Detailed view for LmjF.33.1750

Basic information

TDR Targets ID: 25921
Leishmania major, macrophage migration inhibitory factor-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7056 | Length (AA): 113 | MW (Da): 12585 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01187   Macrophage migration inhibitory factor (MIF)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 113 1uiz (A) 0 113 27.00 0 1 1.41 -1.04
2 113 2gdg (A) 1 113 19.00 0 0.91 1.36 -1.24
1 113 3fwt (A) 0 112 99.99 0 1 2.2258 -1.33
2 58 1otf (A) 2 58 18.00 0.011 0.17 0.684625 -0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3B64:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3FWT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3FWU:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129767)

Species Accession Gene Product
Arabidopsis thaliana AT5G01650   tautomerase/MIF superfamily protein
Arabidopsis thaliana AT5G57170   Tautomerase/MIF superfamily protein
Brugia malayi Bm1_28435   Bm-MIF-1, identical
Caenorhabditis elegans CELE_Y56A3A.3   Protein MIF-1
Entamoeba histolytica EHI_092370   macrophage migration inhibitory factor-like protein
Giardia lamblia GL50803_12091   Macrophage migration inhibitory factor
Homo sapiens 4282   macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Leishmania braziliensis LbrM.33.2010   macrophage migration inhibitory factor-like protein
Leishmania donovani LdBPK_331840.1   macrophage migration inhibitory factor-like protein
Leishmania donovani LdBPK_331850.1   macrophage migration inhibitory factor-like protein
Leishmania infantum LinJ.33.1850   macrophage migration inhibitory factor-like protein
Leishmania infantum LinJ.33.1840   macrophage migration inhibitory factor-like protein
Leishmania major LmjF.33.1750   macrophage migration inhibitory factor-like protein
Leishmania major LmjF.33.1740   macrophage migration inhibitory factor-like protein
Leishmania mexicana LmxM.32.1740   macrophage migration inhibitory factor-like protein
Leishmania mexicana LmxM.32.1750   macrophage migration inhibitory factor-like protein
Loa Loa (eye worm) LOAG_08159   macrophage migration inhibitory factor
Mus musculus ENSMUSG00000033307   macrophage migration inhibitory factor
Neospora caninum NCLIV_042400   Macrophage migration inhibitory factor, related
Oryza sativa 4351273   Os12g0107500
Oryza sativa 4341957   Os06g0699500
Oryza sativa 4349563   Os11g0107500
Plasmodium berghei PBANKA_1444000   macrophage migration inhibitory factor
Plasmodium falciparum PF3D7_1229400   macrophage migration inhibitory factor
Plasmodium knowlesi PKNH_1448700   macrophage migration inhibitory factor, putative
Plasmodium vivax PVX_124095   macrophage migration inhibitory factor, putative
Plasmodium yoelii PY05452   hypothetical protein
