Detailed information for compound 504406

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 573.722 | Formula: C29H40FN5O4S
  • H donors: 2 H acceptors: 4 LogP: 4.53 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@H]1CN(C[C@H]1CN1CCC[C@H](C1)Cc1ccc(cc1)F)C(=O)OC(C)(C)C)Nc1sc(c(n1)C)C(=O)C
  • InChi: 1S/C29H40FN5O4S/c1-18-25(19(2)36)40-27(31-18)33-26(37)32-24-17-35(28(38)39-29(3,4)5)16-22(24)15-34-12-6-7-21(14-34)13-20-8-10-23(30)11-9-20/h8-11,21-22,24H,6-7,12-17H2,1-5H3,(H2,31,32,33,37)/t21-,22+,24+/m0/s1
  • InChiKey: HUEIIQRYVMJFKL-WMTXJRDZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References
Homo sapiens chemokine (C-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phd:f box containing protein 0.0017 0.0129 0.0152
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0089 0.1025 0.1113
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0052 0.0035
Trypanosoma cruzi oxidoreductase, putative 0.0089 0.1025 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0618 0.5817
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0052 0.0034
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0387 0.0456
Brugia malayi hypothetical protein 0.0011 0.0054 0.0037
Echinococcus granulosus microtubule associated protein 2 0.069 0.8497 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0052 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Loa Loa (eye worm) hypothetical protein 0.0089 0.1025 0.1112
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1714 0.1895
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0151 0.0145
Onchocerca volvulus 0.0089 0.1025 0.108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1026 0.1134
Onchocerca volvulus 0.0057 0.062 0.0629
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0669 0.074
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0089 0.1025 0.1113
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0145 0.0171
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0052 0.0035
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0033 0.0317 0.0328
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.062 0.0664
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0129 0.0129
Brugia malayi MAP kinase sur-1 0.0057 0.0618 0.0662
Mycobacterium tuberculosis Conserved protein 0.0073 0.0823 0.0889
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0823 0.091
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0054 0.0054
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0089 0.1025 0.1113
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0054 0.0331
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0387 0.275
Schistosoma mansoni inositol monophosphatase 0.0038 0.0387 0.0428
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0618 0.0661
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0119
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0618 0.5817
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0052 0.0035
Echinococcus multilocularis geminin 0.0358 0.4371 0.4371
Onchocerca volvulus Fatty acid synthase homolog 0.0057 0.062 0.0629
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0089 0.1025 0.1113
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0089 0.1025 0.1113
Mycobacterium ulcerans oxidoreductase 0.0089 0.1025 0.1113
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0823 0.682
Loa Loa (eye worm) carboxylesterase 0.0011 0.0054 0.0035
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0089 0.1025 0.1113
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0115 0.0069
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0129 0.0142
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1664 0.1958
Echinococcus granulosus single minded 2 0.004 0.0411 0.0484
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0734 0.9048 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0052 0.0036
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0734 0.9048 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0054 0.0059
Leishmania major d-xylulose reductase, putative 0.0089 0.1025 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0145 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1016
Echinococcus granulosus acetylcholinesterase 0.0068 0.0755 0.0888
Echinococcus multilocularis 0.0011 0.0052 0.0052
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0054 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1026 0.1208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0748 0.0826
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0823 0.0889
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0026
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0033 0.0317 0.0328
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0052 0.0052
Leishmania major hypothetical protein, conserved 0.0033 0.0317 0.2715
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0129 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0087 0.0659
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0115
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0129 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1026 0.1134
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0823 0.7922
Mycobacterium ulcerans polyketide synthase 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0052 0.0035
Mycobacterium ulcerans lipase LipD 0.0073 0.0823 0.0889
Mycobacterium ulcerans dehydrogenase 0.0089 0.1025 0.1113
Leishmania major protein kinase, putative 0.0015 0.0093 0.0417
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0618 0.595
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0052 0.0035
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0089 0.1025 0.1113
Brugia malayi PAS domain containing protein 0.0054 0.0586 0.0627
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0145 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0618 0.5817
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0727 0.0856
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0033 0.0317 0.0373
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0527 0.056
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0054 0.0037
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0089 0.1025 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0089 0.1025 0.1113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1026 0.1134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1016
Schistosoma mansoni zinc binding dehydrogenase 0.0089 0.1025 0.1133
Onchocerca volvulus 0.0029 0.0269 0.0239
Plasmodium vivax JmjC domain containing protein 0.0017 0.0129 0.0199
Loa Loa (eye worm) hypothetical protein 0.0073 0.0823 0.0888
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0618 0.5817
Trypanosoma cruzi quinone oxidoreductase, putative 0.0033 0.0317 0.2715
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0052 0.0035
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0037
Schistosoma mansoni alcohol dehydrogenase 0.0734 0.9048 1
Leishmania major oxidoreductase-like protein 0.0089 0.1025 1
