Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0028 | 0.6689 | 0.4408 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0037 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.4079 | 0.4079 |
Trypanosoma brucei | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.4079 | 0.4079 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0028 | 0.6689 | 0.4408 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0037 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.4079 | 0.4079 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0037 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0037 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.4079 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma brucei | trans-sialidase | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.4079 | 0.4079 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.4079 | 0.4079 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0037 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0037 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0028 | 0.6689 | 0.4408 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0037 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.4079 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.4079 | 0.4079 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma brucei | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0037 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.4079 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0028 | 0.6689 | 0.4408 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0037 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0037 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.4079 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.4079 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0037 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0028 | 0.669 | 0.441 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0028 | 0.669 | 0.441 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0037 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.