Schmidtea mediterranea mk4.000420.02   Macrophage migration inhibitory factor
Schmidtea mediterranea mk4.000420.01   Macrophage migration inhibitory factor
Toxoplasma gondii TGME49_290040   macrophage migration inhibitory factor, putative
Trichomonas vaginalis TVAG_101850   conserved hypothetical protein
Trichomonas vaginalis TVAG_219770   macrophage migration inhibitory factor, mif, putative

Essentiality

LmjF.33.1750 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1444000 Plasmodium berghei Dispensable plasmo
TGME49_290040 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus macrophage migration inhibitory factor Compounds References
Homo sapiens macrophage migration inhibitory factor (glycosylation-inhibiting factor) Compounds References
Plasmodium falciparum macrophage migration inhibitory factor Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1132 1 1
0.0168 0.3898 1
0.0336 0.5 0.5
0.089 1 1
0.0371 0.368 1
0.0354 0.3315 0.5
0.0176 0.7021 0
0.2215 1 1
0.2492 1 1
0.3208 1 1
0.1759 0.257 1
0.0367 0.6874 1
0.3731 1 1
0.0237 1 0.5
0.2298 1 1
0.0931 1 1
0.1286 1 1
0.0205 0.2509 1
0.0202 0.3866 0.9277
0.0195 1 1
0.1377 1 1
0.0205 1 0.5
0.0039 1 0.5
0.1561 0.8886 0.8885
0.1546 1 0.5
0.1223 0.9373 0.9372
0.2706 1 0.5
0.0341 1 1
0.1877 1 1
0.0331 0.3085 0.9893
0.0884 0.8931 0.9279
0.1819 1 1
0.0205 0.8823 1
0.0205 0.7681 1
0.017 0.3587 1
0.0385 0.4746 1
0.0578 0.7754 1
0.0391 1 0.5
0.1343 0.2661 1
0.017 0.9732 0.5
0.1343 0.2661 1
0.3723 1 1
0.0205 0.2769 0.9437
0.1583 0.7028 0.7302
0.1976 1 1
0.122397 0.289571 0.93883
0.019 0.3829 0.5
0.0359 1 1
0.0383 0.4099 1
0.0564 1 1
0.0205 0.5224 0.5
0.089 1 1
0.2545 1 1
0.0175 0.3665 1
0.0764 1 1
0.0139 0.9141 1
0.153 1 1
0.0167 0.4367 1
0.122397 0.289571 0.93883
0.1204 0.5914 0.5914
0.0697 0.7074 0.7859
0.0384 0.4464 0.5926
0.1947 0.5244 0.8573
0.0348 0.3869 1
0.0343 0.4313 0.5
0.2362 1 0.5
0.2666 0.2639 1
0.1718 1 1
0.3731 1 1
0.2362 1 0.5
0.1139 0.6216 1
0.0572 0.4558 1
0.0331 0.3085 0.9893
0.122397 0.289571 0.93883
0.0587 0.274 1
0.0205 0.3737 0.5442
0.0524 1 1
0.0196 0.423 1
0.0933 1 0.5
0.0803 1 1
0.0205 0.2513 1
0.0205 0.7606 1
0.046 0.9324 1
0.0363 0.2537 1
0.1356 1 1
0.1771 0.7864 1
0.0194 0.273 1
0.0367 0.3313 0
0.0236 0.5718 0
0.1583 0.7028 0.7302
0.084 0.7828 0.7822
0.2112 1 0.5
0.0837 1 1
0.0195 1 0.5
0.0205 0.7681 1
0.3731 1 1
0.122397 0.289571 0.93883
0.0171 0.4951 1
0.0164 0.4658 0.5207
0.222 0.8227 0.8215
0.072 1 0.5
0.0205 0.3973 1
0.1759 0.257 1
0.2391 0.6707 0.6704
0.126 0.7632 0.9844
0.094 1 1
0.0696 0.3155 1
0.0191 0.4473 1
0.0205 1 1
0.1345 0.4124 0.4124
0.0338 0.9185 1
0.0205 1 0.5
0.0524 0.5237 1
0.0177 1 1
0.0205 0.5197 1
0.0837 0.4811 0.4796
0.216 0.8756 0.8752
0.0938219 0.5 0.5
0.0171 1 0.5
0.2666 0.2639 1
0.0524 0.6404 0.7688
0.0205 1 1
0.0367 0.3313 0