Mycobacterium leprae Probable oxidireductase 0.0089 0.1025 0.1113
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0054 0.0054
Mycobacterium leprae putative cytochrome p450 0.0011 0.0052 0.0035
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0387 0.0406
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0145 0.0137
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0823 0.0889
Schistosoma mansoni single-minded 0.0054 0.0586 0.0648
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0087 0.0351
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0052 0.0035
Echinococcus multilocularis ferritin 0.0009 0.002 0.002
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0052 0.0035
Echinococcus multilocularis expressed protein 0.0009 0.002 0.002
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0823 0.0889
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0397 0.2865
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.0875
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0115
Brugia malayi Carboxylesterase family protein 0.0068 0.0755 0.0813
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Loa Loa (eye worm) hypothetical protein 0.0057 0.062 0.0663
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0644 0.7934 0.8766
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0387 0.3441
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0823 0.0889
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0225 0.1772
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0093 0.0417
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0129 0.0152
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0089 0.1025 0.1113
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0151 0.007
Loa Loa (eye worm) hypothetical protein 0.0089 0.1025 0.1112
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0087 0.0659
Schistosoma mansoni cpg binding protein 0.003 0.0289 0.0319
Schistosoma mansoni hypothetical protein 0.0011 0.0052 0.0057
Mycobacterium ulcerans oxidoreductase 0.0033 0.0317 0.0328
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0225 0.1525
Mycobacterium ulcerans hypothetical protein 0.0073 0.0823 0.0889
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0145 0.0145
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0054 0.0059
Onchocerca volvulus 0.0014 0.0087 0.0037
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0054 0.0037
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0115 0.0552
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0145 0.0138
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0052 0.0035
Brugia malayi jmjC domain containing protein 0.0067 0.0748 0.0806
Trypanosoma brucei protein kinase, putative 0.0057 0.0618 0.5008
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0052 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1026 0.1208
Schistosoma mansoni cpg binding protein 0.003 0.0289 0.0319
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0052 0.0035
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0037
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0151 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0151 0.0145
Toxoplasma gondii type I fatty acid synthase 0.0033 0.0317 0.0294
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0052 0.0035
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Possible dehydrogenase 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0052 0.0035
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0052 0.0035
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0089 0.1025 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1026 0.1026
Leishmania major oxidoreductase, putative 0.0089 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0151 0.0144
Trypanosoma brucei unspecified product 0.0019 0.0151 0.0875
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.0875
Brugia malayi beta-lactamase 0.0073 0.0823 0.0889
Leishmania major DNA polymerase eta, putative 0.0019 0.0151 0.1016
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0151 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0077 0.0215
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0129 0.0119
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0734 0.9048 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0145 0.1242
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0052 0.0035
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0089 0.1025 0.1113
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0225 0.3894
Schistosoma mansoni hypothetical protein 0.0358 0.4371 0.4831
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0129 0.0085
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0129 0.0129
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0632 0.0645
Mycobacterium tuberculosis Possible dehydrogenase 0.0089 0.1025 0.1113
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0151 0.0178
Echinococcus multilocularis cpg binding protein 0.003 0.0289 0.0289
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0035
Leishmania major zinc-binding dehydrogenase-like protein 0.0057 0.062 0.5832
Giardia lamblia DINP protein human, muc B family 0.0019 0.0151 0.0129
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.0727 0.0727
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0052 0.0035
Echinococcus granulosus dna polymerase eta 0.0019 0.0151 0.0178
Echinococcus granulosus cpg binding protein 0.003 0.0289 0.034
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.062 0.0664
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.5737 0.6332
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0823 0.0889
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0093 0.0417
Loa Loa (eye worm) cytochrome P450 0.0011 0.0052 0.0034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1026 0.1113
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0035
Leishmania major nuclear receptor binding factor-like protein 0.0057 0.062 0.5832
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0057 0.062 0.0664
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0145 0.0953
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0442 0.4191
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0052 0.0035
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0129 0.0142
Trypanosoma cruzi quinone oxidoreductase, putative 0.0033 0.0317 0.2715
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0151 0.1016
Echinococcus multilocularis neuroligin 0.0011 0.0054 0.0054
Trypanosoma brucei RNA helicase, putative 0.0102 0.1182 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0087 0.0659
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0052 0.0035
Schistosoma mansoni ferritin 0.0009 0.002 0.0023
Mycobacterium leprae Possible regulatory protein 0.0014 0.0087 0.0073
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0089 0.1025 0.1113
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0129 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Leishmania major hypothetical protein, conserved 0.0073 0.0823 0.7922
