pI: 6.9703 |
Length (AA): 173 |
MW (Da): 19573 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 159 | 1vyq (A) | 1 | 159 | 99.99 | 0 | 1 | 1.99 | -0.9 |
1 | 167 | 3t64 (A) | 1 | 167 | 99.99 | 0 | 1 | 2.04612 | -0.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early schizont, early trophozoite, late schizont, late trophozoite, Oocyst, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, early ring, late ring. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 8 hs, Ring, Sporozoite. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Female Gametocyte. | Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_126992)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G46940 | deoxyuridine 5'-triphosphate nucleotidohydrolase |
Babesia bovis | BBOV_IV005770 | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative |
Brugia malayi | Bm1_03525 | dUTP diphosphatase |
Candida albicans | CaO19.3322 | dUTP pyrophosphatase gene isolated by genetic complementation in S. cerevisiae. |
Candida albicans | CaO19.10832 | dUTP pyrophosphatase gene isolated by genetic complementation in S. cerevisiae. |
Caenorhabditis elegans | CELE_K07A1.2 | Protein DUT-1 |
Cryptosporidium hominis | Chro.70577 | deoxyuridine 5-triphosphate nucleotidohydrolase |
Cryptosporidium parvum | cgd7_5170 | deoxyuridinetriphosphatase, possible bacterial origin |
Chlamydia trachomatis | CT_292 | deoxyuridine 5'-triphosphate nucleotidohydrolase |
Dictyostelium discoideum | DDB_G0293374 | dUTP diphosphatase |
Drosophila melanogaster | Dmel_CG4584 | Deoxyuridine triphosphatase |
Echinococcus granulosus | EgrG_000119100 | dUTP pyrophosphatase |
Entamoeba histolytica | EHI_026890 | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative |
Entamoeba histolytica | EHI_034560 | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein |
Entamoeba histolytica | EHI_144170 | hypothetical protein |
Entamoeba histolytica | EHI_072960 | hypothetical protein |
Entamoeba histolytica | EHI_059310 | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein |
Entamoeba histolytica | EHI_137470 | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative |
Entamoeba histolytica | EHI_126430 | hypothetical protein |
Entamoeba histolytica | EHI_018140 | hypothetical protein |
Entamoeba histolytica | EHI_193660 | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein |
Entamoeba histolytica | EHI_116940 | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein |
Echinococcus multilocularis | EmuJ_000119100 | dUTP pyrophosphatase |
Homo sapiens | ENSG00000128951 | deoxyuridine triphosphatase |
Loa Loa (eye worm) | LOAG_13155 | dUTP diphosphatase |
Mus musculus | ENSMUSG00000027203 | deoxyuridine triphosphatase |
Neospora caninum | NCLIV_032950 | deoxyuridine 5-triphosphate nucleotidohydrolase, putative |
Oryza sativa | 4333679 | Os03g0669100 |
Plasmodium berghei | PBANKA_0921300 | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative |
Plasmodium falciparum | PF3D7_1127100 | deoxyuridine 5'-triphosphate nucleotidohydrolase |
Plasmodium knowlesi | PKNH_0925100 | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative |
Plasmodium vivax | PVX_091970 | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative |
Plasmodium yoelii | PY05536 | putative deoxyuridine 5'-triphosphate nucleotidohydrolase |
Saccharomyces cerevisiae | YBR252W | bifunctional dITP/dUTP diphosphatase |
Schistosoma japonicum | Sjp_0204430 | ko:K01520 dUTP pyrophosphatase [EC3.6.1.23], putative |
Schistosoma mansoni | Smp_079240 | deoxyuridine 5'-triphosphate nucleotidohydrolase |
Toxoplasma gondii | TGME49_233140 | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative |
Treponema pallidum | TP0885 | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) |
Theileria parva | TP01_0381 | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative |
Trichomonas vaginalis | TVAG_379830 | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0355 | dUTPase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_K07A1.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K07A1.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K07A1.2 | Caenorhabditis elegans | sterile | wormbase |
YBR252W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_233140 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | multi-cellular organism (CARO:0000012) | bloodstream stage (PLO:0040) | in vivo inhibition (TDR:00016) | Plasmodium falciparum | 567114 |
Annotator: | saralph@unimelb.edu.au. | Comment: | 012/Mar/09. | References: | 15698576 16161998 16821778 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Compound | Source | Reference |
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ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
Curated by TDRTargets | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References | |
ChEMBL23 | References |
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | deoxyuridine triphosphatase | Compounds | References |
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Pviv001447; Recombinant protein: full-length; Source: P vivax; deoxyuridine 5'-triphosphate nucleotidohydrolase, putative homolog ; Identifier: Pv091970 |
Target | Type | Source | Notes |
---|---|---|---|
PF3D7_1127100 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Plasmodium falciparum ( 2 ) |
4 literature references were collected for this gene.