Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GSG2 | 0.0414 | 0.9896 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0075 | 0.0364 | 0.0108 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0075 | 0.0364 | 0.0108 |
Entamoeba histolytica | protein kinase, putative | 0.0323 | 0.7343 | 1 |
Brugia malayi | hypothetical protein | 0.0414 | 0.9896 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0323 | 0.7343 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0075 | 0.0364 | 0.0364 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0075 | 0.0364 | 0.0108 |
Entamoeba histolytica | protein kinase, putative | 0.0178 | 0.3247 | 0.4217 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0323 | 0.7343 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0414 | 0.9896 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0073 | 0.0303 | 0.0303 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0116 | 0.1511 | 0.1298 |
Echinococcus granulosus | dual specificity | 0.0323 | 0.7343 | 0.7351 |
Loa Loa (eye worm) | haspin protein kinase | 0.0414 | 0.9896 | 0.9896 |
Brugia malayi | Protein kinase domain containing protein | 0.0075 | 0.0364 | 0.0064 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0075 | 0.0364 | 0.0147 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0178 | 0.3247 | 0.4181 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0075 | 0.0364 | 0.0108 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0323 | 0.7343 | 0.7351 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.3142 | 0.3142 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0178 | 0.3247 | 0.3099 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0323 | 0.7343 | 0.7343 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0323 | 0.7343 | 1 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0075 | 0.0364 | 0.0108 |
Mycobacterium tuberculosis | Possible chitinase | 0.0062 | 0 | 0.5 |
Brugia malayi | Cell division protein kinase 2 | 0.0075 | 0.0364 | 0.0064 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0414 | 0.9896 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0414 | 0.9896 | 1 |
Schistosoma mansoni | protein kinase | 0.0075 | 0.0364 | 0.0108 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0075 | 0.0364 | 0.0064 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0075 | 0.0364 | 0.0364 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0062 | 0 | 0.5 |
Brugia malayi | Endochitinase | 0.0082 | 0.0551 | 0.0258 |
Echinococcus multilocularis | dual specificity | 0.0323 | 0.7343 | 0.7351 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.3142 | 0.3142 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0323 | 0.7343 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0323 | 0.7343 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0178 | 0.3247 | 0.413 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0323 | 0.7343 | 0.7339 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.1511 | 0.1298 |
Brugia malayi | Protein kinase domain containing protein | 0.0178 | 0.3247 | 0.3069 |
Echinococcus granulosus | dual specificity | 0.0323 | 0.7343 | 0.7351 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0178 | 0.3247 | 0.4217 |
Echinococcus granulosus | dual specificity | 0.0323 | 0.7343 | 0.7351 |
Entamoeba histolytica | protein kinase, putative | 0.0178 | 0.3247 | 0.4217 |
Onchocerca volvulus | Putative endochitinase | 0.0082 | 0.0551 | 0.2052 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0075 | 0.0364 | 0.0108 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0178 | 0.3247 | 0.413 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0323 | 0.7343 | 1 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0075 | 0.0364 | 0.0087 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.9896 | 1 |
Echinococcus granulosus | dual specificity | 0.0178 | 0.3247 | 0.3099 |
Echinococcus multilocularis | dual specificity | 0.0178 | 0.3247 | 0.3099 |
Schistosoma mansoni | serine/threonine kinase | 0.0075 | 0.0364 | 0.0108 |
Onchocerca volvulus | Putative endochitinase | 0.0082 | 0.0551 | 0.2052 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0323 | 0.7343 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0323 | 0.7343 | 1 |
Echinococcus multilocularis | dual specificity | 0.0323 | 0.7343 | 0.7351 |
Brugia malayi | endochitinase | 0.0082 | 0.0551 | 0.0258 |
Onchocerca volvulus | 0.0116 | 0.1511 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0323 | 0.7343 | 1 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0075 | 0.0364 | 0.0087 |
Loa Loa (eye worm) | haspin protein kinase | 0.0414 | 0.9896 | 0.9896 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0323 | 0.7343 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0323 | 0.7343 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0075 | 0.0364 | 0.0108 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0414 | 0.9896 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1511 | 0.1511 |
Onchocerca volvulus | 0.0116 | 0.1511 | 1 | |
Echinococcus multilocularis | dual specificity | 0.0323 | 0.7343 | 0.7351 |
Plasmodium vivax | hypothetical protein, conserved | 0.0116 | 0.1511 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0414 | 0.9896 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0071 | 0.0248 | 0.0248 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0116 | 0.1511 | 0.1259 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0323 | 0.7343 | 1 |
Entamoeba histolytica | chitinase, putative | 0.0073 | 0.0303 | 0.0061 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0116 | 0.1511 | 0.1298 |
Loa Loa (eye worm) | chitinase I | 0.0073 | 0.0303 | 0.0303 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0075 | 0.0364 | 0.0147 |
Entamoeba histolytica | hypothetical protein | 0.0178 | 0.3247 | 0.4217 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1511 | 0.1511 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0178 | 0.3247 | 0.3247 |
Onchocerca volvulus | Putative endochitinase | 0.0082 | 0.0551 | 0.2052 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0075 | 0.0364 | 0.0108 |
Plasmodium falciparum | conserved protein, unknown function | 0.0116 | 0.1511 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0178 | 0.3247 | 0.413 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.92 ug ml-1 | Cytotoxicity against mouse P388 cells after 3 days by MTT assay | ChEMBL. | 10579864 |
ED50 (functional) | > 50 ug ml-1 | Cytotoxicity against human HT-29 cells after 6 days by MTT assay | ChEMBL. | 10579864 |
ED50 (functional) | > 50 ug ml-1 | Cytotoxicity against human A549 cells after 6 days by MTT assay | ChEMBL. | 10579864 |
ED50 (functional) | > 50 ug ml-1 | Cytotoxicity against human KB cells after 3 days by MTT assay | ChEMBL. | 10579864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.