Detailed information for compound 724769

Basic information

Technical information
  • TDR Targets ID: 724769
  • Name: (Z)-3-(2-methoxy-5-nitrophenyl)-2-(6-methyl-1 H-benzimidazol-2-yl)prop-2-enenitrile
  • MW: 334.329 | Formula: C18H14N4O3
  • H donors: 1 H acceptors: 4 LogP: 3.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C/c1cc(ccc1OC)[N+](=O)[O-])/c1nc2c([nH]1)ccc(c2)C
  • InChi: 1S/C18H14N4O3/c1-11-3-5-15-16(7-11)21-18(20-15)13(10-19)8-12-9-14(22(23)24)4-6-17(12)25-2/h3-9H,1-2H3,(H,20,21)/b13-8-
  • InChiKey: HPJYRRPWCFFQDI-JYRVWZFOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-3-(2-methoxy-5-nitro-phenyl)-2-(6-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile
  • (Z)-3-(2-methoxy-5-nitro-phenyl)-2-(6-methyl-1H-benzimidazol-2-yl)acrylonitrile
  • ZINC05028039

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Echinococcus granulosus GPCR family 2 0.0016 0.0083 0.0083
Brugia malayi Carboxylesterase family protein 0.0065 0.0696 0.2864
Loa Loa (eye worm) hypothetical protein 0.0038 0.0353 0.1453
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0256 0.0256
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0389 0.1399
Loa Loa (eye worm) hypothetical protein 0.0065 0.0696 0.2864
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0043 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1028 0.2858
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0394 0.1069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0043 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0527 0.1445
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1028 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0118 0.0289
Echinococcus multilocularis GPCR, family 2 0.0016 0.0083 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Echinococcus granulosus acetylcholinesterase 0.0065 0.0696 0.0696
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0015 0.0015
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0118 0.0373
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0118 0.0487
Brugia malayi Heterochromatin protein 1 0.0068 0.0726 0.2989
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0726 0.2571
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0632 0.778 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0434 0.0434
Schistosoma mansoni chromobox protein 0.0011 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.009 0.0272
Loa Loa (eye worm) hypothetical protein 0.0065 0.0696 0.2864
Schistosoma mansoni hypothetical protein 0.081 1 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0016 0.0016
Onchocerca volvulus 0.003 0.025 0.0899
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0508 0.1389
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0214 0.0719
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.1237 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0177 0.0585
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0253 0.0912
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0256 0.0256
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0394 0.1069
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0353 0.1221
Brugia malayi hypothetical protein 0.0011 0.0016 0.0065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0083 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0214 0.0719
Echinococcus granulosus chromobox protein 2 0.0011 0.0016 0.0016
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0696 0.2864
Trypanosoma brucei unspecified product 0.0013 0.0043 0.0078
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0016 0.0002
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0253 0.1043
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0056 0.0056
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0118 0.0133
Mycobacterium ulcerans hypothetical protein 0.0155 0.1815 0.2318
Loa Loa (eye worm) carboxylesterase 0.0011 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0065
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0137 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0177 0.0585
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0067 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0016 0.0002
Trypanosoma brucei unspecified product 0.0013 0.0043 0.0078
Echinococcus multilocularis chromobox protein 2 0.0011 0.0016 0.0016
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0137 0.0564
Schistosoma mansoni acetylcholinesterase 0.0011 0.0015 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0083 0.0342
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0434 0.1788
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0177 0.0585
Schistosoma mansoni chromobox protein 0.0011 0.0016 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.1327
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0118 0.0289
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0016 0.00000000086504
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Echinococcus granulosus chromobox protein 1 0.0068 0.0726 0.0726
Echinococcus granulosus neuroligin 0.0011 0.0015 0.0015
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0063
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.3557 1
Brugia malayi hypothetical protein 0.0011 0.0015 0.0063
Echinococcus multilocularis neuroligin 0.0011 0.0015 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0118 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1028 0.3664
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1398 0.1398
Schistosoma mansoni DNA polymerase eta 0.0045 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0342
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0016 0.0002
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1028 0.1028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0063
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1028 0.3664
Leishmania major hypothetical protein, conserved 0.0052 0.0527 0.1445
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0053 0.072
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0437 0.1189
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0588 0.242
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2428 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0063
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0056 0.0056
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0102 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0696 0.0696
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0118 0.0373
