Detailed information for compound 91647

Basic information

Technical information
  • TDR Targets ID: 91647
  • Name: 9-methyl-1,2,3,4,4a,6-hexahydropyrazino[1,2-a ]quinoxalin-5-one
  • MW: 217.267 | Formula: C12H15N3O
  • H donors: 2 H acceptors: 1 LogP: 0.77 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccc(cc2N2C1CNCC2)C
  • InChi: 1S/C12H15N3O/c1-8-2-3-9-10(6-8)15-5-4-13-7-11(15)12(16)14-9/h2-3,6,11,13H,4-5,7H2,1H3,(H,14,16)
  • InChiKey: XCMDBWQOUOFRED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-methyl-1,2,3,4,4a,6-hexahydropyrazino[2,1-c]quinoxalin-5-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0077 0.0444 0.044
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1372 1 1
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2794 0.2794
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0808 0.584 0.584
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0204 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0444 0.0358
Onchocerca volvulus 0.0271 0.1875 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Echinococcus multilocularis zinc finger protein 0.002 0.003 0.003
Trypanosoma cruzi phytoene synthase, putative 0.0069 0.0385 0.0298
Trypanosoma cruzi squalene synthase, putative 0.022 0.1502 0.1426
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0436 0.3099 0.3
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1372 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0142 0.0142
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0004 0.0004
Entamoeba histolytica hexokinase 2 0.0271 0.1875 0.5933
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1372 1 1
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0436 0.3099 1
Loa Loa (eye worm) hexokinase 0.0271 0.1875 0.1871
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0165
Toxoplasma gondii hexokinase 0.0271 0.1875 0.1798
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Echinococcus multilocularis lysosomal alpha glucosidase 0.0345 0.2427 0.2427
Schistosoma mansoni cpg binding protein 0.0031 0.0108 0.0108
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.1719 0.1705
Leishmania major hypothetical protein, conserved 0.0029 0.0093 0.0004
Leishmania major alpha glucosidase II subunit, putative 0.0077 0.0444 0.0358
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Onchocerca volvulus 0.02 0.1352 0.7084
Echinococcus multilocularis lysosomal alpha glucosidase 0.0345 0.2427 0.2427
Trypanosoma cruzi squalene synthase, putative 0.022 0.1502 0.1426
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1151 0.1072
Brugia malayi Hexokinase family protein 0.0084 0.0496 0.048
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Loa Loa (eye worm) hypothetical protein 0.0086 0.0513 0.0509
Schistosoma mansoni trans-prenyltransferase 0.0436 0.3099 0.3099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0004 0.0004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.1719 0.1716
Loa Loa (eye worm) hypothetical protein 0.0185 0.124 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Onchocerca volvulus 0.0036 0.0142 0.0326
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Schistosoma mansoni hypothetical protein 0.0395 0.2794 0.2794
Echinococcus granulosus cpg binding protein 0.0031 0.0108 0.0108
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0085
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0089 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0142 0.0053
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0436 0.3099 0.3034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0204
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0436 0.3099 0.3
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0135 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0053
Leishmania major hexokinase, putative 0.0271 0.1875 0.1802
Schistosoma mansoni zinc finger protein 0.002 0.003 0.003
Trypanosoma brucei hexokinase, putative 0.0271 0.1875 0.1802
Trypanosoma cruzi polyprenyl synthase, putative 0.0808 0.584 0.5803
Echinococcus granulosus hexokinase 0.0271 0.1875 0.1875
Trypanosoma cruzi hexokinase, putative 0.0271 0.1875 0.1802
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0436 0.3099 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0108 0.0108
Trichomonas vaginalis sucrase-isomaltase, putative 0.0077 0.0444 0.0358
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1372 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.1529 0.1526
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0436 0.3099 0.3099
Treponema pallidum octaprenyl-diphosphate synthase 0.0808 0.584 1
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0808 0.584 0.5839
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0343 0.2411 0.2342
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0444 0.0358
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2794 0.2794
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0436 0.3099 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.156 0.1439
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0142 0.0125
Giardia lamblia Farnesyl diphosphate synthase 0.1372 1 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0204 0.0188
Echinococcus granulosus hexokinase 0.0271 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0089
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1372 1 1
