Detailed information for compound 414566

Basic information

Technical information
  • TDR Targets ID: 414566
  • Name: 10-(9-hydroxy-8-methoxy-3,3,5-trimethyl-11H-p yrano[3,2-a]carbazol-10-yl)-8-methoxy-3,3,5-t rimethyl-11H-pyrano[3,2-a]carbazol-9-ol
  • MW: 616.702 | Formula: C38H36N2O6
  • H donors: 4 H acceptors: 2 LogP: 8.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2c(c(c1O)c1c(O)c(OC)cc3c1[nH]c1c3cc(c3c1C=CC(O3)(C)C)C)[nH]c1c2cc(C)c2c1C=CC(O2)(C)C
  • InChi: 1S/C38H36N2O6/c1-17-13-21-23-15-25(43-7)33(41)27(31(23)39-29(21)19-9-11-37(3,4)45-35(17)19)28-32-24(16-26(44-8)34(28)42)22-14-18(2)36-20(30(22)40-32)10-12-38(5,6)46-36/h9-16,39-42H,1-8H3
  • InChiKey: DQRAEENKHHFBHV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 10-(9-hydroxy-8-methoxy-3,3,5-trimethyl-11H-pyrano[6,5-i]carbazol-10-yl)-8-methoxy-3,3,5-trimethyl-11H-pyrano[6,5-i]carbazol-9-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Plasmodium falciparum glutathione reductase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast glutathione reductase 500 aa 561 aa 24.4 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin b 0.0171 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0274 0.1018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0495 0.1313
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0495 0.1313
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0495 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0495 0.0495
Leishmania major cysteine peptidase A (CPA) 0.0032 0.086 0.1116
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.3769 0.3769
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0495 0.0495
Onchocerca volvulus 0.0032 0.086 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.2688 0.2688
Onchocerca volvulus 0.0032 0.086 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.086 0.2282
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Plasmodium falciparum glutathione reductase 0.0076 0.3769 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0495 0.0495
Plasmodium falciparum thioredoxin reductase 0.0026 0.0495 0.1313
Loa Loa (eye worm) cysteine protease 0.0032 0.086 0.0603
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0495 0.1841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Plasmodium vivax vivapain-2 0.0032 0.086 0.2282
Brugia malayi Cathepsin L-like precursor 0.0023 0.0274 0.0274
Trypanosoma brucei trypanothione reductase 0.0076 0.3769 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.2688 0.7131
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.086 1
Brugia malayi Cathepsin L-like precursor 0.0032 0.086 0.086
Loa Loa (eye worm) thioredoxin reductase 0.0076 0.3769 0.3594
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0274 0.0274
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Plasmodium falciparum thioredoxin reductase 0.0076 0.3769 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0274 0.0274
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.086 0.086
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.086 0.0603
Echinococcus granulosus cathepsin l1 0.0032 0.086 0.086
Toxoplasma gondii cathepsin CPL 0.0032 0.086 0.1116
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.086 0.086
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.086 0.086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0495 0.0495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.086 0.086
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0274 0.3182
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.086 0.086
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0026 0.0495 0.5
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0495 0.1313
Brugia malayi Cathepsin L-like precursor 0.0032 0.086 0.086
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.0274 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Toxoplasma gondii thioredoxin reductase 0.0076 0.3769 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Onchocerca volvulus 0.0032 0.086 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0274 0.0274
Brugia malayi Cathepsin L-like precursor 0.0032 0.086 0.086
Loa Loa (eye worm) ctsf protein 0.0032 0.086 0.0603
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0495 0.0495
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.086 0.0603
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.086 0.086
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0495 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Onchocerca volvulus Cathepsin F homolog 0.0032 0.086 1
Toxoplasma gondii cathepsin B 0.006 0.2688 0.6697
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0495 0.1313
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Brugia malayi Cathepsin L-like precursor 0.0032 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0495 0.0495
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0495 0.1841
Brugia malayi Cathepsin L-like precursor 0.0032 0.086 0.086
Giardia lamblia Cathepsin B precursor 0.006 0.2688 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.086 0.086
Entamoeba histolytica cysteine protease, putative 0.0032 0.086 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0495 0.0495
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.2688 0.6697
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.086 0.2282
