Detailed information for compound 425147

Basic information

Technical information
  • TDR Targets ID: 425147
  • Name: 2-(3,5-dinitrophenyl)-5-pyridin-4-yl-1,3,4-ox adiazole
  • MW: 313.225 | Formula: C13H7N5O5
  • H donors: 0 H acceptors: 7 LogP: 1.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(cc(c1)[N+](=O)[O-])c1nnc(o1)c1ccncc1
  • InChi: 1S/C13H7N5O5/c19-17(20)10-5-9(6-11(7-10)18(21)22)13-16-15-12(23-13)8-1-3-14-4-2-8/h1-7H
  • InChiKey: BQCCQBYPAQXLOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3,5-dinitrophenyl)-5-(4-pyridyl)-1,3,4-oxadiazole
  • 4-[5-(3,5-dinitrophenyl)-1,3,4-oxadiazol-2-yl]pyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Onchocerca volvulus 0.0145 0.2115 0.2217
Echinococcus multilocularis receptor type guanylyl cyclase 0.0193 0.3144 0.3925
Brugia malayi hypothetical protein 0.0067 0.044 0.044
Mycobacterium ulcerans hypothetical protein 0.0347 0.6431 1
Echinococcus multilocularis nAChR subunit 0.0145 0.2115 0.2638
Schistosoma mansoni nAChR subunit 0.0067 0.044 0.0855
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.042 0.7996 0.7996
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0282 0.5052 1
Schistosoma mansoni nAChR subunit 0.0145 0.2115 0.4177
Trichomonas vaginalis cyclins, putative 0.0083 0.0789 0.4411
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Echinococcus granulosus nAChR subunit 0.0078 0.0681 0.0842
Schistosoma mansoni nAChR subunit 0.0145 0.2115 0.4177
Brugia malayi hypothetical protein 0.0067 0.044 0.044
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.042 0.7996 1
Echinococcus multilocularis nAChR subunit 0.0078 0.0681 0.0842
Loa Loa (eye worm) GABA receptor subunit 0.0078 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Echinococcus multilocularis cyclin B 0.0083 0.0789 0.0977
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0145 0.2115 0.2115
Loa Loa (eye worm) acetyltransferase 0.0149 0.2188 0.2188
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0117 0.1504 0.5
Schistosoma mansoni acetylcholine receptor subunit beta 0.0067 0.044 0.0855
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0051 0.0091 0.0091
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0078 0.0681 0.1333
Schistosoma mansoni nAChR subunit 0.0145 0.2115 0.4177
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.2098 0.2616
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.042 0.7996 0.7996
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0145 0.2115 0.2115
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0145 0.2115 0.4177
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0145 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0083 0.0789 0.0789
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.2115 0.2115
Echinococcus granulosus cyclin B 0.0083 0.0789 0.0977
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0117 0.1504 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.2176 0.2176
Trichomonas vaginalis cyclin B, putative 0.0083 0.0789 0.4411
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Schistosoma mansoni nAChR subunit 0.0145 0.2115 0.4177
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Echinococcus granulosus tyrosine kinase 0.0051 0.0091 0.0103
Schistosoma mansoni tyrosine kinase 0.0051 0.0091 0.0163
Schistosoma mansoni acetylcholine receptor-related 0.0067 0.044 0.0855
Mycobacterium tuberculosis Conserved protein 0.0347 0.6431 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.5052 0.5052
Brugia malayi hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Brugia malayi excitatory GABA receptor EXP-1A 0.0145 0.2115 0.2115
Echinococcus granulosus glycine receptor subunit alpha 1 0.0145 0.2115 0.2638
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0117 0.1504 0.5
Trichomonas vaginalis cyclin B, putative 0.0083 0.0789 0.4411
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0117 0.1504 1
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0117 0.1504 0.1872
Echinococcus granulosus glycine receptor subunit beta 0.0145 0.2115 0.2638
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0067 0.044 0.044
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0145 0.2115 0.2638
Trichomonas vaginalis cyclin A, putative 0.0083 0.0789 0.4411
Schistosoma mansoni integrin alpha-ps 0.0067 0.0443 0.0861
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0145 0.2115 0.4177
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0145 0.2115 0.2638
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.042 0.7996 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0145 0.2115 0.2115
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.044 0.044
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0145 0.2115 0.2115
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.042 0.7996 1
Schistosoma mansoni integrin alpha 0.015 0.2211 0.4368
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.2115 0.2115
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0145 0.2115 0.2115
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0078 0.0681 0.0681
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0117 0.1504 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0513 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0145 0.2115 0.2638
Loa Loa (eye worm) hypothetical protein 0.0282 0.5052 0.5052
Onchocerca volvulus 0.0078 0.0681 0.0319
Trichomonas vaginalis cyclins, putative 0.0083 0.0789 0.4411
