Detailed information for compound 89334

Basic information

Technical information
  • TDR Targets ID: 89334
  • Name: 1-[[2-[5-(4-fluorophenoxy)furan-2-yl]cyclopro pyl]methyl]-1-hydroxyurea
  • MW: 306.289 | Formula: C15H15FN2O4
  • H donors: 2 H acceptors: 2 LogP: 1.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Oc1ccc(o1)C1CC1CN(C(=O)N)O
  • InChi: 1S/C15H15FN2O4/c16-10-1-3-11(4-2-10)21-14-6-5-13(22-14)12-7-9(12)8-18(20)15(17)19/h1-6,9,12,20H,7-8H2,(H2,17,19)
  • InChiKey: WOGQYJHBRFGHHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[[2-[5-(4-fluorophenoxy)-2-furyl]cyclopropyl]methyl]-1-hydroxy-urea
  • 1-[[2-[5-(4-fluorophenoxy)-2-furyl]cyclopropyl]methyl]-1-hydroxyurea
  • 1-[[2-[5-(4-fluorophenoxy)furan-2-yl]cyclopropyl]methyl]-1-hydroxy-urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0033 0.007 0.0104
Toxoplasma gondii RNA-directed DNA polymerase 0.0093 0.092 0.7332
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.007 0.0104
Echinococcus multilocularis BC026374 protein (S09 family) 0.0085 0.0808 0.1197
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0253 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Loa Loa (eye worm) hypothetical protein 0.0085 0.0808 0.1197
Onchocerca volvulus 0.0065 0.053 0.1043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0253 0.0345
Giardia lamblia Cathepsin B precursor 0.0061 0.0463 0.3983
Schistosoma mansoni intermediate filament proteins 0.0058 0.0429 0.0537
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.012 0.0074
Echinococcus multilocularis ankyrin repeat protein 0.0346 0.4536 0.6717
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.1228 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0065 0.053 0.1286
Echinococcus multilocularis neuroligin 0.0085 0.0808 0.1197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Loa Loa (eye worm) hypothetical protein 0.0114 0.1228 0.1818
Onchocerca volvulus 0.0085 0.0808 0.1681
Leishmania major cathepsin L-like protease 0.0065 0.053 0.0905
Brugia malayi Cathepsin L-like precursor 0.0065 0.053 0.0725
Echinococcus granulosus cysteine protease 0.0036 0.011 0.0163
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0161 0.0155
Onchocerca volvulus 0.0065 0.053 0.1043
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.1228 0.1084
Echinococcus granulosus geminin 0.0172 0.2049 0.3034
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.011 0.006
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1228 0.2777
Onchocerca volvulus 0.0058 0.0429 0.0811
Trichomonas vaginalis set domain proteins, putative 0.0265 0.3378 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0093 0.092 0.1959
Brugia malayi cathepsin L-like precursor 0.0045 0.0244 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Leishmania major cysteine peptidase A (CPA) 0.0065 0.053 0.0905
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1228 0.1732
Loa Loa (eye worm) hypothetical protein 0.0161 0.1892 0.2801
Giardia lamblia Cathepsin B precursor 0.0061 0.0463 0.3983
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0244 0.3182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.1228 0.1764
Mycobacterium ulcerans hypothetical protein 0.0172 0.2046 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.1228 0.1818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Toxoplasma gondii ABC1 family protein 0.0114 0.1228 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1087 0.1609
Brugia malayi Latrophilin receptor protein 2 0.0033 0.007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0502 0.6754 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.007 0.0104
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0161 0.0174
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0161 0.5
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0161 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.0229
Loa Loa (eye worm) hypothetical protein 0.0104 0.1087 0.1609
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.0229
Echinococcus multilocularis lamin 0.0058 0.0429 0.0635
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.1228 0.1084
Onchocerca volvulus 0.0045 0.0244 0.0385
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0085 0.0808 0.1197
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0502 0.6754 1
Leishmania major mitochondrial DNA polymerase beta 0.0326 0.4245 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0429 0.0635
Brugia malayi Pre-SET motif family protein 0.0233 0.2919 0.4285
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1276 0.189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Plasmodium vivax vivapain-3 0.0036 0.011 0.0083
Echinococcus multilocularis cathepsin L cysteine protease 0.0065 0.053 0.0785
