Detailed information for compound 1309618

Basic information

Technical information
  • TDR Targets ID: 1309618
  • Name: 7-(3,4-dimethoxyphenyl)-4-methyl-2-[4-(phenyl methyl)piperazin-1-yl]-7,8-dihydro-6H-quinazo lin-5-one
  • MW: 472.579 | Formula: C28H32N4O3
  • H donors: 0 H acceptors: 3 LogP: 3.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1CC(=O)c2c(C1)nc(nc2C)N1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C28H32N4O3/c1-19-27-23(15-22(16-24(27)33)21-9-10-25(34-2)26(17-21)35-3)30-28(29-19)32-13-11-31(12-14-32)18-20-7-5-4-6-8-20/h4-10,17,22H,11-16,18H2,1-3H3
  • InChiKey: UARHQZKJXRGULB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(3,4-dimethoxyphenyl)-4-methyl-2-[4-(phenylmethyl)-1-piperazinyl]-7,8-dihydro-6H-quinazolin-5-one
  • 2-[4-(benzyl)piperazin-1-yl]-7-(3,4-dimethoxyphenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one
  • STK217615
  • MLS000039685
  • SMR000035856

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.029 0.4495
Schistosoma mansoni tyrosine kinase 0.0042 0.0262 0.0367
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0188 0.1776 1
Brugia malayi hypothetical protein 0.0024 0.0074 0.0243
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0521
Loa Loa (eye worm) hypothetical protein 0.0073 0.0587 0.1926
Trypanosoma cruzi fatty acid elongase, putative 0.0063 0.0477 0.0772
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.031 0.3048 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.029 0.0406
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0084 0.0703 0.2306
Loa Loa (eye worm) glutamate receptor 0.0042 0.0262 0.086
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0042 0.0262 0.0262
Echinococcus multilocularis NMDA receptor 0.0082 0.0676 0.0676
Loa Loa (eye worm) inositol-1 0.0045 0.029 0.0951
Schistosoma mansoni rab6-interacting 0.0024 0.0074 0.0104
Echinococcus granulosus metabotropic glutamate receptor 2 0.0042 0.0262 0.0367
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.029 0.029
Leishmania major fatty acid elongase, putative 0.031 0.3048 1
Echinococcus granulosus glutamate receptor 2 0.0057 0.0414 0.058
Leishmania major fatty acid elongase, putative 0.031 0.3048 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.0262 0.086
Toxoplasma gondii fatty acid elongase 0.0063 0.0477 0.0679
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0704 0.7146 0.7146
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0074 0.0104
Echinococcus granulosus metabotropic glutamate receptor 5 0.0042 0.0262 0.0367
Plasmodium vivax GNS1/SUR4 domain containing protein 0.031 0.3048 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0138 0.1264 0.1264
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0063 0.0477 1
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0063 0.0477 0.1356
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.008 0.0113
Echinococcus multilocularis musashi 0.0033 0.0165 0.0165
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0138 0.1264 0.1769
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0452 0.1483
Brugia malayi MH2 domain containing protein 0.0144 0.1324 0.4345
Schistosoma mansoni glutamate receptor AMPA 0.0096 0.0828 0.1159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0025 0.0025
Brugia malayi Inositol-1 0.0045 0.029 0.0951
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0783 0.1096
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.029 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0165 0.0541
Echinococcus multilocularis RUN 0.0024 0.0074 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0025 0.008
Onchocerca volvulus 0.0058 0.0432 0.887
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0291 0.0407
Onchocerca volvulus 0.0063 0.0477 1
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0063 0.0477 0.1566
Loa Loa (eye worm) ELO-9 protein 0.0063 0.0477 0.1566
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0074 0.0104
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0254 0.0834
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0278 0.0389
Trypanosoma brucei Fatty acid elongase 0.0063 0.0477 0.0679
Entamoeba histolytica hypothetical protein 0.0043 0.0278 0.5552
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.029 0.4495
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0063 0.0477 1
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0291 0.0291
Schistosoma mansoni lipoxygenase 0.01 0.0861 0.1205
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0074 0.0243
Echinococcus granulosus nmda type glutamate receptor 0.0042 0.0262 0.0367
Chlamydia trachomatis glutamine binding protein 0.0188 0.1776 0.5
Brugia malayi metabotropic glutamate receptor type 2 0.0042 0.0262 0.086
Loa Loa (eye worm) glutamate receptor 2 0.0096 0.0828 0.2718
