TDR Targets

Basic information

Technical information

TDR Targets ID: 1396791
Name: 3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5- yl]-pyrrolidin-1-ylmethyl]-6,8-dimethyl-1H-qu inolin-2-one
MW: 458.512 | Formula: C25H26N6O3
H donors: 1 H acceptors: 5 LogP: 4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(C)c2c(c1)cc(c(n2)O)C(c1nnnn1Cc1ccc2c(c1)OCO2)N1CCCC1
InChi: 1S/C25H26N6O3/c1-15-9-16(2)22-18(10-15)12-19(25(32)26-22)23(30-7-3-4-8-30)24-27-28-29-31(24)13-17-5-6-20-21(11-17)34-14-33-20/h5-6,9-12,23H,3-4,7-8,13-14H2,1-2H3,(H,26,32)
InChiKey: BMWFDPQGQFDPHU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-6,8-dimethyl-1H-quinolin-2-one
3-[[1-(1,3-benzodioxol-5-ylmethyl)-5-tetrazolyl]-1-pyrrolidinylmethyl]-6,8-dimethyl-1H-quinolin-2-one
3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-6,8-dimethyl-carbostyril
3-[[1-(1,3-benzodioxol-5-ylmethyl)-1,2,3,4-tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-6,8-dimethyl-1H-quinolin-2-one
ASN 05340598
Oprea1_177608
3-[(1-Benzo[1,3]dioxol-5-ylmethyl-1H-tetrazol-5-yl)-pyrrolidin-1-yl-methyl]-6,8-dimethyl-1H-quinolin-2-one
MLS000031245
SMR000004439

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	arachidonate 15-lipoxygenase	Starlite/ChEMBL	No references
Schistosoma mansoni	Thioredoxin glutathione reductase	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	hydroxysteroid (17-beta) dehydrogenase 10	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma japonicum	ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	scully CG7113-PA	Get druggable targets OG5_129031	All targets in OG5_129031
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania infantum	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium parvum	scully CG7113-PA, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	521 aa	21.5 %
Neospora caninum	hypothetical protein	Thioredoxin glutathione reductase	598 aa	485 aa	30.5 %
Onchocerca volvulus		Thioredoxin glutathione reductase	598 aa	533 aa	50.8 %
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	hydroxysteroid (17-beta) dehydrogenase 10	252 aa	251 aa	24.7 %
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Neospora caninum	glutathione reductase, putative	Thioredoxin glutathione reductase	598 aa	532 aa	34.6 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	Thioredoxin glutathione reductase	598 aa	513 aa	25.0 %
Echinococcus granulosus	arachidonate 5 lipoxygenase	arachidonate 15-lipoxygenase	662 aa	590 aa	23.9 %
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	518 aa	22.0 %
Neospora caninum	Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related	Thioredoxin glutathione reductase	598 aa	512 aa	28.3 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin glutathione reductase	598 aa	537 aa	24.2 %
Plasmodium berghei	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	538 aa	25.3 %
Toxoplasma gondii	NADPH-glutathione reductase	Thioredoxin glutathione reductase	598 aa	555 aa	33.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0054	0.0502	0.0502
Echinococcus multilocularis	dnaJ subfamily B	0.043	0.4876	0.4876
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0381	0.1766
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.006	0.006
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0709	0.0709
Plasmodium vivax	multidomain scavenger receptor, putative	0.0024	0.0153	0.0486
Echinococcus multilocularis	cathepsin L cysteine protease	0.018	0.1969	0.1969
Brugia malayi	hypothetical protein	0.002	0.0111	0.0111
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0054	0.0502	0.1129
Brugia malayi	regulator of G-protein signaling egl-10	0.002	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0502	0.1129
Onchocerca volvulus		0.004	0.0345	0.1076
Trypanosoma cruzi	cruzipain precursor, putative	0.023	0.2549	0.2504
Echinococcus granulosus	RUN	0.0024	0.0153	0.0153
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0054	0.0502	0.1129
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0636	0.0636
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0381	0.082
Trichomonas vaginalis	esterase, putative	0.0043	0.0381	0.082
Brugia malayi	glutathione reductase	0.0046	0.0407	0.0407
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0111	0.0111
Schistosoma mansoni	lamin	0.0028	0.0206	0.0206
Onchocerca volvulus		0.018	0.1969	0.614
Echinococcus multilocularis	cysteine protease	0.018	0.1969	0.1969
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0054	0.0502	0.0502
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3975	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.018	0.1969	0.4874
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0153	0.0153
Plasmodium vivax	vivapain-2	0.018	0.1969	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0105	0.1097	0.5431
Schistosoma mansoni	hypothetical protein	0.0033	0.0262	0.0262
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.002	0.0111	0.0111
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0037	0.0303	0.0303
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0129	0.1374	0.1374
Schistosoma mansoni	z-protein (S1r protein)	0.002	0.0111	0.0111
Onchocerca volvulus		0.0129	0.1374	0.4286
Onchocerca volvulus		0.018	0.1969	0.614
Trypanosoma cruzi	cysteine proteinase, putative	0.0105	0.1097	0.1043
