TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.33 | Formula: C15H11N3O5S
H donors: 3 H acceptors: 5 LogP: 2.17 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=O)N(C1)/N=C/c1ccc(s1)c1ccc(c(c1)C(=O)O)O
InChi: 1S/C15H11N3O5S/c19-11-3-1-8(5-10(11)14(21)22)12-4-2-9(24-12)6-16-18-7-13(20)17-15(18)23/h1-6,19H,7H2,(H,21,22)(H,17,20,23)/b16-6+
InChiKey: HCCFUPRXKRNKCF-OMCISZLKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0326	0.7506	0.7506
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Echinococcus granulosus	GPCR family 2	0.0015	0.0015	0.0016
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0015	0.0016
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0064	0.1191	0.1191
Trichomonas vaginalis	cyclins, putative	0.0087	0.1744	0.1981
Echinococcus granulosus	cyclins	0.0036	0.0521	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0015	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Onchocerca volvulus		0.0194	0.4327	0.4391
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.2513	0.255
Schistosoma mansoni	nAChR subunit	0.0119	0.2513	0.2513
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0119	0.2513	0.255
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Trichomonas vaginalis	cyclins, putative	0.0087	0.1744	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Brugia malayi	Receptor family ligand binding region containing protein	0.0028	0.0325	0.0329
Onchocerca volvulus		0.0119	0.2513	0.255
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0018	0.007	0.0071
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0064	0.1186	0.1204
Schistosoma mansoni	neurotransmitter gated ion channel	0.0064	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0442	0.0449
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.2513	0.255
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0028	0.0325	0.0329
Loa Loa (eye worm)	ACC-1 protein	0.0119	0.2513	0.255
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0015	0.0016
Brugia malayi	protein-tyrosine kinase	0.0067	0.1261	0.128
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0423	0.9853	1
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0326	0.7506	0.7618
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0022	0.0189	0.0192
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.0292	0.6693	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0055	0.0969	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.0326	0.7506	0.7618
Schistosoma mansoni	nAChR subunit	0.0119	0.2513	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0067	0.1261	0.128
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3005	0.305
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.009	0.1809	0.241
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0074	0.1433	0.1454
Trypanosoma cruzi	cyclin 6, putative	0.0087	0.1744	0.2324
Schistosoma mansoni	tyrosine kinase	0.0018	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Echinococcus multilocularis	nAChR subunit	0.0064	0.1191	0.1209
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0055	0.0969	0.0984
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0074	0.1433	0.1454
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0055	0.0969	0.0984
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0018	0.007	0.007
Echinococcus multilocularis	cyclins	0.0036	0.0521	0.0529
Schistosoma mansoni	hypothetical protein	0.0033	0.0442	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1744	0.177
Schistosoma mansoni	tyrosine kinase	0.0018	0.007	0.007
Brugia malayi	hypothetical protein	0.0055	0.0969	0.0984
Onchocerca volvulus		0.0055	0.0969	0.0984
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0119	0.2513	0.255
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0055	0.0969	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0055	0.0969	0.0984
Onchocerca volvulus		0.0119	0.2513	0.255
Loa Loa (eye worm)	hypothetical protein	0.0194	0.4327	0.4391
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.2513	0.255
Echinococcus granulosus	cyclins	0.0036	0.0521	0.0529
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.0292	0.6693	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.081	0.0822
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0326	0.7506	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.2513	0.255
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0022	0.0189	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0295	0.675	0.685
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0295	0.675	0.685
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0018	0.007	0.0071
Brugia malayi	Cation transporter family protein	0.0119	0.2513	0.255
Echinococcus multilocularis	tyrosine protein kinase HCK	0.006	0.1085	0.1102
Schistosoma mansoni	nAChR subunit	0.0119	0.2513	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0326	0.7506	1
Leishmania major	cyclin	0.0087	0.1744	0.2324
Entamoeba histolytica	cyclin, putative	0.0087	0.1744	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0055	0.0969	0.0984
Trypanosoma cruzi	cyclin, putative	0.0087	0.1744	0.2324
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0015	0.0016
Loa Loa (eye worm)	acetylcholine receptor protein	0.0055	0.0969	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Echinococcus granulosus	cyclin B	0.0087	0.1744	0.177
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0119	0.2513	0.255
Trichomonas vaginalis	cyclin A, putative	0.0087	0.1744	0.1981
Echinococcus multilocularis	cyclins	0.0036	0.0521	0.0529
Brugia malayi	SRC-1	0.0074	0.1433	0.1454
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0034	0.046	0.0497
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.081	0.0822
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0064	0.1191	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0018	0.007	0.0071
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0119	0.2513	0.255
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0119	0.2513	0.255
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0423	0.9853	1
Plasmodium falciparum	cyclin	0.0036	0.0521	0.0695
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0119	0.2513	0.255
Echinococcus multilocularis	glycine receptor subunit beta	0.0119	0.2513	0.255
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0119	0.2513	0.255
