Detailed information for compound 834875

Basic information

Technical information
  • TDR Targets ID: 834875
  • Name: N-(3-methoxypropyl)-4-[(4-methylphenyl)methyl ]-2,3-dihydro-1,4-benzothiazine-6-carboxamide
  • MW: 370.508 | Formula: C21H26N2O2S
  • H donors: 1 H acceptors: 1 LogP: 3.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)c1ccc2c(c1)N(CCS2)Cc1ccc(cc1)C
  • InChi: 1S/C21H26N2O2S/c1-16-4-6-17(7-5-16)15-23-11-13-26-20-9-8-18(14-19(20)23)21(24)22-10-3-12-25-2/h4-9,14H,3,10-13,15H2,1-2H3,(H,22,24)
  • InChiKey: MUVSGAKVEMMGKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-methoxypropyl)-4-(4-methylbenzyl)-2,3-dihydro-1,4-benzothiazine-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.2544 0.3284
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0755 0.1119
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0041 0.0676 0.058
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0263 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0233 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Mycobacterium ulcerans glutamine synthetase 0.0416 1 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0176 0.0171
Trypanosoma brucei trypanothione reductase 0.005 0.0919 0.1869
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0165 0.0063
Entamoeba histolytica glutamine synthetase, putative 0.0107 0.2336 0.9166
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0739
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0176 0.0171
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0176 0.0171
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0176 0.0171
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0446 0.0397
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.2522 0.2483
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.284 0.2803
Brugia malayi Carboxylesterase family protein 0.0024 0.0275 0.0437
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0458 0.0467
Brugia malayi Pre-SET motif family protein 0.0222 0.5173 1
Echinococcus multilocularis glutamine synthetase 0.0203 0.4696 0.4915
Trypanosoma cruzi glutamine synthetase, putative 0.0203 0.4696 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0176 0.0244
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0176 0.0244
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0102 0.0109
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0052 0.0001
Loa Loa (eye worm) glutathione reductase 0.005 0.0919 0.1777
Loa Loa (eye worm) RGS-3 protein 0.002 0.0176 0.034
Mycobacterium leprae GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (Glutamate--ammonia ligase 1) (GS-I) 0.0214 0.4973 0.3278
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0107 0.2336 0.383
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0263 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0176 0.0126
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0233 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0176 0.0126
Chlamydia trachomatis glutamine binding protein 0.0041 0.0676 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0024 0.0275 0.0275
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0102 0.0052
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0102 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0458 0.0536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Echinococcus multilocularis expressed protein 0.0398 0.9541 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0446 0.1406
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0016 0.0062 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2544 0.4187
Loa Loa (eye worm) glutamate receptor 1 0.0016 0.0062 0.0119
Echinococcus granulosus bloom syndrome protein 0.0023 0.0233 0.0231
Echinococcus granulosus lamin dm0 0.0029 0.0382 0.0387
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0755 0.1514
Schistosoma mansoni glutamine synthetase bacteria 0.0321 0.764 1
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2544 0.4187
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.2544 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0491 0.0946
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0919 0.1869
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0226 0.0376
Schistosoma mansoni lamin 0.0029 0.0382 0.0435
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0102 0.0057
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0041 0.0676 0.0627
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0321 0.764 0.7628
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.2544 0.5366
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0919 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0446 0.0401
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0176 0.0171
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.284 0.2803
Schistosoma mansoni regulator of G protein signaling 0.002 0.0176 0.0164
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.2544 0.2505
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0755 0.1119
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0176 0.0126
Echinococcus granulosus para nitrobenzyl esterase 0.0024 0.0275 0.0275
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0176 0.0171
Trypanosoma brucei glutamine synthetase, putative 0.0203 0.4696 1
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.2544 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0176 0.0171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0531
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0102 0.0067
Brugia malayi Glutamate receptor 2 precursor 0.0016 0.0062 0.0021
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0056 0.1069 0.1108
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0176 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.0713
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0052 0.01
Trichomonas vaginalis spcc417.12 protein, putative 0.0024 0.0275 0.0296
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0062 0.0013
Schistosoma mansoni axis inhibition protein axin 0.002 0.0176 0.0164
