Detailed view for Smp_143060

Basic information

TDR Targets ID: 290040
Schistosoma mansoni, clathrin coat assembly protein AP17
Source Database / ID:  GeneDB

pI: 6.3323 | Length (AA): 152 | MW (Da): 18129 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01217   Clathrin adaptor complex small chain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030122   AP-2 adaptor complex  
GO:0030117   membrane coat  
GO:0008565   protein transporter activity  
GO:0005515   protein binding  
GO:0016192   vesicle-mediated transport  
GO:0015031   protein transport  
GO:0006886   intracellular protein transport  
GO:0006810   transport  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 152 2vgl (S) 1 142 88.00 0 1 2.08041 -1.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128581)

Species Accession Gene Product
Arabidopsis thaliana AT1G47830   SNARE-like superfamily protein
Babesia bovis BBOV_III005320   clathrin adaptor complex small chain family protein
Brugia malayi Bm1_18635   clathrin adaptor complex small chain
Candida albicans CaO19.1136   similar to S. cerevisiae APS2 (YJR058C) small subunit of the clathrin-associated protein AP-2 complex
Candida albicans CaO19.8729   similar to S. cerevisiae APS2 (YJR058C) small subunit of the clathrin-associated protein AP-2 complex
Caenorhabditis elegans CELE_F02E8.3   Protein APS-2
Dictyostelium discoideum DDB_G0289721   adaptor-related protein complex 2, sigma 1 subunit
Drosophila melanogaster Dmel_CG6056   Adaptor Protein complex 2, sigma subunit
Echinococcus granulosus EgrG_000065450   clathrin coat assembly protein ap17
Entamoeba histolytica EHI_009940   clathrin adaptor complex small chain, putative
Echinococcus multilocularis EmuJ_000065450   clathrin coat assembly protein ap17
Giardia lamblia GL50803_5328   Sigma adaptin
Homo sapiens ENSG00000042753   adaptor-related protein complex 2, sigma 1 subunit
Leishmania braziliensis LbrM.20.1830   clathrin coat assembly protein AP17, putative
Leishmania donovani LdBPK_342100.1   clathrin coat assembly protein AP17, putative
Leishmania infantum LinJ.34.2100   clathrin coat assembly protein AP17, putative
Leishmania major LmjF.34.2330   clathrin coat assembly protein AP17, putative
Leishmania mexicana LmxM.33.2330   clathrin coat assembly protein AP17, putative
Loa Loa (eye worm) LOAG_08185   clathrin adaptor complex small chain
Mus musculus ENSMUSG00000008036   adaptor-related protein complex 2, sigma 1 subunit
Neospora caninum NCLIV_056750   Ap4s1 protein, related
Oryza sativa 4351755   Os12g0207300
Plasmodium berghei PBANKA_0314000   AP-2 complex subunit sigma, putative
Plasmodium falciparum PF3D7_0217300   AP-2 complex subunit sigma, putative
Plasmodium knowlesi PKNH_0403600   AP-2 complex subunit sigma, putative
Plasmodium vivax PVX_002675   AP-2 complex subunit sigma, putative
Plasmodium yoelii PY01700   hypothetical protein
Saccharomyces cerevisiae YJR058C   Aps2p
Schistosoma japonicum Sjp_0086800   AP-2 complex subunit sigma-1, putative
Schistosoma mansoni Smp_143060   clathrin coat assembly protein AP17
Trypanosoma cruzi TcCLB.506559.330   clathrin coat assembly protein AP17, putative
Toxoplasma gondii TGME49_313450   AP-2 complex subunit sigma-1, putative
Theileria parva TP02_0416   clathrin assembly protein, putative
Trichomonas vaginalis TVAG_134680   clathrin coat assembly protein ap19, putative
Trichomonas vaginalis TVAG_262470   clathrin coat assembly protein ap19, putative
Trichomonas vaginalis TVAG_214290   clathrin coat assembly protein ap17, putative

Essentiality

Smp_143060 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F02E8.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F02E8.3 Caenorhabditis elegans larval lethal wormbase
CELE_F02E8.3 Caenorhabditis elegans sterile wormbase
TGME49_313450 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus AP-2 complex subunit sigma Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0033 0.5 0.5
0.0032 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_143060 (Schistosoma mansoni), clathrin coat assembly protein AP17
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