0.0184 0.3827 0.5
0.0175 1 1
0.1714 0.9797 0.9797
0.098 1 1
0.0211 1 0.5
0.0205 0.5 0.5
0.0356 0.4147 1
0.1155 0.9351 1
0.0383 0.4658 1
0.0174 1 0.5
0.0857 0.803 0.8027
0.1976 1 1
0.0114 0.35 1
0.0354 0.6862 1
0.0587 0.274 1
0.0345 0.3432 1
0.3669 1 1
0.0358 1 1
0.085 0.3908 0.3889
0.0147 0.2565 1
0.0318 0.3871 1
0.0684 0.7436 0.7711
0.0205 0.395 1
0.0926 1 1
0.1773 0.7216 0.7212
0.2171 1 1
0.0037 1 0.5
0.088 1 1
0.0377 0.3275 0.336
0.2298 1 1
0.018 0.2999 1
0.3221 0.2991 0.7888
0.054 1 0.5
0.2575 1 1
0.3669 1 1
0.0545 1 0.5
0.0205 0.6692 0.5
0.1112 1 1
0.017 1 1
0.0364 0.4437 1
0.0175 1 1
0.0345 0.4336 0.5
0.0913 0.907 1
0.0824 1 1
0.1777 1 1
0.0329 0.3474 1
0.1391 0.6107 0.6334
0.0166 0.4864 1
0.122397 0.289571 0.93883
0.0849 0.3775 0.6188
0.1185 1 1
0.0167 0.5151 1
0.195046 0.881654 0.874649
0.0331 0.3085 0.9893
0.1759 0.257 1
0.0367 0.3503 0.3617
0.1522 0.9268 1
0.1166 1 1
0.0352 0.497 1
0.0273 0.6481 0.5
0.1214 1 1
0.0248 0.5 0.5
0.0366 0.3592 1
0.0164 1 0.5
0.0177 0.2521 0.2473
0.2362 1 0.5
0.0205 0.452 1
0.0691 1 1
0.0696 0.3155 1
0.088 1 1
0.106223 0.5 0.5
0.0205 1 0.5
0.1546 1 0.5
0.1534 1 1
0.2171 1 1
0.0205 1 0.5
0.0205 0.5 0.5
0.0205 0.6371 1
0.0353 1 0.5
0.1644 0.9984 1
0.2391 0.6707 0.6704
0.0511 0.4971 0.4964
0.1215 1 1
0.1123 0.4153 1
0.458 1 1
0.0205 0.7565 1
0.0576 0.5811 1
0.086 1 1
0.0381 0.9959 1
0.0541 0.5191 0.5403
0.2706 1 0.5
0.0368 0.5476 1
0.0696 0.3155 1
0.017 1 1
0.0177 0.488 1
0.0172 1 0.5
0.0172 0.5256 0.5
0.0167 0.4843 1
0.1232 1 0.5
0.0854 1 1
0.0168 1 1
0.0781 1 1
0.2139 0.5257 0.861
0.0176 0.7021 0
0.0145064 0.5 0.5
0.138682 1 1
0.1583 1 1
0.0167 0.4843 1
0.2505 1 1
0.1123 0.4153 1
0.089 1 1
0.0273 0.6481 0.5
0.427 1 1
0.1033 0.7981 0.7975
0.1958 0.6188 0.6178
0.1759 0.257 1
0.0176 1 1
0.0688 0.4087 1
0.0696 0.3155 1
0.0387 1 0.5
0.0856 0.3897 0.3897
0.0186 0.2565 1
0.0352 0.4933 1
0.0861101 1 1
0.0849 0.3775 0.6188
0.2342 1 1
0.105 1 1
0.122397 0.289571 0.93883
0.0205 0.4328 0.9282
0.0896 1 1
0.0336 0.2989 0.2975
0.1141 1 0.5
0.1353 1 1
0.017 0.5552 1
0.1583 0.7028 0.7302
0.2272 1 1
0.248 0.3328 1
0.0694 1 1
0.1352 1 1
0.0176 0.7021 0
0.0371 1 0.5
0.0724 0.7373 1
0.0352 0.4187 1
0.0531 0.5341 1
0.1759 0.257 1
0.0164 0.2841 1
0.0145916 0.5 0.5
0.3731 1 1
0.1232 0.9016 1
0.0205 1 1
0.0339 0.4247 1
0.1389 1 1
0.1343 0.2661 1
0.0347 0.4181 1
0.122397 0.289571 0.93883
0.339 1 1
0.1358 1 1
0.0781 1 1
0.0714 1 1
0.0184 0.6201 1
0.37 1 1
0.0551 0.3248 1
0.0576 1 1
0.0697 0.7518 0.7816
0.0177 0.488 1
0.0337 0.7987 1
0.0205 1 1
0.1343 0.2661 1
0.0352 0.497 1
0.3208 1 1
0.0273 0.6481 0.5
0.0205 0.5 0.5
0.0156496 0.572463 0.544438
0.0892 1 1
0.0402 0.5154 1
0.0273 0.6481 0.5
0.0164 1 0.5
0.0205 0.2785 0.5
0.0524 0.6404 0.7688
0.1343 0.2661 1
0.248 0.3328 1
0.122397 0.289571 0.93883
0.0205 0.905 1
