pI: 5.3435 |
Length (AA): 864 |
MW (Da): 100943 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 21 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
477 | 668 | 1fje (B) | 4 | 174 | 27.00 | 0 | 1 | 0.43 | 0.22 |
588 | 664 | 1p27 (B) | 75 | 148 | 27.00 | 0.00000002 | 1 | 0.61 | -2.14 |
763 | 857 | 1opi (A) | 372 | 469 | 29.00 | 0 | 1 | 0.55 | -1.66 |
12 | 155 | 2efr (A) | 147 | 290 | 12.00 | 0.98 | 0 | 0.434267 | -1.9 |
386 | 478 | 4wik (A) | 499 | 595 | 28.00 | 0.1 | 0.03 | 0.731539 | -4.1 |
471 | 662 | 3smz (A) | 43 | 205 | 28.00 | 0.0077 | 1 | 0.361122 | 0.42 |
585 | 667 | 2jrs (A) | 26 | 105 | 46.00 | 0.0000000006 | 1 | 0.759965 | -1.43 |
605 | 666 | 2dnm (A) | 30 | 91 | 39.00 | 0.000033 | 1 | 0.562659 | -0.1 |
766 | 858 | 2dny (A) | 444 | 536 | 34.00 | 0.01 | 1 | 0.414539 | -0.86 |
785 | 855 | 3v4m (A) | 391 | 467 | 34.00 | 0.0059 | 1 | 0.477076 | -0.74 |
791 | 855 | 2pe8 (A) | 317 | 390 | 38.00 | 0.0037 | 0.95 | 0.404131 | -0.13 |
3 | 84 | 4o9b (A) | 255 | 336 | 9.00 | 0.91 | 0 | 0.287944 | -1.68 |
10 | 220 | 2af5 (A) | 58 | 287 | 28.00 | 0.71 | 0.09 | 0.361553 | 0.16 |
18 | 110 | 3q8t (A) | 173 | 265 | 8.00 | 0.26 | 0 | 0.344855 | -2.22 |
374 | 466 | 4wik (A) | 499 | 595 | 28.00 | 0.1 | 0.02 | 0.746055 | -4.24 |
459 | 650 | 3smz (A) | 43 | 205 | 28.00 | 0.0074 | 1 | 0.348252 | 0.58 |
573 | 655 | 2jrs (A) | 26 | 105 | 46.00 | 0.00000000055 | 1 | 0.778318 | -1.6 |
754 | 846 | 2dny (A) | 444 | 536 | 34.00 | 0.0097 | 1 | 0.397055 | -0.67 |
759 | 840 | 3s6e (A) | 428 | 506 | 37.00 | 0.0000011 | 1 | 0.575144 | -0.78 |
772 | 841 | 1jmt (A) | 74 | 146 | 24.00 | 0.68 | 0.79 | 0.35406 | -0.41 |
779 | 843 | 2pe8 (A) | 317 | 390 | 38.00 | 0.0035 | 0.99 | 0.392191 | 0.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 16 hs, merozoite, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, late schizont. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 40 hs, early schizont. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 48 hs. | Otto TD |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_128375)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G09880 | splicing factor, CC1-like |
Arabidopsis thaliana | AT2G16940 | splicing factor, CC1-like protein |
Babesia bovis | BBOV_III001520 | splicing factor, CC1-like family protein |
Brugia malayi | Bm1_08755 | splicing factor, CC1-like family protein |
Caenorhabditis elegans | CELE_Y55F3AM.3 | Protein Y55F3AM.3, isoform B |
Cryptosporidium hominis | Chro.70582 | splicing factor |
Cryptosporidium parvum | cgd7_5220 | splicing factor with 3 RRM domains |
Dictyostelium discoideum | DDB_G0283687 | RNA recognition motif-containing protein RRM |
Drosophila melanogaster | Dmel_CG11266 | CG11266 gene product from transcript CG11266-RK |
Echinococcus granulosus | EgrG_000598700 | RNA binding protein 39 |
Entamoeba histolytica | EHI_183100 | RNA recognition motif domain containing protein |
Echinococcus multilocularis | EmuJ_000917200 | RNA binding protein 39 |
Echinococcus multilocularis | EmuJ_000598700 | RNA binding protein 39 |
Homo sapiens | ENSG00000100461 | RNA binding motif protein 23 |
Homo sapiens | ENSG00000131051 | RNA binding motif protein 39 |
Loa Loa (eye worm) | LOAG_02757 | hypothetical protein |
Mus musculus | ENSMUSG00000027620 | RNA binding motif protein 39 |
Neospora caninum | NCLIV_056060 | hypothetical protein |
Oryza sativa | 9270364 | Os03g0153000 |
Oryza sativa | 9269341 | Os10g0439600 |
Onchocerca volvulus | OVOC5431 |
|
Onchocerca volvulus | OVOC5432 | Putative splicing factor |
Plasmodium berghei | PBANKA_1337100 | splicing factor 1, putative |
Plasmodium falciparum | PF3D7_1321700 | splicing factor 1 |
Plasmodium knowlesi | PKNH_1207100 | splicing factor 1, putative |
Plasmodium vivax | PVX_116785 | splicing factor 1, putative |
Plasmodium yoelii | PY05435 | putative splicing factor |
Schistosoma japonicum | Sjp_0034280 | RNA-binding protein 39, putative |
Schistosoma japonicum | Sjp_0206110 | RNA-binding protein 39, putative |
Schistosoma mansoni | Smp_064590.3 | splicing factor |
Schistosoma mansoni | Smp_064590.1 | splicing factor |
Schmidtea mediterranea | mk4.004578.06 | Putative splicing factor |
Schmidtea mediterranea | mk4.001263.01 | Putative splicing factor |
Schmidtea mediterranea | mk4.000866.04 | Putative splicing factor |
Toxoplasma gondii | TGME49_312530 | splicing factor, CC1 family protein |
Theileria parva | TP03_0691 | splicing factor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y55F3AM.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y55F3AM.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y55F3AM.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y55F3AM.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y55F3AM.3 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1337100 | Plasmodium berghei | Essential | plasmo |
TGME49_312530 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.