Detailed information for compound 847704

Basic information

Technical information
  • TDR Targets ID: 847704
  • Name: 3-(2,5-dimethoxyphenyl)-1-(5-piperidin-1-yl-1 ,3,4-thiadiazol-2-yl)urea
  • MW: 363.435 | Formula: C16H21N5O3S
  • H donors: 2 H acceptors: 3 LogP: 2.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)Nc1nnc(s1)N1CCCCC1)OC
  • InChi: 1S/C16H21N5O3S/c1-23-11-6-7-13(24-2)12(10-11)17-14(22)18-15-19-20-16(25-15)21-8-4-3-5-9-21/h6-7,10H,3-5,8-9H2,1-2H3,(H2,17,18,19,22)
  • InChiKey: CDZDHZOIVXFPNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,5-dimethoxyphenyl)-1-[5-(1-piperidyl)-1,3,4-thiadiazol-2-yl]urea
  • 3-(2,5-dimethoxyphenyl)-1-(5-piperidino-1,3,4-thiadiazol-2-yl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0077 0.1827 0.1827
Giardia lamblia Kinase, NEK 0.0037 0 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0037 0 0.5
Echinococcus multilocularis transfer RNA-Phe 0.008 0.1955 0.1955
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0037 0 0.5
Schistosoma mansoni cell adhesion molecule 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.434 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0077 0.1827 0.1827
Onchocerca volvulus 0.008 0.1955 0.5332
Echinococcus granulosus c src tyrosine kinase 0.0055 0.0821 0.0821
Brugia malayi Protein kinase domain containing protein 0.0049 0.0526 0.1213
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Onchocerca volvulus Putative titin 0.008 0.1955 0.5332
Echinococcus multilocularis Immunoglobulin 0.0072 0.1557 0.1557
Trichomonas vaginalis protein tyrosine kinase, putative 0.0037 0 0.5
Echinococcus multilocularis titin 0.008 0.1955 0.1955
Echinococcus granulosus active breakpoint cluster region 0.0098 0.2787 0.2787
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi SRC-1 0.0084 0.2122 0.489
Schistosoma mansoni titin 0.008 0.1955 0.1955
Trichomonas vaginalis conserved hypothetical protein 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Onchocerca volvulus 0.0049 0.0526 0.1435
Loa Loa (eye worm) hypothetical protein 0.0072 0.1557 0.1601
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Schistosoma mansoni cell adhesion molecule 0.0104 0.302 0.302
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Trichomonas vaginalis TK family protein kinase 0.0037 0 0.5
Plasmodium falciparum protein kinase, putative 0.0037 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Brugia malayi Disorganized muscle protein 1 0.008 0.1955 0.4504
Entamoeba histolytica protein kinase, putative 0.0066 0.1301 1
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.008 0.1955 0.1955
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0084 0.2122 0.2122
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0118 0.3666 0.3666
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni neuroglian 0.0104 0.302 0.302
Echinococcus granulosus Immunoglobulin 0.0072 0.1557 0.1557
Brugia malayi Myb-like DNA-binding domain containing protein 0.008 0.1955 0.4504
Echinococcus granulosus tyrosine kinase 0.0049 0.0526 0.0526
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis neuroglian 0.0152 0.5223 0.5223
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus tyrosine protein kinase HCK 0.0066 0.1301 0.1301
Loa Loa (eye worm) hypothetical protein 0.0072 0.1557 0.1601
Loa Loa (eye worm) SRC-1 0.0084 0.2122 0.2181
Echinococcus granulosus hemicentin 1 0.0104 0.302 0.302
Onchocerca volvulus 0.008 0.1955 0.5332
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.008 0.1955 0.2009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Toxoplasma gondii protein kinase 0.0037 0 0.5
Schistosoma mansoni hypothetical protein 0.008 0.1955 0.1955
Schistosoma mansoni slit 0.008 0.1955 0.1955
Leishmania major protein kinase, putative 0.0037 0 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0104 0.302 0.302
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Echinococcus granulosus nephrin 0.008 0.1955 0.1955
Schistosoma mansoni hypothetical protein 0.008 0.1955 0.1955
Plasmodium falciparum tyrosine kinase-like protein 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0066 0.1301 0.1301
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1955 0.1955
Plasmodium vivax tyrosine kinase-like protein, putative 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis Immunoglobulin 0.0072 0.1557 0.1557
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0104 0.302 0.302
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0104 0.3023 0.3023
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0118 0.3666 0.3768
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0095 0.2623 0.2623
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0049 0.0526 0.0526
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis twitchin 0.008 0.1955 0.1955
Echinococcus multilocularis tyrosine protein kinase shark 0.0256 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Echinococcus granulosus down syndrome cell adhesion 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0055 0.0821 0.0821
Echinococcus multilocularis tyrosine protein kinase ABL1 0.025 0.9729 0.9729
Echinococcus granulosus tyrosine protein kinase Src64B 0.0084 0.2122 0.2122
Schistosoma mansoni cell adhesion molecule 0.0104 0.302 0.302