0.1406 1 0.5
0.0387 1 1
0.0849 0.3775 0.6188
0.1386 1 1
0.0518 1 1
0.1616 0.7323 0.7323
0.0171 0.4951 1
0.0168 0.3705 1
0.1339 1 1
0.0173 1 0.5
0.0145064 0.5 0.5
0.092 1 1
0.0368 1 0.5
0.0166 0.5475 1
0.0766 1 1
0.3236 1 1
0.1712 0.9761 0.976
0.0348 1 1
0.1339 1 1
0.3596 1 1
0.0205 1 0.5
0.1183 0.9149 0.9149
0.0331 0.3085 0.9893
0.046 0.9324 1
0.033 1 1
0.0179 0.2538 0.2538
0.0205 0.5 0.5
0.0329 0.3474 1
0.0224 0.3918 1
0.1377 1 1
0.0364 1 1
0.1419 0.7241 0.7241
0.3208 1 1
0.1206 1 1
0.0205 0.5 0.5
0.0205 1 1
0.1644 0.9984 1
0.0785 0.6486 1
0.0205 1 1
0.4049 1 1
0.1092 1 1
0.0917 0.4674 1
0.1186 0.601 0.6006
0.0882 0.888 0.9225
0.0153684 1 0.5
0.1561 0.8886 0.8885
0.122397 0.289571 0.93883
0.0171 0.5256 0.5
0.0849 0.8636 0.952
0.0282 0.2802 1
0.1024 0.4527 0.4519
0.2625 1 1
0.06 0.5944 1
0.0857 1 1
0.0837 0.4811 0.4796
0.1583 0.7028 0.7302
0.0198 0.3203 1
0.0689 0.2996 0.5
0.0621 0.6976 1
0.0167 0.9792 1
0.0561 0.5667 1
0.0175957 0.973797 1
0.1759 0.257 1
0.0329 0.4047 0.755
0.2679 1 1
0.0308 0.3545 0.757
0.0556 1 1
0.1795 1 1
0.1175 0.3387 1
0.2139 0.5257 0.861
0.0347 0.4143 1
0.0153684 1 0.5
0.0205 1 1
0.1754 1 1
0.0509 1 1
0.0186 0.4481 1
0.1031 0.4979 0.5064
0.0194 0.2613 0.5
0.035 0.4138 1
0.041 1 1
0.2191 0.8171 1
0.1759 0.257 1
0.1056 0.7796 0.8332
0.1759 0.257 1
0.1381 1 1
0.1546 1 0.5
0.3208 1 1
0.256 1 1
0.1267 0.6533 0.8405
0.0194 0.2613 0.5
0.1358 1 1
0.0426 0.4938 1
0.0541 0.3346 1
0.0738 0.709 1
0.2545 1 1
0.1896 0.702 0.7011
0.0884 0.8931 0.9279
0.085 0.3908 0.3889
0.0348 0.3128 0.3253
0.4055 1 1
0.2298 1 1
0.0373 0.4081 1
0.0889 0.9599 0.9978
0.1644 0.9984 1
0.1337 1 1
0.3723 1 1
0.2736 1 1
0.0248 0.5 0.5
0.4034 1 1
0.0165 0.5257 0.5
0.0205 0.3418 0.5
0.0365 1 1
0.0205 0.5197 1
0.0513 0.339 1
0.017 1 1
0.0524 1 0.5
0.0348 1 1
0.018 0.4837 1
0.0166 0.5581 1
0.0166 0.6068 0.5
0.0205 0.2531 0.5
0.1633 1 1
0.117 1 1
0.0709 0.6807 0.7105
0.1408 1 1
0.0205 0.2531 0.5
0.2139 0.5257 0.861
0.0533 0.627 1
0.0211 1 0.5
0.035 0.4138 1
0.036 0.4505 1
0.0341 0.3111 0.3223
0.1896 0.702 0.7011
0.0669 0.2658 0.2657
0.0697 0.4473 1
0.0195 1 0.5
0.0342 1 1
0.1561 0.8886 0.8885
0.0738 0.709 1
0.1909 0.4041 0.7686
0.103 0.9224 0.9223
0.0576 0.8308 1
0.0967 0.9718 1
0.147309 0.585579 0.563991
0.0305 1 0.5
0.0166 0.37 1
0.0172 0.5562 0.5355
0.0174 0.843 0.5
0.1039 0.5766 0.5766
0.339 1 1
0.0766 1 1
0.058 0.2538 1
0.0179 0.2538 0.2538
0.0205 0.6827 1
0.3221 0.2991 0.7888
0.0205 0.47 1
0.1543 1 1
0.0352 0.497 1
0.1623 1 1
0.0037 1 0.5
0.117 1 1
0.2391 0.6707 0.6704
0.0524 0.5237 1
0.0224 0.5 0.5
0.1343 0.2661 1
0.1775 1 1
0.0194 0.273 1
0.0336 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LmjF.33.1750 (Leishmania major), macrophage migration inhibitory factor-like protein
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