Loa Loa (eye worm) beta-lactamase 0.0073 0.0823 0.0888
Schistosoma mansoni gliotactin 0.0011 0.0054 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0151 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0119
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0442 0.0432
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0145 0.1242
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0054 0.0331
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0052 0.0035
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0089 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0225 0.0225
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0358 0.4371 0.4831
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0387 0.2962
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0035
Schistosoma mansoni ferritin 0.0009 0.002 0.0023
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0644 0.7934 0.8766
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0089 0.1025 0.1113
Leishmania major hypothetical protein, conserved 0.0025 0.0225 0.1772
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0387 0.0372
Loa Loa (eye worm) hypothetical protein 0.0068 0.0755 0.0812
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0387 0.365
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0734 0.9048 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0225 0.3894
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0442 0.4613
Leishmania major quinone oxidoreductase, putative 0.0089 0.1025 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0823 0.0888
Loa Loa (eye worm) hypothetical protein 0.0073 0.0823 0.0888
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0089 0.1025 0.1113
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0054 0.0059
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0145 0.0138
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0089 0.1025 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0823 0.7989
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.0875
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0052 0.0035
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0033 0.0317 0.2715
Brugia malayi CXXC zinc finger family protein 0.0029 0.0269 0.0275
Mycobacterium leprae Probable polyketide synthase Pks1 0.0089 0.1025 0.1113
Echinococcus granulosus acetylcholinesterase 0.0068 0.0755 0.0888
Toxoplasma gondii quinone oxidoreductase, putative 0.0089 0.1025 0.1081
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0129 0.0676
Mycobacterium leprae Probable lipase LipE 0.0073 0.0823 0.0889
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0087 0.0087
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0135
Mycobacterium ulcerans short-chain dehydrogenase 0.0089 0.1025 0.1113
Echinococcus granulosus ferritin 0.0009 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0089 0.1025 0.1112
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0087 0.0659
Onchocerca volvulus 0.0073 0.0823 0.0855
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0145 0.1076
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0089 0.1025 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0129 0.0498
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0129 0.0142
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0052 0.0035
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0089 0.1025 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0052 0.0036
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0727 0.0727
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0317 0.2715
Echinococcus granulosus dna polymerase kappa 0.0019 0.0151 0.0178
Schistosoma mansoni inositol monophosphatase 0.0038 0.0387 0.0428
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0089 0.1025 0.1207
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0337 0.0351
Mycobacterium ulcerans quinone reductase Qor 0.0089 0.1025 0.1113
Schistosoma mansoni ap endonuclease 0.0019 0.0145 0.016
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0033 0.0317 0.2337
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0087 0.0659
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0054 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0052 0.0035
Brugia malayi isocitrate dehydrogenase 0.0016 0.0115 0.0105
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0823 0.0823
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0823 0.0889
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0087 0.0072
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0755 0.0812
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0225 0.1553
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0087 0.0102
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0823 0.0889
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0089 0.1025 0.1113
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0734 0.9048 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Schistosoma mansoni cpg binding protein 0.0029 0.0269 0.0297
Loa Loa (eye worm) inositol-1 0.0038 0.0387 0.0405
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0129 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0087 0.0659
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0089 0.1025 0.1113
Brugia malayi jmjC domain containing protein 0.0017 0.0129 0.012
Mycobacterium ulcerans oxidoreductase 0.0057 0.062 0.0664
Schistosoma mansoni apoferritin-2 0.0009 0.002 0.0023
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0755 0.0888
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0089 0.1025 0.1113
Schistosoma mansoni hypothetical protein 0.0102 0.1182 0.1307
Brugia malayi beta-lactamase family protein 0.0073 0.0823 0.0889
Schistosoma mansoni ap endonuclease 0.0019 0.0145 0.016
Loa Loa (eye worm) carboxylesterase 0.0068 0.0755 0.0812
Leishmania major DNA polymerase kappa, putative 0.0019 0.0151 0.1016
Trypanosoma brucei oxidoreductase, putative 0.0089 0.1025 0.8608
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0089 0.1025 1
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0755 0.0755
Mycobacterium tuberculosis Conserved protein 0.0073 0.0823 0.0889
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0033 0.0317 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Loa Loa (eye worm) hypothetical protein 0.0068 0.0755 0.0812
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0089 0.1025 0.1113
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0093 0.0417
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0387 0.365
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0089 0.1025 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0151 0.0145
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0442 0.4191
Echinococcus multilocularis microtubule associated protein 2 0.069 0.8497 0.8497
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0145 0.1242
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0225 0.1772
Loa Loa (eye worm) hypothetical protein 0.0073 0.0823 0.0888
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1026 0.1026
