Detailed information for compound 819384

Basic information

Technical information
  • TDR Targets ID: 819384
  • Name: 3-(4-tert-butylphenyl)-N-(3-morpholin-4-ylpro pyl)prop-2-enamide
  • MW: 330.464 | Formula: C20H30N2O2
  • H donors: 1 H acceptors: 1 LogP: 3.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C/c1ccc(cc1)C(C)(C)C)NCCCN1CCOCC1
  • InChi: 1S/C20H30N2O2/c1-20(2,3)18-8-5-17(6-9-18)7-10-19(23)21-11-4-12-22-13-15-24-16-14-22/h5-10H,4,11-16H2,1-3H3,(H,21,23)/b10-7+
  • InChiKey: VDIKGFQDVXYXEK-JXMROGBWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(4-tert-butylphenyl)-N-(3-morpholin-4-ylpropyl)prop-2-enamide
  • 3-(4-tert-butylphenyl)-N-(3-morpholinopropyl)prop-2-enamide
  • (E)-3-(4-tert-butylphenyl)-N-(3-morpholinopropyl)prop-2-enamide
  • 3-(4-tert-butylphenyl)-N-(3-morpholinopropyl)acrylamide
  • (E)-3-(4-tert-butylphenyl)-N-(3-morpholinopropyl)acrylamide
  • 3-(4-tert-butylphenyl)-N-[3-(4-morpholinyl)propyl]acrylamide
  • MLS001163401
  • SMR000496703
  • CBMicro_015874
  • BIM-0015942.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.0053 0.03 0.0278
Loa Loa (eye worm) hypothetical protein 0.0137 0.1168 0.1199
Schistosoma mansoni hypothetical protein 0.0152 0.1324 0.1376
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0738
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0103 0.0091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0461 0.0479
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0245 0.2294 0.2299
Giardia lamblia Macrophage migration inhibitory factor 0.0884 0.8931 0.8918
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.1007 0.2545
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0113 0.0118
Entamoeba histolytica hypothetical protein 0.0043 0.0199 0.0198
Schistosoma mansoni microtubule-associated protein tau 0.0781 0.7858 0.8165
Trypanosoma cruzi phosphomannose isomerase, putative 0.0736 0.7389 0.7653
Echinococcus granulosus JmjC domain containing protein 4 0.0039 0.0152 0.0158
Echinococcus granulosus phosphomannomutase 0.0144 0.124 0.1288
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0038 0.0143 0.0114
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0523 0.0439
Schistosoma mansoni hypothetical protein 0.0066 0.0431 0.0448
Trypanosoma brucei phosphomannomutase 0.0144 0.124 0.1268
Plasmodium falciparum phd finger protein, putative 0.0066 0.0431 0.0409
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0053 0.0303 0.0292
Echinococcus multilocularis phd:f box containing protein 0.0039 0.0152 0.0158
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0197 0.0204
Echinococcus multilocularis 6 phosphofructokinase 0.0245 0.2294 0.2384
Loa Loa (eye worm) hexokinase 0.0211 0.1944 0.2007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0113 0.0118
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Loa Loa (eye worm) MH2 domain-containing protein 0.0387 0.3763 0.3901
Plasmodium vivax phosphomannomutase, putative 0.0144 0.124 0.122
Echinococcus granulosus bloom syndrome protein 0.0027 0.003 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0752 0.0782
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0222 0.2054 0.2121
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0103 0.0107
Echinococcus multilocularis microtubule associated protein 2 0.0781 0.7858 0.8165
Echinococcus granulosus microtubule associated protein 2 0.0781 0.7858 0.8165
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0162 0.1426 0.3628
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0081 0.0591 0.0639
Loa Loa (eye worm) hypothetical protein 0.0152 0.1324 0.1362
Loa Loa (eye worm) hypothetical protein 0.016 0.1404 0.1446
Echinococcus granulosus hexokinase 0.0337 0.3249 0.3376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0103 0.0107
Plasmodium falciparum glutathione reductase 0.0053 0.03 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0073 0.0043
Leishmania major macrophage migration inhibitory factor-like protein 0.0884 0.8931 0.9279
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0303 0.0315
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0103 0.0107
Plasmodium falciparum histone acetyltransferase GCN5 0.0129 0.1085 0.1065
Trypanosoma cruzi phosphomannomutase, putative 0.0144 0.124 0.1191
Mycobacterium ulcerans hypothetical protein 0.0107 0.086 0.0872
Brugia malayi Smad1 0.0026 0.0021 0.0006
Trichomonas vaginalis protein kinase inhibitor, putative 0.0069 0.0468 0.0439
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0951 0.9623 1
Schistosoma mansoni zinc finger protein 0.0035 0.0106 0.011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0477 0.048
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0315 0.302 0.3062
Entamoeba histolytica hexokinase 1 0.0337 0.3249 0.3622
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0377 0.3665 0.3799
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0477 0.0496
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0113 0.0091
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0022 0.5
Plasmodium vivax 6-phosphofructokinase, putative 0.0066 0.0436 0.0414
Schistosoma mansoni hypothetical protein 0.007 0.0477 0.0496
Brugia malayi hypothetical protein 0.0507 0.5009 0.5198
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0103 0.0107
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0021 0.0022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0523 0.0439
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0146 0.1268 0.1317
Loa Loa (eye worm) hypothetical protein 0.0053 0.0303 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1162 0.1207
Brugia malayi nuclear hormone receptor 0.0034 0.0103 0.0091
Leishmania major hypothetical protein, conserved 0.0035 0.0106 0.0087
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0483 0.4765 0.4951