Trypanosoma cruzi polyprenyl synthase, putative 0.0808 0.584 0.5803
Leishmania major squalene synthase, putative 0.022 0.1502 0.1426
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0077 0.0444 0.0354
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0345 0.2427 0.2423
Schistosoma mansoni cpg binding protein 0.0028 0.0083 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0316 0.0316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0204 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0436 0.3099 0.3099
Brugia malayi beta-lactamase family protein 0.0036 0.0142 0.0125
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1372 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0444 0.1179
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0343 0.2411 0.2342
Loa Loa (eye worm) hexokinase 0.017 0.1131 0.1127
Schistosoma mansoni bromodomain containing protein 0.0063 0.0341 0.0341
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0083 0.0079
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0051 0.0051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0135 0.0135
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0808 0.584 0.584
Leishmania major hypothetical protein, conserved 0.0036 0.0142 0.0053
Loa Loa (eye worm) polyprenyl synthetase 0.1372 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Leishmania major solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0204 0.0204
Brugia malayi Hexokinase family protein 0.017 0.1131 0.1116
Onchocerca volvulus Hexokinase homolog 0.017 0.1131 0.5848
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1372 1 1
Brugia malayi hexokinase 0.0271 0.1875 0.1861
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0343 0.2411 0.2342
Trypanosoma brucei hexokinase 0.0271 0.1875 0.1802
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Leishmania major hexokinase, putative 0.0271 0.1875 0.1802
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0444 0.1179
Loa Loa (eye worm) hypothetical protein 0.0069 0.0385 0.038
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0313 0.0313
Echinococcus multilocularis hexokinase 0.0271 0.1875 0.1875
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0093 0.0004
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0051 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Brugia malayi follicle stimulating hormone receptor 0.0224 0.1529 0.1515
Loa Loa (eye worm) beta-lactamase 0.0036 0.0142 0.0137
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1372 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0316 0.0316
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0436 0.3099 0.3034
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0069 0.0385 0.1682
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0436 0.3099 0.3099
Brugia malayi Bromodomain containing protein 0.0074 0.0425 0.0408
Echinococcus multilocularis hexokinase 0.0271 0.1875 0.1875
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Schistosoma mansoni alpha-glucosidase 0.0297 0.2072 0.2072
Echinococcus granulosus Squalene phytoene synthase 0.0069 0.0385 0.0385
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0343 0.2411 0.2342
Schistosoma mansoni cpg binding protein 0.0031 0.0108 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0004 0.0004
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Schistosoma mansoni hypothetical protein 0.0069 0.0385 0.0385
Plasmodium vivax hexokinase, putative 0.0271 0.1875 0.1798
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Echinococcus granulosus hexokinase 0.0271 0.1875 0.1875
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0069 0.0385 0.0246
Leishmania major polyprenyl synthase, putative 0.0808 0.584 0.5803
Echinococcus granulosus zinc finger protein 0.002 0.003 0.003
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0343 0.2411 0.2339
Loa Loa (eye worm) hypothetical protein 0.0043 0.0194 0.019
Echinococcus granulosus hexokinase type 2 0.0271 0.1875 0.1875
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0026 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0142 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0093 0.0004
Trichomonas vaginalis esterase, putative 0.0036 0.0142 0.0053
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1372 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0142 0.0142
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1086 0.5599
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0436 0.3099 0.3
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Onchocerca volvulus 0.0036 0.0142 0.0326
Echinococcus granulosus lysosomal alpha glucosidase 0.0345 0.2427 0.2427
Echinococcus multilocularis hexokinase 0.0271 0.1875 0.1875
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0204 0.0204
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0343 0.2411 0.2339
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1372 1 1
Trypanosoma brucei hexokinase 0.0271 0.1875 0.1802
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0051 0.0051
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0343 0.2411 0.2342
Schistosoma mansoni hypothetical protein 0.002 0.0026 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0142 0.0053
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0436 0.3099 0.3
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Brugia malayi Hexokinase family protein 0.0271 0.1875 0.1861
