pI: 6.9586 |
Length (AA): 142 |
MW (Da): 16843 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 142 | 2vgl (S) | 1 | 142 | 87.00 | 0 | 1 | 2.1241 | -1.67 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128581)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G47830 | SNARE-like superfamily protein |
Babesia bovis | BBOV_III005320 | clathrin adaptor complex small chain family protein |
Brugia malayi | Bm1_18635 | clathrin adaptor complex small chain |
Candida albicans | CaO19.1136 | similar to S. cerevisiae APS2 (YJR058C) small subunit of the clathrin-associated protein AP-2 complex |
Candida albicans | CaO19.8729 | similar to S. cerevisiae APS2 (YJR058C) small subunit of the clathrin-associated protein AP-2 complex |
Caenorhabditis elegans | CELE_F02E8.3 | Protein APS-2 |
Dictyostelium discoideum | DDB_G0289721 | adaptor-related protein complex 2, sigma 1 subunit |
Drosophila melanogaster | Dmel_CG6056 | Adaptor Protein complex 2, sigma subunit |
Echinococcus granulosus | EgrG_000065450 | clathrin coat assembly protein ap17 |
Entamoeba histolytica | EHI_009940 | clathrin adaptor complex small chain, putative |
Echinococcus multilocularis | EmuJ_000065450 | clathrin coat assembly protein ap17 |
Giardia lamblia | GL50803_5328 | Sigma adaptin |
Homo sapiens | ENSG00000042753 | adaptor-related protein complex 2, sigma 1 subunit |
Leishmania braziliensis | LbrM.20.1830 | clathrin coat assembly protein AP17, putative |
Leishmania donovani | LdBPK_342100.1 | clathrin coat assembly protein AP17, putative |
Leishmania infantum | LinJ.34.2100 | clathrin coat assembly protein AP17, putative |
Leishmania major | LmjF.34.2330 | clathrin coat assembly protein AP17, putative |
Leishmania mexicana | LmxM.33.2330 | clathrin coat assembly protein AP17, putative |
Loa Loa (eye worm) | LOAG_08185 | clathrin adaptor complex small chain |
Mus musculus | ENSMUSG00000008036 | adaptor-related protein complex 2, sigma 1 subunit |
Neospora caninum | NCLIV_056750 | Ap4s1 protein, related |
Oryza sativa | 4351755 | Os12g0207300 |
Plasmodium berghei | PBANKA_0314000 | AP-2 complex subunit sigma, putative |
Plasmodium falciparum | PF3D7_0217300 | AP-2 complex subunit sigma, putative |
Plasmodium knowlesi | PKNH_0403600 | AP-2 complex subunit sigma, putative |
Plasmodium vivax | PVX_002675 | AP-2 complex subunit sigma, putative |
Plasmodium yoelii | PY01700 | hypothetical protein |
Saccharomyces cerevisiae | YJR058C | Aps2p |
Schistosoma japonicum | Sjp_0086800 | AP-2 complex subunit sigma-1, putative |
Schistosoma mansoni | Smp_143060 | clathrin coat assembly protein AP17 |
Trypanosoma cruzi | TcCLB.506559.330 | clathrin coat assembly protein AP17, putative |
Toxoplasma gondii | TGME49_313450 | AP-2 complex subunit sigma-1, putative |
Theileria parva | TP02_0416 | clathrin assembly protein, putative |
Trichomonas vaginalis | TVAG_134680 | clathrin coat assembly protein ap19, putative |
Trichomonas vaginalis | TVAG_262470 | clathrin coat assembly protein ap19, putative |
Trichomonas vaginalis | TVAG_214290 | clathrin coat assembly protein ap17, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F02E8.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F02E8.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F02E8.3 | Caenorhabditis elegans | sterile | wormbase |
TGME49_313450 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | AP-2 complex subunit sigma | Compounds | References |