Brugia malayi Cation transporter family protein 0.0145 0.2115 0.2115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0009 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0083 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0145 0.2115 0.2115
Brugia malayi hypothetical protein 0.0067 0.044 0.044
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.2188 0.2728
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0117 0.1504 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0347 0.6431 1
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.2211 0.2211
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0145 0.2115 0.2638
Onchocerca volvulus 0.0282 0.5052 0.6104
Brugia malayi Cation transporter family protein 0.0282 0.5052 0.5052
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0145 0.2115 0.2115
Echinococcus multilocularis integrin alpha ps 0.0067 0.0443 0.0544
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0193 0.3144 0.3579
Onchocerca volvulus 0.0078 0.0681 0.0319
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0145 0.2115 0.2115
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0067 0.044 0.054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0145 0.2115 0.2115
Brugia malayi hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0009 0.0009
Onchocerca volvulus 0.0282 0.5052 0.6104
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0145 0.2115 0.2638
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0145 0.2115 0.2638
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.2115 0.2115
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0117 0.1504 0.1872
Schistosoma mansoni nAChR subunit 0.0145 0.2115 0.4177
Loa Loa (eye worm) RGC/RGC protein kinase 0.0068 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0118 0.1522 0.1522
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0145 0.2115 0.2638
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0117 0.1504 0.5
Schistosoma mansoni integrin beta subunit 0.018 0.286 0.5653
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Schistosoma mansoni cyclin B 0.0083 0.0789 0.1548
Brugia malayi Cation transporter family protein 0.0145 0.2115 0.2115
Schistosoma mansoni neurotransmitter gated ion channel 0.0067 0.044 0.0855
Schistosoma mansoni tyrosine kinase 0.0051 0.0091 0.0163
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0117 0.1504 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0145 0.2115 0.2638
Schistosoma mansoni protein kinase 0.0193 0.3144 0.6217
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0067 0.044 0.044
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.3947 0.3947
Loa Loa (eye worm) LGC-31 protein 0.0145 0.2115 0.2115
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0117 0.1504 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0193 0.3144 0.3144
Loa Loa (eye worm) acetylcholine receptor protein 0.0067 0.044 0.044
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0067 0.044 0.054
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.042 0.7996 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0078 0.0681 0.1333
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0067 0.044 0.054
Loa Loa (eye worm) hypothetical protein 0.0113 0.143 0.143
Echinococcus granulosus atrial natriuretic peptide receptor 0.0168 0.2607 0.3253
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0145 0.2115 0.2638
Echinococcus multilocularis integrin alpha 3 0.0115 0.1463 0.1821
Trichomonas vaginalis cyclin B, putative 0.0083 0.0789 0.4411
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0145 0.2115 0.2115
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.2188 0.2188
Schistosoma mansoni nAChR subunit 0.0067 0.044 0.0855
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Echinococcus multilocularis glycine receptor subunit beta 0.0145 0.2115 0.2638
Loa Loa (eye worm) hypothetical protein 0.042 0.7996 0.7996
Brugia malayi Integrin beta pat-3 precursor 0.0306 0.555 0.555
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.143 0.143
Echinococcus granulosus glycine receptor subunit alpha 1 0.0145 0.2115 0.2638
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.042 0.7996 1
Entamoeba histolytica cyclin, putative 0.0083 0.0789 0.0188
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0101 0.1173 0.1173
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.0681 0.0681
Schistosoma mansoni hypothetical protein 0.0101 0.1173 0.2308
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0215 0.3617 0.3617
Echinococcus granulosus integrin alpha ps 0.0067 0.0443 0.0544
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0078 0.0681 0.0681
Echinococcus granulosus glycine receptor subunit beta 0.0145 0.2115 0.2638
Loa Loa (eye worm) ACC-1 protein 0.0145 0.2115 0.2115
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0145 0.2115 0.4177
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0067 0.044 0.054
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0282 0.5052 1
Brugia malayi Guanylyl cyclase protein 23 0.0068 0.0468 0.0468
Loa Loa (eye worm) integrin beta-2 0.0306 0.555 0.555
Onchocerca volvulus 0.0068 0.0468 0.0037
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0117 0.1504 0.1504
Loa Loa (eye worm) hypothetical protein 0.0083 0.0774 0.0774
Schistosoma mansoni nAChR subunit 0.0145 0.2115 0.4177
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0143 0.2058 0.1126