Loa Loa (eye worm) hypothetical protein 0.0052 0.0527 0.2172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Echinococcus multilocularis cpg binding protein 0.006 0.0628 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0107 0.0442
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0016 0.0016
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0016 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0065
Schistosoma mansoni hypothetical protein 0.0342 0.4156 0.4156
Schistosoma mansoni cpg binding protein 0.006 0.0628 0.0628
Echinococcus granulosus caspase 2 0.003 0.0253 0.0253
Onchocerca volvulus 0.0011 0.0015 0.0055
Loa Loa (eye worm) RecQ helicase 0.0021 0.0137 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0256 0.0256
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0227 0.0227
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0726 0.2989
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0118 0.0118
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0118 0.0289
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0528 0.2176
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Echinococcus granulosus Chromo domain 0.0011 0.0016 0.0016
Onchocerca volvulus 0.003 0.0253 0.0912
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0434 0.0434
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0177 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0434 0.1788
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0528 0.2176
Loa Loa (eye worm) helicase 0.0011 0.0016 0.0065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0169 0.0169
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0394 0.1069
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0256 0.1968
Echinococcus granulosus bloom syndrome protein 0.0021 0.0137 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0177 0.0585
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0696 0.0696
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1028 0.3699
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Leishmania major DNA polymerase eta, putative 0.0031 0.027 0.0719
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0015 0.0015
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1028 0.2858
Onchocerca volvulus 0.0232 0.2779 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0118 0.0118
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0082 0.0082
Brugia malayi CHD4 protein 0.0014 0.0056 0.0232
Echinococcus granulosus cpg binding protein 0.006 0.0628 0.0628
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0056 0.0056
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0256 0.0256
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0118 0.0133
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0015 0.0015
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Giardia lamblia Kinase, PLK 0.0092 0.1028 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0527 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.027 0.2085
Brugia malayi Cell death protein 3 precursor 0.003 0.0253 0.1043
Echinococcus granulosus acetylcholinesterase 0.0065 0.0696 0.0696
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0527 0.419
Brugia malayi hypothetical protein 0.0052 0.0527 0.2172
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1028 0.4233
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1619 0.4526
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Loa Loa (eye worm) carboxylesterase 0.0065 0.0696 0.2864
Schistosoma mansoni chromobox protein 0.0068 0.0726 0.0726
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0024 0.0174 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0434 0.0434
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0063
Echinococcus multilocularis chromobox protein 1 0.0068 0.0726 0.0726
Schistosoma mansoni hypothetical protein 0.003 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0023 0.0169 0.0169
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0632 0.778 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.3557 1
Brugia malayi hypothetical protein 0.003 0.0253 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0063
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0347
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0256 0.0256
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0118 0.0118
Echinococcus multilocularis dnaJ subfamily B 0.081 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1028 0.3664
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0016
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0253 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1028 0.3664
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0102 0.0315
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0015 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0083
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0083
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0063
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0105 0.1749
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.027 0.0719
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0253 0.0253
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0016 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0016 0.00000000086504
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1028 0.4233
Echinococcus granulosus Chromobox protein 3 0.0011 0.0016 0.0016
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1028 0.1028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0434 0.0434
Schistosoma mansoni chromobox protein 0.0068 0.0726 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0527 0.1445
Brugia malayi Pre-SET motif family protein 0.0204 0.2428 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0253 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0528 0.2176
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1619 0.4526
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0015 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0016 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0434 0.0434
Onchocerca volvulus 0.0011 0.0015 0.0055
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0527 0.1445
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0437 0.1799
Schistosoma mansoni hypothetical protein 0.0342 0.4156 0.4156
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0395 0.0395
