Detailed information for compound 1369669

Basic information

Technical information
  • TDR Targets ID: 1369669
  • Name: N-methyl-N-(phenylmethyl)-1,3-benzodioxole-5- carboxamide
  • MW: 269.295 | Formula: C16H15NO3
  • H donors: 0 H acceptors: 1 LogP: 2.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)c1ccc2c(c1)OCO2)Cc1ccccc1
  • InChi: 1S/C16H15NO3/c1-17(10-12-5-3-2-4-6-12)16(18)13-7-8-14-15(9-13)20-11-19-14/h2-9H,10-11H2,1H3
  • InChiKey: GCFRGSSFKPOMTP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(benzyl)-N-methyl-1,3-benzodioxole-5-carboxamide
  • ZINC00030208
  • TimTec1_003485
  • BAS 01129844
  • ST043248
  • Oprea1_332021
  • Benzo[1,3]dioxole-5-carboxylic acid benzyl-methyl-amide
  • MLS000075839
  • SMR000010078

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0153 0.1462 0.1809
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0031 0.02 0.0241
Trypanosoma brucei RNA editing exonuclease 2 0.0031 0.02 0.0318
Brugia malayi Protein kinase domain containing protein 0.0187 0.1814 0.2244
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Toxoplasma gondii ABC1 family protein 0.0072 0.062 0.0915
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0093 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0136
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Schistosoma mansoni acetylcholinesterase 0.0022 0.0111 0.0137
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0143 0.1363 0.2171
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0006 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0008
Brugia malayi nuclear hormone receptor 0.0012 0.0006 0.0008
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0093 0.0114
Mycobacterium tuberculosis Conserved protein 0.0072 0.062 0.1251
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0027 0.0033
Schistosoma mansoni hypothetical protein 0.0298 0.2961 0.3664
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0177 0.121
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0177 0.0219
Brugia malayi Carboxylesterase family protein 0.0022 0.0111 0.0137
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.02 0.1364
Giardia lamblia Kinase, CAMK CAMKL 0.0143 0.1363 0.2054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.1084 0.1661
Mycobacterium ulcerans lipase LipD 0.0072 0.062 0.4238
Trypanosoma cruzi mitochondrial protein 99, putative 0.0031 0.02 0.0241
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0187 0.1814 0.2226
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0143 0.1363 0.2108
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0137 0.1297 0.1605
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.6275 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.6275 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0331 0.3301 0.4085
Brugia malayi CXXC zinc finger family protein 0.0061 0.0509 0.063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Loa Loa (eye worm) carboxylesterase 0.0022 0.0111 0.0136
Entamoeba histolytica protein kinase, putative 0.0619 0.6275 1
Leishmania major hypothetical protein, conserved 0.0031 0.02 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1363 0.2171
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0027 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.005 0.005
Loa Loa (eye worm) microfilarial chitinase 0.0077 0.0673 0.0826
Toxoplasma gondii thioredoxin reductase 0.0083 0.0737 0.1103
Echinococcus granulosus serine:threonine protein kinase haspin 0.0794 0.8081 1
Leishmania major RNA-editing complex protein MP100, putative 0.0031 0.02 0.0241
Mycobacterium tuberculosis Probable dehydrogenase 0.0189 0.1834 0.3916
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.1227 0.1518
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0014 0.0027 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0008
Trichomonas vaginalis esterase, putative 0.0072 0.062 0.0987
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0331 0.3301 0.4085
Onchocerca volvulus 0.0125 0.1173 0.4679
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0549 0.0674
Brugia malayi hypothetical protein 0.0014 0.0027 0.0033
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0223 0.0276
Echinococcus multilocularis expressed conserved protein 0.0093 0.0841 0.0841
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0318
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Leishmania major importin beta-1 subunit, putative 0.0023 0.0114 0.0104
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0153 0.1462 0.233
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.062 0.4238
Loa Loa (eye worm) hypothetical protein 0.0099 0.0903 0.1108
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.062 0.1251
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.062 0.0987
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0125 0.1173 0.1451
Brugia malayi beta-lactamase family protein 0.0072 0.062 0.0767
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.062 0.062
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Schistosoma mansoni patched 1 0.0042 0.0319 0.0395
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.0494 0.0611
Echinococcus granulosus expressed protein 0.0014 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0181 0.1749 0.2146
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0027 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0008
Entamoeba histolytica hypothetical protein 0.0137 0.1297 0.2067
Brugia malayi TAR-binding protein 0.0065 0.0549 0.0679
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0318
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0143 0.1363 0.1672
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0031 0.02 0.0318
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0143 0.1363 0.9317
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0136
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0241
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0143 0.1363 0.1362
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0114 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trypanosoma cruzi PAB1-binding protein , putative 0.0132 0.1248 0.1925
Onchocerca volvulus 0.0254 0.2506 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.005 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.02 0.0241