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.2544 0.3284
Schistosoma mansoni neuroligin 3 (S09 family) 0.0024 0.0275 0.0294
Trypanosoma cruzi glutamine synthetase, putative 0.0203 0.4696 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0176 0.0164
Mycobacterium ulcerans hypothetical protein 0.0214 0.4973 0.4921
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.034
Echinococcus granulosus expressed protein 0.0398 0.9541 1
Echinococcus granulosus lamin 0.0029 0.0382 0.0387
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0919 0.1777
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0176 0.0244
Echinococcus multilocularis glutamate receptor 2 0.0016 0.0062 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Brugia malayi Carboxylesterase family protein 0.0024 0.0275 0.0437
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0107 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Echinococcus granulosus axis inhibition protein axin 0.002 0.0176 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0107 0.012
Trichomonas vaginalis set domain proteins, putative 0.0252 0.5934 1
Brugia malayi Glutamate receptor 1 precursor 0.0016 0.0062 0.0021
Echinococcus granulosus dna polymerase eta 0.0015 0.0052 0.0041
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.284 0.2803
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0755 0.0659
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0755 0.0779
Echinococcus granulosus glutamate receptor NMDA 0.0084 0.1755 0.1828
Echinococcus multilocularis carboxylesterase 5A 0.0144 0.3255 0.3402
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.2522 0.2483
Mycobacterium tuberculosis Carboxylesterase LipT 0.0024 0.0275 0.0224
Entamoeba histolytica hypothetical protein 0.002 0.0176 0.0498
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.2544 0.5366
Schistosoma mansoni regulator of G protein signaling 0.002 0.0176 0.0164
Toxoplasma gondii thioredoxin reductase 0.005 0.0919 0.0878
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0531
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0226 0.0175
Brugia malayi Pre-SET motif family protein 0.0032 0.0458 0.0795
Entamoeba histolytica hypothetical protein 0.002 0.0176 0.0498
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0919 0.0873
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0102 0.0052
Loa Loa (eye worm) acetylcholinesterase 1 0.0144 0.3255 0.6291
Echinococcus granulosus glutamine synthetase 0.0203 0.4696 0.4915
Schistosoma mansoni regulator of G protein signaling 0.002 0.0176 0.0164
Trichomonas vaginalis glutamine synthetase, putative 0.0107 0.2336 0.383
Echinococcus multilocularis para nitrobenzyl esterase 0.0024 0.0275 0.0275
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0102 0.0057
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0233 0.0231
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0102 0.0109
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0275 0.0224
Loa Loa (eye worm) carboxylesterase 0.0144 0.3255 0.6291
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0458 0.0536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Echinococcus multilocularis neuroligin 0.0024 0.0275 0.0275
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0919 0.0872
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0382 0.0739
Mycobacterium tuberculosis Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) 0.0214 0.4973 0.4947
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0102 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0176 0.0164
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0176 0.0244
Loa Loa (eye worm) carboxylesterase 0.0024 0.0275 0.0531
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0176 0.0171
Onchocerca volvulus 0.0032 0.0458 0.0325
Schistosoma mansoni intermediate filament proteins 0.0029 0.0382 0.0435
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0176 0.0171
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0263 0.0262
Echinococcus multilocularis BC026374 protein (S09 family) 0.0024 0.0275 0.0275
Schistosoma mansoni glutamate receptor NMDA 0.0016 0.0062 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0491 0.0949
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0052 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0176 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0458 0.0536
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0446 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0491 0.0946
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.034
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.2544 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0446 0.5985
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0024 0.0263 0.0262
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0755 0.0659
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0176 0.0171
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.2544 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0024 0.0275 0.0275
Leishmania major trypanothione reductase 0.005 0.0919 0.1869
Plasmodium falciparum glutamine synthetase, putative 0.0416 1 1
Echinococcus multilocularis acetylcholinesterase 0.0144 0.3255 0.3402
Echinococcus granulosus glutamate receptor 2 0.0024 0.0263 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0176 0.0126
Schistosoma mansoni regulator of G protein signaling 0.002 0.0176 0.0164
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0458 0.0414
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0416 1 1
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.2544 0.2656
Loa Loa (eye worm) Gln-2 protein 0.0203 0.4696 0.9077
Echinococcus multilocularis glutamate receptor NMDA 0.0084 0.1755 0.1828
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0446 0.0589
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0263 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0176 0.0164
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0016 0.0062 0.0051