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0074	0.1433	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0423	0.9853	1
Trichomonas vaginalis	cyclins, putative	0.0087	0.1744	0.1981
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0055	0.0969	0.0984
Echinococcus multilocularis	cyclin B	0.0087	0.1744	0.177
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.2513	0.255
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0055	0.0969	0.0984
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0326	0.7506	1
Trichomonas vaginalis	cyclin B, putative	0.0087	0.1744	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Echinococcus granulosus	receptor type guanylyl cyclase	0.0028	0.0325	0.0329
Echinococcus multilocularis	cyclins	0.0036	0.0521	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0064	0.1191	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0423	0.9853	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0074	0.1433	0.1454
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0105	0.2181	0.276
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0119	0.2513	0.2513
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.2513	0.255
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0119	0.2513	0.255
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0423	0.9853	1
Echinococcus multilocularis	nAChR subunit	0.0119	0.2513	0.255
Schistosoma mansoni	protein kinase	0.0028	0.0325	0.0325
Echinococcus granulosus	tyrosine kinase	0.0067	0.1261	0.128
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0074	0.1433	0.1454
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0074	0.1433	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Onchocerca volvulus		0.0064	0.1191	0.1209
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0064	0.1191	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0119	0.2513	0.255
Loa Loa (eye worm)	hypothetical protein	0.0048	0.081	0.0822
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0034	0.0476	0.0476
Schistosoma mansoni	nAChR subunit	0.0055	0.0969	0.0969
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0028	0.0325	0.0329
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0015	0.0016
Echinococcus granulosus	nAChR subunit	0.0119	0.2513	0.255
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0423	0.9853	1
Schistosoma mansoni	cyclin B	0.0087	0.1744	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Brugia malayi	excitatory GABA receptor EXP-1A	0.0119	0.2513	0.255
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0119	0.2513	0.255
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0326	0.7506	0.7618
Loa Loa (eye worm)	hypothetical protein	0.0051	0.087	0.0883
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0055	0.0969	0.0969
Echinococcus multilocularis	cyclins	0.0036	0.0521	0.0529
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.2513	0.255
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Echinococcus granulosus	glycine receptor subunit beta	0.0119	0.2513	0.255
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0194	0.4327	0.4327
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.2513	0.255
Echinococcus multilocularis	cyclin b3	0.0036	0.0521	0.0529
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.0292	0.6693	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0119	0.2513	0.255
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0036	0.0521	0.0529
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0055	0.0969	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.081	0.0822
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0055	0.0969	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Loa Loa (eye worm)	TK/ROR protein kinase	0.0018	0.0075	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1744	0.177
Loa Loa (eye worm)	TK protein kinase	0.006	0.1085	0.1102
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0326	0.7506	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0119	0.2513	0.255
Echinococcus granulosus	glycine receptor subunit beta	0.0119	0.2513	0.255
Loa Loa (eye worm)	TK protein kinase	0.0067	0.1261	0.128
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.2513	0.255
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0087	0.1744	0.177
Onchocerca volvulus		0.0194	0.4327	0.4391
Schistosoma mansoni	nAChR subunit	0.0119	0.2513	0.2513
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0074	0.1433	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Schistosoma mansoni	neurotransmitter gated ion channel	0.0055	0.0969	0.0969
Loa Loa (eye worm)	ACC-1 protein	0.0119	0.2513	0.255
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1261	0.128
Echinococcus multilocularis	cyclin B3 1	0.0036	0.0521	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Schistosoma mansoni	tyrosine kinase	0.0074	0.1433	0.1433
Schistosoma mansoni	cyclin B3	0.0036	0.0521	0.0521
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0067	0.1261	0.128
Schistosoma mansoni	nAChR subunit	0.0119	0.2513	0.2513
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0074	0.1433	0.1454
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0067	0.1261	0.128
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0423	0.9853	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0423	0.9853	1
Onchocerca volvulus		0.0055	0.0969	0.0984
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0119	0.2513	0.255
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0074	0.1433	0.1454
Onchocerca volvulus		0.0119	0.2513	0.255
Giardia lamblia	G2/mitotic-specific cyclin B	0.0087	0.1744	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0074	0.1433	0.1454
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0119	0.2513	0.255
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.2513	0.255
Schistosoma mansoni	nAChR subunit	0.0119	0.2513	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.0292	0.6693	1
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0326	0.7506	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.2513	0.2513
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0074	0.1433	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Brugia malayi	hypothetical protein	0.0055	0.0969	0.0984
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.0292	0.6693	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0074	0.1433	0.1454
