroxisome assembly protein 26 0.0094 0.0578 0.0578
Echinococcus granulosus geminin 0.0165 0.112 0.112
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0023 0.0032 0.0076
Echinococcus granulosus tubulin alpha chain 0.0094 0.0578 0.0578
Giardia lamblia Hypothetical protein 0.0136 0.0899 0.0971
Trichomonas vaginalis tubulin epsilon chain, putative 0.0031 0.0088 0.0208
Onchocerca volvulus 0.0026 0.0052 0.0122
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0088 0.0208
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.0004 0.0004
Giardia lamblia Cathepsin L-like protease 0.0136 0.0896 0.0968
Loa Loa (eye worm) ctsf protein 0.0575 0.4252 0.4252
Toxoplasma gondii cathepsin CPC1 0.0136 0.0896 0.0968
Loa Loa (eye worm) tubulin beta-4 chain 0.0077 0.0445 0.0445
Brugia malayi cathepsin F-like cysteine proteinase 0.0136 0.0896 0.0896
Schistosoma mansoni tubulin subunit beta 0.0077 0.0445 0.0445
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0136 0.0896 0.1939
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0504 0.3712 0.8729
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0136 0.0896 0.2107
Trypanosoma brucei epsilon tubulin 0.0062 0.0332 0.0781
Brugia malayi Cathepsin L-like precursor 0.0178 0.1215 0.1215
Schistosoma mansoni serine/threonine protein kinase 0.095 0.7123 0.7123
Brugia malayi SH2 domain containing protein 0.0026 0.0052 0.0052
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0083 0.049 0.049
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0056 0.0056
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Brugia malayi Methionine aminopeptidase protein type I 0.0042 0.0175 0.0175
Echinococcus multilocularis SHC transforming protein 3 0.0019 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.2257 0.5307
Loa Loa (eye worm) hypothetical protein 0.1121 0.8432 0.8432
Loa Loa (eye worm) hypothetical protein 0.0178 0.1215 0.1215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Toxoplasma gondii cathepsin CPL 0.0575 0.4252 0.4991
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0102 0.0635 0.0635
Onchocerca volvulus 0.0575 0.4252 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0019 0.0004 0.0004
Entamoeba histolytica SH2 domain containing protein 0.0019 0.0004 0.0009
Schistosoma mansoni protein kinase 0.0094 0.0576 0.0576
Plasmodium falciparum tubulin beta chain 0.0077 0.0445 0.0855
Echinococcus multilocularis Tubulin beta 2C chain 0.0077 0.0445 0.0445
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0899 0.0899
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0896 0.2107
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0575 0.4252 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0102 0.0635 0.0635
Giardia lamblia Cathepsin L precursor 0.0136 0.0896 0.0968
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0314 0.2257 0.2257
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0136 0.0899 0.0899
Leishmania major zeta tubulin, putative 0.0303 0.2172 0.5108
Echinococcus multilocularis tubulin alpha 0.0062 0.0332 0.0332
Schistosoma mansoni cathepsin S (C01 family) 0.0136 0.0896 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0136 0.0896 0.2107
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0136 0.0899 0.0899
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Giardia lamblia Cathepsin B precursor 0.0504 0.3712 0.4343
Brugia malayi hypothetical protein 0.0026 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0026 0.0052 0.0052
Plasmodium vivax unspecified product 0.0178 0.1215 0.2707
Brugia malayi Tyrosine-protein kinase abl-1 0.051 0.3761 0.3761
Schistosoma mansoni intermediate filament proteins 0.0026 0.0056 0.0056
Schistosoma mansoni tubulin subunit gamma 0.0089 0.0534 0.0534
Schistosoma mansoni tyrosine kinase 0.0102 0.0635 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0136 0.0896 0.2107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0896 0.0896
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Schistosoma mansoni alpha tubulin 0.0094 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Onchocerca volvulus 0.0035 0.0124 0.0291
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Brugia malayi SH2 domain containing protein 0.0019 0.0004 0.0004
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.1946
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0038 0.0149 0.0149
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0094 0.0576 0.0584
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus multilocularis Tubulin beta 2C chain 0.0077 0.0445 0.0445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Brugia malayi Stress-activated protein kinase jnk-1 0.095 0.7123 0.7123