Onchocerca volvulus 0.017 0.1131 0.5848
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0436 0.3099 0.3099
Plasmodium falciparum hexokinase 0.0271 0.1875 0.1798
Schistosoma mansoni alpha-glucosidase 0.0297 0.2072 0.2072
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0436 0.3099 0.5
Echinococcus multilocularis hexokinase type 2 0.0271 0.1875 0.1875
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0436 0.3099 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0142 0.0142
Schistosoma mansoni alpha glucosidase 0.0077 0.0444 0.0444
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0142 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0204 0.0204
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1372 1 1
Mycobacterium ulcerans phytoene synthase, CrtB 0.0069 0.0385 0.0246
Trichomonas vaginalis maltase-glucoamylase, putative 0.0077 0.0444 0.0358
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1151 0.1072
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0053
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0444 0.0358
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1372 1 1
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0343 0.2411 0.2339
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0343 0.2411 0.2339
Loa Loa (eye worm) hypothetical protein 0.0037 0.0152 0.0148
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0142 0.0053
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0004 0.0004
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0436 0.3099 0.3034
Brugia malayi beta-lactamase 0.0036 0.0142 0.0125
Brugia malayi CXXC zinc finger family protein 0.0028 0.0083 0.0066
Leishmania major farnesyl pyrophosphate synthase 0.1372 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0283 0.0192
Brugia malayi hypothetical protein 0.0029 0.0093 0.0076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0077 0.0444 0.0428
Loa Loa (eye worm) hexokinase type II 0.0271 0.1875 0.1871
Loa Loa (eye worm) polyprenyl synthetase 0.0436 0.3099 0.3096
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0436 0.3099 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0053
Schistosoma mansoni hexokinase 0.0271 0.1875 0.1875
Brugia malayi hexokinase type II 0.0086 0.0513 0.0497
Toxoplasma gondii ABC1 family protein 0.0036 0.0142 0.0049
Brugia malayi PHD-finger family protein 0.0026 0.0068 0.0051
Loa Loa (eye worm) hexokinase 0.0084 0.0496 0.0492
Schistosoma mansoni glutathione synthetase 0.0436 0.3099 0.3099
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Echinococcus multilocularis neutral alpha glucosidase AB 0.0077 0.0444 0.0444
Loa Loa (eye worm) hexokinase 0.0271 0.1875 0.1871
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0204
Entamoeba histolytica hexokinase 1 0.0271 0.1875 0.5933
Trypanosoma cruzi hexokinase, putative 0.0271 0.1875 0.1802
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0343 0.2411 0.2339
Brugia malayi beta-lactamase family protein 0.0036 0.0142 0.0125
Brugia malayi Glycosyl hydrolases family 31 protein 0.0345 0.2427 0.2414
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0808 0.584 0.584
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0808 0.584 0.5833
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0142 0.0142
Onchocerca volvulus 0.0036 0.0142 0.0326
Loa Loa (eye worm) hypothetical protein 0.0086 0.0513 0.0509
Echinococcus granulosus neutral alpha glucosidase AB 0.0077 0.0444 0.0444
Onchocerca volvulus 0.0271 0.1875 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.0053
Brugia malayi Bromodomain containing protein 0.0037 0.0151 0.0135
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0444 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.0053
Brugia malayi Polyprenyl synthetase family protein 0.0436 0.3099 0.3087
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0089 0.0072
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1372 1 1
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1372 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0436 0.3099 0.3037
Leishmania major hypothetical protein, conserved 0.0069 0.0385 0.0298
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1372 1 1
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0436 0.3099 0.5
Trypanosoma brucei squalene synthase, putative 0.022 0.1502 0.1426
Trypanosoma brucei glucosidase, putative 0.0077 0.0444 0.0358
Echinococcus multilocularis Squalene phytoene synthase 0.0069 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0093 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0436 0.3099 0.3
Loa Loa (eye worm) hypothetical protein 0.0068 0.0383 0.0378
Onchocerca volvulus 0.0271 0.1875 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibitory activity using [3H]-mesulergine as radioligand with receptor membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptor at a concentration of 1 microM ChEMBL. 10987434
Inhibition (binding) = 0 % Inhibitory activity using [3H]-mesulergine as radioligand with receptor membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptor at a concentration of 1 microM ChEMBL. 10987434
ND (binding) 0 nM Binding affinity using [125I]-DOI as radioligand with membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptor; Not determined ChEMBL. 10987434

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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