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0031 0.02 0.0247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0679
Leishmania major serine/threonine kinase-like protein, putative 0.0143 0.1363 0.2108
Entamoeba histolytica hypothetical protein 0.0023 0.0114 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0008
Entamoeba histolytica protein kinase domain containing protein 0.0187 0.1814 0.289
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0114 0.0104
Brugia malayi beta-lactamase family protein 0.0072 0.062 0.0767
Loa Loa (eye worm) hypothetical protein 0.0067 0.0575 0.0705
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0006 0.0008
Leishmania major pantothenate kinase subunit, putative 0.0031 0.02 0.0241
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0008
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.02 0.0245
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0031 0.02 0.0318
Plasmodium vivax SET domain protein, putative 0.0033 0.0223 0.1526
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.1363 0.2171
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.062 0.1251
Plasmodium vivax hypothetical protein, conserved 0.0125 0.1173 0.8021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0331 0.3301 0.4052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0087 0.0087
Leishmania major hypothetical protein, conserved 0.0031 0.02 0.0241
Echinococcus granulosus importin subunit beta 1 0.0028 0.0169 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0331 0.3301 0.4085
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0008
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0241
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Brugia malayi hypothetical protein 0.0132 0.1248 0.1544
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.062 0.0915
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.6275 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0153 0.1462 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0189 0.1834 0.3916
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Echinococcus multilocularis cpg binding protein 0.0064 0.0545 0.0545
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.005 0.0061
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0027 0.0033
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0027 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0132 0.1248 0.1925
Brugia malayi RNA binding protein 0.0065 0.0549 0.0679
Onchocerca volvulus 0.0014 0.0027 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0177 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Plasmodium vivax ataxin-2 like protein, putative 0.0132 0.1248 0.8535
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0619 0.6275 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.1245 0.1529
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0241
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0187 0.1814 0.2833
Schistosoma mansoni hypothetical protein 0.0348 0.3477 0.4303
Echinococcus multilocularis deoxyribonuclease 1 2 0.0031 0.02 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.0391
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.062 0.0767
Loa Loa (eye worm) RNA binding protein 0.0065 0.0549 0.0674
Brugia malayi Carboxylesterase family protein 0.0022 0.0111 0.0137
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0177 0.0279
Loa Loa (eye worm) hypothetical protein 0.0125 0.1173 0.144
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0027 0.0033
Brugia malayi ecdysteroid receptor 0.0012 0.0006 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0093 0.0633
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0245
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0549 0.0549
Trichomonas vaginalis ap endonuclease, putative 0.0153 0.1462 0.233
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0245
Echinococcus multilocularis traf and tnf receptor associated protein 0.0031 0.02 0.0199
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0049 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0246 0.0245
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.005 0.005
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0794 0.8081 0.8081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0509 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0006 0.0008
Trypanosoma cruzi mitochondrial protein 99, putative 0.0031 0.02 0.0241
Leishmania major hypothetical protein, conserved 0.0072 0.062 0.0915
Schistosoma mansoni nocturnin 0.0031 0.02 0.0247
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0027 0.0033
Plasmodium falciparum thioredoxin reductase 0.0029 0.0177 0.121
Onchocerca volvulus Putative neutral sphingomyelinase 0.0031 0.02 0.0796
Onchocerca volvulus 0.0031 0.02 0.0796
Brugia malayi Endochitinase 0.0088 0.0793 0.0981
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0241
Brugia malayi hypothetical protein 0.0085 0.0763 0.0944
Echinococcus multilocularis dual specificity 0.0187 0.1814 0.1814
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0241
Onchocerca volvulus 0.0022 0.0111 0.0442
Brugia malayi Carboxylesterase family protein 0.0132 0.1245 0.1541
Schistosoma mansoni cpg binding protein 0.0064 0.0545 0.0674
Mycobacterium ulcerans chitinase/cellulase 0.0067 0.0575 0.3929
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.0391
Loa Loa (eye worm) glutathione reductase 0.0083 0.0737 0.0904
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.2961 0.3635
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0006 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.062 0.0988
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0111 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0008
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0027 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0223 0.0223
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0319 0.0395
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0006 0.0008
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0177 0.0282
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0318
Brugia malayi Protein kinase domain containing protein 0.0143 0.1363 0.1686
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0006 0.0008
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0027 0.0027
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0125 0.1173 0.1173