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Entamoeba histolytica hypothetical protein, conserved 0.0347 0.6431 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0168 0.2607 0.3253
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0117 0.1504 0.2965
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Onchocerca volvulus 0.0145 0.2115 0.2217
Loa Loa (eye worm) hypothetical protein 0.0049 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Echinococcus multilocularis integrin alpha ps 0.0067 0.0443 0.0544
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Echinococcus granulosus integrin beta 2 0.0226 0.3854 0.4814
Brugia malayi Cyclin, N-terminal domain containing protein 0.0083 0.0789 0.0789
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1173 0.1173
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0145 0.2115 0.2115
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0145 0.2115 0.2638
Giardia lamblia G2/mitotic-specific cyclin B 0.0083 0.0789 0.5
Onchocerca volvulus 0.0282 0.5052 0.6104
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0117 0.1504 0.5
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0145 0.2115 0.2638
Schistosoma mansoni neurotransmitter gated ion channel 0.0067 0.044 0.0855
Trichomonas vaginalis cyclins, putative 0.0083 0.0789 0.4411
Trichomonas vaginalis cyclins, putative 0.0083 0.0789 0.4411
Echinococcus granulosus nAChR subunit 0.0145 0.2115 0.2638
Loa Loa (eye worm) RGC/RGC protein kinase 0.0193 0.3144 0.3144
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.042 0.7996 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.2115 0.2115
Echinococcus multilocularis glycine receptor subunit beta 0.0145 0.2115 0.2638
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Brugia malayi Cyclin, N-terminal domain containing protein 0.0083 0.0789 0.0789
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0145 0.2115 0.4177
Loa Loa (eye worm) hypothetical protein 0.0067 0.044 0.044
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0117 0.1504 0.1504
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0145 0.2115 0.2638
Onchocerca volvulus Putative nachr subunit 0.042 0.7996 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0067 0.044 0.044
Onchocerca volvulus 0.0083 0.0789 0.0462
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.044 0.044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0078 0.0681 0.1333
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.2188 0.4321
Mycobacterium ulcerans hypothetical protein 0.0347 0.6431 1
Echinococcus granulosus integrin alpha 3 0.0115 0.1463 0.1821
Trichomonas vaginalis cyclin B, putative 0.0083 0.0789 0.4411
Loa Loa (eye worm) hypothetical protein 0.0148 0.2176 0.2176
Onchocerca volvulus 0.0145 0.2115 0.2217
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.2115 0.2115
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0145 0.2115 0.2638
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0145 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Echinococcus multilocularis integrin beta 2 0.0226 0.3854 0.4814
Brugia malayi Receptor family ligand binding region containing protein 0.0193 0.3144 0.3144
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0067 0.044 0.054
Echinococcus granulosus receptor type guanylyl cyclase 0.0193 0.3144 0.3925
Schistosoma mansoni nAChR subunit 0.0145 0.2115 0.4177
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0078 0.0681 0.0681
Loa Loa (eye worm) ACC-1 protein 0.0145 0.2115 0.2115
Mycobacterium leprae conserved hypothetical protein 0.0347 0.6431 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.2115 0.2115
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0145 0.2115 0.2115
Echinococcus multilocularis tyrosine kinase 0.0051 0.0091 0.0103
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0009 0.0009
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0067 0.044 0.044

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) = 77.1 uM Cytotoxicity against Vero cells ChEMBL. 17562368
MIC (functional) = 6.39 uM Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis CIBIN 687 isolates ChEMBL. 17562368
MIC (functional) = 6.39 uM Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis CIBIN 687 isolates ChEMBL. 17562368
MIC (functional) = 12.77 uM Antimycobacterial activity against streptomycin, isoniazid, ethambutol-resistant Mycobacterium tuberculosis CIBIN 112 isolates ChEMBL. 17562368
MIC (functional) = 12.77 uM Antimycobacterial activity against streptomycin, isoniazid, ethambutol-resistant Mycobacterium tuberculosis CIBIN 112 isolates ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis CIBIN 650 isolates ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against streptomycin and isoniazid-resistant Mycobacterium tuberculosis CIBIN 675 isolates ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against streptomycin, isoniazid, rifampicin, pyrazinamide-resistant Mycobacterium tuberculosis CIBIN 234 isolates ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis CIBIN 650 isolates ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against streptomycin and isoniazid-resistant Mycobacterium tuberculosis CIBIN 675 isolates ChEMBL. 17562368
MIC (functional) = 25.54 uM Antimycobacterial activity against streptomycin, isoniazid, rifampicin, pyrazinamide-resistant Mycobacterium tuberculosis CIBIN 234 isolates ChEMBL. 17562368

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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