Detailed information for compound 49322

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 708.932 | Formula: C33H52N6O7S2
  • H donors: 6 H acceptors: 7 LogP: 3.87 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(C[C@@H](C([C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NS(=O)(=O)N1CCOCC1)Cc1ccccc1)Cc1csc(n1)N)CC1CCCCC1)O)O)C
  • InChi: 1S/C33H52N6O7S2/c1-22(2)17-29(40)30(41)26(18-23-9-5-3-6-10-23)36-31(42)27(20-25-21-47-33(34)35-25)37-32(43)28(19-24-11-7-4-8-12-24)38-48(44,45)39-13-15-46-16-14-39/h4,7-8,11-12,21-23,26-30,38,40-41H,3,5-6,9-10,13-20H2,1-2H3,(H2,34,35)(H,36,42)(H,37,43)/t26-,27-,28-,29-,30?/m0/s1
  • InChiKey: QGJKHQRFJGLJLV-NWCBYQDHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0119 0.0119
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0119 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0118 0.0495 0.0495
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0925 0.4725 0.4627
Schistosoma mansoni hypothetical protein 0.0525 0.2627 0.2627
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0823 0.419 0.5608
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0085 0.0085
Echinococcus granulosus para nitrobenzyl esterase 0.0135 0.0584 0.0584
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0295 0.0472
Echinococcus multilocularis jumonji domain containing protein 0.0033 0.0049 0.0049
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0085 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Schistosoma mansoni nuclear hormone receptor 0.004 0.0085 0.0085
Loa Loa (eye worm) acetylcholinesterase 1 0.0801 0.4073 0.4073
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1589 0.3792
Mycobacterium ulcerans beta-lactamase 0.008 0.0295 0.4373
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0295 0.0472
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Echinococcus granulosus cathepsin L cysteine protease 0.0824 0.4193 0.4193
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0177 0.0803 0.1072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0129 0.0129
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0135 0.0584 0.1689
Echinococcus granulosus cathepsin L 0.0824 0.4193 0.4193
Plasmodium falciparum plasmepsin VI 0.0177 0.0803 0.1095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Schistosoma mansoni thyroid hormone receptor 0.004 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Toxoplasma gondii ABC1 family protein 0.008 0.0295 0.0403
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0295 0.0157
Onchocerca volvulus 0.0135 0.0584 0.0797
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0823 0.419 0.419
Trichomonas vaginalis esterase, putative 0.008 0.0295 0.0377
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0085 0.0085
Echinococcus multilocularis transcription factor eb 0.0119 0.0498 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Onchocerca volvulus 0.0327 0.1589 0.2168
Plasmodium falciparum plasmepsin III 0.0042 0.0094 0.0129
Schistosoma mansoni cathepsin F (C01 family) 0.1422 0.7329 0.7329
Loa Loa (eye worm) hypothetical protein 0.0075 0.0268 0.0268
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0085 0.0085
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0177 0.0803 0.0803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Onchocerca volvulus 0.0925 0.4725 0.6447
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0295 0.0377
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Plasmodium vivax aspartyl protease, putative 0.0042 0.0094 0.0129
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Echinococcus granulosus neuroligin 0.0135 0.0584 0.0584
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Schistosoma mansoni survival motor neuron protein 0.0103 0.0415 0.0415
Onchocerca volvulus 0.1422 0.7329 1
Brugia malayi intermediate filament protein 0.0027 0.0016 0.0016
Brugia malayi Cathepsin L-like cysteine proteinase 0.0925 0.4725 0.4725
Echinococcus granulosus FTZ F1 alpha 0.004 0.0085 0.0085
Onchocerca volvulus Cathepsin L homolog 0.0327 0.1589 0.2168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0925 0.4725 0.6437
Onchocerca volvulus 0.0103 0.0415 0.0566
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0327 0.1589 0.2168
Echinococcus granulosus jumonji domain containing protein 0.0033 0.0049 0.0049
Plasmodium vivax aspartyl proteinase, putative 0.0042 0.0094 0.0129
Loa Loa (eye worm) zinc finger protein 0.0309 0.1494 0.1494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1589 0.2147
Onchocerca volvulus Cathepsin L homolog 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0094
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.4275 0.4275
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Echinococcus granulosus carboxylesterase 5A 0.0801 0.4073 0.4073
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0135 0.0584 0.0773
Schistosoma mansoni hypothetical protein 0.0229 0.1077 0.1077
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0085 0.0085
Loa Loa (eye worm) cathepsin B 0.0823 0.419 0.419
Loa Loa (eye worm) hypothetical protein 0.0925 0.4725 0.4725
Brugia malayi Pepsin A precursor 0.0042 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0327 0.1589 0.2147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0059 0.0183 0.0224
Echinococcus granulosus transcription factor eb 0.0119 0.0498 0.0498