Toxoplasma gondii thioredoxin reductase 0.0053 0.03 0.0278
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0113 0.0091
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0736 0.7389 0.7675
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1162 0.1207
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.031 0.0288
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0053 0.0303 0.0725
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0103 0.0107
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0036 0.0124 0.0106
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0066 0.0436 0.0414
Chlamydia trachomatis 6-phosphogluconolactonase 0.0036 0.0124 0.0106
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0461 0.0457
Trichomonas vaginalis phosphofructokinase, putative 0.0245 0.2294 0.2271
Brugia malayi Hexokinase family protein 0.0211 0.1944 0.2007
Loa Loa (eye worm) hypothetical protein 0.007 0.0477 0.048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.1007 0.2545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0103 0.0091
Brugia malayi Thioredoxin reductase 0.0053 0.03 0.0296
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0113 0.0235
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0081 0.0591 0.1471
Loa Loa (eye worm) hexokinase type II 0.0337 0.3249 0.3365
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1162 0.1207
Trichomonas vaginalis phosphofructokinase, putative 0.0245 0.2294 0.2271
Echinococcus multilocularis peregrin 0.0083 0.0608 0.0631
Entamoeba histolytica phosphomannomutase, putative 0.0144 0.124 0.1366
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0103 0.0107
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0303 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0103 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0103 0.0091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0147 0.0153
Trichomonas vaginalis phosphofructokinase, putative 0.0066 0.0436 0.0407
Leishmania major trypanothione reductase 0.0053 0.03 0.0289
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0461 0.0457
Brugia malayi MH1 domain containing protein 0.0026 0.0021 0.0006
Leishmania major ATP-dependent phosphofructokinase 0.0245 0.2294 0.2366
Echinococcus granulosus peregrin 0.0083 0.0608 0.0631
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0039 0.0152 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0303 0.0292
Loa Loa (eye worm) DnaJ domain-containing protein 0.0069 0.0468 0.047
Trypanosoma cruzi hexokinase, putative 0.0337 0.3249 0.3302
Schistosoma mansoni mannose-6-phosphate isomerase 0.0736 0.7389 0.7679
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.003 0.0015
Leishmania major hypothetical protein, conserved 0.0039 0.0152 0.0135
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0113 0.0118
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0331 0.3183 0.3547
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0036 0.0124 0.0129
Echinococcus granulosus mannose 6 phosphate isomerase 0.0736 0.7389 0.7679
Brugia malayi MH1 domain containing protein 0.0026 0.0021 0.0006
Schistosoma mansoni chromobox protein 0.0079 0.0566 0.0589
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0242 0.0212
Echinococcus granulosus citrate lyase subunit beta protein 0.0107 0.086 0.0893
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0107 0.086 0.0872
Trichomonas vaginalis conserved hypothetical protein 0.0884 0.8931 0.8928
Trypanosoma brucei hexokinase, putative 0.0337 0.3249 0.3361
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0163 0.0146
Schistosoma mansoni hypothetical protein 0.0055 0.0315 0.0327
Schistosoma mansoni hypothetical protein 0.0043 0.0199 0.0207
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0245 0.2294 0.2366
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.1147 0.2908
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0143 0.0114
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0523 0.0544
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0103 0.0107
Brugia malayi follicle stimulating hormone receptor 0.0262 0.247 0.2554
Loa Loa (eye worm) phosphofructokinase 0.0245 0.2294 0.2371
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0103 0.0107
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0197 0.0204
Echinococcus multilocularis jumonji domain containing 1A 0.0039 0.0152 0.0158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0736 0.7389 0.7673
Onchocerca volvulus 0.0211 0.1944 0.3753
Echinococcus multilocularis GPCR, family 2 0.007 0.0477 0.0496
Schistosoma mansoni kinase 0.021 0.1927 0.2002
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0039 0.0152 0.0135
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0951 0.9623 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0146 0.1268 0.1317
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0152 0.0142
Brugia malayi isocitrate dehydrogenase 0.0035 0.0113 0.0102
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0103 0.0107
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0736 0.7389 0.7383
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0113 0.0102
Onchocerca volvulus 0.0035 0.0107 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1162 0.1207
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0884 0.8931 0.8929
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0036 0.0124 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0066 0.0436 0.043
Echinococcus granulosus chromobox protein 1 0.0079 0.0566 0.0589
Entamoeba histolytica aminopeptidase, putative 0.0081 0.0591 0.0639
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0103 0.0107
Leishmania major hypothetical protein, conserved 0.0054 0.031 0.03