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0136 0.0899 0.0899
Brugia malayi Tensin 0.0019 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0314 0.2257 0.5307
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0578 0.1359
Trichomonas vaginalis tubulin gamma chain, putative 0.0089 0.0534 0.1255
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.0896 0.0896
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Schistosoma mansoni lamin 0.0026 0.0056 0.0056
Schistosoma mansoni tyrosine kinase 0.0045 0.0197 0.0197
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0098 0.0231
Plasmodium falciparum serine repeat antigen 6 0.0136 0.0896 0.1939
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0136 0.0899 0.0899
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0136 0.0899 0.2114
Loa Loa (eye worm) hypothetical protein 0.012 0.077 0.077
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0136 0.0896 0.1939
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0136 0.0896 0.1939
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0899 0.2114
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0136 0.0896 0.1939
Echinococcus multilocularis tubulin delta chain 0.0031 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0322 0.2321 0.2321
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Echinococcus granulosus hypothetical protein 0.0019 0.0004 0.0004
Loa Loa (eye worm) tubulin beta chain 0.0031 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0397 0.2892 0.2892
Entamoeba histolytica protein kinase, putative 0.0094 0.0576 0.1354
Echinococcus multilocularis tensin 0.0019 0.0004 0.0004
Echinococcus granulosus c src tyrosine kinase 0.0045 0.0197 0.0197
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0042 0.0175 0.0175
Chlamydia trachomatis methionine aminopeptidase 0.0042 0.0175 0.5
Schistosoma mansoni tubulin subunit delta 0.0031 0.0088 0.0088
Echinococcus multilocularis tubulin gamma 1 chain 0.0089 0.0534 0.0534
Brugia malayi Tubulin beta chain 0.0032 0.0098 0.0098
Brugia malayi Cam kinase protein 1 0.0094 0.0576 0.0576
Onchocerca volvulus 0.0023 0.0029 0.0067
Giardia lamblia Alpha-tubulin 0.0094 0.0578 0.0587
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0102 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Onchocerca volvulus 0.0019 0.0004 0.0009
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0136 0.0896 0.1939
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0314 0.2257 0.2257
Brugia malayi STAT protein, DNA binding domain containing protein 0.0019 0.0004 0.0004
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0124 0.0124
Trypanosoma brucei methionine aminopeptidase, putative 0.0042 0.0175 0.041
Onchocerca volvulus 0.0064 0.0347 0.0817
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0984 0.7388 0.7388
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0136 0.0896 0.0968
Onchocerca volvulus 0.0575 0.4252 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0896 0.0896
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0131 0.0308
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0131 0.0308
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0004
Trypanosoma cruzi tubulin gamma chain 0.0089 0.0534 0.0534
Echinococcus granulosus beta tubulin 0.0077 0.0445 0.0445
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Plasmodium falciparum serine repeat antigen 5 0.0136 0.0896 0.1939
Plasmodium vivax tubulin epsilon chain, putative 0.0062 0.0332 0.0585
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0042 0.0175 1
Echinococcus multilocularis jun protein 0.0082 0.0482 0.0482
Toxoplasma gondii alpha tubulin TUBA1 0.0094 0.0578 0.0587
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0136 0.0896 0.0896
Echinococcus multilocularis tubulin subunit TubB 0.0094 0.0578 0.0578
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0042 0.0175 0.0175
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.0098 0.0231
Loa Loa (eye worm) hypothetical protein 0.0159 0.1074 0.1074
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0136 0.0896 0.0896
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0042 0.0175 1
Entamoeba histolytica tubulin gamma chain 0.0089 0.0534 0.1255
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0482 0.0482
Echinococcus multilocularis tubulin epsilon chain 0.0062 0.0332 0.0332
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0136 0.0899 0.0899
Giardia lamblia Cathepsin L precursor 0.0136 0.0896 0.0968
Leishmania major gamma-tubulin 0.0089 0.0534 0.1255
Trypanosoma brucei beta tubulin 0.0077 0.0445 0.1046
Echinococcus multilocularis tyrosine protein kinase HCK 0.0063 0.0341 0.0341
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0576 0.1354