Echinococcus granulosus aspartyl aminopeptidase 0.0059 0.0183 0.0183
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0085 0.0085
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Brugia malayi beta-lactamase family protein 0.008 0.0295 0.0295
Toxoplasma gondii cathepsin B 0.0823 0.419 0.5717
Onchocerca volvulus 0.1422 0.7329 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1422 0.7329 0.7329
Schistosoma mansoni neuroligin 3 (S09 family) 0.0135 0.0584 0.0584
Plasmodium falciparum plasmepsin X 0.0042 0.0094 0.0129
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0824 0.4193 0.4193
Mycobacterium tuberculosis Conserved protein 0.008 0.0295 0.0472
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Trypanosoma cruzi cruzipain precursor, putative 0.0497 0.2479 0.2339
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0505 0.2522 0.2522
Echinococcus granulosus acetylcholinesterase 0.0801 0.4073 0.4073
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Brugia malayi PAS domain containing protein 0.005 0.0139 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Plasmodium vivax unspecified product 0.0824 0.4193 0.5721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0295 0.0377
Echinococcus multilocularis muscleblind protein 0.0319 0.1547 0.1547
Entamoeba histolytica cysteine proteinase 1, putative 0.0824 0.4193 0.5612
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0327 0.1589 0.1589
Trypanosoma cruzi cruzipain precursor, putative 0.1422 0.7329 0.7279
Loa Loa (eye worm) hypothetical protein 0.0059 0.0183 0.0183
Echinococcus multilocularis musashi 0.0027 0.0016 0.0016
Schistosoma mansoni intermediate filament proteins 0.0027 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0085 0.0085
Echinococcus granulosus cathepsin L 0.0327 0.1589 0.1589
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0295 0.0472
Loa Loa (eye worm) aspartyl protease 6 0.0042 0.0094 0.0094
Echinococcus multilocularis lamin dm0 0.0027 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0042 0.0094 0.0094
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0295 0.0472
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0415 0.0415
Toxoplasma gondii cathepsin CPL 0.1422 0.7329 1
Echinococcus granulosus microtubule associated protein 2 0.0672 0.3398 0.3398
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0327 0.1589 0.2168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Schistosoma mansoni single-minded 0.005 0.0139 0.0139
Echinococcus multilocularis cathepsin L 0.0327 0.1589 0.1589
Schistosoma mansoni BC026374 protein (S09 family) 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0319 0.1547 0.1547
Echinococcus multilocularis cathepsin L cysteine protease 0.1422 0.7329 0.7329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Onchocerca volvulus 0.1422 0.7329 1
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0295 0.0114
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Schistosoma mansoni lamin 0.0027 0.0016 0.0016
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0512 0.2559 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0085 0.0085
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0057 0.0057
Schistosoma mansoni calcium-activated potassium channel 0.0167 0.0749 0.0749
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0177 0.0803 0.0803
Schistosoma mansoni hypothetical protein 0.0075 0.0268 0.0268
Loa Loa (eye worm) fli-1 protein 0.018 0.0818 0.0818
Giardia lamblia Cathepsin B precursor 0.0823 0.419 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0085 0.0085
Plasmodium vivax serine-repeat antigen (SERA) 0.0327 0.1589 0.2168
Echinococcus granulosus cathepsin L cysteine proteinase 0.1422 0.7329 0.7329
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.3398 0.3398
Giardia lamblia Hypothetical protein 0.0327 0.1589 0.3792
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0295 0.0472
Trypanosoma cruzi cysteine protease, putative 0.0824 0.4193 0.4085
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0177 0.0803 0.0803
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0823 0.419 0.5706
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0135 0.0584 0.0584
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0085 0.0085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0085 0.0085
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Brugia malayi Papain family cysteine protease containing protein 0.0824 0.4193 0.4193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Giardia lamblia Cathepsin B precursor 0.0823 0.419 1
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Onchocerca volvulus 0.0135 0.0584 0.0797
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0016 0.0016
Brugia malayi bHLH-PAS transcription factor 0.0037 0.007 0.007
Brugia malayi steroid hormone receptor 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Schistosoma mansoni cathepsin S (C01 family) 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0295 0.0295
Echinococcus granulosus cathepsin l1 0.0925 0.4725 0.4725
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.045 0.045
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0085 0.0085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0085 0.0085
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0059 0.0186 0.0186
