New genomes in TDR Targets.
Posted: 7.Mar.2008

The genomes of Brugia malayi and its Wolbachia endosymbiont, Mycobacterium leprae, Toxoplasma gondii and Plasmodium vivax are now included in TDR Targets. For a summary of available data for these genomes, check the summary table at the bottom of this page.

TDR Targets site updated
Posted: 7.June.2007

The TDR Targets site has been updated. This update brings new functionality that allow users to publish individual queries and/or query sets; and an update of the data from the ongoing curation effort that now includes Leishmania and Plasmodium.

Pilot survey on drug targets for Human African Trypanosomiasis.
Posted: 11.April.2007

A pilot survey on drug targets for Human African Trypanosomiasis is being run now. The idea to survey the scientific community came from a workshop on Drug Discovery for Trypanosomatid Diseases (Dundee, February 2007). This exercise will be used to design similar surveys for other neglected infectious diseases. The output of this community-driven survey will be posted on this site. For more information about the survey see The Scientific Community Human African Trypanosomiasis Drug Target Survey.

Welcome

This site is part of a WHO/TDR project seeking to exploit the availability of diverse datasets, from multiple species, to facilitate target identification and prioritization in pathogens causing neglected diseases.

Drug target discovery has provided the primary motivation for this project, but these tools may also be useful for other applications (e.g. diagnostic or vaccine target identification). See Enhancing Drug Discovery for Neglected Tropical Diseases and Innovative lead discovery strategies for tropical diseases for insight into how this project fits into the larger landscape of parasite drug discovery efforts.

Getting started

 

 

 

 

 

 

 

Summary of available data:

Parent Group Organism Genes Essential
genes		 Curated
targets		 PDB
Structures		 Modbase
models		 Pfam
domains		 EC
numbers		 GO
terms		 Druggability Pathways Antigenicity
Bacteria Mycobacterium tuberculosis 4049 ● ● ● ● ● ● ● ● ● ●
Protist - Apicomplexa Plasmodium falciparum 5590   ● ● ● ● ● ● ● ● ●
Protist - Kinetoplastida Leishmania major 9222   ● ● ● ● ● ● ● ● ●
Protist - Kinetoplastida Trypanosoma brucei 10965 ● ● ● ● ● ● ● ● ● ●
Protist - Kinetoplastida Trypanosoma cruzi 25013     ● ● ● ● ● ● ● ●
Bacteria Wolbachia endosymbiont of Brugia malayi 805         ● ● ●   ● ●
Bacteria Mycobacterium leprae 1608         ● ● ●   ● ●
Helminth - Nematoda Brugia malayi 11508         ●   ●     ●
Protist - Apicomplexa Toxoplasma gondii 8032       ● ● ● ● ●   ●
Protist - Apicomplexa Plasmodium vivax 5446       ● ● ● ● ●   ●
Helminth - Trematoda Schistosoma mansoni In process.
Helminth - Nematoda Onchocerca volvulus Coming soon.
 

Supported by