Plasmodium vivax tubulin beta chain, putative 0.0077 0.0445 0.0855
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0899 0.0899
Entamoeba histolytica cysteine proteinase, putative 0.0314 0.2257 0.5307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 0.4252 1
Loa Loa (eye worm) alpha-tubulin 0.0094 0.0578 0.0578
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0578 0.1359
Schistosoma mansoni hypothetical protein 0.0165 0.112 0.112
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0094 0.0576 0.1171
Brugia malayi Tubulin alpha chain 0.0031 0.0088 0.0088
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Trypanosoma cruzi cysteine peptidase, putative 0.0575 0.4252 0.4252
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0026 0.0052 0.0052
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Trypanosoma cruzi cruzipain precursor, putative 0.0575 0.4252 0.4252
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0153 0.1026 0.1026
Echinococcus granulosus tubulin beta 4A class IVa 0.0077 0.0445 0.0445
Plasmodium vivax serine-repeat antigen (SERA) 0.0136 0.0896 0.1939
Schistosoma mansoni tubulin subunit alpha 0.0094 0.0578 0.0578
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.095 0.7123 0.7123
Echinococcus granulosus SH2 motif 0.0019 0.0004 0.0004
Brugia malayi Protein kinase domain containing protein 0.0026 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0056
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0136 0.0899 0.0899
Echinococcus granulosus tubulin alpha chain 0.0094 0.0578 0.0578
Schistosoma mansoni adapter molecule crk 0.0038 0.0149 0.0149
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0094 0.0576 0.0576
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0899 0.0971
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0136 0.0899 0.0899
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0899 0.0899
Echinococcus granulosus tubulin alpha chain 0.0094 0.0578 0.0578
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0899 0.0899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0131 0.0308
Echinococcus multilocularis tyrosine protein kinase Blk 0.0083 0.049 0.049
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Plasmodium falciparum serine repeat antigen 9 0.0136 0.0896 0.1939
Loa Loa (eye worm) tubulin gamma chain 0.0089 0.0534 0.0534
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1326 1 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0136 0.0896 0.1939
Brugia malayi hypoxia-induced factor 1 0.0147 0.0979 0.0979
Brugia malayi Cytochrome P450 family protein 0.0026 0.005 0.005
Echinococcus granulosus Tubulin beta 2C chain 0.0077 0.0445 0.0445
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0094 0.0576 0.0576
Trichomonas vaginalis tubulin epsilon chain, putative 0.0077 0.0445 0.1046
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Onchocerca volvulus 0.0575 0.4252 1
Leishmania major alpha tubulin 0.0094 0.0578 0.1359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 0.4252 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0896 0.0896
Loa Loa (eye worm) hypothetical protein 0.0397 0.2892 0.2892
Schistosoma mansoni alpha tubulin 0.0094 0.0578 0.0578
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0019 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0314 0.2257 0.5307
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0635 0.0635
Brugia malayi Sex muscle abnormal protein 5 0.0038 0.0149 0.0149
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1121 0.8432 0.8432
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0042 0.0175 0.0175
Echinococcus multilocularis Tubulin beta 2C chain 0.0077 0.0445 0.0445
Giardia lamblia Cathepsin B precursor 0.0136 0.0896 0.0968
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0136 0.0899 0.0899
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0042 0.0175 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 0.4252 1
Schistosoma mansoni tensin 0.0019 0.0004 0.0004
Brugia malayi tubulin alpha chain - mouse 0.0094 0.0578 0.0578
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0136 0.0899 0.0899
Brugia malayi SRC-1 0.0102 0.0635 0.0635
Leishmania major beta tubulin 0.0077 0.0445 0.1046
Trypanosoma cruzi alpha tubulin, putative 0.0094 0.0578 0.0578
Onchocerca volvulus Huntingtin homolog 0.012 0.077 0.1811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0896 0.2107
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0308 0.0308
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0899 0.2114
Leishmania major hypothetical protein, conserved 0.0136 0.0899 0.2114
Echinococcus granulosus cathepsin l cysteine peptidase 0.0575 0.4252 0.4252
