Detailed information for compound 439075

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 305.284 | Formula: C18H11NO4
  • H donors: 2 H acceptors: 4 LogP: 3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)C(=O)N(C2=O)c1cccc2c1cccc2O
  • InChi: 1S/C18H11NO4/c20-10-7-8-13-14(9-10)18(23)19(17(13)22)15-5-1-4-12-11(15)3-2-6-16(12)21/h1-9,20-21H
  • InChiKey: MNDVGMQESBSTIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0447 0.1612
Brugia malayi PHD-finger family protein 0.0009 0.0006 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0089 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0089 0.0131
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0591 0.0742
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0149 0.0149
Brugia malayi Metabotropic glutamate receptor precursor. 0.0017 0.0095 0.0141
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0266 0.0266
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0208 0.0207
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0134 0.0199
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0396
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.0053 0.0188
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.026 0.2923 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0134 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0089 0.0088
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0322 0.0322
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0322 0.218
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0013 0.0053 0.0518
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0149 0.0222
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.1289 0.1289
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0693 0.7958 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0089 0.0131
Brugia malayi nuclear hormone receptor 0.0016 0.0089 0.0131
Onchocerca volvulus 0.0095 0.1006 0.363
Onchocerca volvulus 0.0026 0.0201 0.0722
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0089 0.0088
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0944 0.7206
Schistosoma mansoni lipoxygenase 0.0061 0.0604 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0129 0.0462
Brugia malayi steroid hormone receptor 0.0016 0.0089 0.0131
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0055 0.0174
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0693 0.7958 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0273 0.0983
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.087 0.661
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0124 0.0147
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.1289 0.1619
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1009 0.3758
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0322 0.1201
Echinococcus multilocularis musashi 0.0055 0.0541 0.054
Brugia malayi hypothetical protein 0.002 0.0129 0.0191
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0055 0.0197
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0134 0.0467
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.024 0.2684 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0089 0.0088
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0273 0.0332
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0222
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0273 0.1781
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0322 0.3302
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0134 0.016
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0242 0.036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.0053 0.0053
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0273 0.2782
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0089 0.0088
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0129 0.0191
Echinococcus multilocularis dnaJ subfamily B 0.0868 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0201 0.0717
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0089 0.0131
Schistosoma mansoni bromodomain containing protein 0.0009 0.0006 0.0006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0134 0.1321
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0273 0.2701
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0017 0.0095 0.0141
Schistosoma mansoni glutamate receptor NMDA 0.0097 0.1021 0.1021
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0693 0.7958 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0322 0.1162
Onchocerca volvulus 0.0055 0.0541 0.1949
Schistosoma mansoni regulator of G protein signaling 0.002 0.0129 0.0129
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0055 0.002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0591 0.0742
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0089 0.0088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0089 0.0088
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0055 0.0174
Brugia malayi hypothetical protein 0.0066 0.0661 0.0986
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.024 0.2684 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.024 0.2684 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0089 0.0088
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0013 0.0053 0.0464
Brugia malayi Receptor family ligand binding region containing protein 0.0017 0.0095 0.0141
Loa Loa (eye worm) RGC/RGC protein kinase 0.0017 0.0095 0.0141
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0013 0.0053 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.7889 0.7889
Echinococcus granulosus cpg binding protein 0.0033 0.0279 0.0279
Schistosoma mansoni polycystin 1-related 0.0022 0.0149 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0201 0.0299
Echinococcus granulosus lamin dm0 0.0055 0.0541 0.054
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0273 0.0499
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0129 0.0129
Echinococcus granulosus microtubule associated protein 2 0.0687 0.7889 0.7889
Brugia malayi Glutamate receptor 2 precursor 0.0033 0.0284 0.0423
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0119 0.1276 0.1276
Echinococcus granulosus jun protein 0.0084 0.0869 0.0869
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0089 0.0088
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0013 0.0053 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1009 0.3639
Echinococcus multilocularis glutamate receptor 2 0.005 0.0483 0.0482
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0494 0.5648 0.8435