Echinococcus granulosus intermediate filament protein 0.0058 0.0429 0.0635
Loa Loa (eye worm) hypothetical protein 0.0033 0.0076 0.0112
Loa Loa (eye worm) hypothetical protein 0.0045 0.0244 0.0361
Echinococcus multilocularis cysteine protease 0.0065 0.053 0.0785
Mycobacterium ulcerans hypothetical protein 0.0114 0.1228 0.5658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0076 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.012 0.0177
Onchocerca volvulus 0.0065 0.053 0.1043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Schistosoma mansoni lamin 0.0058 0.0429 0.0537
Echinococcus granulosus cathepsin l1 0.0045 0.0244 0.0361
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0065 0.053 0.0785
Plasmodium vivax circumsporozoite (CS) protein 0.0324 0.4224 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1087 0.1554
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0148 0.1705 0.3857
Loa Loa (eye worm) hypothetical protein 0.0045 0.0244 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Brugia malayi intermediate filament protein 0.0058 0.0429 0.0574
Plasmodium vivax vivapain-2 0.0065 0.053 0.1096
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1228 0.342
Loa Loa (eye worm) hypothetical protein 0.0114 0.1228 0.1818
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1276 0.189
Onchocerca volvulus 0.0085 0.0808 0.1681
Brugia malayi hypothetical protein 0.0085 0.0808 0.1139
Echinococcus granulosus acetylcholinesterase 0.0502 0.6754 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0161 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0993 0.1381
Leishmania major cathepsin L-like protease 0.0065 0.053 0.0905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0993 0.1381
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1228 0.2703
Brugia malayi cathepsin B-like cysteine proteinase 0.0161 0.1892 0.2754
Echinococcus granulosus cathepsin b 0.0161 0.1892 0.2801
Brugia malayi Carboxylesterase family protein 0.0502 0.6754 1
Loa Loa (eye worm) beta-lactamase 0.0114 0.1228 0.1818
Leishmania major cathepsin L-like protease 0.0065 0.053 0.0905
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0808 0.1105
Echinococcus granulosus cathepsin L cysteine protease 0.0036 0.011 0.0163
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1892 0.2726
Loa Loa (eye worm) hypothetical protein 0.0502 0.6754 1
Echinococcus multilocularis cathepsin L 0.0036 0.011 0.0163
Echinococcus granulosus para nitrobenzyl esterase 0.0085 0.0808 0.1197
Loa Loa (eye worm) hypothetical protein 0.0114 0.1228 0.1818
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.1228 0.1084
Onchocerca volvulus 0.0065 0.053 0.1043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0993 0.1471
Schistosoma mansoni hypothetical protein 0.0036 0.012 0.0074
Plasmodium vivax telomerase reverse transcriptase, putative 0.0093 0.092 0.2036
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0161 0.0123
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.053 0.0725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0244 0.0409
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.053 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0244 0.0409
Brugia malayi Cathepsin L-like precursor 0.0065 0.053 0.0725
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 0.4245 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1228 0.1732
Echinococcus granulosus lamin dm0 0.0058 0.0429 0.0635
Schistosoma mansoni ap endonuclease 0.0039 0.0161 0.0135
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.1228 0.5658
Plasmodium vivax unspecified product 0.0319 0.4153 0.983
Loa Loa (eye worm) hypothetical protein 0.0057 0.0414 0.0613
Plasmodium falciparum circumsporozoite (CS) protein 0.0324 0.4224 1
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.1228 0.1084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.1228 0.1084
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0346 0.4536 0.6682
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0093 0.092 0.1959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Mycobacterium tuberculosis Carboxylesterase LipT 0.0085 0.0808 0.0658
Echinococcus multilocularis lamin dm0 0.0058 0.0429 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Loa Loa (eye worm) hypothetical protein 0.0071 0.0616 0.0913
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1228 0.342
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0396 0.0691
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.1228 0.1818
Brugia malayi Carboxylesterase family protein 0.0502 0.6754 1
Onchocerca volvulus 0.0114 0.1228 0.2642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0993 0.1471
