Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.004 | 0.5233 | 0.5233 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.004 | 0.5233 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0058 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.0058 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0058 | 1 | 1 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0058 | 0.981 | 0.981 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0033 | 0.3399 | 0.3271 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0033 | 0.3399 | 0.3399 |
Schistosoma mansoni | multidrug resistance protein | 0.0058 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0038 | 0.4752 | 0.4752 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0058 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.5233 | 0.5233 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0058 | 1 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0033 | 0.3399 | 0.6364 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0032 | 0.3209 | 0.9442 |
Onchocerca volvulus | 0.0058 | 1 | 0.5 | |
Brugia malayi | multidrug resistance related protein 1 | 0.0033 | 0.3399 | 0.3399 |
Schistosoma mansoni | multidrug resistance protein | 0.0033 | 0.3399 | 0.3399 |
Trypanosoma brucei | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Leishmania major | pentamidine resistance protein 1 | 0.0033 | 0.3399 | 0.3271 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0058 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0033 | 0.3399 | 0.3399 |
Brugia malayi | ABC transporter family protein | 0.0021 | 0.019 | 0.019 |
Trypanosoma cruzi | trans-sialidase, putative | 0.003 | 0.2679 | 0.4936 |
Trypanosoma cruzi | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Leishmania major | p-glycoprotein | 0.0058 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0033 | 0.3399 | 0.3399 |
Leishmania major | ABC-thiol transporter | 0.0033 | 0.3399 | 0.3271 |
Schistosoma mansoni | multidrug resistance protein | 0.0033 | 0.3399 | 0.3399 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0033 | 0.3399 | 0.3399 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.0058 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0058 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0033 | 0.3399 | 0.3399 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0058 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.004 | 0.5233 | 0.5141 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3399 | 0.3399 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0058 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.004 | 0.5233 | 0.5141 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.019 | 0.5 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0021 | 0.019 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.003 | 0.2679 | 0.4936 |
Loa Loa (eye worm) | ABC transporter | 0.0021 | 0.019 | 0.019 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0033 | 0.3399 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0033 | 0.3399 | 0.3399 |
Wolbachia endosymbiont of Brugia malayi | ABC-type protease secretion system, ATPase and permease component, AprD | 0.0021 | 0.019 | 0.5 |
Schistosoma mansoni | smdr2 | 0.0058 | 1 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0033 | 0.3399 | 0.3399 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0033 | 0.3399 | 0.3271 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0038 | 0.4752 | 0.4752 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0033 | 0.3399 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0058 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.019 | 0.5 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.004 | 0.5233 | 0.5233 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0021 | 0.019 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0033 | 0.3399 | 0.6364 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0058 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0033 | 0.3399 | 0.3271 |
Mycobacterium ulcerans | drugs-transport transmembrane ATP-binding protein ABC transporter | 0.0021 | 0.019 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.0058 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | abcb9, putative | 0.0058 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0058 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0033 | 0.3399 | 0.6364 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.019 | 0.019 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0058 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0058 | 1 | 1 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0058 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0033 | 0.3399 | 0.3399 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0033 | 0.3399 | 0.6364 |
Wolbachia endosymbiont of Brugia malayi | ABC-type multidrug transport system, ATPase and permease component | 0.0021 | 0.019 | 0.5 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0058 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0033 | 0.3399 | 0.3271 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0058 | 1 | 1 |
Brugia malayi | ABC transporter | 0.0021 | 0.019 | 0.019 |
Brugia malayi | multidrug Resistance Protein family member (mrp-5), putative | 0.0021 | 0.019 | 0.019 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0058 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0058 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0033 | 0.3399 | 0.3399 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Trichomonas vaginalis | abcb9, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.003 | 0.2679 | 0.4936 |
Trichomonas vaginalis | ABC transporter, putative | 0.0058 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.019 | 0.5 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0058 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Giardia lamblia | ABC transporter, putative | 0.0033 | 0.3399 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0033 | 0.3399 | 0.6364 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0058 | 1 | 1 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.004 | 0.5233 | 0.5141 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.004 | 0.5233 | 0.5233 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.0058 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0033 | 0.3399 | 0.3399 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0058 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.004 | 0.5233 | 0.5233 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0058 | 0.981 | 0.9807 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.004 | 0.5233 | 0.5141 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0021 | 0.019 | 0.019 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.004 | 0.5233 | 0.5233 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0033 | 0.3399 | 0.3271 |
Trichomonas vaginalis | ABC transporter, putative | 0.0058 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.3399 | 0.3399 |
Schistosoma mansoni | multidrug resistance protein | 0.0058 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0058 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0058 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0038 | 0.4752 | 0.4651 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0021 | 0.019 | 0.019 |
Entamoeba histolytica | P-glycoprotein-5 | 0.0058 | 1 | 1 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0058 | 1 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0033 | 0.3399 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Schistosoma mansoni | multidrug resistance protein | 0.0021 | 0.019 | 0.019 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.004 | 0.5233 | 0.5233 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0058 | 1 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) | 0.0021 | 0.019 | 0.019 |
Leishmania major | p-glycoprotein e | 0.0033 | 0.3399 | 0.3271 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3209 | 0.3209 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0021 | 0.019 | 0.019 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0058 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0021 | 0.019 | 0.019 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0058 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0058 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0021 | 0.019 | 0.019 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.004 | 0.5233 | 0.5233 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0033 | 0.3399 | 0.3271 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0033 | 0.3399 | 0.3271 |
Schistosoma mansoni | smdr1 | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | taga, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0033 | 0.3399 | 0.6364 |
Trypanosoma brucei | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0033 | 0.3399 | 0.3399 |
Brugia malayi | hypothetical protein | 0.0021 | 0.019 | 0.019 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0033 | 0.3399 | 0.6364 |
Mycobacterium ulcerans | component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD | 0.0021 | 0.019 | 0.5 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0058 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.981 | 0.981 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | ABC transporter, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Entamoeba histolytica | P-glycoprotein-1 | 0.0058 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.5233 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0058 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.5233 | 0.5233 |
Brugia malayi | P-glycoprotein-like protein | 0.0021 | 0.019 | 0.019 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0058 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0058 | 1 | 1 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.003 | 0.268 | 0.4938 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0033 | 0.3399 | 0.3399 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.5233 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Trichomonas vaginalis | abcb9, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.003 | 0.2679 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3399 | 0.3399 |
Trypanosoma brucei | trans-sialidase | 0.003 | 0.268 | 0.4938 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0058 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0038 | 0.4752 | 0.4752 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.004 | 0.5233 | 0.5141 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.003 | 0.268 | 0.4938 |
Brugia malayi | ABC transporter family protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0021 | 0.019 | 0.019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.3 uM | Antitubercular activity against Mycobacterium tuberculosis | ChEMBL. | 19900810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.