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0273 0.019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0055 0.0082
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.026 0.2923 0.3572
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0273 0.019
Schistosoma mansoni ap endonuclease 0.002 0.0134 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0322 0.1162
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0132 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1289 0.4652
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0055 0.0206
Loa Loa (eye worm) hypothetical protein 0.0081 0.0843 0.1258
Brugia malayi follicle stimulating hormone receptor 0.0494 0.5648 0.8435
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0089 0.0088
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0889 0.1117
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.024 0.2684 1
Schistosoma mansoni bromodomain containing protein 0.0009 0.0006 0.0006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0089 0.0088
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0134 0.0655
Brugia malayi intermediate filament protein 0.0055 0.0541 0.0806
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1289 0.4786
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0273 0.0335
Loa Loa (eye worm) hypothetical protein 0.0026 0.0201 0.0299
Loa Loa (eye worm) hypothetical protein 0.0026 0.0201 0.0299
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1009 0.3639
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0639 0.7336 0.9217
Giardia lamblia DNA-directed RNA polymerase subunit B 0.001 0.0009 0.0081
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0693 0.7958 1
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0013 0.0053 0.0165
Loa Loa (eye worm) hypothetical protein 0.002 0.0124 0.0184
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0129 0.0129
Loa Loa (eye worm) RGC/RGC protein kinase 0.0017 0.0095 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0089 0.0131
Echinococcus granulosus expressed protein 0.0388 0.4413 0.4412
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0591 0.2176
Onchocerca volvulus 0.0016 0.0089 0.0317
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0591 0.0882
Loa Loa (eye worm) RGS-3 protein 0.002 0.0129 0.0191
Trypanosoma cruzi extracellular receptor, putative 0.0017 0.0095 0.0355
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1289 0.4652
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1009 0.3639
Leishmania major ATP-dependent phosphofructokinase 0.012 0.1289 0.4786
Loa Loa (eye worm) hypothetical protein 0.002 0.0124 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1009 0.3639
Loa Loa (eye worm) RGC/RGC protein kinase 0.0017 0.0095 0.0141
Onchocerca volvulus 0.0055 0.0541 0.1949
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.001 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.026 0.2923 0.3564
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0022 0.0149 0.0149
Chlamydia trachomatis glutamine binding protein 0.0085 0.0889 0.0977
Schistosoma mansoni ATP-binding cassette transporter 0.0033 0.0284 0.0284
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0017 0.0095 0.0141
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.1289 0.1619
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1289 0.1925
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0266 0.0266
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1815 0.1815
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0013 0.0053 0.0078
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0033 0.0284 0.0284
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0134 0.0467
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0089 0.0088
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0591 0.0591
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0124 0.0145
Entamoeba histolytica hypothetical protein 0.002 0.0129 0.0614
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0273 0.2782
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0064 0.0637 0.0799
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0129 0.0129
Mycobacterium ulcerans hypothetical protein 0.0026 0.0201 0.0251
Echinococcus multilocularis RUN 0.0022 0.0149 0.0149
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0149 0.018
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1289 0.1925
Schistosoma mansoni hypothetical protein 0.0171 0.1891 0.1891
Brugia malayi 6-phosphofructokinase 0.012 0.1289 0.1925
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0089 0.0131
Schistosoma mansoni cpg binding protein 0.0033 0.0279 0.0279
Echinococcus granulosus lamin 0.0055 0.0541 0.054
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0022 0.0032
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1289 0.1289
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0266 0.0266
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0089 0.0317
Brugia malayi Doublecortin family protein 0.0022 0.0149 0.0222
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0089 0.0088
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0021 0.003
Schistosoma mansoni ap endonuclease 0.002 0.0134 0.0134
Trypanosoma brucei calpain, putative 0.024 0.2684 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0191
Schistosoma mansoni rab6-interacting 0.0022 0.0149 0.0149
Entamoeba histolytica hypothetical protein 0.002 0.0129 0.0614
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0013 0.0053 0.0055
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1289 0.4652
Brugia malayi PXA domain containing protein 0.002 0.0129 0.0191
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0008
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0944 0.7206
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0273 0.0983
Schistosoma mansoni kinase 0.0049 0.0462 0.0462
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1009 0.3639
Brugia malayi Receptor family ligand binding region containing protein 0.0017 0.0095 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0089 0.0131
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0541 0.0806
Loa Loa (eye worm) hypothetical protein 0.0027 0.0208 0.0309
Leishmania major extracellular receptor, putative 0.0017 0.0095 0.0323
Schistosoma mansoni lipoxygenase 0.0022 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Schistosoma mansoni tyrosine kinase 0.0017 0.0095 0.0095
Echinococcus granulosus RUN 0.0022 0.0149 0.0149
