TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 268.393 | Formula: C19H24O
H donors: 0 H acceptors: 1 LogP: 5.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC[C@H]1C(=CC=C([C@H]1c1ccccc1)C=O)C
InChi: 1S/C19H24O/c1-3-4-6-11-18-15(2)12-13-17(14-20)19(18)16-9-7-5-8-10-16/h5,7-10,12-14,18-19H,3-4,6,11H2,1-2H3/t18-,19+/m0/s1
InChiKey: FZJBVGCYNYLPQW-RBUKOAKNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	IMP dehydrogenas	0.0152	0.1071	0.1085
Entamoeba histolytica	Rho family GTPase	0.0012	0.0019	0.0019
Mycobacterium leprae	AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)	0.0044	0.0254	0.1642
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0071	0.0072
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.008	0.053	0.0519
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0147	0.1032	0.1028
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0147	0.1032	0.1028
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.1126
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0058	0.0363	0.0349
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0152	0.1071	0.1068
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0044	0.0254	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0363	0.0349
Mycobacterium tuberculosis	Conserved hypothetical protein	0.011	0.0754	0.6753
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0298
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0186	0.1328	0.1345
Giardia lamblia	Guanine phosphoribosyltransferase	0.0186	0.1328	1
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.1319	0.9876	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-3	0.0157	0.1113	0.111
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0058	0.0363	0.0349
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.029	0.0272
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0071	0.0052
Loa Loa (eye worm)	hypothetical protein	0.1336	1	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0147	0.1032	0.1015
Onchocerca volvulus		0.0017	0.0055	0.0278
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0071	0.0053
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0058	0.0363	0.0349
Mycobacterium tuberculosis	Conserved hypothetical protein	0.011	0.0754	0.6753
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0279	0.203	0.1998
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0071	0.0053
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0058	0.0363	0.0367
Trichomonas vaginalis	sensor histidine kinase, putative	0.0022	0.0094	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0071	0.0053
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0044	0.0254	0.0236
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0186	0.1328	0.1282
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0152	0.1071	0.1085
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0044	0.0254	0.0258
Trichomonas vaginalis	receptor histidine kinase, putative	0.0022	0.0094	0.0076
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0058	0.0363	0.2628
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.0254	0.0258
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.2732
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0186	0.1328	0.1345
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0022	0.0094	0.0076
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0157	0.1113	0.111
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0052
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0147	0.1032	0.1028
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0152	0.1071	0.1055
Brugia malayi	Kringle domain containing protein	0.0017	0.0055	0.0036
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0152	0.1071	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Brugia malayi	Eukaryotic translation initiation factor 4E type 3, putative	0.0157	0.1113	0.1096
Plasmodium vivax	phosphodiesterase gamma, putative	0.0058	0.0363	0.2732
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0055	0.0036
Trichomonas vaginalis	sensor histidine kinase, putative	0.0022	0.0094	0.0076
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0058	0.0363	0.0349
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0071	0.0053
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0157	0.1113	0.1126
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0058	0.0363	0.0298
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0186	0.1328	1
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0254	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0071	0.0053
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.1319	0.9876	1
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	0.0044	0.0254	0.0203
Echinococcus multilocularis	expressed protein	0.0373	0.2742	0.2762
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0058	0.0363	0.0349
Leishmania major	eukaryotic translation initiation factor 4e, putative	0.0157	0.1113	0.1077
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0058	0.0363	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0052
Entamoeba histolytica	Rho family GTPase	0.0012	0.0019	0.0019
Plasmodium falciparum	orotate phosphoribosyltransferase	0.0044	0.0254	0.1566
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Mycobacterium leprae	PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	0.0044	0.0254	0.1642
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0058	0.0363	0.2417
Giardia lamblia	Hypothetical protein	0.0058	0.0363	0.2628
Mycobacterium leprae	conserved hypothetical protein	0.011	0.0754	0.6753
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0071	0.0072
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0186	0.1328	0.1345
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0071	0.0053
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0384	0.0371
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0071	0.0053
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0071	0.0053
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0044	0.0254	0.0187
Toxoplasma gondii	kringle domain-containing protein	0.0017	0.0055	0.0056
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0058	0.0363	0.2417
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0071	0.0052
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Trypanosoma brucei	GMP reductase	0.0152	0.1071	0.102
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0298
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0071	0.0053
Loa Loa (eye worm)	TK/ROR protein kinase	0.0017	0.0055	0.0036
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0071	0.0072
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0157	0.1113	0.111
Onchocerca volvulus	Adenine phosphoribosyltransferase homolog	0.0044	0.0254	0.1801
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.008	0.0527	0.4435
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.0254	0.1642
Trichomonas vaginalis	hypothetical protein	0.0157	0.1113	0.111
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0147	0.1032	0.1045
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0071	0.0053
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0058	0.0363	0.0349
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Entamoeba histolytica	hypothetical protein	0.0019	0.0071	0.0072
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0384	0.297
