Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0466 | 0.5333 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0619 | 0.7241 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1572 | 0.1572 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.1572 | 0.6078 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1572 | 0.6078 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0303 | 0.3299 | 0.5896 |
Loa Loa (eye worm) | ILVBL protein | 0.0282 | 0.3046 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1572 | 0.1572 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.1572 | 0.5163 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0466 | 0.5333 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0151 | 0.1409 | 0.5 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0199 | 0.2015 | 0.3304 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0466 | 0.5333 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0398 | 0.449 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0151 | 0.1409 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0267 | 0.2853 | 0.4994 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1572 | 0.6078 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0267 | 0.2853 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1572 | 0.2949 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.2587 | 0.8493 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.2587 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0267 | 0.2853 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0466 | 0.5333 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0158 | 0.0296 |
Onchocerca volvulus | 0.005 | 0.0158 | 1 | |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0151 | 0.1409 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0466 | 0.5333 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0303 | 0.3299 | 0.5734 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0151 | 0.1409 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0466 | 0.5333 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1572 | 0.2949 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.1572 | 0.1572 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.2587 | 0.2587 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0466 | 0.5333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1572 | 0.5163 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0158 | 0.0351 |
Schistosoma mansoni | acetolactate synthase | 0.0398 | 0.449 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.1572 | 0.5163 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0267 | 0.2853 | 0.4994 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0267 | 0.2853 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0267 | 0.2853 | 0.4994 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.1572 | 0.3502 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0466 | 0.5333 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0267 | 0.2859 | 0.9385 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0158 | 0.0351 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0151 | 0.1409 | 0.208 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0303 | 0.3299 | 0.5896 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0083 | 0.0566 | 0.0378 |
Brugia malayi | hypothetical protein | 0.0245 | 0.2587 | 0.4851 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0619 | 0.7241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1572 | 0.5163 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 30 nM | Inhibition of equine (Eq) Butyrylcholinesterase | ChEMBL. | 11425559 |
Ki (binding) | = 30 nM | Inhibition of equine (Eq) Butyrylcholinesterase | ChEMBL. | 11425559 |
Ki (binding) | = 100 nM | Inhibition of acetylcholinesterase (AChE) of fetal bovine serum (FBS) | ChEMBL. | 11425559 |
Ki (binding) | = 100 nM | Inhibition of acetylcholinesterase (AChE) of fetal bovine serum (FBS) | ChEMBL. | 11425559 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.