Loa Loa (eye worm) glutamate receptor 1 0.0033 0.0284 0.0423
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0959 0.3458
Onchocerca volvulus 0.0066 0.0661 0.2382
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1009 0.3738
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0483 0.0482
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0273 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Echinococcus granulosus glutamate NMDA receptor subunit 0.0097 0.1021 0.1021
Brugia malayi Glutamate receptor 1 precursor 0.0033 0.0284 0.0423
Schistosoma mansoni rab6-interacting 0.0022 0.0149 0.0149
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1009 0.1506
Schistosoma mansoni hypothetical protein 0.0068 0.0687 0.0687
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0111 0.0139
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0129 0.0191
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.0053 0.0058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1815 0.2709
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.024 0.2684 1
Echinococcus multilocularis expressed protein 0.0388 0.4413 0.4412
Loa Loa (eye worm) acetyltransferase 0.031 0.3507 0.5237
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0013 0.0053 0.0078
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0959 0.1197
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0132 0.0132
Schistosoma mansoni protein kinase 0.0017 0.0095 0.0095
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1009 0.1009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0322 0.0481
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.0053 0.0055
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.024 0.2684 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.024 0.2684 1
Onchocerca volvulus 0.0012 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0322 0.0481
Schistosoma mansoni lamin 0.0055 0.0541 0.054
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0013 0.0053 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0089 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0089 0.0131
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0483 0.0482
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0129 0.0129
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0544 0.0812
Echinococcus granulosus receptor type guanylyl cyclase 0.0017 0.0095 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1009 0.3639
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.024 0.2684 1
Brugia malayi hypothetical protein 0.002 0.0129 0.0191
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0129 0.0129
Brugia malayi small heat shock protein 0.0584 0.6696 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.031 0.3507 0.3507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0266 0.0266
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0693 0.7958 1
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0639 0.7336 0.9217
Loa Loa (eye worm) hypothetical protein 0.002 0.0124 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0089 0.0131
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0693 0.7958 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0182 0.0271
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0201 0.0717
Schistosoma mansoni tyrosine kinase 0.0017 0.0095 0.0095
Schistosoma mansoni loxhd1 0.0022 0.0149 0.0149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0089 0.0088
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0483 0.0482
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0129 0.0129
Brugia malayi Pre-SET motif family protein 0.0032 0.0266 0.0396
Echinococcus granulosus axis inhibition protein axin 0.002 0.0129 0.0129
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0013 0.0053 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0273 0.0983
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0033 0.0284 0.0284
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0134 0.0167
Onchocerca volvulus 0.0022 0.0149 0.0537
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0089 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0132 0.0132
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1815 0.1815
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0944 0.7206
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0089 0.0131
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0089 0.0088
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1289 1
Echinococcus multilocularis geminin 0.0171 0.1891 0.1891
Echinococcus granulosus glutamate receptor 2 0.0017 0.0095 0.0095
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0591 0.0742
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0322 0.1162
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0483 0.0482
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0055 0.0197
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0322 0.218
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.026 0.2923 1
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0013 0.0053 0.0078
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0055 0.0197
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0129 0.0129
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0089 0.0088
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0033 0.0284 0.0284
Echinococcus granulosus nmda type glutamate receptor 0.0017 0.0095 0.0095
Echinococcus multilocularis tyrosine kinase 0.0017 0.0095 0.0095
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.024 0.2684 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0124 0.0155
Onchocerca volvulus 0.0032 0.0266 0.0958
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0089 0.0088
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0017 0.0095 0.0095
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.026 0.2923 0.3672
Brugia malayi Pre-SET motif family protein 0.0217 0.2423 0.3617
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0322 0.1172
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0089 0.0088
Schistosoma mansoni coup transcription factor 0.0016 0.0089 0.0088
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.024 0.2684 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0089 0.0088
Schistosoma mansoni axis inhibition protein axin 0.002 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0149 0.0149
Echinococcus granulosus intermediate filament protein 0.0055 0.0541 0.054
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0693 0.7958 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0273 0.0983