Schistosoma mansoni jumonji/arid domain-containing protein 0.015 0.131 0.1362
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0081 0.0589 0.0613
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0107 0.086 0.0832
Trypanosoma brucei polo-like protein kinase 0.0413 0.4035 0.4179
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0461 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0103 0.0091
Brugia malayi hexokinase type II 0.0107 0.0861 0.088
Echinococcus multilocularis Smad4 0.0026 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0107 0.0861 0.088
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0021 0.0022
Brugia malayi jmjC domain containing protein 0.0039 0.0152 0.0142
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0147 0.0153
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.1007 0.2545
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0736 0.7389 0.7675
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Treponema pallidum hexokinase (hxk) 0.0337 0.3249 0.3361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0103 0.0091
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0242 0.0212
Brugia malayi jmjC domain containing protein 0.0282 0.2676 0.2769
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0523 0.0544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0147 0.0153
Brugia malayi Bm-MIF-1, identical 0.0884 0.8931 0.928
Trichomonas vaginalis phosphomannomutase, putative 0.0144 0.124 0.1214
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0413 0.4035 0.4193
Toxoplasma gondii phosphomannomutase 0.0144 0.124 0.122
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0413 0.4035 0.4179
Echinococcus multilocularis lysine specific demethylase 6a 0.0039 0.0152 0.0158
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.031 0.03
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0408 0.3983 0.4125
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0021 0.0006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0242 0.0282
Schistosoma mansoni 6-phosphofructokinase 0.0245 0.2294 0.2384
Trichomonas vaginalis CAMK family protein kinase 0.0413 0.4035 0.4017
Schistosoma mansoni hexokinase 0.0337 0.3249 0.3376
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0103 0.0091
Leishmania major phosphomannose isomerase 0.0736 0.7389 0.7673
Brugia malayi hypothetical protein 0.0054 0.031 0.0307
Trypanosoma brucei 6-phosphogluconolactonase 0.0036 0.0124 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0147 0.0153
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0413 0.4035 0.4017
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0081 0.0591 0.0593
Onchocerca volvulus 0.0337 0.3249 0.6412
Echinococcus granulosus GPCR family 2 0.007 0.0477 0.0496
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0736 0.7389 0.7381
Schistosoma mansoni Smad4 0.0026 0.0021 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0199 0.0207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0523 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0103 0.0091
Echinococcus multilocularis chromobox protein 1 0.0079 0.0566 0.0589
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0146 0.1262 0.1236
Onchocerca volvulus 0.0507 0.5009 1
Echinococcus multilocularis aspartyl aminopeptidase 0.0081 0.0591 0.0615
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Trichomonas vaginalis CAMK family protein kinase 0.0413 0.4035 0.4017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0752 0.0782
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0431 0.0409
Brugia malayi PHD-finger family protein 0.0066 0.0431 0.0432
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0147 0.0153
Loa Loa (eye worm) aspartyl aminopeptidase 0.0081 0.0591 0.0599
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0137
Brugia malayi hypothetical protein 0.0043 0.0199 0.0191
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0736 0.7389 0.7675
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0725 0.0753
Trichomonas vaginalis phosphofructokinase, putative 0.0245 0.2294 0.2271
Echinococcus multilocularis jumonji domain containing protein 0.0092 0.0698 0.0725
Echinococcus granulosus geminin 0.0382 0.3717 0.3863
Trichomonas vaginalis phosphofructokinase, putative 0.0245 0.2294 0.2271
Schistosoma mansoni survival motor neuron protein 0.0055 0.0315 0.0327
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0103 0.0091
Brugia malayi Aspartyl aminopeptidase 0.0081 0.0591 0.0599
Loa Loa (eye worm) jmjC domain-containing protein 0.015 0.131 0.1348
Trichomonas vaginalis phosphofructokinase, putative 0.0066 0.0436 0.0407
Echinococcus multilocularis lysine specific demethylase 5A 0.0146 0.1266 0.1315
Loa Loa (eye worm) glutaminase 2 0.0587 0.5849 0.6072
Trichomonas vaginalis phosphofructokinase, putative 0.0066 0.0436 0.0407
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0146 0.1262 0.1243
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0152 0.0142
Schistosoma mansoni phosphomannomutase 0.0144 0.124 0.1288
Schistosoma mansoni smad 0.0026 0.0021 0.0022
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0038 0.0143 0.0114
Echinococcus multilocularis hexokinase type 2 0.0337 0.3249 0.3376
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.03 0.0311
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0408 0.3983 0.4074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0222 0.2054 0.2121
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0103 0.0091
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0566 0.0538
Trichomonas vaginalis glutaminase, putative 0.0587 0.5849 0.5837
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0113 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.093 0.9403 0.9769