Leishmania major hypothetical protein, conserved 0.008 0.0295 0.0157
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Echinococcus multilocularis cathepsin b 0.1931 1 1
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0085 0.0116
Echinococcus granulosus lysine specific demethylase 5A 0.0029 0.0026 0.0026
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0327 0.1589 0.2168
Entamoeba histolytica cysteine protease, putative 0.1422 0.7329 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis survival motor neuron protein 1 0.0505 0.2522 0.2522
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.007 0.007
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0268 0.0268
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0085 0.0085
Giardia lamblia Cathepsin L-like protease 0.0327 0.1589 0.3792
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Onchocerca volvulus Huntingtin homolog 0.0127 0.054 0.0736
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Loa Loa (eye worm) cysteine protease 0.1422 0.7329 0.7329
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Echinococcus granulosus intermediate filament protein 0.0027 0.0016 0.0016
Plasmodium falciparum plasmepsin IX 0.0042 0.0094 0.0129
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0229 0.1077 0.1077
Brugia malayi Papain family cysteine protease containing protein 0.1422 0.7329 0.7329
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.0692 0.0692
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1931 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0824 0.4193 0.4085
Schistosoma mansoni jumonji domain containing protein 0.0062 0.02 0.02
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0026 0.0026
Mycobacterium ulcerans lipase LipD 0.008 0.0295 0.4373
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Entamoeba histolytica cysteine proteinase 2 0.0824 0.4193 0.5612
Plasmodium falciparum plasmepsin VIII, putative 0.0042 0.0094 0.0129
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Loa Loa (eye worm) hypothetical protein 0.1422 0.7329 0.7329
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0295 0.0295
Onchocerca volvulus 0.008 0.0295 0.0403
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.045 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Brugia malayi hypothetical protein 0.0135 0.0584 0.0584
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0443 0.0364
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0135 0.0584 0.1689
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0801 0.4073 0.4073
Loa Loa (eye worm) carboxylesterase 0.0135 0.0584 0.0584
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0327 0.1589 0.2168
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0327 0.1589 0.2147
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0118 0.0495 0.0495
Plasmodium vivax vivapain-1 0.0824 0.4193 0.5721
Leishmania major cysteine peptidase A (CPA) 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0925 0.4725 0.4725
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0085 0.0085
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.3398 0.3398
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0497 0.2479 0.2479
Plasmodium vivax unspecified product 0.0327 0.1589 0.2168
Echinococcus granulosus geminin 0.0525 0.2627 0.2627
Plasmodium falciparum cysteine proteinase falcipain 3 0.1422 0.7329 1
Echinococcus multilocularis protein patched 0.0046 0.0119 0.0119
Brugia malayi Carboxylesterase family protein 0.0801 0.4073 0.4073
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Toxoplasma gondii cathepsin CPC2 0.0327 0.1589 0.2168
Echinococcus granulosus GPCR family 2 0.0035 0.0057 0.0057
Onchocerca volvulus 0.0042 0.0094 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1589 0.2147
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0452 0.0452
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0497 0.2479 0.2479
Plasmodium falciparum plasmepsin II 0.0177 0.0803 0.1095
Plasmodium vivax aspartyl protease, putative 0.0042 0.0094 0.0129
Plasmodium falciparum plasmepsin IV 0.0177 0.0803 0.1095
Echinococcus granulosus small conductance calcium activated potassium 0.0167 0.0749 0.0749
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0085 0.0085
Echinococcus granulosus single minded 2 0.0037 0.007 0.007
Echinococcus granulosus acetylcholinesterase 0.0801 0.4073 0.4073
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0327 0.1589 0.3792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0824 0.4193 0.571
Onchocerca volvulus 0.0135 0.0584 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0327 0.1589 0.2147
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0133 0.0133
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0327 0.1589 0.2168
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0085 0.0116
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Entamoeba histolytica hypothetical protein 0.0327 0.1589 0.1967
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0443 0.0443
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1589 0.3792
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1931 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0183 0.0183
Brugia malayi ecdysteroid receptor 0.004 0.0085 0.0085
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0327 0.1589 0.1589