Brugia malayi beta-lactamase family protein 0.0114 0.1228 0.1764
Echinococcus multilocularis cathepsin L cysteine protease 0.0065 0.053 0.0785
Echinococcus multilocularis cathepsin b 0.0161 0.1892 0.2801
Onchocerca volvulus 0.0114 0.1228 0.2642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0993 0.1415
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.1228 0.1818
Loa Loa (eye worm) carboxylesterase 0.0085 0.0808 0.1197
Mycobacterium tuberculosis Conserved protein 0.0114 0.1228 0.1084
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0161 0.1892 0.431
Mycobacterium tuberculosis Conserved protein 0.0114 0.1228 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0339 0.4434 1
Onchocerca volvulus 0.0265 0.3378 0.7576
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1892 0.2726
Brugia malayi Pre-SET motif family protein 0.0033 0.0076 0.0047
Brugia malayi Carboxylesterase family protein 0.0085 0.0808 0.1139
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0065 0.053 0.0785
Echinococcus granulosus cathepsin l cysteine peptidase 0.0065 0.053 0.0785
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.011 0.0098
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.2919 0.4322
Loa Loa (eye worm) hypothetical protein 0.0065 0.053 0.0785
Leishmania major cathepsin L-like protease 0.0168 0.1991 0.4483
Onchocerca volvulus 0.0085 0.0808 0.1681
Echinococcus granulosus carboxylesterase 5A 0.0502 0.6754 1
Schistosoma mansoni acetylcholinesterase 0.0085 0.0808 0.1105
Echinococcus granulosus acetylcholinesterase 0.0502 0.6754 1
Leishmania major cathepsin L-like protease 0.0065 0.053 0.0905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Echinococcus granulosus BC026374 protein S09 family 0.0085 0.0808 0.1197
Mycobacterium leprae conserved hypothetical protein 0.0114 0.1228 0.5
Plasmodium vivax unspecified product 0.0036 0.011 0.0083
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0161 0.0205
Loa Loa (eye worm) carboxylesterase 0.0085 0.0808 0.1197
Loa Loa (eye worm) hypothetical protein 0.0085 0.0808 0.1197
Echinococcus multilocularis acetylcholinesterase 0.0502 0.6754 1
Schistosoma mansoni hypothetical protein 0.0172 0.2049 0.296
Leishmania major telomerase reverse transcriptase, putative 0.0093 0.092 0.186
Echinococcus granulosus lamin 0.0058 0.0429 0.0635
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0058 0.0086
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0061 0.0463 0.0854
Brugia malayi hypothetical protein 0.0036 0.012 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0076 0.0008
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.011 0.006
Onchocerca volvulus 0.0085 0.0808 0.1681
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.1991 0.455
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.053 0.0785
Brugia malayi MH2 domain containing protein 0.0118 0.1276 0.1836
Mycobacterium leprae Probable lipase LipE 0.0114 0.1228 0.5
Leishmania major cathepsin L-like protease 0.0065 0.053 0.0905
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0161 0.0238
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0076 0.0112
Echinococcus multilocularis transient receptor potential cation channel 0.0353 0.4637 0.6866
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0065 0.053 0.1021
Onchocerca volvulus Cathepsin L homolog 0.0065 0.053 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0463 0.1081
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0161 0.1892 0.2726
Brugia malayi beta-lactamase family protein 0.0114 0.1228 0.1764
Brugia malayi Carboxylesterase family protein 0.0085 0.0808 0.1139
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.2046 0.1916
Brugia malayi beta-lactamase 0.0114 0.1228 0.1764
Echinococcus granulosus cathepsin L 0.0036 0.011 0.0163
Plasmodium vivax vivapain-2 0.0065 0.053 0.1096
Schistosoma mansoni ap endonuclease 0.0039 0.0161 0.0135
Brugia malayi Telomerase reverse transcriptase 0.0246 0.3114 0.4575
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.1228 0.1084
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.053 0.0688
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0429 0.0574
Loa Loa (eye worm) hypothetical protein 0.0085 0.0808 0.1197
Onchocerca volvulus 0.0085 0.0808 0.1681
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0085 0.0808 0.1197
Trypanosoma cruzi cruzipain precursor, putative 0.0168 0.1991 0.455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0616 0.0853
Onchocerca volvulus 0.0065 0.053 0.1043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.007 0.0104
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1798 0.4009
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.053 0.1016
