pI: 6.4501 |
Length (AA): 962 |
MW (Da): 106950 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 960 | 3wqy (A) | 58 | 904 | 25.00 | 0 | 1 | 0.964581 | 1.27 |
3 | 452 | 5knn (A) | 4 | 453 | 70.00 | 0 | 1 | 1.39248 | -1.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126799)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G50200 | Alanyl-tRNA synthetase |
Arabidopsis thaliana | AT5G22800 | probable alanine--tRNA ligase |
Babesia bovis | BBOV_III011650 | alanyl-tRNA synthetase family protein |
Brugia malayi | Bm1_41830 | Alanyl-tRNA synthetase |
Brugia malayi | Bm1_53535 | alanyl-tRNA synthetase family protein |
Candida albicans | CaO19.5746 | likely cytoplasmic alanyl-tRNA synthetase similar to S. cerevisiae ALA1 (YOR335C) |
Candida albicans | CaO19.13169 | likely cytoplasmic alanyl-tRNA synthetase similar to S. cerevisiae ALA1 (YOR335C) |
Caenorhabditis elegans | CELE_F28H1.3 | Protein AARS-2 |
Cryptosporidium hominis | Chro.60075 | cytosolic tRNA-Ala synthetase |
Cryptosporidium parvum | cgd6_560 | alanyl-tRNA synthetase (with HxxxH domain) |
Chlamydia trachomatis | CT_749 | alanine--tRNA ligase |
Dictyostelium discoideum | DDB_G0277823 | alanine-tRNA ligase |
Dictyostelium discoideum | DDB_G0275655 | alanine-tRNA ligase |
Drosophila melanogaster | Dmel_CG4633 | mitochondrial alanyl-tRNA synthetase |
Drosophila melanogaster | Dmel_CG13391 | Alanyl-tRNA synthetase |
Escherichia coli | b2697 | alanyl-tRNA synthetase |
Echinococcus granulosus | EgrG_000437500 | alanyl tRNA synthetase cytoplasmic |
Entamoeba histolytica | EHI_198790 | alanyl-tRNA synthetase, putative |
Echinococcus multilocularis | EmuJ_000437500 | alanyl tRNA synthetase, cytoplasmic |
Giardia lamblia | GL50803_96460 | Alanyl-tRNA synthetase |
Homo sapiens | ENSG00000124608 | alanyl-tRNA synthetase 2, mitochondrial |
Homo sapiens | ENSG00000090861 | alanyl-tRNA synthetase |
Leishmania braziliensis | LbrM.22.1440 | alanyl-tRNA synthetase, putative |
Leishmania donovani | LdBPK_221390.1 | alanyl-tRNA synthetase, putative |
Leishmania infantum | LinJ.22.1390 | alanyl-tRNA synthetase, putative |
Leishmania major | LmjF.22.1540 | alanyl-tRNA synthetase, putative |
Leishmania mexicana | LmxM.22.1540 | alanyl-tRNA synthetase, putative |
Loa Loa (eye worm) | LOAG_02129 | alanyl-tRNA synthetase |
Loa Loa (eye worm) | LOAG_08551 | alanyl-tRNA synthetase |
Mycobacterium leprae | ML0512 | Probable alanyl-tRNA synthetase AlaS (Alanine--tRNA ligase) (Alanine translase) AlaRS) |
Mus musculus | ENSMUSG00000023938 | alanyl-tRNA synthetase 2, mitochondrial (putative) |
Mus musculus | 234734 | alanyl-tRNA synthetase |
Mycobacterium tuberculosis | Rv2555c | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS) |
Mycobacterium ulcerans | MUL_1754 | alanyl-tRNA synthetase |
Neospora caninum | NCLIV_061050 | hypothetical protein |
Oryza sativa | 9266147 | Os06g0245800 |
Oryza sativa | 4348211 | Os10g0182000 |
Plasmodium berghei | PBANKA_1143600 | alanine--tRNA ligase, putative |
Plasmodium falciparum | PF3D7_1367700 | alanine--tRNA ligase |
Plasmodium knowlesi | PKNH_1103500 | alanine--tRNA ligase, putative |
Plasmodium vivax | PVX_115345 | alanine--tRNA ligase, putative |
Plasmodium yoelii | PY03081 | alanyl-tRNA synthetase, putative |
Saccharomyces cerevisiae | YOR335C | alanine--tRNA ligase |
Schistosoma japonicum | Sjp_0075600 | ko:K01872 alanyl-tRNA synthetase [EC6.1.1.7], putative |
Schistosoma japonicum | Sjp_0300520 | ko:K01872 alanyl-tRNA synthetase [EC6.1.1.7], putative |
Schistosoma mansoni | Smp_038240 | alanyl-tRNA synthetase |
Schmidtea mediterranea | mk4.039773.00 | |
Schmidtea mediterranea | mk4.032719.04 | |
Schmidtea mediterranea | mk4.000455.00 | AlanineALQ-tRNA ligase, cytoplasmic |
Schmidtea mediterranea | mk4.002899.01 | AlanineALQ-tRNA ligase, mitochondrial |
Schmidtea mediterranea | mk4.006608.04 | |
Trypanosoma brucei gambiense | Tbg972.6.390 | alanyl-tRNA synthetase, putative |
Trypanosoma brucei | Tb927.6.700 | alanyl-tRNA synthetase, putative |
Trypanosoma congolense | TcIL3000_6_250 | alanyl-tRNA synthetase, putative |
Trypanosoma cruzi | TcCLB.506863.10 | alanyl-tRNA synthetase, putative |
Trypanosoma cruzi | TcCLB.511825.220 | alanyl-tRNA synthetase, putative |
Toxoplasma gondii | TGME49_219540 | cytosolic tRNA-Ala synthetase |
Treponema pallidum | TP1017 | alanyl-tRNA synthetase |
Theileria parva | TP01_1004 | alanyl-tRNA synthetase, putative |
Trichomonas vaginalis | TVAG_299450 | alanyl-tRNA synthetase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0361 | alanyl-tRNA synthetase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.700 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.700 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2697 | Escherichia coli | essential | goodall |
CELE_F28H1.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F28H1.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F28H1.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F28H1.3 | Caenorhabditis elegans | sterile | wormbase |
YOR335C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1143600 | Plasmodium berghei | Essential | plasmo |
TGME49_219540 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.