Echinococcus granulosus muscleblind protein 0.0319 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Echinococcus multilocularis GPCR, family 2 0.0035 0.0057 0.0057
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0142 0.0142
Schistosoma mansoni thyroid hormone receptor 0.004 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0085 0.0085
Onchocerca volvulus 0.0086 0.0325 0.0444
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0119 0.0136
Loa Loa (eye worm) fibroinase 0.1422 0.7329 0.7329
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Plasmodium vivax vivapain-2 0.1422 0.7329 1
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Schistosoma mansoni ets-related 0.018 0.0818 0.0818
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0295 0.0377
Plasmodium falciparum cysteine proteinase falcipain 1 0.0824 0.4193 0.5721
Brugia malayi Ets-domain containing protein 0.0059 0.0186 0.0186
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0327 0.1589 0.2168
Schistosoma mansoni lamin 0.0027 0.0016 0.0016
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0584 0.0584
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0584 0.0584
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0327 0.1589 0.1589
Plasmodium vivax plasmepsin IV, putative 0.0177 0.0803 0.1095
Loa Loa (eye worm) hypothetical protein 0.0497 0.2479 0.2479
Schistosoma mansoni acetylcholinesterase 0.0135 0.0584 0.0584
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1931 1 1
Onchocerca volvulus 0.008 0.0295 0.0403
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0177 0.0803 0.1095
Brugia malayi hypothetical protein 0.0505 0.2522 0.2522
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0059 0.0183 0.0224
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1931 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0129 0.0129
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0327 0.1589 0.2168
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0295 0.0377
Onchocerca volvulus 0.0027 0.0016 0.0022
Toxoplasma gondii preprocathepsin c precursor, putative 0.0327 0.1589 0.2168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Onchocerca volvulus 0.004 0.0085 0.0116
Brugia malayi hypoxia-induced factor 1 0.0156 0.0692 0.0692
Mycobacterium leprae conserved hypothetical protein 0.008 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0443 0.0443
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0026 0.0026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0085 0.0085
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0443 0.0443
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Echinococcus multilocularis acetylcholinesterase 0.0801 0.4073 0.4073
Toxoplasma gondii aspartyl protease 0.0042 0.0094 0.0129
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Echinococcus multilocularis cathepsin L cysteine protease 0.1422 0.7329 0.7329
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1422 0.7329 0.7329
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni cathepsin F (C01 family) 0.1422 0.7329 0.7329
Echinococcus multilocularis cathepsin b 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.054 0.054
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0327 0.1589 0.2168
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0135 0.0584 1
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0119 0.0119
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0327 0.1589 0.2168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0327 0.1589 0.2147
Plasmodium falciparum serine repeat antigen 6 0.0327 0.1589 0.2168
Onchocerca volvulus 0.0027 0.0016 0.0022
Plasmodium falciparum serine repeat antigen 2 0.0327 0.1589 0.2168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Mycobacterium tuberculosis Conserved protein 0.008 0.0295 0.0472
Schistosoma mansoni calcium-activated potassium channel 0.0159 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Brugia malayi hypothetical protein 0.0229 0.1077 0.1077
Plasmodium vivax aspartyl proteinase, putative 0.0177 0.0803 0.1095
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0085 0.0085
Brugia malayi Ets-domain containing protein 0.0059 0.0186 0.0186
Onchocerca volvulus 0.1422 0.7329 1
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Toxoplasma gondii cathepsin CPC1 0.0327 0.1589 0.2168
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0327 0.1589 0.2168
Brugia malayi fibroinase precursor 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0925 0.4725 0.6437
Echinococcus multilocularis acetylcholinesterase 0.0801 0.4073 0.4073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Schistosoma mansoni hypothetical protein 0.0103 0.0415 0.0415
Onchocerca volvulus 0.1422 0.7329 1
Onchocerca volvulus 0.0094 0.0369 0.0504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0085 0.0085
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Onchocerca volvulus 0.0135 0.0584 0.0797
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Plasmodium vivax plasmepsin V, putative 0.0042 0.0094 0.0129
Brugia malayi aspartic protease BmAsp-2, identical 0.0042 0.0094 0.0094
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0059 0.0183 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0085 0.0085
Plasmodium vivax serine-repeat antigen (SERA) 0.0327 0.1589 0.2168