Onchocerca volvulus 0.0058 0.0429 0.0811
Schistosoma mansoni lamin 0.0058 0.0429 0.0537
Loa Loa (eye worm) cysteine protease 0.0065 0.053 0.0785
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0244 0.026
Loa Loa (eye worm) acetylcholinesterase 1 0.0502 0.6754 1
Toxoplasma gondii exonuclease III APE 0.0039 0.0161 0.0738
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.1798 0.4082
Echinococcus granulosus neuroligin 0.0085 0.0808 0.1197
Trypanosoma cruzi major cysteine proteinase, putative 0.0118 0.1285 0.2841
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.012 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1228 0.2703
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0161 0.0123
Schistosoma mansoni gliotactin 0.0085 0.0808 0.1105
Onchocerca volvulus 0.0114 0.1228 0.2642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0993 0.1471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Loa Loa (eye worm) hypothetical protein 0.0085 0.0808 0.1197
Echinococcus multilocularis geminin 0.0172 0.2049 0.3034
Brugia malayi Carboxylesterase family protein 0.0085 0.0808 0.1139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1228 0.342
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0808 0.1105
Echinococcus granulosus GPCR family 2 0.0033 0.007 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Mycobacterium tuberculosis Conserved protein 0.0114 0.1228 0.1084
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0085 0.0808 0.2137
Loa Loa (eye worm) cathepsin B 0.0061 0.0463 0.0686
Schistosoma mansoni BC026374 protein (S09 family) 0.0085 0.0808 0.1105
Entamoeba histolytica cysteine protease, putative 0.0065 0.053 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.007 0.0104
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1798 0.4082
Toxoplasma gondii cathepsin CPL 0.0065 0.053 0.3946
Brugia malayi Cathepsin L-like precursor 0.0065 0.053 0.0725
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0065 0.053 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0253 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0993 0.1381
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0076 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0065 0.053 0.1286
Echinococcus granulosus transient receptor potential cation channel 0.0353 0.4637 0.6866
Echinococcus granulosus cathepsin l1 0.0065 0.053 0.0785
Echinococcus granulosus ankyrin repeat protein 0.0346 0.4536 0.6717
Loa Loa (eye worm) ctsf protein 0.0065 0.053 0.0785
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0161 0.0238
Plasmodium vivax vivapain-1 0.0036 0.011 0.0083
Loa Loa (eye worm) hypothetical protein 0.0085 0.0808 0.1197
Loa Loa (eye worm) hypothetical protein 0.0085 0.0808 0.1197
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.0229
Brugia malayi Cathepsin L-like precursor 0.0065 0.053 0.0725
Toxoplasma gondii hypothetical protein 0.0053 0.0349 0.2371
Trypanosoma brucei cysteine peptidase C (CPC) 0.0061 0.0463 0.0854
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0993 0.1471
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1228 0.342
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.007 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1228 0.342
Brugia malayi Cytochrome P450 family protein 0.0038 0.0136 0.0138
Trichomonas vaginalis spcc417.12 protein, putative 0.0085 0.0808 0.2137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1087 0.1554
Echinococcus granulosus cathepsin L cysteine proteinase 0.0065 0.053 0.0785
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0253 0.0345
Loa Loa (eye worm) hypothetical protein 0.0058 0.0429 0.0635
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0808 0.1105
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.011 0.006
Brugia malayi Cathepsin L-like precursor 0.0065 0.053 0.0725
Brugia malayi Cathepsin L-like precursor 0.0045 0.0244 0.0298
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.1991 0.455
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0085 0.0808 0.0658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Schistosoma mansoni neuroligin 3 (S09 family) 0.0085 0.0808 0.1105
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0161 0.5
Brugia malayi Carboxylesterase family protein 0.0085 0.0808 0.1139
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0076 0.0112
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0044 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.4245 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0065 0.053 0.1021
Mycobacterium ulcerans beta-lactamase 0.0114 0.1228 0.5658
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0061 0.0463 0.0741
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0161 0.0238