Brugia malayi fatty acid elongation protein 3 0.0063 0.0477 0.1566
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0291 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.0262 0.086
Trypanosoma cruzi fatty acid elongase, putative 0.031 0.3048 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0025 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1324 0.4345
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.029 0.4495
Loa Loa (eye worm) hypothetical protein 0.0063 0.0477 0.1566
Brugia malayi hypothetical protein 0.0043 0.0278 0.0912
Schistosoma mansoni lamin 0.0033 0.0165 0.0231
Echinococcus granulosus glutamate receptor subunit protein glur 0.0082 0.0676 0.0947
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0541
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0063 0.0477 0.1356
Schistosoma mansoni hypothetical protein 0.0082 0.0676 0.0947
Schistosoma mansoni glutamate receptor NMDA 0.0704 0.7146 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0074 0.0074
Schistosoma mansoni elongation of fatty acids protein 1 0.0063 0.0477 0.0668
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0291 0.0102
Brugia malayi intermediate filament protein 0.0033 0.0165 0.0541
Loa Loa (eye worm) hypothetical protein 0.0024 0.0074 0.0243
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0074 0.0104
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0278 0.0278
Echinococcus multilocularis tyrosine kinase 0.0042 0.0262 0.0262
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.008 0.0264
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0025 0.0034
Brugia malayi fatty acid elongation protein 3 0.0063 0.0477 0.1566
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0074 0.0074
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.0262 0.086
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0291 0.0102
Loa Loa (eye worm) hypothetical protein 0.0041 0.0254 0.0834
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0042 0.0262 0.086
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Onchocerca volvulus 0.0042 0.0262 0.4669
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0188 0.1776 0.5
Schistosoma mansoni intermediate filament proteins 0.0033 0.0165 0.0231
Brugia malayi Fatty acid elongation protein 3 0.031 0.3048 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0025 0.0025
Schistosoma mansoni survival motor neuron protein 0.0058 0.0432 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0291 0.4504
Schistosoma mansoni hypothetical protein 0.0043 0.0278 0.0389
Trypanosoma cruzi fatty acid elongase, putative 0.0063 0.0477 0.0772
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0079 0.0645 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0082 0.0676 0.0676
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0074 0.0074
Brugia malayi hypothetical protein 0.0042 0.0262 0.086
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0042 0.0262 0.086
Trypanosoma cruzi fatty acid elongase, putative 0.0063 0.0477 0.0772
Loa Loa (eye worm) GNS1/SUR4 family protein 0.031 0.3048 1
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0063 0.0477 1
Schistosoma mansoni glutamate receptor NMDA 0.0138 0.1264 0.1769
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1306 0.1306
Echinococcus granulosus lamin dm0 0.0033 0.0165 0.0231
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Schistosoma mansoni hypothetical protein 0.0024 0.0074 0.0104
Loa Loa (eye worm) hypothetical protein 0.0286 0.2793 0.9163
Echinococcus granulosus lamin 0.0033 0.0165 0.0231
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2793 0.2793
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0291 0.0291
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0269 0.2626 0.2626
Schistosoma mansoni glutamate receptor kainate 0.0096 0.0828 0.1159
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.008 0.008
Schistosoma mansoni protein kinase 0.0042 0.0262 0.0367
Trypanosoma cruzi fatty acid elongase, putative 0.031 0.3048 1
Onchocerca volvulus 0.0042 0.0262 0.4669
Brugia malayi GNS1/SUR4 family protein 0.031 0.3048 1
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0262 0.086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0074 0.0243
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0188 0.1776 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.008 0.0113
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0291 0.0407
Schistosoma mansoni ATP-binding cassette transporter 0.0096 0.0828 0.1159
Echinococcus granulosus GPCR family 2 0.0019 0.0025 0.0034
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.008 0.008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0025 0.0034
Schistosoma mansoni glutamate receptor AMPA 0.0096 0.0828 0.1159