Schistosoma mansoni glutamate receptor NMDA 0.0108 0.2349 0.3027
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0176 0.0171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0263 0.0262
Brugia malayi Carboxylesterase family protein 0.0144 0.3255 0.6254
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0755 0.1514
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0102 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0107 0.012
Brugia malayi Carboxylesterase family protein 0.0024 0.0275 0.0437
Brugia malayi intermediate filament protein 0.0029 0.0382 0.0646
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.034
Echinococcus granulosus carboxylesterase 5A 0.0144 0.3255 0.3402
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0051 0.0098
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.2544 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0016 0.0062 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0531
Schistosoma mansoni BC026374 protein (S09 family) 0.0024 0.0275 0.0294
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0176 0.034
Brugia malayi 6-phosphofructokinase 0.0116 0.2544 0.4866
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Trypanosoma brucei unspecified product 0.0037 0.058 0.1139
Echinococcus granulosus dna polymerase kappa 0.0044 0.0755 0.0779
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.034
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0024 0.0275 0.0296
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0062 0.0013
Brugia malayi phosphofructokinase 0.0116 0.2544 0.4866
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0275 0.0294
Brugia malayi PXA domain containing protein 0.002 0.0176 0.0244
Schistosoma mansoni lamin 0.0029 0.0382 0.0435
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0176 0.0171
Echinococcus multilocularis acetylcholinesterase 0.0144 0.3255 0.3402
Schistosoma mansoni gliotactin 0.0024 0.0275 0.0294
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0321 0.764 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Echinococcus granulosus BC026374 protein S09 family 0.0024 0.0275 0.0275
Plasmodium vivax glutathione reductase, putative 0.005 0.0919 0.0873
Leishmania major glutamine synthetase, putative 0.0203 0.4696 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0176 0.034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0052 0.0041
Echinococcus granulosus glutamate NMDA receptor subunit 0.0016 0.0062 0.0051
Loa Loa (eye worm) carboxylesterase 0.0024 0.0275 0.0531
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0114 0.0083
Echinococcus multilocularis musashi 0.0029 0.0382 0.0387
Echinococcus multilocularis lamin 0.0029 0.0382 0.0387
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0446 0.5985
Entamoeba histolytica hypothetical protein 0.002 0.0176 0.0498
Echinococcus multilocularis nmda type glutamate receptor 0.014 0.3155 0.3297
Onchocerca volvulus 0.0029 0.0382 0.019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0531
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0176 0.0171
Schistosoma mansoni axis inhibition protein axin 0.002 0.0176 0.0164
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0176 0.0171
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0176 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Plasmodium falciparum glutathione reductase 0.005 0.0919 0.0826
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0102 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0446 0.0589
Echinococcus multilocularis nmda type glutamate receptor 0.0092 0.1956 0.2039
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0016 0.0062 0.0051
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0041 0.0676 1
Brugia malayi hypothetical protein 0.002 0.0176 0.0244
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0176 0.0244
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0429 0.0437
Echinococcus granulosus intermediate filament protein 0.0029 0.0382 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0226 0.0376
Schistosoma mansoni glutamate receptor AMPA 0.0016 0.0062 0.0013
Giardia lamblia DINP protein human, muc B family 0.0022 0.0226 0.361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Loa Loa (eye worm) glutamate receptor 2 0.0016 0.0062 0.0119
Mycobacterium tuberculosis Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) 0.0214 0.4973 0.4947
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0531
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0531
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0025
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0263 0.0262
Onchocerca volvulus 0.0252 0.5934 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0016 0.0062 0.0051
Brugia malayi hypothetical protein 0.002 0.0176 0.0244
Echinococcus granulosus acetylcholinesterase 0.0144 0.3255 0.3402
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0041 0.0676 0.2349
Brugia malayi PXA domain containing protein 0.002 0.0176 0.0244
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0176 0.034
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.2544 0.2656
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0275 0.0224
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0016 0.0062 0.0051
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0176 0.0171
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0062 0.0013
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0446 0.0397
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0176 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0458 0.0536
Plasmodium falciparum thioredoxin reductase 0.005 0.0919 0.0826
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.2522 0.2483
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0446 0.0347
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.058 0.1139
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Echinococcus multilocularis dna polymerase eta 0.0015 0.0052 0.0041
Echinococcus granulosus neuroligin 0.0024 0.0275 0.0275