Loa Loa (eye worm) carboxylesterase 0.0502 0.6754 1
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.0229
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0429 0.0635
Schistosoma mansoni hypothetical protein 0.0071 0.0616 0.0817
Echinococcus multilocularis cysteine protease 0.0065 0.053 0.0785
Schistosoma mansoni hypothetical protein 0.0172 0.2049 0.296
Brugia malayi Cathepsin L-like precursor 0.0065 0.053 0.0725
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.007 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Onchocerca volvulus 0.0065 0.053 0.1043
Echinococcus multilocularis cathepsin b 0.0161 0.1892 0.2801
Loa Loa (eye worm) hypothetical protein 0.0114 0.1228 0.1818
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0993 0.1471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Loa Loa (eye worm) hypothetical protein 0.0114 0.1228 0.1818
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0463 0.0588
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0076 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.011 0.0098
Toxoplasma gondii cathepsin B 0.0061 0.0463 0.3364
Mycobacterium ulcerans carboxylesterase, LipT 0.0085 0.0808 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Onchocerca volvulus 0.0065 0.053 0.1043
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0104
Onchocerca volvulus Cathepsin F homolog 0.0065 0.053 0.1043
Leishmania major cathepsin L-like protease 0.0168 0.1991 0.4483
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0161 0.1206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1991 0.455
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0161 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.1228 0.2703
Trichomonas vaginalis esterase, putative 0.0114 0.1228 0.342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0076 0.0008
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.053 1
Onchocerca volvulus Cathepsin L homolog 0.0065 0.053 0.1043
Giardia lamblia Cathepsin B precursor 0.0061 0.0463 0.3983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.053 0.1286
Echinococcus granulosus cathepsin b 0.0161 0.1892 0.2801
Echinococcus multilocularis acetylcholinesterase 0.0502 0.6754 1
Echinococcus multilocularis musashi 0.0058 0.0429 0.0635
Giardia lamblia Telomerase catalytic subunit 0.0093 0.092 1
Mycobacterium ulcerans lipase LipD 0.0114 0.1228 0.5658
Echinococcus multilocularis para nitrobenzyl esterase 0.0085 0.0808 0.1197
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.4245 1
Brugia malayi Cathepsin L-like precursor 0.0045 0.0244 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.053 0.1286
Loa Loa (eye worm) fibroinase 0.0065 0.053 0.0785
Leishmania major cathepsin L-like protease 0.0168 0.1991 0.4483
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.1991 0.455
Echinococcus multilocularis carboxylesterase 5A 0.0502 0.6754 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.1228 0.5658
Leishmania major hypothetical protein, conserved 0.0114 0.1228 0.2612
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0136 0.0202
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0065 0.053 0.1021
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0085 0.0808 0.0658
Brugia malayi Cathepsin L-like cysteine proteinase 0.0045 0.0244 0.0298
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1892 0.2726
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.053 0.0688
Loa Loa (eye worm) hypothetical protein 0.0085 0.0808 0.1197
Trypanosoma brucei telomerase reverse transcriptase 0.0093 0.092 0.1959
Plasmodium falciparum telomerase reverse transcriptase 0.0093 0.092 0.1969
Loa Loa (eye worm) hypothetical protein 0.0114 0.1228 0.1818
Loa Loa (eye worm) hypothetical protein 0.0045 0.0244 0.0361

Activities

Activity type Activity value Assay description Source Reference
GT rate (ADMET) = 0.74 nM min-1 (mg of protein)-1 Rate of glucuronidation (nmol/min/mg protein) in monkey microsomes ChEMBL. 9207936
Inhibition (functional) = 50 % Percent inhibition of LTE4 formation in rats from peritoneal fluids at a dose of 200 micro mol/Kg ChEMBL. 9207936
Inhibition (functional) = 50 % Percent inhibition of LTE4 formation in rats from peritoneal fluids at a dose of 200 micro mol/Kg ChEMBL. 9207936
Inhibition (functional) = 77 % The compound was tested for stimulation of human whole blood with calcium ionophore (A23187) to produce LTB4. ChEMBL. 9207936
Inhibition (functional) = 77 % The compound was tested for stimulation of human whole blood with calcium ionophore (A23187) to produce LTB4. ChEMBL. 9207936

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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