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0103 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.031 0.0288
Echinococcus granulosus jumonji domain containing protein 0.0092 0.0698 0.0725
Entamoeba histolytica hexokinase 2 0.0337 0.3249 0.3622
Leishmania major hexokinase, putative 0.0337 0.3249 0.3361
Echinococcus granulosus lysine specific demethylase 5A 0.015 0.131 0.1362
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0036 0.0124 0.0019
Loa Loa (eye worm) RecQ helicase 0.0027 0.003 0.0015
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0038 0.0143 0.0114
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.03 0.0717
Leishmania major macrophage migration inhibitory factor-like protein 0.0884 0.8931 0.9279
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.247 0.2554
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0096
Entamoeba histolytica acyl-coA synthetase, putative 0.0053 0.0303 0.0315
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0103 0.0107
Loa Loa (eye worm) Smad1 0.0026 0.0021 0.0006
Plasmodium vivax JmjC domain containing protein 0.0039 0.0152 0.013
Toxoplasma gondii hexokinase 0.0337 0.3249 0.3234
Brugia malayi TAR-binding protein 0.0136 0.1162 0.1193
Echinococcus multilocularis JmjC domain containing protein 4 0.0039 0.0152 0.0158
Echinococcus multilocularis chromobox protein 1 0.0079 0.0566 0.0589
Loa Loa (eye worm) hypothetical protein 0.013 0.1103 0.1132
Echinococcus granulosus 6 phosphofructokinase 0.0245 0.2294 0.2384
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0566 0.0573
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0951 0.9623 1
Entamoeba histolytica phosphomannose isomerase, putative 0.0736 0.7389 0.8269
Mycobacterium tuberculosis Conserved protein 0.0107 0.086 0.2164
Schistosoma mansoni hypothetical protein 0.0382 0.3717 0.3863
Toxoplasma gondii phosphofructokinase PFKII 0.0066 0.0436 0.0414
Loa Loa (eye worm) PHD-finger family protein 0.0066 0.0431 0.0432
Schistosoma mansoni chromobox protein 0.0079 0.0566 0.0589
Loa Loa (eye worm) jmjC domain-containing protein 0.0136 0.1158 0.1189
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0107 0.086 0.0872
Echinococcus granulosus methyl CpG binding domain protein 2 0.0038 0.0147 0.0153
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.033 0.3173 0.8146
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.187 0.1846
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0207 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0143 0.0114
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0113 0.0118
Loa Loa (eye worm) PHD-finger family protein 0.0047 0.0231 0.0224
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0103 0.0107
Brugia malayi hypothetical protein 0.0035 0.0111 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0036 0.0124 0.0019
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0431 0.0409
Schistosoma mansoni glutaminase 0.0587 0.5849 0.6078
Brugia malayi acetyltransferase, GNAT family protein 0.0483 0.4765 0.4943
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0399 0.389 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0725 0.0753
Trypanosoma cruzi polo-like protein kinase, putative 0.0413 0.4035 0.4128
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0021 0.0022
Echinococcus multilocularis hexokinase 0.0337 0.3249 0.3376
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0036 0.0124 0.0095
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0066 0.0431 0.0448
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0303 0.0315
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0736 0.7389 0.7679
Onchocerca volvulus Putative phosphomannomutase 0.0144 0.124 0.2317
Brugia malayi phosphomannomutase 2 0.0144 0.124 0.1274
Loa Loa (eye worm) acetyltransferase 0.0483 0.4765 0.4943
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0413 0.4035 0.4183
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0043 0.0197 0.0205
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0621 0.6197 0.6432
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.1162 0.1193
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.2527 0.2626
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.1007 0.2545
Schistosoma mansoni smad1 5 8 and 0.0026 0.0021 0.0022
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0163 0.0362
Loa Loa (eye worm) hypothetical protein 0.004 0.0163 0.0153
Brugia malayi jmjC domain containing protein 0.015 0.131 0.1348
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0477 0.048
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0461 0.0479
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0107 0.086 0.2164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.014 0.0304
Entamoeba histolytica phosphofructokinase, putative 0.0245 0.2294 0.255
Loa Loa (eye worm) hypothetical protein 0.0081 0.0591 0.0599
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0399 0.389 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0021 0.0022
Loa Loa (eye worm) phosphomannomutase 2 0.0144 0.124 0.1274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0103 0.0107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0752 0.0782
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0987 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0282 0.2676 0.2781
Loa Loa (eye worm) glutaminase 0.0587 0.5849 0.6072
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.1147 0.2908
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0337 0.3247 0.3619
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0073 0.0043
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0081 0.0591 0.0615
Brugia malayi nuclear receptor NHR-88 0.0034 0.0103 0.0091
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0039 0.0152 0.013
Onchocerca volvulus Hexokinase homolog 0.0211 0.1944 0.3753