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0143 0.1363 0.2171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0223 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.062 0.0987
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0111 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0177 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1363 0.2171
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0177 0.121
Plasmodium falciparum glutathione reductase 0.0083 0.0737 0.5037
Onchocerca volvulus Putative endochitinase 0.0088 0.0793 0.3162
Schistosoma mansoni hypothetical protein 0.0031 0.02 0.0247
Brugia malayi cyclin-dependent kinase 7 homolog 0.0143 0.1363 0.1686
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0031 0.02 0.0318
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0111 0.0111
Leishmania major hypothetical protein, conserved 0.0031 0.02 0.0241
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.02 0.0318
Loa Loa (eye worm) hypothetical protein 0.0072 0.062 0.0761
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0177 0.121
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.062 0.0767
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0027 0.0033
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0331 0.3301 0.3301
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0919 0.1137
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.02 0.0245
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0027 0.0033
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.02 0.0245
Brugia malayi hypothetical protein 0.0794 0.8081 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0006 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.062 0.0767
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0027 0.0043
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0153 0.1462 0.1795
Echinococcus granulosus acetylcholinesterase 0.0132 0.1245 0.1541
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0093 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.0036
Echinococcus granulosus neuroligin 0.0022 0.0111 0.0137
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0027 0.0043
Onchocerca volvulus 0.0072 0.062 0.2472
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0111 0.0134
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0143 0.1363 0.1362
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0177 0.0204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0331 0.3301 0.4085
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0031 0.02 0.0241
Onchocerca volvulus Putative endochitinase 0.0079 0.0695 0.277
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Onchocerca volvulus 0.0022 0.0111 0.0442
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0189 0.1834 0.3916
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Schistosoma mansoni synaptojanin 0.0031 0.02 0.0247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0153 0.1462 0.2269
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0027 0.0033
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1245 0.1245
Echinococcus granulosus dual specificity 0.0619 0.6275 0.7766
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0027 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0008
Plasmodium vivax importin-beta 2, putative 0.0028 0.0169 0.1154
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Schistosoma mansoni hypothetical protein 0.0035 0.0246 0.0304
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.0391
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0093 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0008
Schistosoma mansoni serine/threonine kinase 0.0143 0.1363 0.1686
Echinococcus granulosus tar DNA binding protein 0.0065 0.0549 0.0679
Brugia malayi Cell division protein kinase 2 0.0143 0.1363 0.1686
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) hypothetical protein 0.0181 0.1749 0.2146
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.6275 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0153 0.1462 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0177 0.121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.0036
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0318
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0111 0.0137
Giardia lamblia Inositol 5-phosphatase 4 0.0031 0.02 0.0173
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0006 0.0008
Onchocerca volvulus 0.0072 0.062 0.2472
Brugia malayi Pre-SET motif family protein 0.0223 0.2189 0.2709
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.062 0.0987
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.062 0.0767
Onchocerca volvulus 0.0014 0.0027 0.0108
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0027 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.062 0.0987
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0027 0.0033
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0903 0.1439
Mycobacterium tuberculosis Probable oxidoreductase 0.021 0.2052 0.4395
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0006 0.0008
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0136
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0027 0.0033
Brugia malayi Carboxylesterase family protein 0.0132 0.1245 0.1541
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.005 0.008
Onchocerca volvulus 0.0012 0.0006 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0072 0.062 0.4238
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0027 0.0033
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.0737 0.5037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0136
Plasmodium falciparum importin beta, putative 0.0028 0.0169 0.1154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0114 0.0182
Mycobacterium ulcerans hypothetical protein 0.0072 0.062 0.4238
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0093 0.0148
Giardia lamblia Kinase, CMGC DYRK 0.0619 0.6275 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0177 0.5
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0903 0.1117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0189 0.1834 0.3916
Entamoeba histolytica protein kinase domain containing protein 0.0619 0.6275 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.062 0.1251