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0104 0.302 0.3104
Schistosoma mansoni titin 0.008 0.1955 0.1955
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Brugia malayi kettin 0.008 0.1955 0.4504
Brugia malayi Fibronectin type III domain containing protein 0.0072 0.1557 0.3588
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0104 0.302 0.302
Brugia malayi SH2 domain containing protein 0.0049 0.0526 0.1213
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Onchocerca volvulus 0.008 0.1955 0.5332
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni nephrin related 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0049 0.0526 0.1213
Onchocerca volvulus 0.008 0.1955 0.5332
Echinococcus granulosus titin 0.008 0.1955 0.1955
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Loa Loa (eye worm) projectin 0.008 0.1955 0.2009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Leishmania major hypothetical protein, conserved 0.0037 0 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0118 0.3666 0.3666
Brugia malayi Immunoglobulin I-set domain containing protein 0.0132 0.4334 0.9987
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Echinococcus multilocularis roundabout 2 0.0104 0.302 0.302
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus neuroglian 0.0104 0.302 0.302
Echinococcus multilocularis neuroglian 0.0104 0.302 0.302
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Onchocerca volvulus 0.008 0.1955 0.5332
Echinococcus multilocularis active breakpoint cluster region 0.0098 0.2787 0.2787
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Schistosoma mansoni hypothetical protein 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Plasmodium falciparum protein kinase, putative 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Schistosoma mansoni titin 0.008 0.1955 0.1955
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Loa Loa (eye worm) hypothetical protein 0.0175 0.6289 0.6464
Echinococcus granulosus tyrosine protein kinase ABL1 0.025 0.9729 0.9729
Echinococcus multilocularis titin 0.008 0.1955 0.1955
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Schistosoma mansoni septate junction protein 0.0104 0.302 0.302
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.2122 0.2122
Echinococcus multilocularis 0.008 0.1955 0.1955
Echinococcus granulosus insulin growth factor binding 0.008 0.1955 0.1955
Schistosoma mansoni cell adhesion molecule 0.0104 0.302 0.302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Schistosoma mansoni tyrosine kinase 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.008 0.1955 0.1955
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0055 0.0821 0.0821
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Trichomonas vaginalis AGC family protein kinase 0.0037 0 0.5
Onchocerca volvulus 0.008 0.1955 0.5332
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trypanosoma cruzi protein kinase, putative 0.0037 0 0.5
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0037 0 0.5
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis roundabout 2 0.0104 0.302 0.302
Trypanosoma brucei Pseudokinase, putative 0.0037 0 0.5
Loa Loa (eye worm) CAMK protein kinase 0.008 0.1955 0.2009
Trichomonas vaginalis conserved hypothetical protein 0.0037 0 0.5
Brugia malayi Peroxidasin 0.0104 0.302 0.696
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis hemicentin 1 0.0104 0.302 0.302
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0055 0.0821 0.0821
Schistosoma mansoni myosin-binding protein-related 0.008 0.1955 0.1955
Loa Loa (eye worm) hypothetical protein 0.0072 0.1557 0.1601
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0037 0 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0 0.5
Echinococcus granulosus twitchin 0.0152 0.5223 0.5223
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.2122 0.2122
Echinococcus multilocularis tyrosine protein kinase Blk 0.0077 0.1827 0.1827
Echinococcus multilocularis lachesin 0.0104 0.302 0.302
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0072 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Echinococcus multilocularis tyrosine protein kinase otk 0.0104 0.302 0.302
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.1557 0.3588
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni tyrosine kinase 0.0084 0.2122 0.2122
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Schistosoma mansoni hypothetical protein 0.008 0.1955 0.1955
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Loa Loa (eye worm) one IG domain family member 0.008 0.1955 0.2009
Trichomonas vaginalis conserved hypothetical protein 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Loa Loa (eye worm) hypothetical protein 0.0049 0.0526 0.0541
Loa Loa (eye worm) disorganized muscle protein 1 0.008 0.1955 0.2009
Echinococcus granulosus contactin 0.0104 0.302 0.302
Loa Loa (eye worm) TK/ABL protein kinase 0.025 0.9729 1
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Echinococcus granulosus tyrosine protein kinase Srms 0.0049 0.0526 0.0526
Onchocerca volvulus 0.0049 0.0526 0.1435
Echinococcus granulosus titin 0.008 0.1955 0.1955
Trichomonas vaginalis CAMK family protein kinase 0.0037 0 0.5
