TDR Targets

Basic information

Technical information

TDR Targets ID: 909568
Name: N-[5-(5-nitro-2-oxo-1H-indol-3-ylidene)-4-oxo -1,3-thiazol-2-yl]benzenesulfonamide
MW: 430.415 | Formula: C17H10N4O6S2
H donors: 2 H acceptors: 6 LogP: 1.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N=C(S/C/1=C/1\C(=O)Nc2c1cc(cc2)[N+](=O)[O-])NS(=O)(=O)c1ccccc1
InChi: 1S/C17H10N4O6S2/c22-15-13(11-8-9(21(24)25)6-7-12(11)18-15)14-16(23)19-17(28-14)20-29(26,27)10-4-2-1-3-5-10/h1-8H,(H,18,22)(H,19,20,23)/b14-13+
InChiKey: FAJRVLBSDPFARW-BUHFOSPRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(5E)-5-(5-nitro-2-oxo-1H-indol-3-ylidene)-4-oxo-1,3-thiazol-2-yl]benzenesulfonamide
N-[5-(5-nitro-2-oxo-indolin-3-ylidene)-4-oxo-thiazol-2-yl]benzenesulfonamide
N-[(5E)-5-(5-nitro-2-oxo-indolin-3-ylidene)-4-oxo-thiazol-2-yl]benzenesulfonamide
N-[5-(5-nitro-2-oxo-3-indolinylidene)-4-oxo-2-thiazolyl]benzenesulfonamide
N-[(5E)-5-(5-nitro-2-oxo-3-indolinylidene)-4-oxo-2-thiazolyl]benzenesulfonamide
N-[4-keto-5-(2-keto-5-nitro-indolin-3-ylidene)thiazol-2-yl]benzenesulfonamide
N-[(5E)-4-keto-5-(2-keto-5-nitro-indolin-3-ylidene)thiazol-2-yl]benzenesulfonamide
STOCK1S-46338
CBMicro_011800
BIM-0011805.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.4787	0.4002
Giardia lamblia	Multidrug resistance-associated protein 1	0.0021	0.3604	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.4787	0.4002
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.6577	0.6577
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Trichomonas vaginalis	abcb9, putative	0.0025	0.4787	0.4002
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0021	0.3604	0.3523
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0039	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0015	0.1309	0.1309
Schistosoma mansoni	smdr2	0.0025	0.4787	0.185
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0021	0.3604	0.3604
Trichomonas vaginalis	taga, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Schistosoma mansoni	multidrug resistance protein	0.0025	0.4787	0.185
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0021	0.3604	0.3604
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0039	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.4787	0.4002
Echinococcus multilocularis	multidrug resistance protein 1	0.0025	0.4787	0.4787
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Entamoeba histolytica	P-glycoprotein-2, putative	0.0025	0.4787	0.185
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.6579	0.6579
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0039	1	1
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0039	1	1
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.6577	0.6577
Brugia malayi	ABC transporter family protein	0.0025	0.4787	0.185
Giardia lamblia	Multidrug resistance-associated protein 1	0.0021	0.3604	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.4787	0.4787
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3604	0.3523
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Echinococcus multilocularis	ATP binding cassette sub family B	0.0024	0.4662	0.4662
Echinococcus granulosus	multidrug resistance protein 1	0.0015	0.1309	0.1309
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.4787	0.4002
Brugia malayi	multidrug resistance protein 3	0.0025	0.4787	0.185
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0025	0.4787	0.4721
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0039	1	1
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.4787	0.4002
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0021	0.3604	0.3604
Entamoeba histolytica	P-glycoprotein 5, putative	0.0025	0.4787	0.185
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0025	0.4787	0.185
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.4787	0.4002
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.6577	0.6577
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.4787	0.4787
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.4787	0.4002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3604	0.3523
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0039	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0039	1	1
Entamoeba histolytica	P-glycoprotein-2	0.0025	0.4787	0.185
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.4787	0.4787
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	abcb9, putative	0.0025	0.4787	0.4002
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0039	1	1
Schistosoma mansoni	multidrug resistance protein	0.0025	0.4787	0.185
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0021	0.3604	0.3604
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.4787	0.4787
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3478	0.3395
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0024	0.4662	0.4662
Echinococcus granulosus	multidrug resistance associated protein 1	0.0021	0.3604	0.3604
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.4787	0.4787
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.4787	0.4787
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.4787	0.4787
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.4787	0.4787
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.4787	0.4787
Echinococcus multilocularis	multidrug resistance protein 1	0.0015	0.1309	0.1309
Trypanosoma brucei	trans-sialidase, putative	0.003	0.6579	0.4651
Echinococcus granulosus	multidrug resistance associated protein 7	0.0021	0.3604	0.3604
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.4787	0.4002
Entamoeba histolytica	P-glycoprotein-5	0.0025	0.4787	0.185
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.4787	0.4787
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0039	1	1
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0039	1	1
Trypanosoma brucei	trans-sialidase, putative	0.003	0.6579	0.4651
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0025	0.4787	0.185
Trypanosoma brucei	trans-sialidase	0.003	0.6579	0.4651
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.4787	0.4787
Trypanosoma brucei	trans-sialidase, putative	0.003	0.6579	0.4651
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0039	1	1
Trypanosoma brucei	trans-sialidase, putative	0.003	0.6579	0.4651
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Entamoeba histolytica	P-glyco protein 6, putative	0.0025	0.4787	0.185
Entamoeba histolytica	P-glycoprotein-2	0.0025	0.4787	0.185
Schistosoma mansoni	multidrug resistance protein	0.0025	0.4787	0.185
Loa Loa (eye worm)	multidrug resistance protein 3	0.0025	0.4787	0.4721
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Giardia lamblia	MRP-like ABC transporter	0.0021	0.3604	1
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.6579	0.6579
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.6577	0.6577
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.4787	0.4002
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.4787	0.4787
Echinococcus multilocularis	multidrug resistance protein 1	0.0025	0.4787	0.4787
Loa Loa (eye worm)	hypothetical protein	0.0025	0.4787	0.4721
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	abcb9, putative	0.0025	0.4787	0.4002
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0039	1	1
Giardia lamblia	ABC transporter, putative	0.0021	0.3604	1
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0025	0.4787	0.5
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0039	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.4787	0.4721
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.4787	0.4002
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0039	1	1
Trypanosoma brucei	trans-sialidase, putative	0.003	0.6579	0.4651
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.4787	0.4002
Entamoeba histolytica	P-glycoprotein-1	0.0025	0.4787	0.185
Onchocerca volvulus		0.0025	0.4787	0.5
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.6579	0.6579
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0021	0.3604	0.3604
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0039	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.4787	0.4002
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.6579	0.6579
Loa Loa (eye worm)	hypothetical protein	0.0024	0.4662	0.4594
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0025	0.4787	0.185
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0025	0.4787	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.4787	0.4002
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0039	1	1
Leishmania major	p-glycoprotein	0.0025	0.4787	0.185
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0025	0.4787	0.4002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 909568