Toxoplasma gondii GNS1/SUR4 family protein 0.031 0.3048 1
Echinococcus multilocularis lamin dm0 0.0033 0.0165 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1324 0.4345
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0034
Schistosoma mansoni glutamate receptor kainate 0.0096 0.0828 0.1159
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0034
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0082 0.0676 0.0676
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0034
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0063 0.0477 0.1356
Onchocerca volvulus 0.0033 0.0165 0.2256
Schistosoma mansoni polycystin 1-related 0.0024 0.0074 0.0104
Echinococcus granulosus elongation of very long chain fatty acids 0.0063 0.0477 0.0668
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0291 0.4504
Onchocerca volvulus 0.0033 0.0165 0.2256
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.031 0.3048 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.029 0.01
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0165 0.0541
Schistosoma mansoni lamin 0.0033 0.0165 0.0231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0452 0.1483
Echinococcus multilocularis lamin 0.0033 0.0165 0.0165
Schistosoma mansoni fatty acid acyl transferase-related 0.0063 0.0477 0.0668
Echinococcus granulosus atrial natriuretic peptide receptor 0.0042 0.0262 0.0367
Echinococcus multilocularis elongation of very long chain fatty acids 0.0063 0.0477 0.0477
Entamoeba histolytica hypothetical protein 0.0043 0.0278 0.5552
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0241 0.5
Echinococcus granulosus tyrosine kinase 0.0042 0.0262 0.0367
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0084 0.0703 0.2306
Schistosoma mansoni loxhd1 0.0024 0.0074 0.0104
Brugia malayi hypothetical protein 0.0024 0.0074 0.0243
Echinococcus granulosus glutamate NMDA receptor subunit 0.0704 0.7146 1
Schistosoma mansoni hypothetical protein 0.0041 0.0254 0.0356
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.029 0.01
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0138 0.1264 0.1769
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Brugia malayi hypothetical protein 0.0286 0.2793 0.9163
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0138 0.1264 0.1264
Trypanosoma brucei Long chain fatty acyl elongase 0.0063 0.0477 0.0679
Echinococcus multilocularis nmda type glutamate receptor 0.0269 0.2626 0.2626
Entamoeba histolytica hypothetical protein 0.0043 0.0278 0.5552
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0082 0.0676 0.0676
Schistosoma mansoni inositol monophosphatase 0.0045 0.029 0.0406
Echinococcus granulosus intermediate filament protein 0.0033 0.0165 0.0231
Brugia malayi fatty acid elongation protein 3 0.0063 0.0477 0.1566
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0082 0.0676 0.0947
Trypanosoma brucei Fatty acid elongase 0.031 0.3048 1
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0291 0.0002
Schistosoma mansoni tyrosine kinase 0.0042 0.0262 0.0367
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0082 0.0676 0.0947
Schistosoma mansoni metabotropic glutamate receptor 0.0042 0.0262 0.0367
Schistosoma mansoni hypothetical protein 0.0058 0.0432 0.0604
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0042 0.0262 0.086
Echinococcus multilocularis elongation of very long chain fatty acids 0.0063 0.0477 0.0477
Echinococcus multilocularis glutamate receptor 2 0.0138 0.1264 0.1264
Schistosoma mansoni elongation of fatty acids protein 1 0.0063 0.0477 0.0668
Echinococcus granulosus RUN 0.0024 0.0074 0.0104
Loa Loa (eye worm) glutamate receptor 1 0.0096 0.0828 0.2718
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0165 0.0541
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Echinococcus granulosus voltage gated potassium channel 0.0024 0.008 0.0113
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0291 0.0407
Trypanosoma brucei Fatty acid elongase 0.0063 0.0477 0.0679
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0025 0.008
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0783 0.1096
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0188 0.1776 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0291 0.0291
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0138 0.1264 0.1264
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0291 0.4504
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0264
Leishmania major fatty acid elongase, putative 0.0063 0.0477 0.0772
Trypanosoma cruzi fatty acid elongase, putative 0.0063 0.0477 0.0772
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0084 0.0703 0.0703
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0063 0.0477 0.0772
Echinococcus granulosus elongation of very long chain fatty acids 0.0063 0.0477 0.0668