Schistosoma mansoni vesicular amine transporter 0.0072 0.1557 0.1557
Echinococcus granulosus roundabout 2 0.0104 0.302 0.302
Leishmania major protein kinase, putative 0.0037 0 0.5
Echinococcus granulosus titin 0.008 0.1955 0.1955
Schistosoma mansoni titin 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0104 0.302 0.3104
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Schistosoma mansoni titin 0.008 0.1955 0.1955
Schistosoma mansoni titin 0.0104 0.302 0.302
Onchocerca volvulus 0.008 0.1955 0.5332
Onchocerca volvulus 0.008 0.1955 0.5332
Loa Loa (eye worm) animal heme peroxidase 0.008 0.1955 0.2009
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.2122 0.2122
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0084 0.2122 0.2122
Loa Loa (eye worm) TK protein kinase 0.0066 0.1301 0.1337
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.1557 0.1601
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Toxoplasma gondii protein kinase domain-containing protein 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.1557 0.1601
Echinococcus granulosus roundabout 2 0.0104 0.302 0.302
Echinococcus multilocularis tyrosine protein kinase Srms 0.0077 0.1827 0.1827
Trypanosoma brucei protein kinase, putative 0.0037 0 0.5
Brugia malayi Prion-like- 0.008 0.1955 0.4504
Trypanosoma cruzi protein kinase, putative 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni hypothetical protein 0.008 0.1955 0.1955
Schistosoma mansoni nephrin 0.0152 0.5223 0.5223
Onchocerca volvulus Netrin receptor homolog 0.008 0.1955 0.5332
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Echinococcus multilocularis tyrosine kinase 0.0049 0.0526 0.0526
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus pro neuregulin 2 membrane bound 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0104 0.302 0.3104
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Onchocerca volvulus Tyrosine kinase homolog 0.0118 0.3666 1
Schistosoma mansoni cell adhesion molecule 0.008 0.1955 0.1955
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0116 0.0116
Echinococcus granulosus defective proboscis extension response 0.0072 0.1557 0.1557
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Onchocerca volvulus 0.008 0.1955 0.5332
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis roundabout 2 0.0175 0.6289 0.6289
Schistosoma mansoni titin 0.008 0.1955 0.1955
Echinococcus multilocularis titin 0.008 0.1955 0.1955
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0104 0.302 0.3104
Onchocerca volvulus Peroxidasin homolog 0.008 0.1955 0.5332
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0084 0.2122 0.2122
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0084 0.2122 0.2122
Plasmodium falciparum protein kinase, putative 0.0037 0 0.5
Toxoplasma gondii STE kinase 0.0037 0 0.5
Onchocerca volvulus 0.008 0.1955 0.5332
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi protein-tyrosine kinase 0.0077 0.1827 0.421
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0104 0.302 0.302
Echinococcus multilocularis peroxidasin 0.0104 0.302 0.302
Plasmodium vivax protein kinase, putative 0.0037 0 0.5
Echinococcus granulosus leucine rich repeat containing protein 4 0.008 0.1955 0.1955
Echinococcus granulosus roundabout 2 0.0175 0.6289 0.6289
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.008 0.1955 0.1955
Echinococcus multilocularis insulin growth factor binding 0.008 0.1955 0.1955
Plasmodium falciparum tyrosine kinase-like protein 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0175 0.6289 0.6464
Giardia lamblia Kinase 0.0037 0 0.5
Echinococcus multilocularis hemicentin 1 0.0104 0.302 0.302
Echinococcus granulosus tyrosine protein kinase Blk 0.0077 0.1827 0.1827
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Trichomonas vaginalis protein kinase atn1, putative 0.0037 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0037 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.2122 0.2122
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni hypothetical protein 0.008 0.1955 0.1955
Onchocerca volvulus Peroxidasin homolog 0.008 0.1955 0.5332
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.008 0.1955 0.1955
Brugia malayi protein unc-22 0.008 0.1955 0.4504
Brugia malayi hypothetical protein 0.0049 0.0526 0.1213
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0037 0 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0084 0.2122 0.2122
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Onchocerca volvulus 0.0049 0.0526 0.1435
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.3973 0.9154
Echinococcus granulosus tyrosine protein kinase otk 0.0104 0.302 0.302
Trichomonas vaginalis conserved hypothetical protein 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.1557 0.1601
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Schistosoma mansoni tyrosine kinase 0.0141 0.4732 0.4732
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0084 0.2122 0.2122
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Loa Loa (eye worm) TK protein kinase 0.0118 0.3666 0.3768
Brugia malayi Immunoglobulin I-set domain containing protein 0.0118 0.3666 0.8448
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0072 0.1557 0.1557