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Schistosoma mansoni cpg binding protein 0.0061 0.0509 0.063
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0111 0.0134
Schistosoma mansoni neutral sphingomyelinase 0.0031 0.02 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0331 0.3301 0.4085
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.062 0.1251
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0093 0.0114
Echinococcus granulosus serine:threonine protein kinase haspin 0.0794 0.8081 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0031 0.02 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Mycobacterium tuberculosis Conserved protein 0.0072 0.062 0.1251
Schistosoma mansoni gliotactin 0.0022 0.0111 0.0137
Schistosoma mansoni hypothetical protein 0.0348 0.3477 0.4303
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0318
Trichomonas vaginalis ap endonuclease, putative 0.0153 0.1462 0.233
Entamoeba histolytica chitinase, putative 0.0079 0.0695 0.1106
Brugia malayi hypothetical protein 0.0035 0.0246 0.0304
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0241
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.062 0.1251
Giardia lamblia Kinase, CAMK CAMKL 0.0143 0.1363 0.2054
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0319 0.0508
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0177 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.1363 0.1686
Mycobacterium tuberculosis Possible chitinase 0.0067 0.0575 0.1152
Schistosoma mansoni serine/threonine protein kinase 0.0619 0.6275 0.7766
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0031 0.02 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.005 0.034
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0549 0.0679
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0027 0.0043
Entamoeba histolytica hypothetical protein 0.0187 0.1814 0.289
Onchocerca volvulus 0.0014 0.0027 0.0108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0136
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0125 0.1173 0.1451
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0177 0.121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0008
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0111 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0008
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0027 0.0027
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0169 0.0169
Trichomonas vaginalis ran, putative 0.0021 0.0093 0.0147
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0679
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.6275 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.1245 0.1541
Schistosoma mansoni carbon catabolite repressor protein 0.0031 0.02 0.0247
Leishmania major hypothetical protein, conserved 0.0132 0.1248 0.1925
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.02 0.0318
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0049 0.006
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0177 0.0204
Onchocerca volvulus 0.0031 0.02 0.0796
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0027 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0241
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.005 0.034
Brugia malayi Thioredoxin reductase 0.0083 0.0737 0.0911
Echinococcus multilocularis expressed protein 0.0014 0.0027 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0246 0.0304
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0177 0.121
Echinococcus multilocularis protein dispatched 1 0.0048 0.0381 0.0381
Onchocerca volvulus 0.0022 0.0111 0.0442
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0031 0.02 0.0318
Plasmodium vivax glutathione reductase, putative 0.0083 0.0737 0.5037
Schistosoma mansoni ap endonuclease 0.0153 0.1462 0.1809
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.0742 0.0742
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0111 0.0137
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0098 0.0121
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.1245 0.1245
Brugia malayi Importin beta-1 subunit 0.0028 0.0169 0.0209
Schistosoma mansoni protein kinase 0.0143 0.1363 0.1686
Mycobacterium ulcerans beta-lactamase 0.0072 0.062 0.4238
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Plasmodium vivax exodeoxyribonuclease III, putative 0.0031 0.02 0.1364
Leishmania major trypanothione reductase 0.0083 0.0737 0.1103
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0111 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0331 0.3301 0.3301
Leishmania major GTP-binding protein, putative 0.0021 0.0093 0.0069
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0375
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0027 0.0033
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0153 0.1462 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0006 0.0025
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0027 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0072 0.062 0.0761
Brugia malayi Isocitrate dehydrogenase 0.0016 0.005 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0006 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0241
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0153 0.1462 1
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0619 0.6275 1
Trichomonas vaginalis helicase, putative 0.0014 0.0023 0.0036
Mycobacterium tuberculosis Probable reductase 0.0189 0.1834 0.3916
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0031 0.02 0.0241
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0111 0.0137
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0153 0.1462 0.2215
Plasmodium falciparum MO15-related protein kinase 0.0143 0.1363 0.9317
Entamoeba histolytica cell division protein kinase 2, putative 0.0143 0.1363 0.2171
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0049 0.006
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0031 0.02 0.0241
Brugia malayi glutathione reductase 0.0083 0.0737 0.0911
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Echinococcus granulosus cpg binding protein 0.0064 0.0545 0.0674
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0189 0.1834 0.3916
Brugia malayi endochitinase 0.0088 0.0793 0.0981
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0033
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0111 0.0137
