Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trans-sialidase | 0.0324 | 0.2547 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0324 | 0.2547 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1184 | 1 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1184 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.0892 | 0.0892 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.0892 | 0.0892 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0324 | 0.2547 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Giardia lamblia | Protein tyrosine phosphatase | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0324 | 0.2547 | 0.9998 |
Trypanosoma brucei | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1172 | 0.9895 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0324 | 0.2547 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.0892 | 0.0892 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0729 | 0.6055 | 0.6119 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1184 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1184 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.1172 | 0.9895 | 1 |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.003 | 0 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0324 | 0.2547 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.