Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CAMK protein kinase | 0.0018 | 0.0038 | 0.0038 |
Echinococcus multilocularis | roundabout 2 | 0.002 | 0.0103 | 0.0149 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.3825 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0359 | 0.0361 |
Echinococcus multilocularis | Immunoglobulin | 0.0029 | 0.0359 | 0.052 |
Echinococcus granulosus | neuroglian | 0.0032 | 0.046 | 0.0462 |
Echinococcus granulosus | Immunoglobulin | 0.0029 | 0.0359 | 0.0361 |
Echinococcus multilocularis | neuroglian | 0.002 | 0.0103 | 0.0149 |
Brugia malayi | hypothetical protein | 0.0106 | 0.2606 | 0.2606 |
Echinococcus granulosus | roundabout 2 | 0.0049 | 0.0946 | 0.095 |
Schistosoma mansoni | neuroglian | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | titin | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0563 | 0.0566 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0019 | 0.0059 | 0.0086 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0106 | 0.2606 | 0.2606 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | protein kinase | 0.0108 | 0.2643 | 0.2643 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0106 | 0.2606 | 0.2606 |
Schistosoma mansoni | nephrin | 0.0046 | 0.0843 | 0.0843 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0742 | 0.0742 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0359 | 0.0361 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0106 | 0.2606 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.2606 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0742 | 0.0745 |
Echinococcus granulosus | roundabout 2 | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0038 | 0.0623 | 0.0625 |
Echinococcus granulosus | roundabout 2 | 0.002 | 0.0103 | 0.0103 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.2653 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.002 | 0.0103 | 0.0149 |
Schistosoma mansoni | protein kinase | 0.0254 | 0.6911 | 0.6911 |
Echinococcus granulosus | titin | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0029 | 0.0359 | 0.0359 |
Schistosoma mansoni | protein kinase | 0.0361 | 1 | 1 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0106 | 0.2606 | 0.377 |
Schistosoma mansoni | cell adhesion molecule | 0.002 | 0.0103 | 0.0103 |
Echinococcus multilocularis | 0.0254 | 0.6911 | 1 | |
Echinococcus multilocularis | neuroglian | 0.0032 | 0.046 | 0.0666 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0106 | 0.2606 | 0.2615 |
Echinococcus granulosus | contactin | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2606 | 0.2615 |
Schistosoma mansoni | nephrin | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.0002 | 0.0002 |
Schistosoma mansoni | vam6/vps39 related | 0.0106 | 0.2606 | 0.2606 |
Echinococcus granulosus | twitchin | 0.0034 | 0.0498 | 0.05 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.002 | 0.0103 | 0.0149 |
Echinococcus granulosus | protein kinase | 0.0254 | 0.6911 | 0.6937 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0042 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0254 | 0.6911 | 0.6937 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0038 | 0.0038 |
Schistosoma mansoni | ephrin receptor | 0.0019 | 0.0059 | 0.0059 |
Schistosoma mansoni | vesicular amine transporter | 0.0029 | 0.0359 | 0.0359 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0103 | 0.0103 |
Echinococcus granulosus | defective proboscis extension response | 0.0029 | 0.0359 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0462 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0742 | 0.0745 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0108 | 0.2643 | 0.2653 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.002 | 0.0103 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2606 | 0.2615 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.2653 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0029 | 0.0359 | 0.052 |
Echinococcus granulosus | neuroglian | 0.002 | 0.0103 | 0.0103 |
Echinococcus multilocularis | roundabout 2 | 0.002 | 0.0103 | 0.0149 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.002 | 0.0103 | 0.0103 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0106 | 0.2606 | 0.2606 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0106 | 0.2606 | 0.2615 |
Echinococcus multilocularis | Immunoglobulin | 0.0029 | 0.0359 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0563 | 0.0566 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0106 | 0.2606 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0019 | 0.0059 | 0.006 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0033 | 0.0462 | 0.0464 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0017 | 0.0002 | 0.0002 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.002 | 0.0103 | 0.0149 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0359 | 0.9962 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.002 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0108 | 0.2643 | 0.2653 |
Brugia malayi | Protein kinase domain containing protein | 0.0108 | 0.2643 | 0.2643 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0108 | 0.2643 | 0.3825 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0017 | 0.0002 | 0.0003 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.0623 | 0.0623 |
Onchocerca volvulus | 0.0018 | 0.0038 | 0.0145 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0742 | 0.0745 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.9962 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0042 | 0.0742 | 0.0742 |
Echinococcus multilocularis | roundabout 2 | 0.0049 | 0.0946 | 0.1369 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0359 | 0.0361 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0021 | 0.0141 | 0.0141 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.2643 | 0.2643 |
Schistosoma mansoni | cell adhesion molecule | 0.002 | 0.0103 | 0.0103 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0106 | 0.2606 | 0.5 |
Echinococcus granulosus | titin | 0.0018 | 0.0038 | 0.0038 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0106 | 0.2606 | 0.2606 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0029 | 0.0359 | 0.0359 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.2643 | 0.2643 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.2606 | 0.2606 |
Brugia malayi | protein unc-22 | 0.0018 | 0.0038 | 0.0038 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0108 | 0.2643 | 0.3825 |
Echinococcus multilocularis | titin | 0.0018 | 0.0038 | 0.0055 |
Schistosoma mansoni | cell adhesion molecule | 0.0046 | 0.0845 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2606 | 0.2615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.