Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0359 | 0.0361 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0021 | 0.0141 | 0.0141 |
Echinococcus multilocularis | roundabout 2 | 0.0049 | 0.0946 | 0.1369 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.9962 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0042 | 0.0742 | 0.0742 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0106 | 0.2606 | 0.2606 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0106 | 0.2606 | 0.5 |
Echinococcus granulosus | titin | 0.0018 | 0.0038 | 0.0038 |
Schistosoma mansoni | cell adhesion molecule | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.2643 | 0.2643 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.2606 | 0.2606 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.2643 | 0.2643 |
Brugia malayi | protein unc-22 | 0.0018 | 0.0038 | 0.0038 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0029 | 0.0359 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2606 | 0.2615 |
Schistosoma mansoni | cell adhesion molecule | 0.0046 | 0.0845 | 0.0845 |
Echinococcus multilocularis | titin | 0.0018 | 0.0038 | 0.0055 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0108 | 0.2643 | 0.3825 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0106 | 0.2606 | 0.2606 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0106 | 0.2606 | 0.2615 |
Echinococcus multilocularis | Immunoglobulin | 0.0029 | 0.0359 | 0.052 |
Echinococcus granulosus | neuroglian | 0.002 | 0.0103 | 0.0103 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0029 | 0.0359 | 0.052 |
Echinococcus multilocularis | roundabout 2 | 0.002 | 0.0103 | 0.0149 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.002 | 0.0103 | 0.0103 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.002 | 0.0103 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2606 | 0.2615 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.2653 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0106 | 0.2606 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0563 | 0.0566 |
Brugia malayi | Protein kinase domain containing protein | 0.0108 | 0.2643 | 0.2643 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.3825 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0108 | 0.2643 | 0.2653 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0359 | 0.9962 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.002 | 0.0103 | 0.0103 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0019 | 0.0059 | 0.006 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0033 | 0.0462 | 0.0464 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.002 | 0.0103 | 0.0149 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0017 | 0.0002 | 0.0002 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0742 | 0.0745 |
Onchocerca volvulus | 0.0018 | 0.0038 | 0.0145 | |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0017 | 0.0002 | 0.0003 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.0623 | 0.0623 |
Echinococcus multilocularis | 0.0254 | 0.6911 | 1 | |
Schistosoma mansoni | cell adhesion molecule | 0.002 | 0.0103 | 0.0103 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0106 | 0.2606 | 0.377 |
Echinococcus multilocularis | neuroglian | 0.0032 | 0.046 | 0.0666 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0106 | 0.2606 | 0.2615 |
Schistosoma mansoni | protein kinase | 0.0361 | 1 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0029 | 0.0359 | 0.0359 |
Echinococcus granulosus | titin | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0018 | 0.0038 | 0.0038 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0042 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0254 | 0.6911 | 0.6937 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0038 | 0.0038 |
Schistosoma mansoni | vam6/vps39 related | 0.0106 | 0.2606 | 0.2606 |
Echinococcus granulosus | twitchin | 0.0034 | 0.0498 | 0.05 |
Echinococcus granulosus | protein kinase | 0.0254 | 0.6911 | 0.6937 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.002 | 0.0103 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2606 | 0.2615 |
Schistosoma mansoni | nephrin | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.0002 | 0.0002 |
Echinococcus granulosus | contactin | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | vesicular amine transporter | 0.0029 | 0.0359 | 0.0359 |
Schistosoma mansoni | ephrin receptor | 0.0019 | 0.0059 | 0.0059 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0462 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0742 | 0.0745 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0108 | 0.2643 | 0.2653 |
Echinococcus granulosus | defective proboscis extension response | 0.0029 | 0.0359 | 0.0361 |
Echinococcus granulosus | Immunoglobulin | 0.0029 | 0.0359 | 0.0361 |
Echinococcus multilocularis | neuroglian | 0.002 | 0.0103 | 0.0149 |
Echinococcus multilocularis | Immunoglobulin | 0.0029 | 0.0359 | 0.052 |
Echinococcus granulosus | neuroglian | 0.0032 | 0.046 | 0.0462 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0359 | 0.0361 |
Echinococcus multilocularis | roundabout 2 | 0.002 | 0.0103 | 0.0149 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0018 | 0.0038 | 0.0038 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.3825 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0106 | 0.2606 | 0.2606 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0103 | 0.0103 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0019 | 0.0059 | 0.0086 |
Schistosoma mansoni | titin | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0563 | 0.0566 |
Brugia malayi | hypothetical protein | 0.0106 | 0.2606 | 0.2606 |
Schistosoma mansoni | neuroglian | 0.002 | 0.0103 | 0.0103 |
Echinococcus granulosus | roundabout 2 | 0.0049 | 0.0946 | 0.095 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0018 | 0.0038 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0359 | 0.0361 |
Schistosoma mansoni | nephrin | 0.0046 | 0.0843 | 0.0843 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | protein kinase | 0.0108 | 0.2643 | 0.2643 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0106 | 0.2606 | 0.2606 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.002 | 0.0103 | 0.0149 |
Schistosoma mansoni | protein kinase | 0.0254 | 0.6911 | 0.6911 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.2653 |
Echinococcus granulosus | roundabout 2 | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0038 | 0.0623 | 0.0625 |
Echinococcus granulosus | roundabout 2 | 0.002 | 0.0103 | 0.0103 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0106 | 0.2606 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.2606 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0742 | 0.0745 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0103 | 0.0103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.