Brugia malayi nuclear hormone receptor 0.004 0.0085 0.0085
Echinococcus multilocularis protein dispatched 1 0.0053 0.0153 0.0153
Echinococcus granulosus cathepsin l1 0.1422 0.7329 0.7329
Plasmodium vivax vivapain-2 0.1422 0.7329 1
Schistosoma mansoni cathepsin D (A01 family) 0.0522 0.2611 0.2611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0824 0.4193 0.571
Mycobacterium leprae Probable lipase LipE 0.008 0.0295 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0823 0.419 0.5608
Onchocerca volvulus 0.1422 0.7329 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0327 0.1589 0.2168
Echinococcus granulosus expressed conserved protein 0.0102 0.0408 0.0408
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1589 0.3792
Echinococcus multilocularis zinc finger transcription factor gli2 0.0309 0.1494 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni cathepsin s 0.0497 0.2479 0.2479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0057 0.0057
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0057 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0085 0.0085
Onchocerca volvulus 0.1422 0.7329 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Trypanosoma cruzi cysteine peptidase, putative 0.0497 0.2479 0.2339
Mycobacterium tuberculosis Carboxylesterase LipT 0.0135 0.0584 0.1689
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0078 0.0285 0.0285
Echinococcus multilocularis geminin 0.0525 0.2627 0.2627
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0497 0.2479 0.2479
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Plasmodium vivax unspecified product 0.0497 0.2479 0.3383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0824 0.4193 0.5612
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Onchocerca volvulus 0.0038 0.0073 0.01
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0085 0.0085
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0078 0.0285 0.0285
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Loa Loa (eye worm) carboxylesterase 0.0135 0.0584 0.0584
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Brugia malayi Zinc finger, C2H2 type family protein 0.0309 0.1494 0.1494
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0925 0.4725 0.4725
Echinococcus multilocularis muscleblind protein 1 0.0319 0.1547 0.1547
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0327 0.1589 0.2147
Loa Loa (eye worm) hypothetical protein 0.0167 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) ctsf protein 0.1422 0.7329 0.7329
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0295 0.4373
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0085 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.0803 0.0803
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0823 0.419 0.4082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0229 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0094 0.0369 0.0369
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0295 0.0377
Schistosoma mansoni cathepsin D (A01 family) 0.0522 0.2611 0.2611
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Echinococcus granulosus cysteine protease 0.0824 0.4193 0.4193
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1422 0.7329 0.7329
Brugia malayi cathepsin F-like cysteine proteinase 0.0497 0.2479 0.2479
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Brugia malayi Muscleblind-like protein 0.0319 0.1547 0.1547
Echinococcus granulosus survival motor neuron protein 1 0.0505 0.2522 0.2522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0824 0.4193 0.5612
Plasmodium falciparum plasmepsin V 0.0042 0.0094 0.0129
Loa Loa (eye worm) beta-lactamase 0.008 0.0295 0.0295
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0824 0.4193 0.4193
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Brugia malayi MH2 domain containing protein 0.0131 0.0564 0.0564
Schistosoma mansoni patched 1 0.0046 0.0119 0.0119
Brugia malayi cathepsin Z-like cysteine proteinase 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Plasmodium falciparum serine repeat antigen 4 0.0327 0.1589 0.2168
Loa Loa (eye worm) hypothetical protein 0.0094 0.0369 0.0369
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0295 0.4373
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0319 0.1547 0.1547
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0801 0.4073 0.4073
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0564 0.0564
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0584 0.0584
Echinococcus multilocularis neuroligin 0.0135 0.0584 0.0584
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.011 0.045 0.045
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Trypanosoma cruzi cysteine proteinase, putative 0.0824 0.4193 0.4085
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0085 0.0116
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Echinococcus granulosus BC026374 protein S09 family 0.0135 0.0584 0.0584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Plasmodium falciparum serine repeat antigen 1 0.0327 0.1589 0.2168
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Echinococcus multilocularis expressed conserved protein 0.0102 0.0408 0.0408
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0059 0.0183 0.0183
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0824 0.4193 0.4193