Echinococcus granulosus histone acetyltransferase KAT2B 0.0464 0.457 0.4749
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0207 0.0177
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0066 0.0436 0.0464
Trichomonas vaginalis CAMK family protein kinase 0.0413 0.4035 0.4017
Loa Loa (eye worm) hypothetical protein 0.0108 0.0868 0.0887
Mycobacterium tuberculosis Probable reductase 0.0121 0.1007 0.2545
Giardia lamblia Histone acetyltransferase GCN5 0.0129 0.1085 0.0973
Echinococcus multilocularis hexokinase 0.0337 0.3249 0.3376
Leishmania major hypothetical protein, conserved 0.0408 0.3983 0.4125
Entamoeba histolytica phosphofructokinase, putative 0.0245 0.2294 0.255
Leishmania major hexokinase, putative 0.0337 0.3249 0.3361
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.1147 0.2908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0103 0.0091
Giardia lamblia Kinase, PLK 0.0413 0.4035 0.396
Plasmodium vivax glutathione reductase, putative 0.0053 0.03 0.0278
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0987 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0103 0.0091
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0053 0.0303 0.0292
Schistosoma mansoni coup transcription factor 0.0034 0.0103 0.0107
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0987 1 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0523 0.0562
Loa Loa (eye worm) hypothetical protein 0.0044 0.0207 0.0199
Trichomonas vaginalis bromodomain-containing protein, putative 0.0146 0.1262 0.1236
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0523 0.0529
Onchocerca volvulus 0.0337 0.3249 0.6412
Brugia malayi jmjC domain containing protein 0.0039 0.0152 0.0142
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0107 0.086 0.0872
Brugia malayi Bromodomain containing protein 0.0098 0.0766 0.0781
Onchocerca volvulus 0.0055 0.0315 0.0431
Brugia malayi Hexokinase family protein 0.0104 0.0831 0.0849
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0303 0.0292
Echinococcus granulosus Smad4 0.0026 0.0021 0.0022
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0039 0.0152 0.013
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0621 0.6197 0.6189
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0113 0.0091
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0408 0.3983 0.4074
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0066 0.0436 0.0414
Loa Loa (eye worm) transcription factor SMAD2 0.0387 0.3763 0.3901
Loa Loa (eye worm) hypothetical protein 0.0053 0.0303 0.0299
Brugia malayi MH2 domain containing protein 0.0026 0.0021 0.0006
Echinococcus granulosus PHD finger protein rhinoceros 0.0066 0.0431 0.0448
Loa Loa (eye worm) hypothetical protein 0.0081 0.0591 0.0599
Schistosoma mansoni smad1 5 8 and 0.0026 0.0021 0.0022
Mycobacterium ulcerans glutaminase 0.0587 0.5849 0.6069
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0039 0.0152 0.0049
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.031 0.0288
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0461 0.0479
Schistosoma mansoni 6-phosphogluconolactonase 0.0036 0.0124 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0103 0.0091
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.1147 0.2908
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0951 0.9623 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0331 0.3183 0.3547
Brugia malayi jmjC domain containing protein 0.0039 0.0152 0.0142
Loa Loa (eye worm) hexokinase 0.0337 0.3249 0.3365
Echinococcus multilocularis citrate lyase subunit beta protein 0.0107 0.086 0.0893
Echinococcus multilocularis zinc finger protein 0.0056 0.0328 0.0341
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0103 0.0107
Brugia malayi glutaminase DH11.1 0.0587 0.5849 0.6072
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0081 0.0591 0.057
Echinococcus granulosus hexokinase type 2 0.0337 0.3249 0.3376
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0276 0.0287
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0377 0.3665 0.3799
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0303 0.0725
Echinococcus multilocularis 6 phosphogluconolactonase 0.0036 0.0124 0.0129
Loa Loa (eye worm) 6-phosphofructokinase 0.0245 0.2294 0.2371
Schistosoma mansoni hypothetical protein 0.0382 0.3717 0.3863
Plasmodium vivax 6-phosphofructokinase, putative 0.0066 0.0436 0.0414
Brugia malayi chromobox protein homolog 3 0.0044 0.0207 0.0199
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0113 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.0066 0.0436 0.0407
Echinococcus granulosus hexokinase 0.0337 0.3249 0.3376
Toxoplasma gondii 6-phosphofructokinase 0.0066 0.0436 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0143 0.0114
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0107 0.086 0.0872
Echinococcus granulosus 6 phosphogluconolactonase 0.0036 0.0124 0.0129
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0103 0.0107
Brugia malayi hexokinase 0.0337 0.3249 0.3365
Loa Loa (eye worm) hypothetical protein 0.0087 0.0647 0.0657
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0752 0.0782
Toxoplasma gondii phosphomannose isomerase type I protein 0.0736 0.7389 0.7383
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0431 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.031 0.0215
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.1162 0.1193
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0477 0.0496
Plasmodium vivax hexokinase, putative 0.0337 0.3249 0.3234
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0306 0.2925 0.2962
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0081 0.0591 0.0593
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0884 0.8931 0.8929