Echinococcus multilocularis cathepsin b 0.0171 1 1
Plasmodium falciparum glutathione reductase 0.0026 0.0495 0.1313
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0495 0.1313
Brugia malayi Cathepsin L-like precursor 0.0032 0.086 0.086
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.2688 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.086 0.086
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.086 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0495 0.5
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0034 0.0034
Onchocerca volvulus 0.0032 0.086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0274 0.1018
Loa Loa (eye worm) hypothetical protein 0.0171 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Giardia lamblia Cathepsin B precursor 0.006 0.2688 1
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Echinococcus granulosus cathepsin l1 0.0023 0.0274 0.0274
Onchocerca volvulus Cathepsin L homolog 0.0032 0.086 1
Loa Loa (eye worm) glutathione reductase 0.0076 0.3769 0.3594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma cruzi trypanothione reductase, putative 0.0076 0.3769 0.3769
Echinococcus multilocularis cysteine protease 0.0032 0.086 0.086
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0495 0.1313
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0495 0.0495
Brugia malayi Thioredoxin reductase 0.0076 0.3769 0.3769
Echinococcus multilocularis cysteine protease 0.0032 0.086 0.086
Onchocerca volvulus Cathepsin L homolog 0.0032 0.086 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0034 0.0034
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0495 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.3769 0.3769
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.2688 0.2688
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0076 0.3769 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0495 0.0495
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.086 0.2282
Plasmodium vivax thioredoxin reductase, putative 0.0076 0.3769 1
Brugia malayi glutathione reductase 0.0076 0.3769 0.3769
Giardia lamblia Cathepsin B precursor 0.006 0.2688 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0495 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Onchocerca volvulus 0.0032 0.086 1
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0495 0.0495
Echinococcus granulosus cathepsin b 0.0171 1 1
Plasmodium vivax vivapain-2 0.0032 0.086 0.2282
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.086 0.086
Brugia malayi cathepsin L-like precursor 0.0023 0.0274 0.0274
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0495 0.5
Loa Loa (eye worm) fibroinase 0.0032 0.086 0.0603
Onchocerca volvulus 0.0032 0.086 1
Onchocerca volvulus 0.0032 0.086 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.086 0.0603
Plasmodium vivax glutathione reductase, putative 0.0076 0.3769 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0495 0.5
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0495 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0495 0.0495
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0495 0.1313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Treponema pallidum NADH oxidase 0.0026 0.0495 0.5
Leishmania major cathepsin L-like protease 0.0032 0.086 0.1116
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.086 0.3201
Leishmania major trypanothione reductase 0.0076 0.3769 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.086 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.086 0.3201
Echinococcus granulosus cathepsin b 0.0171 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.086 0.2282
Loa Loa (eye worm) cathepsin B 0.006 0.2688 0.2482
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0495 0.1313

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.18 ug ml-1 Inhibition of human Cathepsin K ChEMBL. 17027271
IC50 (binding) = 1.18 ug ml-1 Inhibition of human Cathepsin K ChEMBL. 17027271
IC50 (binding) = 1.3 ug ml-1 Inhibition of cathepsin B mediated osteoporotic activity ChEMBL. 12662104
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against A549 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against BGC823 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against SGC7901 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against DU145 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against MDA-MB-231 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against HT29 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against BEL7402 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against MCF7 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against B16 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against A549 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against DU145 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against MDA-MB-231 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against HT29 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against MCF7 cells ChEMBL. 17027271
IC50 (ADMET) = 1.6 ug ml-1 Cytotoxicity against B16 cells ChEMBL. 17027271

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 17027271
Homo sapiens ChEMBL23 17027271

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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