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Plasmodium falciparum serine repeat antigen 9 0.0327 0.1589 0.2168
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Brugia malayi Trypsin family protein 0.0094 0.0369 0.0369
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0327 0.1589 0.2168
Echinococcus multilocularis lysine specific demethylase 5A 0.0029 0.0026 0.0026
Echinococcus granulosus cathepsin l cysteine peptidase 0.1422 0.7329 0.7329
Brugia malayi Aspartyl aminopeptidase 0.0059 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0057 0.0057
Plasmodium falciparum serine repeat antigen 7 0.0327 0.1589 0.2168
Echinococcus granulosus cathepsin b 0.1931 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.045 0.045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0085 0.0085
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Entamoeba histolytica cysteine proteinase, putative 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Brugia malayi Cathepsin L-like precursor 0.0497 0.2479 0.2479
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0085 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Echinococcus multilocularis cathepsin L 0.0824 0.4193 0.4193
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Schistosoma mansoni hypothetical protein 0.0525 0.2627 0.2627
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0295 0.0295
Onchocerca volvulus Cathepsin L homolog 0.1422 0.7329 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0059 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Onchocerca volvulus Cathepsin F homolog 0.1422 0.7329 1
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Brugia malayi beta-lactamase 0.008 0.0295 0.0295
Onchocerca volvulus 0.0042 0.0094 0.0129
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0295 0.0472
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0016 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0085 0.0085
Brugia malayi hypothetical protein 0.0169 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0169 0.0761 0.0761
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0129 0.0129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0295 0.0295
Brugia malayi Cathepsin L-like precursor 0.0925 0.4725 0.4725
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Plasmodium vivax vivapain-3 0.0824 0.4193 0.5721
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0313 0.0313
Giardia lamblia Encystation-specific protease 0.0327 0.1589 0.3792
Loa Loa (eye worm) carboxylesterase 0.0801 0.4073 0.4073
Schistosoma mansoni gliotactin 0.0135 0.0584 0.0584
Schistosoma mansoni cathepsin C 0.0327 0.1589 0.1589
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0295 0.0472
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0085 0.0085
Loa Loa (eye worm) aspartyl aminopeptidase 0.0059 0.0183 0.0183
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0135 0.0584 0.0584
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Echinococcus multilocularis para nitrobenzyl esterase 0.0135 0.0584 0.0584
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0564 0.0564
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.0687 0.0687
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0094
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0327 0.1589 0.2168
Toxoplasma gondii aspartyl protease ASP1 0.0177 0.0803 0.1095
Plasmodium falciparum plasmepsin I 0.0177 0.0803 0.1095
Plasmodium falciparum serine repeat antigen 3 0.0327 0.1589 0.2168
Echinococcus granulosus zinc finger transcription factor gli2 0.0309 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0497 0.2479 0.2479
Plasmodium vivax aspartyl protease, putative 0.0042 0.0094 0.0129
Echinococcus multilocularis lamin 0.0027 0.0016 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1422 0.7329 0.7329
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Brugia malayi Cathepsin L-like precursor 0.0925 0.4725 0.4725
Brugia malayi cathepsin Z-like cysteine proteinase 0.0327 0.1589 0.1589
Onchocerca volvulus 0.0135 0.0584 0.0797
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0059 0.0183 0.025
Loa Loa (eye worm) hypothetical protein 0.0801 0.4073 0.4073
Schistosoma mansoni coup transcription factor 0.004 0.0085 0.0085
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Brugia malayi cathepsin L-like precursor 0.0925 0.4725 0.4725
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0295 0.0114
Trichomonas vaginalis spcc417.12 protein, putative 0.0135 0.0584 0.0773
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Schistosoma mansoni cathepsin F (C01 family) 0.0925 0.4725 0.4725
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus granulosus GA binding protein alpha chain 0.0059 0.0186 0.0186
Mycobacterium ulcerans hypothetical protein 0.008 0.0295 0.4373
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0127 0.054 0.054
Trypanosoma cruzi cysteine proteinase, putative 0.0824 0.4193 0.4085
Echinococcus multilocularis GA binding protein alpha chain 0.0059 0.0186 0.0186
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Giardia lamblia Cathepsin B precursor 0.0823 0.419 1
Mycobacterium tuberculosis Conserved protein 0.008 0.0295 0.0472
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0327 0.1589 0.1967
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Brugia malayi jmjC domain containing protein 0.0078 0.0285 0.0285