Entamoeba histolytica protein kinase, putative 0.0187 0.1814 0.289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0169 0.0191
Echinococcus multilocularis neuroligin 0.0022 0.0111 0.0111
Mycobacterium ulcerans chitinase/cellulase 0.0067 0.0575 0.3929
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0177 0.0282
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0031 0.02 0.1364
Trichomonas vaginalis protein kinase atmrk1, putative 0.0143 0.1363 0.2171
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.0494 0.0494
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0223 0.0276
Loa Loa (eye worm) hypothetical protein 0.0132 0.1245 0.1529
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0093 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0187 0.1814 0.2833
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0031 0.02 0.0318
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0031 0.02 0.1364
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0111 0.0176
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0031 0.02 0.1364
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0049 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.0036
Schistosoma mansoni synaptojanin 0.0031 0.02 0.0247
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0318
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0143 0.1363 0.2108
Onchocerca volvulus 0.0125 0.1173 0.4679
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0027 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0006 0.0008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0093 0.0069
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.062 0.4238
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.1342 0.1661
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0027 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1363 0.2171
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0006
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0027 0.0033
Onchocerca volvulus Putative endochitinase 0.0088 0.0793 0.3162
Echinococcus granulosus expressed conserved protein 0.0093 0.0841 0.1041
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0031 0.02 0.0318
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.02 0.0241
Loa Loa (eye worm) haspin protein kinase 0.0794 0.8081 0.992
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0031 0.02 0.0241
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0223 0.0279
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0028 0.0169 0.0207
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0375
Loa Loa (eye worm) hypothetical protein 0.0125 0.1173 0.144
Schistosoma mansoni hypothetical protein 0.0059 0.0494 0.0611
Entamoeba histolytica protein kinase domain containing protein 0.0143 0.1363 0.2171
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0197 0.0244
Giardia lamblia hypothetical protein 0.0031 0.02 0.0173
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0375
Giardia lamblia Kinase, CAMK CAMKL 0.0143 0.1363 0.2054
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0111 0.0757
Brugia malayi beta-lactamase 0.0072 0.062 0.0767
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0153 0.1462 0.1462
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0737 0.1103
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0177 0.0177
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0187 0.1814 0.2833
Schistosoma mansoni cript-related 0.0031 0.02 0.0247
Plasmodium falciparum DNase I-like protein, putative 0.0031 0.02 0.1364
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.005 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.021 0.2052 0.4395
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0031 0.02 0.0241
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0027 0.0033
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0318
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0093 0.0092
Toxoplasma gondii exonuclease III APE 0.0153 0.1462 0.2269
Brugia malayi RNA, U transporter 1 0.0079 0.0701 0.0867
Echinococcus multilocularis snurportin 1 0.0298 0.2961 0.2961
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0153 0.1462 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0679
Mycobacterium tuberculosis Conserved protein 0.0072 0.062 0.1251
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0679
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.062 0.0761
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0375
Entamoeba histolytica hypothetical protein 0.0035 0.0246 0.0391
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0027 0.0043
Schistosoma mansoni ran 0.0021 0.0093 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0031 0.02 0.0199
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0619 0.6275 1
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0619 0.6275 1
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0137 0.1297 0.1605
Brugia malayi exodeoxyribonuclease III family protein 0.0153 0.1462 0.1809
Entamoeba histolytica G protein alpha subunit, putative 0.0014 0.0027 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.0737 0.0904
Echinococcus multilocularis protein patched 0.0042 0.0319 0.0319
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0143 0.1363 0.9317
Treponema pallidum hypothetical protein 0.0031 0.02 0.0176
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0319 0.0319
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0072 0.062 0.0761
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.021 0.2052 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0027 0.0027
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0143 0.1363 0.2108
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0143 0.1363 0.1686
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0331 0.3301 0.4085
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0619 0.6275 0.7766
Brugia malayi hypothetical protein 0.0022 0.0111 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0031 0.02 0.1364
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0006 0.0006
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0031 0.02 0.0318
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0031 0.02 0.1364
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0153 0.1462 0.2269
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0027 0.0033