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0072	0.047	0.3849
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0071	0.0053
Mycobacterium tuberculosis	Probable pyrimidine operon regulatory protein PyrR	0.0044	0.0254	0.1642
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0363	0.0349
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.1319	0.9876	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	Ribose-phosphate pyrophosphokinase, putative	0.0044	0.0254	0.0239
Plasmodium vivax	orotate phosphoribosyltransferase, putative	0.0044	0.0254	0.1916
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0058	0.0363	0.0345
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0071	0.0052
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0147	0.1032	0.1028
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0363	0.0349
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0186	0.1328	0.1328
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0071	0.0053
Leishmania major	eukaryotic translation initiation factor-like protein	0.1319	0.9876	1
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0363	0.0349
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0022	0.0094	0.0076
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0071	0.0053
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0071	0.0052
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Giardia lamblia	Hypothetical protein	0.0157	0.1113	0.8354
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0363	0.0349
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0071	0.0053
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Treponema pallidum	adenine phosphoribosyltransferase	0.0044	0.0254	1
Leishmania major	adenine phosphoribosyltransferase	0.0044	0.0254	0.0203
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Schistosoma mansoni	cell polarity protein	0.0139	0.0978	0.099
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-4	0.0157	0.1113	0.1062
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0071	0.0052
Brugia malayi	GMP reductase	0.0063	0.0402	0.0384
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0063	0.0402	0.0384
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0152	0.1071	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0147	0.1032	0.7771
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Onchocerca volvulus		0.0186	0.1328	1
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0072	0.047	0.3048
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0384	0.2352
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0071	0.0052
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Entamoeba histolytica	hypothetical protein	0.0157	0.1113	0.1126
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.0254	0.0258
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0152	0.1071	0.792
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.0254	0.0239
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0384	0.0335
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Entamoeba histolytica	Rho family GTPase	0.0012	0.0019	0.0019
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0058	0.0363	0.0349
Brugia malayi	Adenine phosphoribosyltransferase	0.0044	0.0254	0.0236
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0044	0.0254	0.1642
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.1319	0.9876	1
Giardia lamblia	Translation elongation factor	0.0157	0.1113	0.8354
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0143	0.1003	0.7449
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0022	0.0094	0.0076
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0071	0.0052
Giardia lamblia	hypothetical protein	0.0157	0.1113	0.8354
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0071	0.0053
Mycobacterium leprae	conserved hypothetical protein	0.011	0.0754	0.6753
Entamoeba histolytica	Rho family GTPase	0.0012	0.0019	0.0019
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0071	0.0072
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0186	0.1328	0.1282
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0363	0.0345
Brugia malayi	hypothetical protein	0.0019	0.0071	0.0052
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0058	0.0363	0.0349
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0142	0.1	0.9268
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0384	0.0389
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0017	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0052
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-3	0.0157	0.1113	0.1062
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0044	0.0254	0.0187
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0254	0.0239
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0363	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0236	0.171	0.1694
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.0157	0.1113	0.1126
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0186	0.1328	0.1328
Trypanosoma brucei	Eukaryotic translation initiation factor 4E type 5	0.0157	0.1113	0.1062
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0071	0.0072
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.1126
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0058	0.0363	0.0349
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0071	0.0052
Entamoeba histolytica	translation initiation factor 4e, putative	0.0157	0.1113	0.1126
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E type 3	0.0157	0.1113	0.1096
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0044	0.0254	0.0258
Schistosoma mansoni	sensor histidine kinase/response regulator	0.0022	0.0094	0.0095
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.1319	0.9876	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.2417
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0186	0.1328	1
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0019	0.0071	0.0124
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus multilocularis	ras gtpase	0.0139	0.0978	0.0973
Trichomonas vaginalis	ribose-phosphate pyrophosphokinase, putative	0.0044	0.0254	0.0239
Brugia malayi	PXA domain containing protein	0.0019	0.0071	0.0052
Trichomonas vaginalis	receptor histidine kinase, putative	0.0022	0.0094	0.0076
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0071	0.0072
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0071	0.0072
Trichomonas vaginalis	DNA helicase recq1, putative	0.0019	0.0071	0.0053
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.0254	0.0258
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0147	0.1032	0.1028
Leishmania major	hypothetical protein, conserved	0.0058	0.0363	0.0313
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0071	0.0052
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0071	0.0053
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0071	0.0052
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0186	0.1328	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0071	0.0053
Echinococcus multilocularis	tissue type plasminogen activator	0.0017	0.0055	0.0037
Brugia malayi	GTP-binding protein, identical	0.0139	0.0978	0.0961
Loa Loa (eye worm)	translation initiation factor 4E	0.1319	0.9876	0.9876
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0384	0.2352
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0254	0.0239