Brugia malayi jmjC domain containing protein 0.0017 0.0129 0.012
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0087 0.0351
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0087 0.0659
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0145 0.0138
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0089 0.1025 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1714 0.1714
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0115 0.0103
Trichomonas vaginalis esterase, putative 0.0073 0.0823 0.7989
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0115 0.0641
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0087 0.5
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0618 0.5817
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0149 0.0176
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0618 0.595
Mycobacterium tuberculosis Conserved protein 0.0073 0.0823 0.0889
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0755 0.0834
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0823 0.0889
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0089 0.1025 1
Onchocerca volvulus 0.004 0.0411 0.0397
Toxoplasma gondii type I fatty acid synthase, putative 0.0089 0.1025 0.1081
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0734 0.9048 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0052 0.0035
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0054 0.0037
Trypanosoma cruzi oxidoreductase, putative 0.0057 0.062 0.5832
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1016
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0129 0.0119
Loa Loa (eye worm) hypothetical protein 0.0073 0.0823 0.0888
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0052 0.0035
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0087 0.0102
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0037
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0052 0.0035
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0115 0.0552
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0618 0.0728
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0129 0.0129
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0151 0.0151
Brugia malayi cytochrome P450 0.0011 0.0052 0.0036
Schistosoma mansoni cytochrome P450 0.0011 0.0052 0.0058
Trypanosoma cruzi oxidoreductase, putative 0.0033 0.0317 0.2715
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0387 0.3441
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0089 0.1025 0.1025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0823 0.091
Brugia malayi Cytochrome P450 family protein 0.0049 0.0527 0.0562
Echinococcus granulosus expressed protein 0.0009 0.002 0.0024
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0129 0.0142
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0618 0.0618
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0145 0.0953
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0129 0.0085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1026 0.1114
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0087 0.0659
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0115 0.0115
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0052 0.0061
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0337 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0151 0.0875
Brugia malayi hypothetical protein 0.0182 0.2176 0.2388
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0823 0.0889
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0052 0.0035
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0089 0.1025 0.1113
Onchocerca volvulus Putative alcohol dehydrogenase 0.0734 0.9048 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0115 0.0641
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0089 0.1025 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0618 0.595
Loa Loa (eye worm) acyl carrier protein 0.0057 0.062 0.0663
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0054 0.0059
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0151 0.1302
Trypanosoma cruzi oxidoreductase, putative 0.0089 0.1025 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0151 0.0167
Loa Loa (eye worm) hypothetical protein 0.0073 0.0823 0.0888
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0151 0.0145
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0823 0.7989
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0823 0.7989
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0823 0.7922
Schistosoma mansoni ferritin 0.0009 0.002 0.0023
Leishmania major protein kinase, putative 0.0015 0.0093 0.0417
Onchocerca volvulus 0.0073 0.0823 0.0855
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0151 0.0145
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0035
Schistosoma mansoni quinone oxidoreductase 0.0033 0.0317 0.035
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0052 0.0035
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0823 0.0969
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0387 0.365
Onchocerca volvulus 0.0073 0.0823 0.0855
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0087 0.0351
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0052 0.0035
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0411 0.0411
Schistosoma mansoni DNA polymerase eta 0.0019 0.0151 0.0167
Schistosoma mansoni hypothetical protein 0.0011 0.0052 0.0058
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0129 0.0152
Brugia malayi Carboxylesterase family protein 0.0068 0.0755 0.0813
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0035
Leishmania major zinc binding dehydrogenase-like protein 0.0089 0.1025 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0052 0.0034
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0748 0.088
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0151 0.1302
Leishmania major hypothetical protein, conserved 0.0033 0.0317 0.2715
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0442 0.052
Echinococcus granulosus geminin 0.0358 0.4371 0.5144
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0387 0.3441
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0618 0.5817
Brugia malayi jmjC domain containing protein 0.0066 0.0727 0.0783
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0151 0.0167
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0052 0.0035
Brugia malayi Alcohol dehydrogenase class III 0.0734 0.9048 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0054 0.0063
Toxoplasma gondii ABC1 family protein 0.0073 0.0823 0.0857
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0089 0.1025 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0618 0.0618
Brugia malayi hypothetical protein 0.0016 0.0114 0.0103
Schistosoma mansoni microtubule-associated protein tau 0.069 0.8497 0.9391
Brugia malayi jmjC domain containing protein 0.0017 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0072
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0115 0.0127