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0327 0.1589 0.1589
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0085 0.0085
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Brugia malayi jmjC domain containing protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Brugia malayi Papain family cysteine protease containing protein 0.0824 0.4193 0.4193
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0057 0.0173 0.0173
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0177 0.0803 0.0803
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0854 0.435 0.435
Onchocerca volvulus Huntingtin homolog 0.0127 0.054 0.0736
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Brugia malayi nuclear receptor NHR-88 0.004 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0327 0.1589 0.1589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0129 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Giardia lamblia Hypothetical protein 0.0327 0.1589 0.3792
Echinococcus granulosus lamin dm0 0.0027 0.0016 0.0016
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0042 0.0094 0.0129
Echinococcus multilocularis aspartyl aminopeptidase 0.0059 0.0183 0.0183
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0327 0.1589 0.1967
Brugia malayi aspartic protease BmAsp-1, identical 0.0042 0.0094 0.0094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Echinococcus multilocularis small conductance calcium activated potassium 0.0167 0.0749 0.0749
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0085 0.0085
Giardia lamblia Cathepsin L-like protease 0.0327 0.1589 0.3792
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0059 0.0183 0.025
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0085 0.0085
Plasmodium vivax hypothetical protein, conserved 0.008 0.0295 0.0403
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0443 0.0443
Echinococcus multilocularis carboxylesterase 5A 0.0801 0.4073 0.4073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0085 0.0085
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0135 0.0584 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0085 0.0085
Toxoplasma gondii aspartyl protease ASP3 0.0042 0.0094 0.0129
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Brugia malayi Carboxylesterase family protein 0.0801 0.4073 0.4073
Echinococcus granulosus tm gpcr rhodopsin 0.0854 0.435 0.435
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0129 0.0129
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Schistosoma mansoni gabp alpha 0.0059 0.0186 0.0186
Brugia malayi hypothetical protein 0.0127 0.054 0.054
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0042 0.0094 0.0094
Brugia malayi Fli-1 protein 0.018 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni cathepsin B (C01 family) 0.0327 0.1589 0.1589
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Brugia malayi cathepsin L-like cysteine proteinase 0.0327 0.1589 0.1589
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Echinococcus multilocularis cysteine protease 0.1422 0.7329 0.7329
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0085 0.0085
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Plasmodium falciparum serine repeat antigen 8 0.0327 0.1589 0.2168
Brugia malayi Cytochrome P450 family protein 0.0033 0.0046 0.0046
Plasmodium falciparum serine repeat antigen 5 0.0327 0.1589 0.2168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0129 0.0129
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0085 0.0085
Brugia malayi hypothetical protein 0.0042 0.0094 0.0094
Plasmodium falciparum plasmepsin VII 0.0042 0.0094 0.0129
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0824 0.4193 0.4085
Brugia malayi cathepsin L precursor 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0085 0.0085
Brugia malayi CHE-14 protein 0.0046 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0075 0.0268 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Schistosoma mansoni hypothetical protein 0.0167 0.0749 0.0749
Brugia malayi beta-lactamase family protein 0.008 0.0295 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0327 0.1589 0.1589
Echinococcus multilocularis cysteine protease 0.1422 0.7329 0.7329
Brugia malayi hypothetical protein 0.0042 0.0094 0.0094
Trypanosoma cruzi major cysteine proteinase, putative 0.0327 0.1589 0.1432
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Trypanosoma cruzi major cysteine proteinase, putative 0.0327 0.1589 0.1432
Schistosoma mansoni transcription factor LCR-F1 0.0229 0.1077 0.1077
Entamoeba histolytica cysteine proteinase, putative 0.1422 0.7329 1
Onchocerca volvulus 0.008 0.0295 0.0403
Brugia malayi Eukaryotic aspartyl protease family protein 0.0042 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus granulosus lamin 0.0027 0.0016 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0925 0.4725 0.6356
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0295 0.0295
Echinococcus granulosus cathepsin b 0.1931 1 1

Activities

Activity type Activity value Assay description Source Reference
S (ADMET) = 0.002 mg ml-1 Evaluated for the solubility in water at 5.8 pH of filtered solution ChEMBL. 8496918

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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