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0186	0.1328	0.1282
Loa Loa (eye worm)	GMP reductase	0.0063	0.0402	0.0384
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0157	0.1113	0.111
Mycobacterium tuberculosis	Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)	0.0044	0.0254	0.1642
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.1319	0.9876	1
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0186	0.1328	0.1296
Echinococcus granulosus	ras gtpase	0.0139	0.0978	0.0973
Brugia malayi	translation initiation factor 4E	0.1319	0.9876	0.9876
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0384	0.0389
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0071	0.0053
Schistosoma mansoni	cell polarity protein	0.0139	0.0978	0.099
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0058	0.0363	0.0349
Mycobacterium tuberculosis	Conserved protein	0.0044	0.0254	0.1642
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0186	0.1328	0.1328
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0071	0.0016
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.1113	0.111
Toxoplasma gondii	hypothetical protein	0.0157	0.1113	0.1126
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.1113	0.111
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0071	0.0072
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0058	0.0363	0.0349
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.171	0.1716
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.1319	0.9876	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0157	0.1113	0.111
Treponema pallidum	hypothetical protein	0.0044	0.0254	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0071	0.0052
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0071	0.0072
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0147	0.1032	0.1028
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0157	0.1113	0.111
Loa Loa (eye worm)	GTP-binding protein	0.0139	0.0978	0.0961
Brugia malayi	eukaryotic translation initiation factor 4E-1	0.0157	0.1113	0.1096
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0152	0.1071	1
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0147	0.1032	0.098
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0152	0.1071	0.102
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0363	0.0349
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0152	0.1071	0.1068
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.1319	0.9876	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0071	0.0053
Trypanosoma brucei	hypothetical protein, conserved	0.0058	0.0363	0.0298
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0071	0.0053
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0071	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.1113	0.111
Plasmodium falciparum	phosphodiesterase delta, putative	0.0058	0.0363	0.2417
Onchocerca volvulus	Putative eukaryotic translation initiation factor 4e	0.0157	0.1113	0.8354
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0071	0.0053
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0071	0.0072
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Onchocerca volvulus	Putative GMP reductase	0.0063	0.0402	0.2929
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0058	0.0363	0.0367
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0186	0.1328	0.1312
Plasmodium falciparum	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.8307
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.1319	0.9876	1
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0143	0.1003	0.7555
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0279	0.203	0.201
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0058	0.0363	0.0345
Brugia malayi	hypothetical protein	0.0236	0.171	0.1694
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0157	0.1113	0.111
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0254	0.13
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0363	0.0349
Leishmania major	hypothetical protein, conserved	0.0157	0.1113	0.1077
Schistosoma mansoni	rac gtpase	0.0012	0.0019	0.0019
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0071	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0055	0.0036
Leishmania major	hypothetical protein, conserved	0.0058	0.0363	0.0313
Plasmodium vivax	hypothetical protein, conserved	0.0157	0.1113	0.8378
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0071	0.0053
Echinococcus granulosus	expressed protein	0.0373	0.2742	0.2762
Schistosoma mansoni	gtpase_rho	0.0012	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0052
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Schistosoma mansoni	hypothetical protein	0.0048	0.029	0.0294
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0071	0.0053
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0071	0.0072
Onchocerca volvulus		0.0048	0.029	0.2073
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0071	0.0053
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0071	0.0053
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0147	0.1032	0.1045
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0044	0.0254	0.0239
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0143	0.1003	0.7369
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.0254	0.0239
Echinococcus granulosus	tissue type plasminogen activator	0.0017	0.0055	0.0037
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0157	0.1113	0.111
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0071	0.0052
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0071	0.0053
Leishmania major	eukaryotic translation initiation factor-like	0.1319	0.9876	1
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.008	0.0527	0.4435
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0044	0.0254	0.0239
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0152	0.1071	0.1068
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0071	0.0052
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0384	0.0371
Mycobacterium tuberculosis	Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)	0.0044	0.0254	0.1642
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E-1	0.0157	0.1113	0.1096
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0152	0.1071	0.1068
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0071	0.0072
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.1319	0.9876	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0052
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Giardia lamblia	Hypothetical protein	0.0157	0.1113	0.8354
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0147	0.1032	0.1045
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0017	0.0055	0.0415
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0071	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0052
Leishmania major	hypothetical protein, conserved	0.0157	0.1113	0.1077
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.2732
Giardia lamblia	Sgs1 DNA helicase, putative	0.0019	0.0071	0.0398
Giardia lamblia	hypothetical protein	0.0058	0.0363	0.2628
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.1319	0.9876	1
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0152	0.1071	0.1068
Mycobacterium ulcerans	bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase	0.0044	0.0254	0.13
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0157	0.1113	0.111