Brugia malayi	Cation transporter family protein	0.0194	0.4327	0.4391
Onchocerca volvulus		0.0055	0.0969	0.0984
Schistosoma mansoni	tyrosine kinase	0.0074	0.1433	0.1433
Onchocerca volvulus	Putative nachr subunit	0.0423	0.9853	1
Onchocerca volvulus		0.0064	0.1191	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0194	0.4327	0.4391
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0087	0.1744	0.2324
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0442	0.0449
Echinococcus granulosus	cyclins	0.0036	0.0521	0.0529
Brugia malayi	hypothetical protein	0.0055	0.0969	0.0984
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0064	0.1186	0.1204
Echinococcus granulosus	cyclins	0.0036	0.0521	0.0529
Onchocerca volvulus		0.0194	0.4327	0.4391
Trichomonas vaginalis	cyclins, putative	0.0059	0.1081	0.0907
Schistosoma mansoni	nAChR subunit	0.0055	0.0969	0.0969
Schistosoma mansoni	acetylcholine receptor-related	0.0055	0.0969	0.0969
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0119	0.2513	0.255
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.2513	0.255
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0119	0.2513	0.255
Echinococcus multilocularis	cyclins	0.0036	0.0521	0.0529
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.2513	0.255
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Entamoeba histolytica	hypothetical protein	0.0064	0.1191	0.5476
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.2513	0.255
Trichomonas vaginalis	cyclin B, putative	0.0087	0.1744	0.1981
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0087	0.1744	0.177
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.2513	0.255
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.2513	0.2513
Echinococcus granulosus	cyclin B3 1	0.0036	0.0521	0.0529
Loa Loa (eye worm)	cyclin domain-containing protein	0.0036	0.0521	0.0529
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0055	0.0969	0.0984
Trichomonas vaginalis	cyclins, putative	0.0087	0.1744	0.1981
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0074	0.1433	0.1454
Echinococcus multilocularis	c src tyrosine kinase	0.0018	0.007	0.0071
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0119	0.2513	0.255
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0036	0.0521	0.0529
Loa Loa (eye worm)	SRC-1	0.0074	0.1433	0.1454
Trypanosoma cruzi	cyclin, putative	0.0087	0.1744	0.2324
Onchocerca volvulus		0.0087	0.1744	0.177
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0119	0.2513	0.255
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0015	0.0016
Echinococcus granulosus	cyclins	0.0036	0.0521	0.0529
Schistosoma mansoni	neurotransmitter gated ion channel	0.0055	0.0969	0.0969
Schistosoma mansoni	serine-type protease inhibitor	0.043	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.2513	0.2513
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0028	0.0325	0.0329
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0087	0.1744	0.2324
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0074	0.1433	0.1454
Echinococcus multilocularis	glycine receptor subunit beta	0.0119	0.2513	0.255
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0326	0.7506	0.7618
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0064	0.1191	0.1191
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Entamoeba histolytica	protein kinase, putative	0.006	0.1085	0.4612
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0119	0.2513	0.255
Schistosoma mansoni	nAChR subunit	0.0119	0.2513	0.2513
Brugia malayi	Cation transporter family protein	0.0119	0.2513	0.255
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0423	0.9853	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.2513	0.255
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2513	0.255
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0074	0.1433	0.1454
Trichomonas vaginalis	cyclin B, putative	0.0087	0.1744	0.1981
Echinococcus multilocularis	cyclins	0.0036	0.0521	0.0529
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0075	0.0076
Schistosoma mansoni	cyclins	0.0036	0.0521	0.0521
Toxoplasma gondii	hypothetical protein	0.0028	0.0311	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1191	0.1209
Brugia malayi	hypothetical protein	0.0055	0.0969	0.0984
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0055	0.0969	0.0984
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0326	0.7506	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.006	0.1085	0.1102
Echinococcus granulosus	tyrosine protein kinase Blk	0.0067	0.1261	0.128
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0074	0.1433	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Echinococcus granulosus	c src tyrosine kinase	0.0018	0.007	0.0071
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0036	0.0521	0.0529
Trichomonas vaginalis	cyclin B, putative	0.0087	0.1744	0.1981
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0326	0.7506	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0119	0.2513	0.255
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0055	0.0969	0.0984
Echinococcus granulosus	cyclin b3	0.0036	0.0521	0.0529
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0015	0.0016
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0326	0.7506	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0064	0.1191	0.1209
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0028	0.0325	0.0329
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0055	0.0969	0.0984
Echinococcus multilocularis	cyclins	0.0036	0.0521	0.0529
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0194	0.4327	0.4327
Loa Loa (eye worm)	LGC-31 protein	0.0119	0.2513	0.255
Brugia malayi	Tyrosine-protein kinase abl-1	0.0018	0.007	0.0071
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0074	0.1433	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0969	0.0984
Echinococcus granulosus	nAChR subunit	0.0064	0.1191	0.1209
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0015	0.0016
Loa Loa (eye worm)	GABA receptor subunit	0.0064	0.1191	0.1209

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 34 uM	Inhibition of lymphoid specific tyrosine phosphatase (unknown origin)	ChEMBL.	18434147
IC50 (binding)	= 34 uM	Inhibition of lymphoid specific tyrosine phosphatase (unknown origin)	ChEMBL.	18434147

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 509306