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1245 0.1245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0177 0.0282
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0031 0.02 0.0241
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0006 0.0008
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0143 0.1363 0.2108
Entamoeba histolytica protein kinase, putative 0.0187 0.1814 0.289
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0031 0.02 0.0318
Loa Loa (eye worm) hypothetical protein 0.0033 0.0223 0.0274
Toxoplasma gondii LsmAD domain-containing protein 0.0132 0.1248 0.1925
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0031 0.02 0.0318
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.02 0.0245
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.062 0.0987
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0679
Echinococcus granulosus serine:threonine protein kinase NLK 0.0143 0.1363 0.1686
Echinococcus granulosus snurportin 1 0.0298 0.2961 0.3664
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Echinococcus multilocularis dual specificity 0.0619 0.6275 0.6275
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0111 0.0176
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0006 0.0008
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0031 0.02 0.0247
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0006 0.0008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.0036
Plasmodium falciparum glutathione reductase 0.0029 0.0177 0.121
Echinococcus multilocularis dual specificity 0.0619 0.6275 0.6275
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0027 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.0742 0.0918
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0033
Brugia malayi steroid hormone receptor 0.0012 0.0006 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0006 0.0006
Echinococcus multilocularis geminin 0.0348 0.3477 0.3477
Loa Loa (eye worm) hypothetical protein 0.0052 0.0418 0.0513
Echinococcus multilocularis neutral sphingomyelinase 0.0031 0.02 0.0199
Leishmania major endonuclease/exonuclease protein-like protein 0.0031 0.02 0.0241
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0006 0.0008
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0318
Loa Loa (eye worm) carboxylesterase 0.0022 0.0111 0.0136
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0153 0.1462 0.3101
Echinococcus multilocularis synaptojanin 1 0.0031 0.02 0.0199
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0177 0.0204
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.2189 0.2687
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0619 0.6275 0.7704
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0111 0.0137
Trypanosoma brucei PAB1-binding protein , putative 0.0132 0.1248 0.1989
Mycobacterium tuberculosis Probable exported protein 0.0031 0.02 0.0329
Echinococcus granulosus serine:threonine protein kinase haspin 0.0794 0.8081 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0136
Onchocerca volvulus 0.0033 0.0223 0.089
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0143 0.1363 0.1672
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0027 0.0027
Echinococcus granulosus carboxylesterase 5A 0.0132 0.1245 0.1541
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0031 0.02 0.0247
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0177 0.121
Echinococcus multilocularis cyclin dependent kinase 9 0.0143 0.1363 0.1362
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0031 0.02 0.0318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0223 0.0276
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0241
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0027 0.0033
Schistosoma mansoni ap endonuclease 0.0153 0.1462 0.1809
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) hypothetical protein 0.0072 0.062 0.0761
Loa Loa (eye worm) hypothetical protein 0.0072 0.062 0.0761
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0027 0.0033
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.005 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0169 0.0269
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0033
Leishmania major chitinase 0.0079 0.0695 0.1035
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0031 0.02 0.0318
Echinococcus granulosus traf and tnf receptor associated protein 0.0031 0.02 0.0247
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0153 0.1462 0.2269
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.02 0.0245
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0008
Echinococcus granulosus cyclin dependent kinase 9 0.0143 0.1363 0.1686
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.062 0.0915
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0031 0.02 0.0318
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.4605 1
Trypanosoma brucei protein kinase, putative 0.0143 0.1363 0.2171
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.021 0.2052 0.4395
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0098 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Onchocerca volvulus 0.0022 0.0111 0.0442
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.005 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0087 0.0107
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0189 0.1834 0.8478
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0014 0.0027 0.0033
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0027 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0245
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0031 0.02 0.0247
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0177 0.0204
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.005 0.005
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0027 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1363 0.2171
Plasmodium vivax hypothetical protein, conserved 0.0031 0.02 0.1364
Loa Loa (eye worm) carboxylesterase 0.0132 0.1245 0.1529
Echinococcus granulosus dual specificity 0.0619 0.6275 0.7766
Schistosoma mansoni hypothetical protein 0.0125 0.1173 0.1451
Brugia malayi endochitinase 0.0079 0.0695 0.0859
Echinococcus granulosus dual specificity 0.0187 0.1814 0.2244
Plasmodium falciparum ataxin-2 like protein, putative 0.0132 0.1248 0.8535
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.0036
Loa Loa (eye worm) histone methyltransferase 0.002 0.0087 0.0107