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1009 0.1009
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0483 0.0482
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Brugia malayi bZIP transcription factor family protein 0.0084 0.0869 0.1298
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0013 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0171 0.1891 0.1891
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0684 0.7113
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0483 0.0482
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0055 0.0197
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0089 0.0088
Echinococcus multilocularis receptor type guanylyl cyclase 0.0017 0.0095 0.0095
Brugia malayi hypothetical protein 0.0022 0.0149 0.0222
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0266 0.2707
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0129 0.0191
Entamoeba histolytica hypothetical protein 0.002 0.0129 0.0614
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0242 0.036
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0097 0.1021 0.1021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0089 0.0088
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0071 0.0719 0.0893
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0129 0.0129
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1815 0.1815
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0447 0.1612
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1009 0.7731
Schistosoma mansoni alpha glucosidase 0.0037 0.0322 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0089 0.0131
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0013 0.0053 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0089 0.0088
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0129 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0089 0.0131
Brugia malayi 6-phosphofructokinase 0.012 0.1289 0.1925
Echinococcus multilocularis glutamate receptor 2 0.0017 0.0095 0.0095
Echinococcus multilocularis lamin dm0 0.0055 0.0541 0.054
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0013 0.0053 0.0464
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0129 0.0129
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0889 0.1117
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0089 0.0131
Trypanosoma brucei glucosidase, putative 0.0037 0.0322 0.1172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0089 0.0131
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.024 0.2684 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0017 0.0095 0.0141
Loa Loa (eye worm) hypothetical protein 0.002 0.0124 0.0184
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0322 0.1162
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0055 0.0197
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.024 0.2684 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0129 0.0129
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0591 0.0591
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0266 0.0266
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0085 0.0889 0.2709
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0266 0.0266
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0245 0.0245
Loa Loa (eye worm) glutamate receptor 0.0017 0.0095 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0111 0.0139
Echinococcus granulosus metabotropic glutamate receptor 5 0.0017 0.0095 0.0095
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0149 0.0177
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0541 0.0806
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0132 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0124 0.0184
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0089 0.0088
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0273 0.0983
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0201 0.1194
Schistosoma mansoni metabotropic glutamate receptor 0.0017 0.0095 0.0095
Brugia malayi Cytochrome P450 family protein 0.0025 0.0182 0.0271
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1815 0.2709
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0201 0.0251
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0322 0.1162
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.031 0.3507 0.3507
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0132 0.0197
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0033 0.0284 0.0284
Onchocerca volvulus UPF0528 protein homolog 0.0042 0.0391 0.1407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0201 0.0251
Echinococcus granulosus tyrosine kinase 0.0017 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0191
Echinococcus multilocularis nmda type glutamate receptor 0.0119 0.1276 0.1276
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0959 1
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0013 0.0053 0.0197
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0284 0.0284
Brugia malayi Guanylyl cyclase protein 23 0.0017 0.0095 0.0141
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0017 0.0095 0.0342
Brugia malayi nuclear receptor NHR-88 0.0016 0.0089 0.0131
Echinococcus multilocularis nmda type glutamate receptor 0.0017 0.0095 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0201 0.0299
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0013 0.0053 0.0188
Schistosoma mansoni axis inhibition protein axin 0.002 0.0129 0.0129
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0055 0.0197
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0033 0.0284 0.0284
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0959 0.3458
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0191
Loa Loa (eye worm) hypothetical protein 0.0584 0.6696 1
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0541 0.0806
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0085 0.0889 0.0977
Echinococcus multilocularis NMDA receptor 0.0033 0.0284 0.0284
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0604 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0129 0.0462
Echinococcus multilocularis zinc finger protein 0.0009 0.0006 0.0006
Trypanosoma brucei polo-like protein kinase 0.0096 0.1009 0.3738
Echinococcus granulosus zinc finger protein 0.0009 0.0006 0.0006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0208 0.0207
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0017 0.0095 0.0141