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0103 0.0107
Echinococcus granulosus smad 0.0026 0.0021 0.0022
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0081 0.0591 0.057
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0725 0.0753
Echinococcus multilocularis PHD finger protein rhinoceros 0.0066 0.0431 0.0448
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0303 0.0725
Loa Loa (eye worm) hypothetical protein 0.004 0.0163 0.0153
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0113 0.0095
Echinococcus granulosus jumonji domain containing 1A 0.0039 0.0152 0.0158
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0103 0.0091
Loa Loa (eye worm) hypothetical protein 0.0268 0.2527 0.2614
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0303 0.0292
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0951 0.9623 1
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0884 0.8931 0.8928
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0081 0.0591 0.051
Brugia malayi Bromodomain containing protein 0.0181 0.1626 0.1676
Brugia malayi ecdysteroid receptor 0.0034 0.0103 0.0091
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0113 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0752 0.0767
Brugia malayi Bromodomain containing protein 0.0083 0.0608 0.0616
Plasmodium falciparum macrophage migration inhibitory factor 0.0884 0.8931 0.8929
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0951 0.9623 1
Onchocerca volvulus 0.0053 0.0303 0.0407
Echinococcus multilocularis geminin 0.0382 0.3717 0.3863
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0222 0.2054 0.2121
Brugia malayi 6-phosphogluconolactonase family protein 0.0036 0.0124 0.0113
Entamoeba histolytica acetyltransferase, GNAT family 0.0129 0.1085 0.1193
Trichomonas vaginalis CAMK family protein kinase 0.0413 0.4035 0.4017
Echinococcus multilocularis smad 0.0026 0.0021 0.0022
Echinococcus granulosus hexokinase 0.0337 0.3249 0.3376
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0461 0.0457
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0951 0.9623 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0113 0.0091
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0103 0.0107
Brugia malayi jmjC domain containing protein 0.0039 0.0152 0.0142
Leishmania major phosphomannomutase, putative 0.0144 0.124 0.1268
Schistosoma mansoni 6-phosphofructokinase 0.0245 0.2294 0.2384
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0523 0.0544
Trypanosoma cruzi hexokinase, putative 0.0337 0.3249 0.3302
Loa Loa (eye worm) TAR-binding protein 0.0136 0.1162 0.1193
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0103 0.0107
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.2527 0.2626
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0036 0.0124 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0103 0.0091
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0162 0.1426 0.1461
Brugia malayi MH2 domain containing protein 0.0026 0.0021 0.0006
Entamoeba histolytica hypothetical protein 0.0043 0.0199 0.0198
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0113 0.0008
Giardia lamblia Fructose-bisphosphate aldolase 0.0331 0.3183 0.3097
Trichomonas vaginalis phosphofructokinase, putative 0.0066 0.0436 0.0407
Loa Loa (eye worm) hypothetical protein 0.0104 0.0824 0.0841
Loa Loa (eye worm) hypothetical protein 0.0222 0.2054 0.2121
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0276 0.0287
Schistosoma mansoni jumonji domain containing protein 0.0039 0.0152 0.0158
Loa Loa (eye worm) hexokinase 0.0104 0.0831 0.0849
Echinococcus granulosus tar DNA binding protein 0.0136 0.1162 0.1207
Schistosoma mansoni hypothetical protein 0.0035 0.0106 0.011
Leishmania major hypothetical protein, conserved 0.093 0.9403 0.9771
Onchocerca volvulus Alhambra homolog 0.0066 0.0431 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0413 0.4035 0.4017
Schistosoma mansoni phosphatidylserine receptor 0.0039 0.0152 0.0158
Echinococcus multilocularis phosphomannomutase 0.0144 0.124 0.1288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0113 0.0118
Loa Loa (eye worm) hypothetical protein 0.0066 0.0431 0.0432
Brugia malayi steroid hormone receptor 0.0034 0.0103 0.0091
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0199 0.0207
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0207 0.0211
Schistosoma mansoni jumonji domain containing protein 0.0238 0.2216 0.2303
Mycobacterium ulcerans hypothetical protein 0.0053 0.0303 0.0292
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0477 0.0496
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0303 0.0299
Brugia malayi glutathione reductase 0.0053 0.03 0.0296
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0053 0.0303 0.0292
Loa Loa (eye worm) hypothetical protein 0.0039 0.0152 0.0142
Plasmodium falciparum phosphomannomutase, putative 0.0144 0.124 0.122
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0303 0.0292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.014 0.0304
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0038 0.0147 0.0153
Echinococcus multilocularis dnaJ subfamily C 6 0.0069 0.0468 0.0486
Brugia malayi Latrophilin receptor protein 2 0.007 0.0477 0.048
Loa Loa (eye worm) hypothetical protein 0.004 0.0163 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0103 0.0091
Trypanosoma brucei trypanothione reductase 0.0053 0.03 0.0289
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0066 0.0436 0.043
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.0307
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0282 0.2676 0.2781
Loa Loa (eye worm) hypothetical protein 0.004 0.0163 0.0153
Echinococcus granulosus dnaJ subfamily C 6 0.0069 0.0468 0.0486
Mycobacterium ulcerans 6-phosphofructokinase 0.0245 0.2294 0.2366