Echinococcus multilocularis down syndrome cell adhesion 0.008 0.1955 0.1955
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0526 0.0541
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi hypothetical protein 0.0072 0.1557 0.3588
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0072 0.1557 0.1557
Echinococcus multilocularis titin 0.008 0.1955 0.1955
Schistosoma mansoni tyrosine kinase 0.0245 0.9474 0.9474
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.2122 0.2122
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0104 0.302 0.302
Brugia malayi SH2 domain containing protein 0.0049 0.0526 0.1213
Brugia malayi Prion-like- 0.008 0.1955 0.4504
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0084 0.2122 0.2122
Onchocerca volvulus 0.008 0.1955 0.5332
Echinococcus granulosus titin 0.008 0.1955 0.1955
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0104 0.302 0.8238
Brugia malayi Leucine Rich Repeat family protein 0.008 0.1955 0.4504
Schistosoma mansoni cell adhesion molecule 0.008 0.1955 0.1955
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0037 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0049 0.0526 0.0526
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Onchocerca volvulus 0.0049 0.0526 0.1435
Echinococcus multilocularis c src tyrosine kinase 0.0055 0.0821 0.0821
Schistosoma mansoni tyrosine kinase 0.0049 0.0526 0.0526
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Echinococcus multilocularis tyrosine protein kinase Abl 0.0132 0.434 0.434
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.008 0.1955 0.1955
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0037 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.302 0.696
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Brugia malayi Prion-like- 0.008 0.1955 0.4504
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.2122 0.2122
Schistosoma mansoni titin 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0037 0 0.5
Echinococcus granulosus titin 0.008 0.1955 0.1955
Echinococcus granulosus tyrosine kinase 0.0077 0.1827 0.1827
Loa Loa (eye worm) hypothetical protein 0.0114 0.3519 0.3617
Schistosoma mansoni tyrosine kinase 0.0055 0.0821 0.0821
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.2122 0.2122
Schistosoma mansoni nephrin 0.0104 0.302 0.302
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus lachesin 0.0104 0.302 0.302
Loa Loa (eye worm) TK protein kinase 0.0077 0.1827 0.1878
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Brugia malayi Protein kinase domain containing protein 0.0049 0.0526 0.1213
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Schistosoma mansoni tyrosine kinase 0.0084 0.2122 0.2122
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0116 0.0116
Echinococcus granulosus peroxidasin 0.0104 0.302 0.302
Schistosoma mansoni tyrosine kinase 0.0055 0.0821 0.0821
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.008 0.1955 0.1955
Loa Loa (eye worm) hypothetical protein 0.0095 0.2623 0.2696
Schistosoma mansoni roundabout 0.0104 0.302 0.302
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0084 0.2122 0.2122
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0104 0.302 0.302
Brugia malayi Prion-like- 0.0104 0.302 0.696
Schistosoma mansoni hypothetical protein 0.008 0.1955 0.1955
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Echinococcus granulosus neuroglian 0.0152 0.5223 0.5223
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Giardia lamblia Protein 21.1 0.0037 0 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1955 0.2009
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.008 0.1955 0.4504
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Trichomonas vaginalis STE family protein kinase 0.0037 0 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.1955 0.2009
Schistosoma mansoni tyrosine kinase 0.0239 0.9203 0.9203
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0295 0.0295
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.2122 0.2122
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0526 0.4045
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0104 0.302 0.302
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Schistosoma mansoni septate junction protein 0.0104 0.302 0.302
Brugia malayi Protein kinase domain containing protein 0.0049 0.0526 0.1213
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0132 0.4334 0.4455
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni cell adhesion molecule 0.0095 0.2623 0.2623
Brugia malayi Animal haem peroxidase family protein 0.008 0.1955 0.4504
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0049 0.0526 0.1213
Onchocerca volvulus 0.0049 0.0526 0.1435
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1955 0.4504
Giardia lamblia Kinase, NEK 0.0037 0 0.5
Onchocerca volvulus 0.0049 0.0526 0.1435
Loa Loa (eye worm) hypothetical protein 0.0104 0.302 0.3104
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5
Schistosoma mansoni hemicentin 0.008 0.1955 0.1955
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0037 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0037 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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