Brugia malayi GSG2 0.0794 0.8081 1
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1363 0.2171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0245
Trypanosoma brucei trypanothione reductase 0.0083 0.0737 0.1174
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.0737 0.1508
Plasmodium falciparum conserved protein, unknown function 0.0125 0.1173 0.8021
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Echinococcus granulosus dual specificity 0.0619 0.6275 0.7766
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Brugia malayi G-protein alpha subunit 0.0014 0.0027 0.0033
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0177 0.0282
Schistosoma mansoni ran 0.0021 0.0093 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0177 0.0219
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.062 0.1251
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.1363 0.2171
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0031 0.02 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0036
Trichomonas vaginalis set domain proteins, putative 0.0254 0.2506 0.3994
Onchocerca volvulus 0.0061 0.0509 0.2031
Echinococcus granulosus geminin 0.0348 0.3477 0.4303
Onchocerca volvulus 0.0022 0.0111 0.0442
Schistosoma mansoni hypothetical protein 0.0794 0.8081 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0177 0.0204
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0319 0.0392
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0177 0.0282
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0794 0.8081 0.8081
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0319 0.0395
Echinococcus multilocularis hypothetical protein 0.0137 0.1297 0.1297
Echinococcus granulosus synaptojanin 1 0.0031 0.02 0.0247
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.062 0.1251
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0169 0.0269
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0392
Plasmodium falciparum thioredoxin reductase 0.0083 0.0737 0.5037
Schistosoma mansoni cpg binding protein 0.0064 0.0545 0.0674
Echinococcus multilocularis dual specificity 0.0619 0.6275 0.6275
Loa Loa (eye worm) haspin protein kinase 0.0794 0.8081 0.992
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0031 0.02 0.0318
Echinococcus granulosus neutral sphingomyelinase 0.0031 0.02 0.0247
Plasmodium falciparum ataxin-2 like protein, putative 0.0132 0.1248 0.8535
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0006
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0027 0.0043
Brugia malayi Carboxylesterase family protein 0.0022 0.0111 0.0137
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0027 0.0043
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0031 0.02 0.0241
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0153 0.1462 0.233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0223 0.0276
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0031 0.02 0.0199
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0049 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.6275 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0903 0.0903
Trichomonas vaginalis Phospholipase C precursor, putative 0.0031 0.02 0.0318
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.0036
Onchocerca volvulus 0.0072 0.062 0.2472
Trichomonas vaginalis serine/threonine kinase, putative 0.0143 0.1363 0.2171
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.1363 0.2171
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) cuticular endochitinase 0.0079 0.0695 0.0852
Loa Loa (eye worm) hypothetical protein 0.0132 0.1245 0.1529
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0114 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1814 0.2244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0246 0.0304
Brugia malayi Pre-SET motif family protein 0.0033 0.0223 0.0276
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0111 0.0111
Brugia malayi CHE-14 protein 0.0042 0.0319 0.0395
Brugia malayi isocitrate dehydrogenase 0.0016 0.005 0.0061
Brugia malayi nuclear receptor NHR-88 0.0012 0.0006 0.0008
Onchocerca volvulus Putative endochitinase 0.0088 0.0793 0.3162
Schistosoma mansoni coup transcription factor 0.0012 0.0006 0.0008
Brugia malayi Carboxylesterase family protein 0.0022 0.0111 0.0137
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0031 0.02 0.0318
Loa Loa (eye worm) hypothetical protein 0.0132 0.1248 0.1532
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0072 0.062 0.0761
Schistosoma mansoni importin beta-1 0.0028 0.0169 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0223 0.0276
Onchocerca volvulus Putative endochitinase 0.0079 0.0695 0.277
Echinococcus granulosus acetylcholinesterase 0.0132 0.1245 0.1541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0085 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1363 0.2171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0033
Echinococcus granulosus mitogen activated protein kinase 15 0.0143 0.1363 0.1686
Toxoplasma gondii hypothetical protein 0.0125 0.1173 0.1804
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0027 0.0043
Brugia malayi CCR4 0.0031 0.02 0.0247
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0549 0.0674
Loa Loa (eye worm) beta-lactamase 0.0072 0.062 0.0761
Entamoeba histolytica Ran family GTPase 0.0021 0.0093 0.0147
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0033
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0031 0.02 0.0318
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.005 0.008
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0027 0.0033
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0177 0.0204
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0903 0.1117
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0031 0.02 0.0245
Loa Loa (eye worm) chitinase I 0.0079 0.0695 0.0852
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0187 0.1814 0.289
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0008
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0177 0.0136
Loa Loa (eye worm) haspin protein kinase 0.08 0.8146 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0027 0.0033

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1778 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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