Brugia malayi	Papain family cysteine protease containing protein	0.018	0.1969	0.1969
Schistosoma mansoni	cpg binding protein	0.003	0.0227	0.0227
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.1087	0.3374
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0054	0.0502	0.0502
Brugia malayi	Cathepsin L-like precursor	0.0051	0.0471	0.0471
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0054	0.0502	0.0502
Trypanosoma cruzi	cysteine peptidase, putative	0.0105	0.1097	0.1043
Echinococcus multilocularis	beta adrenergic receptor kinase	0.002	0.0111	0.0111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1374	0.1374
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0502	0.1129
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0407	0.1817
Onchocerca volvulus		0.0054	0.0502	0.1566
Brugia malayi	hypothetical protein	0.002	0.0111	0.0111
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0054	0.0502	0.2315
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0054	0.0502	0.2315
Brugia malayi	hypothetical protein	0.0024	0.0153	0.0153
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0262	0.0262
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0395	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1374	0.1374
Onchocerca volvulus		0.0043	0.0381	0.119
Brugia malayi	beta-lactamase family protein	0.0043	0.0381	0.0381
Entamoeba histolytica	cysteine proteinase, putative	0.018	0.1969	0.4808
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0054	0.0502	0.1129
Echinococcus granulosus	sodium:glucose cotransporter 2	0.004	0.0345	0.0345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0502	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0395	0.0395
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Brugia malayi	hypothetical protein	0.0159	0.1723	0.1723
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.0153	0.0153
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0111	0.0111
Entamoeba histolytica	cysteine proteinase 2	0.0105	0.1097	0.2551
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.004	0.0345	0.0843
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0054	0.0502	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0502	0.0502
Echinococcus multilocularis	lamin	0.0028	0.0206	0.0206
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0395	0.0337
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.002	0.0111	0.0111
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.018	0.1969	1
Brugia malayi	hypothetical protein	0.0024	0.0153	0.0153
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0054	0.0502	0.2315
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0381	0.082
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0395	0.0395
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0262	0.0262
Onchocerca volvulus		0.0024	0.0153	0.0477
Onchocerca volvulus		0.018	0.1969	0.614
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0069	0.0681	0.204
Echinococcus granulosus	cathepsin L cysteine protease	0.0105	0.1097	0.1097
Plasmodium vivax	SET domain protein, putative	0.0037	0.0303	0.1271
Leishmania major	cathepsin L-like protease	0.018	0.1969	0.5647
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0395	0.0855
Echinococcus multilocularis	cathepsin L	0.0054	0.0502	0.0502
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0111	0.0111
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.0681	0.0681
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0153	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0111	0.0129
Giardia lamblia	Cathepsin B precursor	0.0307	0.344	0.8632
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.006	0.5
Brugia malayi	fibroinase precursor	0.0054	0.0502	0.0502
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0303	0.0303
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0728	0.3672
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0728	0.0728
Entamoeba histolytica	cysteine proteinase, putative	0.0129	0.1374	0.3269
Schistosoma mansoni	cathepsin B (C01 family)	0.0054	0.0502	0.0502
Schistosoma mansoni	hypothetical protein	0.0024	0.0153	0.0153
Onchocerca volvulus		0.0024	0.0153	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0471	0.0471
Onchocerca volvulus		0.018	0.1969	0.614
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0381	0.1766
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0502	0.0502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Schistosoma mansoni	loxhd1	0.0024	0.0153	0.0153
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0381	0.095
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0111	0.0129
Plasmodium falciparum	serine repeat antigen 9	0.0054	0.0502	0.2315
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0111	0.0111
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0502	0.1129
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Giardia lamblia	Cathepsin B precursor	0.0054	0.0502	0.1129
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Leishmania major	cathepsin L-like protease	0.018	0.1969	0.5647
Echinococcus multilocularis	regulator of G protein signaling	0.002	0.0111	0.0111
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0728	0.1976
Onchocerca volvulus		0.0028	0.0206	0.0643
Brugia malayi	Sodium:solute symporter family protein	0.004	0.0345	0.0345
