TDR Targets v5 release
The fifth release of the database is out! This release includes new functionality allowing users to retrieve compounds associated to gene lists and viceversa; new functionality to map a list of genes to orthologs in other species; new datasets such as essentiality evidence for T. brucei, curated phenotypes for T. cruzi, new protein 3D models, etc. For more information please check out the release notes.
Identification of drug targets.
A paper describing the use of the TDR Targets database in the identification of attractive drug targets has been published in the August 2010 Issue of PLoS Neglected Tropical Diseases.
TDR Targets v4 release.
The fourth release of the TDR Targets database is out. This release
includes new datasets (chemical compounds) and updated data across all
areas of the database. Please check the release notes for additional
details on the changes included in this release.
TDR Targets v3 release.
This is our third release, which brings increased data coverage for all genomes. Check the release notes for a detailed description of changes in this release.
TDR Targets publication.
A paper describing the TDR Targets database has been published in the November, 2008 issue of Nature Reviews Drug Discovery.
Read old news posts here.
The TDR Targets project seeks to exploit the availability of diverse datasets to facilitate the identification and prioritization of drugs and drug targets in neglected disease pathogens. This database functions both as a website where researchers can look for information on targets of interest, and as a tool for prioritization of targets in whole genomes. Using the TDRtargets database as a tool, researchers can quickly prioritize genes of interest by running simple queries (such as looking for small enzymes, or proteins with high quality structural models), assigning numerical weights to each query (in the history page), and combining these results to produce a ranked list of candidate targets. The name of the database includes the initialism 'TDR' for Tropical Disease Research, a special programme within the World Health Organization.
- Distinct forms are used to search for targets, or search for compounds.
- If you are a first time user and you want to leverage the full benefits of the database, you may want to browse our slideshow tutorials.
- To examine and work with queries that you have previously run (for example to give scores to each query and then combine them to obtain a prioritized list of targets), click on history.
- To examine and use queries that others have made publicly available, click on posted lists of targets.
- To examine the entries in the TDR Targets Survey, click on targets survey.