Trichomonas vaginalis helicase, putative 0.0013 0.0038 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0043 0.0078
Echinococcus multilocularis Chromo domain 0.0011 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0177 0.0585
Brugia malayi SET domain containing protein 0.0013 0.0045 0.0184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0696 0.0696
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0353 0.1269
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.1029
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0394 0.1069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0083 0.0342
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0726 0.2571
Onchocerca volvulus 0.0011 0.0015 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0038 0.0082
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0016 0.00000000036248
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1028 0.3664
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0322 0.1327
Onchocerca volvulus 0.0057 0.0588 0.2115
Onchocerca volvulus 0.0011 0.0016 0.0057
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0051 0.0285
Plasmodium vivax SET domain protein, putative 0.003 0.0256 0.4697
Loa Loa (eye worm) hypothetical protein 0.0045 0.0437 0.1799
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0389 0.1352
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0447 0.1561
Schistosoma mansoni cpg binding protein 0.0057 0.0588 0.0588
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0177 0.0585
Leishmania major DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.3557 1
Brugia malayi hypothetical protein 0.0034 0.0297 0.1222
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0063
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.3557 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0389 0.1352
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0696 0.0696
Schistosoma mansoni cpg binding protein 0.006 0.0628 0.0628
Echinococcus multilocularis dna polymerase eta 0.0045 0.0437 0.0437
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0118 0.0118
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0067 0.0067
Brugia malayi Protein cec-1. 0.0011 0.0016 0.0065
Brugia malayi Carboxylesterase family protein 0.0065 0.0696 0.2864
Echinococcus granulosus geminin 0.0342 0.4156 0.4156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0177 0.0585
Onchocerca volvulus 0.0041 0.0395 0.1422
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0118 0.1012
Loa Loa (eye worm) hypothetical protein 0.0052 0.0528 0.2176
Trypanosoma brucei polo-like protein kinase 0.0092 0.1028 0.2858
Leishmania major DNA polymerase eta, putative 0.0045 0.0437 0.1189
Echinococcus granulosus chromobox protein 1 0.0068 0.0726 0.0726
Schistosoma mansoni kinase 0.0047 0.0462 0.0462
Schistosoma mansoni hypothetical protein 0.0036 0.0322 0.0322
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0015 0.0015
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0696 0.0696
Loa Loa (eye worm) carboxylesterase 0.0011 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0065
Loa Loa (eye worm) histone methyltransferase 0.0019 0.011 0.0453
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0353 0.1221
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0016 0.0065
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2779 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Schistosoma mansoni gliotactin 0.0011 0.0015 0.0015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1619 0.4526
Onchocerca volvulus 0.0011 0.0015 0.0055
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1028 0.2858
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Brugia malayi CXXC zinc finger family protein 0.0057 0.0588 0.242
Onchocerca volvulus 0.0011 0.0016 0.0057
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0437 0.1189
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0065
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0137 0.044
Echinococcus multilocularis geminin 0.0342 0.4156 0.4156
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0065
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0118 0.0487
Echinococcus multilocularis chromobox protein 1 0.0068 0.0726 0.0726
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0002
Trypanosoma brucei unspecified product 0.0019 0.0118 0.0289
Onchocerca volvulus 0.0011 0.0015 0.0055
Toxoplasma gondii hypothetical protein 0.0047 0.047 0.3723
Trichomonas vaginalis hypothetical protein 0.0011 0.0016 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0118 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0256 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0016 0.0016
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0015 0.0015
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0063
Brugia malayi Pre-SET motif family protein 0.003 0.0256 0.1055
Echinococcus granulosus dna polymerase kappa 0.0019 0.0118 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0016 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0289
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0118 0.0289
Echinococcus granulosus dna polymerase eta 0.0045 0.0437 0.0437
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.011 0.011
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0137 0.044
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1028 0.3664
Brugia malayi chromobox protein homolog 3 0.0038 0.0353 0.1453
Echinococcus multilocularis caspase 2 0.003 0.0253 0.0253
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1815 0.2318
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0527 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1028 0.1028
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0016 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0447 0.1561
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0016 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1028 0.3664
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0016 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0065
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0118 0.0133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.1055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0016 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.011 0.011
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0056 0.0232

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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