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0071	0.0072
Trypanosoma cruzi	GMP reductase	0.0152	0.1071	0.1068
Entamoeba histolytica	hypothetical protein	0.0157	0.1113	0.1126
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0063	0.0402	0.0384
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0186	0.1328	0.1328
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0055	0.0037
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0058	0.0363	0.2417
Trypanosoma cruzi	GMP reductase	0.0152	0.1071	0.1068
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.1126
Schistosoma mansoni	survival motor neuron protein	0.0048	0.029	0.0294
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Mycobacterium ulcerans	orotate phosphoribosyltransferase	0.0044	0.0254	0.13
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0279	0.203	0.204
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0186	0.1328	0.1328
Brugia malayi	hypothetical protein	0.0019	0.0071	0.0052
Mycobacterium ulcerans	amidophosphoribosyltransferase	0.0044	0.0254	0.13
Entamoeba histolytica	hypothetical protein	0.0019	0.0071	0.0072
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0363	0.0345
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0058	0.0363	0.0298
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0058	0.0363	0.0349
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0022	0.0094	0.0076
Echinococcus granulosus	eukaryotic translation initiation factor 4E type	0.0157	0.1113	0.111
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0071	0.0053
Mycobacterium tuberculosis	Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)	0.0044	0.0254	0.1642
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0071	0.0052
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0058	0.0363	0.0349
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0186	0.1328	0.1328
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.0157	0.1113	0.1126
Entamoeba histolytica	Rho family GTPase	0.0012	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.1278	0.9564	0.9563
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0058	0.0363	0.0345
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0044	0.0254	0.1642
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.1319	0.9876	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0384	0.2352
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0071	0.0053
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0157	0.1113	0.111
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0071	0.0052
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0152	0.1071	0.1035
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0254	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0071	0.0053
Mycobacterium ulcerans	adenine phosphoribosyltransferase	0.0044	0.0254	0.13
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0071	0.0072
Trypanosoma brucei	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.0254	0.0187
Loa Loa (eye worm)	adenine phosphoribosyltransferase	0.0044	0.0254	0.0236
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0071	0.0072
Toxoplasma gondii	orotate phosphoribosyltransferase	0.0044	0.0254	0.0258
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0071	0.0053
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.1319	0.9876	1
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0044	0.0254	1
Leishmania major	eukaryotic translation initiation factor, putative	0.0157	0.1113	0.1077
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0186	0.1328	0.1328
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Leishmania major	guanosine monophosphate reductase	0.0152	0.1071	0.1035
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0186	0.1328	0.1328
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0157	0.1113	0.111
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0157	0.1113	0.111
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Entamoeba histolytica	Rho family GTPase	0.0012	0.0019	0.0019
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0044	0.0254	0.0236
Brugia malayi	PXA domain containing protein	0.0019	0.0071	0.0052
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0157	0.1113	0.111
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Loa Loa (eye worm)	PDE1B protein	0.0147	0.1032	0.1015
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0058	0.0363	0.0345
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0071	0.0072
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0044	0.0254	0.0239
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0186	0.1328	0.1328
Plasmodium falciparum	eukaryotic translation initiation factor 4E	0.0157	0.1113	0.8307
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0071	0.0053
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.171	0.1716
Plasmodium vivax	translation initiation factor 4E, putative	0.0157	0.1113	0.8378
Entamoeba histolytica	hypothetical protein	0.0019	0.0071	0.0072
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.0254	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0363	0.0345
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.0349
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Mycobacterium tuberculosis	Conserved protein	0.0044	0.0254	0.1642
Leishmania major	xanthine phosphoribosyltransferase	0.0186	0.1328	0.1296
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0071	0.0053
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0152	0.1071	0.1055
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0142	0.1	0.9268
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-2	0.0157	0.1113	0.1062
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0058	0.0363	0.0349
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0384	0.0389
Giardia lamblia	Adenine phosphoribosyltransferase	0.0044	0.0254	0.1801
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.1319	0.9876	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0058	0.0363	0.0349
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0058	0.0363	0.0345
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0058	0.0363	0.0367
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0058	0.0363	0.0367
Brugia malayi	GTP-binding protein	0.0139	0.0978	0.0961
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0058	0.0363	0.0349
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0363	0.0349
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0071	0.0053
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0058	0.0363	0.2417
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0058	0.0363	0.0349
Chlamydia trachomatis	two component regulatory system response regulator/ATPase	0.0022	0.0094	0.5
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0147	0.1032	0.0995
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0071	0.0053

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	> 100 ug ml-1	Antibacterial activity against Escherichia coli after 16 hrs	ChEMBL.	18678500
MIC (functional)	> 100 ug ml-1	Antifungal activity against Saccharomyces cerevisiae after 16 hrs	ChEMBL.	18678500

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL451384

Bibliographic References

No literature references available for this target.

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Detailed information for compound 950717