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0618 1
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0755 0.0755
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0077 0.0215
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0089 0.1025 0.1113
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0225 0.0192
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0052 0.0062
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0442 0.0432
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1714 0.1877
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0052 0.0035
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0149 0.0149
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0269 0.0273
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0057 0.062 0.5021
Trypanosoma brucei unspecified product 0.0013 0.0077 0.0215
Mycobacterium ulcerans oxidoreductase FadB5 0.0089 0.1025 0.1113
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0052 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0618 0.0683
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0115 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0145 0.0953
Trypanosoma brucei unspecified product 0.0013 0.0077 0.0215
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0618 0.0728
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0093 0.0417
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0129 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0823 0.7989
Brugia malayi hypothetical protein 0.0025 0.0225 0.0226
Loa Loa (eye worm) oxidoreductase 0.0033 0.0317 0.0327
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0823 0.0889
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0052 0.0035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0145 0.0821
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0823 1
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0755 0.0755
Trypanosoma brucei oxidoreductase, putative 0.0089 0.1025 0.8608
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0397 1
Schistosoma mansoni acetylcholinesterase 0.0011 0.0054 0.0059
Loa Loa (eye worm) acetyltransferase 0.0145 0.1714 0.1875
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0089 0.1025 0.1113
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0052 0.0035
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0052 0.0035
Schistosoma mansoni ferritin light chain 0.0009 0.002 0.0023
Brugia malayi Inositol-1 0.0038 0.0387 0.0406
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0618 0.595
Echinococcus multilocularis dna polymerase eta 0.0019 0.0151 0.0151
Mycobacterium ulcerans beta-lactamase 0.0073 0.0823 0.0889
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0151 0.1016
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0618 0.0629
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0052 0.0035
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0087 0.0659
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0052 0.0035
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0129 0.0129
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0054 0.0059
Mycobacterium ulcerans putative regulatory protein 0.004 0.0411 0.0432
Brugia malayi jmjC domain containing protein 0.0017 0.0129 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0052 0.0035
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0089 0.1025 0.1113
Echinococcus granulosus neuroligin 0.0011 0.0054 0.0063
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0823 0.0889
Mycobacterium ulcerans quinone oxidoreductase 0.0089 0.1025 0.1113
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0089 0.1025 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0618 0.5008
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0037
Brugia malayi hypoxia-induced factor 1 0.0168 0.2001 0.2194
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.2001 0.2192
Schistosoma mansoni jumonji domain containing protein 0.0066 0.0727 0.0804
Leishmania major hypothetical protein, conserved 0.0017 0.0129 0.0785
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0033 0.0317 0.0328
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0115 0.0069
Brugia malayi Cytochrome P450 family protein 0.0011 0.0052 0.0036
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0387 0.0387
Loa Loa (eye worm) carboxylesterase 0.0011 0.0054 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0823 0.7989
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0087 0.0659
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0052 0.0035
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0089 0.1025 0.1113
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0087 0.0659
Schistosoma mansoni apoferritin-2 0.0009 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0035
Brugia malayi bHLH-PAS transcription factor 0.004 0.0411 0.0433
Loa Loa (eye worm) hypothetical protein 0.0182 0.2176 0.2387
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0586 0.0648
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0052 0.0035
Schistosoma mansoni ferritin 0.0009 0.002 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0145 0.0429
Brugia malayi beta-lactamase family protein 0.0073 0.0823 0.0889
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0734 0.9048 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0748 0.0804
Mycobacterium ulcerans quinone oxidoreductase 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0089 0.1025 0.1113
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0052 0.0034
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0115 0.0641
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0089 0.1025 0.1113
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0052 0.0035
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0387 0.365
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0089 0.1025 1
Schistosoma mansoni ferritin light chain 0.0009 0.002 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0077 0.0215
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0052 0.0035
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0115 0.0105
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0734 0.9048 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0823 0.0888
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0875
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0054 0.0063
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0734 0.9048 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0748 0.0826
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0397 0.5329

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.6 nM Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins ChEMBL. 17418570
IC50 (binding) = 2.6 nM Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins ChEMBL. 17418570
IC50 (ADMET) = 800 nM Inhibition of human recombinant CYP2D6 ChEMBL. 17418570
IC50 (ADMET) = 800 nM Inhibition of human recombinant CYP2D6 ChEMBL. 17418570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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