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0381	0.1056
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Brugia malayi	beta-lactamase family protein	0.0043	0.0381	0.0381
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0502	0.1129
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0407	0.0407
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0728	0.0728
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.002	0.0111	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0111	0.0129
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.002	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0502	0.0502
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0054	0.0502	0.2315
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0111	0.0111
Giardia lamblia	Cathepsin L-like protease	0.0054	0.0502	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0502	0.1129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0054	0.0502	0.1129
Giardia lamblia	Hypothetical protein	0.0054	0.0502	0.1129
Entamoeba histolytica	cysteine proteinase, putative	0.018	0.1969	0.4808
Giardia lamblia	Hypothetical protein	0.0054	0.0502	0.1129
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0111	0.0111
Giardia lamblia	Cathepsin L-like protease	0.0054	0.0502	0.1129
Trypanosoma cruzi	cysteine peptidase, putative	0.023	0.2549	0.2504
Plasmodium falciparum	serine repeat antigen 5	0.0054	0.0502	0.2315
Schistosoma mansoni	cpg binding protein	0.0032	0.0247	0.0247
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0111	0.0111
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0054	0.0502	0.2315
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0303	0.0303
Leishmania major	cysteine peptidase A (CPA)	0.018	0.1969	0.5647
Schistosoma mansoni	high-affinity choline transporter	0.0366	0.4125	0.4125
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0262	0.0262
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0502	0.1013
Plasmodium vivax	vivapain-2	0.018	0.1969	1
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0407	0.1817
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0252	0.2803	0.2803
Loa Loa (eye worm)	PXA domain-containing protein	0.002	0.0111	0.0111
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0502	0.1013
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0381	0.0381
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3975	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.006	0.006
Giardia lamblia	Cysteine protease	0.0054	0.0502	0.1129
Echinococcus multilocularis	Regulator of G protein signaling 20	0.002	0.0111	0.0111
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.0627	0.0627
Schistosoma mansoni	lamin	0.0028	0.0206	0.0206
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0307	0.344	1
Schistosoma mansoni	cathepsin F (C01 family)	0.018	0.1969	0.1969
Brugia malayi	Cathepsin L-like precursor	0.0129	0.1374	0.1374
Giardia lamblia	Cathepsin L precursor	0.0054	0.0502	0.1129
Echinococcus granulosus	cathepsin L cysteine proteinase	0.018	0.1969	0.1969
Schistosoma mansoni	hypothetical protein	0.043	0.4876	0.4876
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0381	0.1056
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0054	0.0502	0.1013
Giardia lamblia	Cathepsin L precursor	0.0054	0.0502	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0709	0.0709
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0054	0.0502	0.1307
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0069	0.0681	0.0681
Trypanosoma cruzi	cysteine peptidase, putative	0.023	0.2549	0.2504
Brugia malayi	cathepsin L-like cysteine proteinase	0.0054	0.0502	0.0502
Trypanosoma cruzi	cysteine peptidase, putative	0.023	0.2549	0.2504
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0307	0.344	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0381	0.1056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1097	0.2647
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0111	0.0111
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0012	0.0012
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0067	0.0651	0.0651
Giardia lamblia	Cathepsin B precursor	0.0054	0.0502	0.1129
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0054	0.0502	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0054	0.0502	0.1129
Trypanosoma cruzi	cruzipain precursor, putative	0.0051	0.0471	0.0413
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0054	0.0502	0.2315
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.1222	0.3818
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0206	0.0206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.018	0.1969	0.4874
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0502	0.0502
Schistosoma mansoni	hypothetical protein	0.0033	0.0262	0.0262
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0054	0.0502	0.0502
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0407	0.1817
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0381	0.0381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0502	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0502	0.1129
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0054	0.0502	0.2315
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0395	0.0855
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0111