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0446 0.0589
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0144 0.3255 0.4221
Echinococcus multilocularis lamin dm0 0.0029 0.0382 0.0387
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2544 0.4187
Mycobacterium tuberculosis Probable reductase 0.0115 0.2522 0.2483
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0755 0.1514
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0102 0.0109
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0446 0.0347
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0102 0.0051
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0176 0.0126
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0176 0.0164
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0275 0.0294
Echinococcus granulosus axis inhibition protein axin 0.002 0.0176 0.0171
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0458 0.0467
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.2544 0.5366
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0416 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0062 0.0013
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.2544 0.2467
Schistosoma mansoni acetylcholinesterase 0.0024 0.0275 0.0294
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.034
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0446 0.158
Brugia malayi Carboxylesterase family protein 0.0024 0.0275 0.0437
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0382 0.0739
Echinococcus granulosus nmda type glutamate receptor 0.014 0.3155 0.3297
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0176 0.0164
Plasmodium vivax SET domain protein, putative 0.0032 0.0458 0.041
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0446 0.0401
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0102 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.034
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0102 0.0094
Brugia malayi glutathione reductase 0.005 0.0919 0.1696
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0176 0.034
Onchocerca volvulus Glutamine synthetase homolog 0.0203 0.4696 0.7812
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.2522 0.2483
Loa Loa (eye worm) hypothetical protein 0.0144 0.3255 0.6291
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2544 0.4187
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0382 0.0646
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.2522 0.2483
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0016 0.0062 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.5173 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0102 0.0109
Leishmania major DNA polymerase kappa, putative 0.0022 0.0226 0.0376
Brugia malayi Thioredoxin reductase 0.005 0.0919 0.1696
Loa Loa (eye worm) phosphofructokinase 0.0116 0.2544 0.4917
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0176 0.0164
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0275 0.0294
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0176 0.0171
Brugia malayi Carboxylesterase family protein 0.0144 0.3255 0.6254
Mycobacterium ulcerans carboxylesterase, LipT 0.0024 0.0275 0.0174
Echinococcus multilocularis NMDA receptor 0.0016 0.0062 0.0051
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0446 0.0589
Schistosoma mansoni ATP-binding cassette transporter 0.0016 0.0062 0.0013
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0263 0.0262
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0102 0.0109
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0176 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0176 0.0164
Brugia malayi polk-prov protein 0.0033 0.0491 0.0859
Loa Loa (eye worm) hypothetical protein 0.0015 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.0144 0.3255 0.6291
Onchocerca volvulus 0.0029 0.0382 0.019
Plasmodium vivax glutamine synthetase, putative 0.0416 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0458 0.0886
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0102 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0446 0.0589
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.284 0.0426
Loa Loa (eye worm) RecQ helicase 0.0023 0.0233 0.0451
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0102 0.0094
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0919 0.0951
Schistosoma mansoni glutamine synthetase bacteria 0.0321 0.764 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0458 0.0467
Brugia malayi 6-phosphofructokinase 0.0116 0.2544 0.4866
Toxoplasma gondii glutamine synthetase, type I, putative 0.0416 1 1
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0446 0.0401
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0024 0.0263 0.0262
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0446 0.0589
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0052 0.0001
Echinococcus granulosus acetylcholinesterase 0.0144 0.3255 0.3402
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0531
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0233 0.0356
Schistosoma mansoni glutamate receptor AMPA 0.0016 0.0062 0.0013
Entamoeba histolytica glutamine synthetase, putative 0.0107 0.2336 0.9166
Mycobacterium ulcerans hypothetical protein 0.0107 0.2336 0.2257
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.2544 0.4917
Echinococcus granulosus glutamate receptor subunit protein glur 0.0016 0.0062 0.0051
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.2544 0.4917
Brugia malayi hypothetical protein 0.0024 0.0275 0.0437
Mycobacterium tuberculosis Conserved hypothetical protein 0.0214 0.4973 0.4947
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0203 0.4696 0.612
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0446 1
Echinococcus granulosus nmda type glutamate receptor 0.0092 0.1956 0.2039
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0041 0.0676 0.2349

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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