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0199 0.0207
Trypanosoma brucei phosphomannose isomerase 0.0736 0.7389 0.7673
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0303 0.0299
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0951 0.9623 1
Loa Loa (eye worm) glutathione reductase 0.0053 0.03 0.0296
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0081 0.0591 0.0563
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0081 0.0589 0.0613
Brugia malayi Heterochromatin protein 1 0.0079 0.0566 0.0573
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0103 0.0107
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0162 0.1426 0.3628
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.031 0.0215
Schistosoma mansoni protein phosphatase 2C 0.0039 0.0152 0.0158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0103 0.0107
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0245 0.2294 0.5873
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0461 0.1134
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0039 0.0152 0.0049
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0725 0.0738
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0081 0.0591 0.0563
Echinococcus granulosus lysine specific demethylase 6a 0.0039 0.0152 0.0158
Echinococcus multilocularis tar DNA binding protein 0.0136 0.1162 0.1207
Brugia malayi 6-phosphofructokinase 0.0245 0.2294 0.2371
Brugia malayi 6-phosphofructokinase 0.0245 0.2294 0.2371
Loa Loa (eye worm) bromodomain containing protein 0.0052 0.0283 0.0278
Loa Loa (eye worm) hypothetical protein 0.0107 0.0861 0.088
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0523 0.0522
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0461 0.0457
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0987 1 1
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0884 0.8931 1
Entamoeba histolytica hypothetical protein 0.0043 0.0199 0.0198
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0951 0.9623 1
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0081 0.0591 0.0593
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.03 0.0311
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0036 0.0124 0.0113
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0081 0.0591 0.0615
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0103 0.0091
Loa Loa (eye worm) RNA binding protein 0.0136 0.1162 0.1193
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0066 0.0436 0.0407
Echinococcus multilocularis bloom syndrome protein 0.0027 0.003 0.0031
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0245 0.2294 0.5873
Echinococcus granulosus zinc finger protein 0.0056 0.0328 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0103 0.0091
Plasmodium falciparum hexokinase 0.0337 0.3249 0.3234
Trypanosoma brucei hexokinase 0.0337 0.3249 0.3361
Schistosoma mansoni hypothetical protein 0.007 0.0477 0.0496
Loa Loa (eye worm) 6-phosphofructokinase 0.0245 0.2294 0.2371
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1162 0.1207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0752 0.0782
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0103 0.0091
Treponema pallidum fructose-bisphosphate aldolase 0.0331 0.3183 0.3292
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0303 0.0292
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0043 0.0197 0.0205
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0146 0.1262 0.1243
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0146 0.1262 0.1243
Mycobacterium ulcerans hypothetical protein 0.0107 0.086 0.0872
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0884 0.8931 0.928
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Brugia malayi hypothetical protein 0.0268 0.2527 0.2614
Schistosoma mansoni hypothetical protein 0.007 0.0477 0.0496
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0103 0.0107
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.1007 0.2545
Onchocerca volvulus 0.0337 0.3249 0.6412
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0036 0.0124 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0103 0.0091
Brugia malayi serine/threonine-protein kinase plk-2 0.0413 0.4035 0.4183
Leishmania major 6-phosphogluconolactonase 0.0036 0.0124 0.0106
Trypanosoma cruzi phosphomannose isomerase, putative 0.0736 0.7389 0.7653
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0987 1 1
Schistosoma mansoni bromodomain containing protein 0.0154 0.1352 0.1405
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.014 0.0304
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.03 0.0203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.014 0.0304
Trypanosoma brucei hexokinase 0.0337 0.3249 0.3361
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0113 0.0095
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0315 0.0311
Entamoeba histolytica hypothetical protein 0.0043 0.0199 0.0198
Giardia lamblia PHD finger protein 15 0.0066 0.0431 0.031
Schistosoma mansoni smad1 5 8 and 0.0026 0.0021 0.0022
Schistosoma mansoni hypothetical protein 0.0047 0.0231 0.024
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0736 0.7389 0.7383
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0081 0.0591 0.0563
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0163 0.014
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0066 0.0436 0.043
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0523 0.0529
Brugia malayi Hexokinase family protein 0.0337 0.3249 0.3365
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0081 0.0591 0.1471
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0107 0.086 0.0792
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0036 0.0124 0.0264
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0163 0.014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0103 0.0091