Plasmodium vivax	unspecified product	0.0105	0.1097	0.5431
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0111
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.018	0.1969	0.1969
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0381	0.0381
Echinococcus granulosus	solute carrier family 5	0.004	0.0345	0.0345
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.006	0.5
Giardia lamblia	Cysteine protease	0.0054	0.0502	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1374	0.1374
Brugia malayi	Cathepsin L-like precursor	0.018	0.1969	0.1969
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1097	0.2551
Leishmania major	cathepsin L-like protease	0.018	0.1969	0.5647
Schistosoma mansoni	hypothetical protein	0.0033	0.0262	0.0262
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0105	0.1097	0.1097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Echinococcus granulosus	sodium:myo inositol cotransporter	0.004	0.0345	0.0345
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0054	0.0502	0.2315
Schistosoma mansoni	lipoxygenase	0.0067	0.0651	0.0651
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Trypanosoma cruzi	cysteine protease, putative	0.0105	0.1097	0.1043
Giardia lamblia	Cathepsin B precursor	0.0054	0.0502	0.1129
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.006	0.006
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.0153	0.0486
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0111	0.0111
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.0153	0.0153
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0054	0.0502	0.0502
Onchocerca volvulus		0.0028	0.0206	0.0643
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1097	0.3067
Trypanosoma cruzi	cysteine proteinase, putative	0.0105	0.1097	0.1043
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0728	0.3672
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.1879	0.5978
Loa Loa (eye worm)	cathepsin B	0.0307	0.344	0.344
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0054	0.0502	0.2315
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.1087	0.3374
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0395	0.0395
Onchocerca volvulus		0.018	0.1969	0.614
Plasmodium falciparum	serine repeat antigen 3	0.0054	0.0502	0.2315
Echinococcus granulosus	cathepsin l1	0.018	0.1969	0.1969
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.1087	0.3374
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0206	0.0206
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.004	0.0345	0.0345
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.1097	0.1097
Echinococcus granulosus	expressed protein	0.0393	0.4439	0.4439
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0051	0.0471	0.0471
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0502	0.0502
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Trypanosoma cruzi	cysteine peptidase, putative	0.018	0.1969	0.192
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0407	0.0407
Toxoplasma gondii	cathepsin CPC1	0.0054	0.0502	0.1307
Toxoplasma gondii	cathepsin CPC2	0.0054	0.0502	0.1307
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0381	0.1056
Loa Loa (eye worm)	hypothetical protein	0.018	0.1969	0.1969
Brugia malayi	Pre-SET motif family protein	0.0252	0.2803	0.2803
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0227	0.0227
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.002	0.0111	0.0111
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0069	0.0681	0.1837
Echinococcus multilocularis	musashi	0.0028	0.0206	0.0206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0381	0.0381
Echinococcus granulosus	cathepsin L	0.0054	0.0502	0.0502
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0381	0.0381
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.006	0.006
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0262	0.0262
Schistosoma mansoni	inositol transporter	0.004	0.0345	0.0345
Schistosoma mansoni	cathepsin S (C01 family)	0.0054	0.0502	0.0502
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0502	0.1129
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0111	0.0111
Echinococcus granulosus	cathepsin L	0.0105	0.1097	0.1097
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0502	0.0502
Schistosoma mansoni	sodium/solute symporter	0.004	0.0345	0.0345
Plasmodium vivax	unspecified product	0.0054	0.0502	0.2315
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.1222	0.5611
Plasmodium vivax	vivapain-1	0.0105	0.1097	0.5431
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.018	0.1969	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0111	0.0129
Toxoplasma gondii	ABC1 family protein	0.0043	0.0381	0.095
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.1879	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0037	0.0303	0.0303
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0381	0.1056
Entamoeba histolytica	cysteine proteinase 1, putative	0.0105	0.1097	0.2551
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0111	0.0111
Mycobacterium tuberculosis	Probable reductase	0.0104	0.1087	0.3374
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.018	0.1969	0.1969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0036	0.0036
Leishmania major	cathepsin L-like protease	0.023	0.2549	0.7364