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0284 0.0284
Schistosoma mansoni intermediate filament proteins 0.0055 0.0541 0.054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0089 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0322 0.1162
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0191
Schistosoma mansoni alpha-glucosidase 0.0142 0.1548 0.1548
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0284 0.0284
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0678 0.0678
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0129 0.0191
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.0053 0.0188
Giardia lamblia Kinase, PLK 0.0096 0.1009 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0055 0.0082
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0273 0.2782
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0089 0.0317
Loa Loa (eye worm) hypothetical protein 0.033 0.3735 0.5577
Brugia malayi CXXC zinc finger family protein 0.0031 0.0259 0.0386
Schistosoma mansoni zinc finger protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) DNA-directed RNA polymerase 0.0011 0.0025 0.0036
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0124 0.0155
Onchocerca volvulus 0.0247 0.277 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0149 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0111 0.0139
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0055 0.0197
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1289 0.4803
Entamoeba histolytica hypothetical protein 0.0017 0.0095 0.0343
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0959 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0869 0.0869
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.087 0.1083
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1009 0.1009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0134 0.0134
Schistosoma mansoni alpha-glucosidase 0.0142 0.1548 0.1548
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0129 0.0462
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0134 0.0167
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0129 0.0129
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0201 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0129 0.0462
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0089 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0089 0.0131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0134 0.0499
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0089 0.0088
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.024 0.2684 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0201 0.0299
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2423 0.3617
Toxoplasma gondii hypothetical protein 0.0042 0.0391 0.4019
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.7889 0.7889
Schistosoma mansoni metabotropic glutamate receptor 0.0017 0.0095 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0201 0.0299
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0322 0.1162
Trypanosoma brucei calpain-like protein, putative 0.024 0.2684 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0322 0.1201
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0055 0.0206
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0022
Echinococcus granulosus atrial natriuretic peptide receptor 0.0017 0.0095 0.0095
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0129 0.0129
Schistosoma mansoni regulator of G protein signaling 0.002 0.0129 0.0129
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0089 0.0088
Brugia malayi hypothetical protein 0.0127 0.1369 0.2044
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0191
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0483 0.0482
Schistosoma mansoni jun-related protein 0.0068 0.0687 0.0687
Echinococcus granulosus axis inhibition protein axin 0.002 0.0129 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0129 0.0462
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0013 0.0053 0.0078
Plasmodium vivax DNA-directed RNA polymerase I subunit RPA2, putative 0.001 0.0009 0.0003
Echinococcus granulosus glutamate receptor 2 0.005 0.0483 0.0482
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.1289 0.4143
Brugia malayi Bromodomain containing protein 0.0009 0.0006 0.0008
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0149 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1009 0.3639
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.024 0.2684 1
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0284 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0089 0.0131
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0089 0.0131
Loa Loa (eye worm) hypothetical protein 0.0055 0.0541 0.0806
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.0033 0.0279 0.0279
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0129 0.0129
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0089 0.0317
Schistosoma mansoni regulator of G protein signaling 0.002 0.0129 0.0129
Onchocerca volvulus 0.0031 0.0259 0.0932
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0013 0.0053 0.0165
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1009 0.3758
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0149 0.0149
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0201 0.1194
Schistosoma mansoni hypothetical protein 0.0033 0.0284 0.0284
Echinococcus granulosus nmda type glutamate receptor 0.0119 0.1276 0.1276
Brugia malayi metabotropic glutamate receptor type 2 0.0017 0.0095 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0089 0.0131
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0013 0.0053 0.0078
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0273 0.0983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0089 0.0131
Schistosoma mansoni hypothetical protein 0.0868 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0131
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0944 0.7206
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0089 0.0131
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0013 0.0053 0.0518
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.1289 0.3999
Schistosoma mansoni lamin 0.0055 0.0541 0.054
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0134 0.0199
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0129 0.0129
Schistosoma mansoni regulator of G protein signaling 0.002 0.0129 0.0129
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.0053 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0201 0.0251