Entamoeba histolytica hypothetical protein 0.0043 0.0278 0.5552
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0063 0.0477 0.0679
Schistosoma mansoni metabotropic glutamate receptor 0.0042 0.0262 0.0367
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0291 0.0407
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.008 0.0113
Echinococcus granulosus nmda type glutamate receptor 0.0269 0.2626 0.3675
Leishmania major fatty acid elongase, putative 0.031 0.3048 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0291 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0008 0.0026
Onchocerca volvulus 0.0063 0.0477 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0084 0.0703 0.0984
Schistosoma mansoni lipoxygenase 0.0142 0.1306 0.1828
Schistosoma mansoni elongation of fatty acids protein 1 0.0063 0.0477 0.0668
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0188 0.1776 0.5
Echinococcus granulosus receptor type guanylyl cyclase 0.0042 0.0262 0.0367
Echinococcus granulosus glutamate receptor 2 0.0138 0.1264 0.1769
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0063 0.0477 0.1566
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.029 0.01
Echinococcus multilocularis nmda type glutamate receptor 0.0042 0.0262 0.0262
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0262 0.086
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0042 0.0262 0.0262
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0042 0.0262 0.4669
Loa Loa (eye worm) hypothetical protein 0.006 0.0452 0.1483
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.031 0.3048 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0082 0.0676 0.0947
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Schistosoma mansoni inositol monophosphatase 0.0045 0.029 0.0406
Brugia malayi GNS1/SUR4 family protein 0.0063 0.0477 0.1566
Trypanosoma cruzi fatty acid elongase, putative 0.0063 0.0477 0.0772
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1306 0.1828
Trypanosoma cruzi fatty acid elongase, putative 0.031 0.3048 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2793 0.3909
Brugia malayi Guanylyl cyclase protein 23 0.0042 0.0262 0.086
Echinococcus multilocularis receptor type guanylyl cyclase 0.0042 0.0262 0.0262
Loa Loa (eye worm) fatty acid elongation protein 3 0.0063 0.0477 0.1566
Brugia malayi Glutamate receptor 2 precursor 0.0096 0.0828 0.2718
Loa Loa (eye worm) hypothetical protein 0.0045 0.0291 0.0953
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0138 0.1264 0.1769
Brugia malayi Doublecortin family protein 0.0024 0.0074 0.0243
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0042 0.0262 0.086
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0414 0.0414
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0138 0.1264 0.1264
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0291 0.0102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0025 0.008
Schistosoma mansoni glutamate receptor kainate 0.0096 0.0828 0.1159
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Loa Loa (eye worm) fatty acid elongation protein 3 0.0063 0.0477 0.1566
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0432 0.1416
Loa Loa (eye worm) fatty acid elongation protein 3 0.031 0.3048 1
Trypanosoma cruzi fatty acid elongase, putative 0.031 0.3048 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0278 0.0389
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0138 0.1264 0.1769
Trypanosoma cruzi fatty acid elongase, putative 0.0063 0.0477 0.0772
Schistosoma mansoni rab6-interacting 0.0024 0.0074 0.0104
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0008 0.0026
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0079 0.0645 1
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.008
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0291 0.0407
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0452 0.1483
Loa Loa (eye worm) fatty acid elongation protein 3 0.0063 0.0477 0.1566
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0291 0.0953
Brugia malayi Glutamate receptor 1 precursor 0.0096 0.0828 0.2718
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.029 0.9802
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.086
Schistosoma mansoni elongation of fatty acids protein 1 0.0063 0.0477 0.0668
Echinococcus multilocularis glutamate receptor 2 0.0096 0.0828 0.0828
Brugia malayi fatty acid elongation protein 3 0.0063 0.0477 0.1566
Brugia malayi Metabotropic glutamate receptor precursor. 0.0042 0.0262 0.086

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0251 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1961 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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