Loa Loa (eye worm) hypothetical protein 0.0039 0.0152 0.0142
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0483 0.4765 0.4951
Trichomonas vaginalis CAMK family protein kinase 0.0413 0.4035 0.4017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0103 0.0107
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Entamoeba histolytica serine/threonine protein kinase, putative 0.0413 0.4035 0.4504
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0066 0.0436 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.3183 0.3162
Schistosoma mansoni serine/threonine protein kinase 0.0413 0.4035 0.4193
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.03 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.187 0.1846
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0276 0.0287
Schistosoma mansoni 6-phosphogluconolactonase 0.0036 0.0124 0.0129
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0103 0.0107
Brugia malayi MH2 domain containing protein 0.0387 0.3763 0.3901
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0752 0.0782
Trypanosoma brucei ISWI complex protein 0.0035 0.0106 0.0087
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0461 0.044
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0107 0.086 0.0792
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0066 0.0436 0.0315
Onchocerca volvulus Serine\/threonine kinase homolog 0.0413 0.4035 0.8014
Loa Loa (eye worm) hypothetical protein 0.0034 0.0103 0.0091
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.1262 0.1312
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0103 0.0107
Echinococcus granulosus aspartyl aminopeptidase 0.0081 0.0591 0.0615
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0103 0.0091
Schistosoma mansoni hypothetical protein 0.007 0.0477 0.0496
Entamoeba histolytica phosphofructokinase, putative 0.0245 0.2294 0.255
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0566 0.0538
Schistosoma mansoni hypothetical protein 0.0069 0.0468 0.0486
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0987 1 1
Trichomonas vaginalis hypothetical protein 0.0038 0.0143 0.0114
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0245 0.2294 0.2366
Loa Loa (eye worm) hypothetical protein 0.023 0.2136 0.2207
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0103 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.031 0.0288
Brugia malayi PHD-finger family protein 0.0068 0.0453 0.0455
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0163 0.0146
Trypanosoma brucei hypothetical protein, conserved 0.093 0.9403 0.9771
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0752 0.0767
Loa Loa (eye worm) hexokinase 0.0337 0.3249 0.3365
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.1007 0.2545
Brugia malayi glucose-6-phosphate dehydrogenase 0.0951 0.9623 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0113 0.0118
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0021 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.015 0.131 0.1362
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.03 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0103 0.0091
Brugia malayi phosphofructokinase 0.0245 0.2294 0.2371
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0103 0.0107
Loa Loa (eye worm) hypothetical protein 0.004 0.0163 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0303 0.0299
Schistosoma mansoni phd/f-box containing protein 0.0039 0.0152 0.0158
Echinococcus granulosus chromobox protein 1 0.0079 0.0566 0.0589
Brugia malayi RNA binding protein 0.0136 0.1162 0.1193
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0736 0.7389 0.7675
Schistosoma mansoni zinc finger protein 0.0056 0.0328 0.0341
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0103 0.0107
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0951 0.9623 1
Brugia malayi latrophilin 2 splice variant baaae 0.0152 0.1324 0.1362
Brugia malayi DnaJ domain containing protein 0.0069 0.0468 0.047
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0413 0.4035 0.4193
Onchocerca volvulus 0.0094 0.0725 0.1267
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0477 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0103 0.0091
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0021 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0752 0.0782
Loa Loa (eye worm) hypothetical protein 0.0507 0.5009 0.5198
Loa Loa (eye worm) hypothetical protein 0.0053 0.0303 0.0299
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0103 0.0107
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0081 0.0591 0.051
Echinococcus multilocularis hexokinase 0.0337 0.3249 0.3376
Trypanosoma cruzi hypothetical protein, conserved 0.093 0.9403 0.9769
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0303 0.0292
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0036 0.0124 0.0114
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0036 0.0124 0.0019
Plasmodium falciparum JmjC domain-containing protein, putative 0.0039 0.0152 0.013
Trypanosoma cruzi polo-like protein kinase, putative 0.0413 0.4035 0.4128
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0113 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.0066 0.0436 0.0407
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0036 0.0124 0.0106
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0152 0.0142
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0103 0.0107
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0147 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0303 0.0725
Echinococcus granulosus phd:f box containing protein 0.0039 0.0152 0.0158

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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