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0201 0.0251
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1009 0.3639
Brugia malayi ecdysteroid receptor 0.0016 0.0089 0.0131
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0322 0.0322
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.087 0.8624
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0042 0.0391 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0089 0.0131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1289 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0022
Echinococcus granulosus 6 phosphofructokinase 0.012 0.1289 0.1289
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0201 0.1194
Echinococcus granulosus glutamate receptor subunit protein glur 0.0033 0.0284 0.0284
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0134 0.0499
Echinococcus multilocularis cpg binding protein 0.0033 0.0279 0.0279
Brugia malayi hypothetical protein 0.0022 0.0149 0.0222
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0944 0.7206
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0201 0.0717
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0259 0.0386
Echinococcus granulosus histone acetyltransferase KAT2B 0.0302 0.3406 0.3406
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0869 0.0869
Schistosoma mansoni cpg binding protein 0.0031 0.0259 0.0259
Brugia malayi phosphofructokinase 0.012 0.1289 0.1925
Brugia malayi PXA domain containing protein 0.002 0.0129 0.0191
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0013 0.0053 0.0165
Onchocerca volvulus 0.0017 0.0095 0.0342
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0129 0.0191
Plasmodium vivax SET domain protein, putative 0.0032 0.0266 0.0326
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0132 0.0132
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1289 0.4652
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0089 0.0131
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0085 0.0889 0.2709
Echinococcus granulosus metabotropic glutamate receptor 2 0.0017 0.0095 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0201 0.0251
Trypanosoma brucei hypothetical protein 0.024 0.2684 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0134 0.0481
Schistosoma mansoni regulator of G protein signaling 0.002 0.0129 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0129 0.0462
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0129 0.0191
Echinococcus multilocularis jun protein 0.0084 0.0869 0.0869
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0693 0.7958 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0196 0.0291
Toxoplasma gondii exonuclease III APE 0.002 0.0134 0.1317
Loa Loa (eye worm) hypothetical protein 0.0054 0.0529 0.0789
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0055 0.0197
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0284 0.0284
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0089 0.0131
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1289 1
Echinococcus multilocularis lamin 0.0055 0.0541 0.054
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0483 0.0482
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0191
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0134 0.0481
Loa Loa (eye worm) phosphofructokinase 0.012 0.1289 0.1925
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0013 0.0053 0.0053
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0201 0.0251
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0129 0.0129
Loa Loa (eye worm) glutamate receptor 2 0.0033 0.0284 0.0423
Brugia malayi acetyltransferase, GNAT family protein 0.031 0.3507 0.5237
Loa Loa (eye worm) hypothetical protein 0.0026 0.0196 0.0291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0089 0.0088
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0201 0.0251
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0284 0.0284
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0089 0.0131
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0129 0.0129
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1289 0.1289
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0322 0.1162
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0132 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0266 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0273 0.0983
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0089 0.0088
Echinococcus granulosus geminin 0.0171 0.1891 0.1891
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0273 0.0332
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0129 0.0462
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0483 0.0482
Brugia malayi NC domain containing protein 0.0042 0.0391 0.0582
Brugia malayi hypothetical protein 0.0017 0.0095 0.0141
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0132 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0201 0.0251
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0959 0.0958
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0055 0.0197
Trichomonas vaginalis set domain proteins, putative 0.0247 0.277 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0111 0.0139
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0017 0.0095 0.0095
Onchocerca volvulus 0.0022 0.0149 0.0537
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0013 0.0053 0.0053
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0322 0.1162
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.001 0.0009 0.0033
Trypanosoma cruzi calpain cysteine peptidase, putative 0.024 0.2684 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0017 0.0095 0.0095
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0129 0.0129
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1009 0.1506
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0033 0.0284 0.0284
Onchocerca volvulus 0.0017 0.0095 0.0342

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 802 nM Inhibition of human LBD of of ERalpha ChEMBL. 17049855
IC50 (binding) = 802 nM Inhibition of human LBD of of ERalpha ChEMBL. 17049855
IC50 (binding) = 2810 nM Inhibition of human LBD of ERbeta ChEMBL. 17049855
IC50 (binding) = 2810 nM Inhibition of human LBD of ERbeta ChEMBL. 17049855
Ratio IC50 (binding) = 4 Selectivity for human LBD of ERbeta over human LBD of ERalpha ChEMBL. 17049855

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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