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0019 0.0004 0.0004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0136 0.0896 0.0896
Echinococcus granulosus tyrosine kinase 0.0026 0.0052 0.0052
Plasmodium falciparum calcium-dependent protein kinase 2 0.0094 0.0576 0.1171
Echinococcus multilocularis growth factor receptor bound protein 2 0.0038 0.0149 0.0149
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0136 0.0899 0.0899
Schistosoma mansoni amine GPCR 0.0211 0.1473 0.1473
Leishmania major cathepsin L-like protease 0.0575 0.4252 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0361 0.2615 0.2615
Trypanosoma brucei epsilon tubulin 0.0062 0.0332 0.0781
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.0578 0.0578
Schistosoma mansoni jun-related protein 0.0067 0.0365 0.0365
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0038 0.0149 0.0149
Schistosoma mansoni tubulin subunit alpha 0.0031 0.0088 0.0088
Trypanosoma cruzi beta tubulin, putative 0.0077 0.0445 0.0445
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0042 0.0175 0.0175
Echinococcus granulosus suppressor of cytokine signaling 7 0.0019 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0308 0.0308
Entamoeba histolytica cysteine proteinase, putative 0.0314 0.2257 0.5307
Echinococcus multilocularis cysteine protease 0.0575 0.4252 0.4252
Trypanosoma brucei beta tubulin 0.0077 0.0445 0.1046
Onchocerca volvulus 0.0136 0.0896 0.2107
Onchocerca volvulus 0.0575 0.4252 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0131 0.0131
Plasmodium falciparum calcium-dependent protein kinase 3 0.0094 0.0576 0.1171
Trypanosoma brucei hypothetical protein, conserved 0.0136 0.0899 0.2114
Echinococcus granulosus tubulin delta chain 0.0031 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.0896 0.2107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0136 0.0896 0.2107
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0052 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.005 0.005

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Agonist activity at human H3 receptor expressed in 293-EBNA cells by luciferase reporter gene assay at 10 uM ChEMBL. 16942032
Activity (functional) 0 Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay at 10 uM ChEMBL. 16942032
Activity (functional) 0 Activity at human H3 receptor expressed in 293-EBNA cells by luciferase reporter gene assay at 100 uM ChEMBL. 16942032
Activity (functional) 0 Activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay at 100 uM ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H2 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H3 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H2 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H3 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
EC50 (functional) > 10000 nM Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) = 37 nM Antagonist activity at human H3 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) = 37 nM Antagonist activity at human H3 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) = 1500 nM Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) = 1500 nM Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) > 10000 nM Antagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) > 10000 nM Antagonist activity at human H2 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) > 10000 nM Antagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
IC50 (functional) > 10000 nM Antagonist activity at human H2 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay ChEMBL. 16942032
Inhibition (functional) = 100 % Inhibition of histamine agonist activity at human H3 receptor at 100 uM ChEMBL. 16942032
Inhibition (functional) > 100 % Inhibition of histamine agonist activity at human H4 receptor at 100 uM ChEMBL. 16942032
Inhibition (functional) = 100 % Inhibition of histamine agonist activity at human H3 receptor at 100 uM ChEMBL. 16942032
Inhibition (functional) > 100 % Inhibition of histamine agonist activity at human H4 receptor at 100 uM ChEMBL. 16942032
Ki (binding) = 5.3 nM Displacement of [3H]Nalpha-methylhistamine form human H3 receptor ChEMBL. 16942032
Ki (binding) = 5.3 nM Displacement of [3H]Nalpha-methylhistamine form human H3 receptor ChEMBL. 16942032
Ki (binding) = 127 nM Displacement of [3H]histamine form human H4 receptor ChEMBL. 16942032
Ki (binding) = 127 nM Displacement of [3H]histamine form human H4 receptor ChEMBL. 16942032
Selectivity index (binding) = 0.042 Selectivity index, Ki for human H3 receptor/Ki for human H4 receptor ChEMBL. 16942032

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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