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0111	0.0111
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0381	0.082
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0395	0.0736
Leishmania major	cathepsin L-like protease	0.023	0.2549	0.7364
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0129	0.1374	0.3356
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0381	0.0381
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0395	0.0991
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0395	0.0395
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.0681	0.0681
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0054	0.0502	0.1129
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0381	0.0381
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0153	0.0153
Echinococcus granulosus	sodium:glucose cotransporter	0.004	0.0345	0.0345
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0728	0.2195
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Echinococcus multilocularis	cysteine protease	0.018	0.1969	0.1969
Echinococcus multilocularis	cpg binding protein	0.0032	0.0247	0.0247
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.1879	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0111
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Onchocerca volvulus		0.0287	0.3206	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0395	0.0991
Loa Loa (eye worm)	RGS-3 protein	0.002	0.0111	0.0111
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0381	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0013	0.003	0.003
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0502	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0502	0.0502
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0381	0.0381
Brugia malayi	cathepsin L-like precursor	0.0129	0.1374	0.1374
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0307	0.344	0.34
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.0681	0.3413
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0053	0.0053
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0206	0.0206
Giardia lamblia	Cathepsin L precursor	0.0054	0.0502	0.1129
Brugia malayi	Cathepsin L-like precursor	0.018	0.1969	0.1969
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0069	0.0681	0.0681
Echinococcus multilocularis	cathepsin L	0.0105	0.1097	0.1097
Schistosoma mansoni	cathepsin F (C01 family)	0.0129	0.1374	0.1374
Echinococcus granulosus	high affinity choline transporter 1	0.0366	0.4125	0.4125
Loa Loa (eye worm)	hypothetical protein	0.0013	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0111
Giardia lamblia	Cathepsin B precursor	0.0307	0.344	0.8632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Echinococcus multilocularis	lamin dm0	0.0028	0.0206	0.0206
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0303	0.0303
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0381	0.082
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0728	0.1976
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0111	0.0129
Leishmania major	trypanothione reductase	0.0046	0.0407	0.1026
Brugia malayi	GH02984p	0.0366	0.4125	0.4125
Loa Loa (eye worm)	ctsf protein	0.018	0.1969	0.1969
Echinococcus granulosus	lamin dm0	0.0028	0.0206	0.0206
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0262	0.0262
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0728	0.3672
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1097	0.2551
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.004	0.0345	0.0345
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0262	0.0262
Trichomonas vaginalis	set domain proteins, putative	0.0287	0.3206	0.8035
Brugia malayi	cathepsin L precursor	0.0054	0.0502	0.0502
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.002	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0381	0.0381
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0502	0.1129
Echinococcus multilocularis	cathepsin L cysteine protease	0.018	0.1969	0.1969
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0111	0.0111
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0012	0.0012
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0054	0.0502	0.2315
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0395	0.0855
Giardia lamblia	Encystation-specific protease	0.0054	0.0502	0.1129
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0054	0.0502	0.2315
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0381	0.0323
Loa Loa (eye worm)	fibroinase	0.018	0.1969	0.1969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0262	0.0262
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0129	0.1374	0.3356
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0381	0.0381
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0381	0.1766
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Plasmodium falciparum	glutathione reductase	0.0046	0.0407	0.1817
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0054	0.0502	0.0502
Brugia malayi	PXA domain containing protein	0.002	0.0111	0.0111
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0051	0.0471	0.0471
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0407	0.1026
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0502	0.1129
Leishmania major	hypothetical protein, conserved	0.0043	0.0381	0.095
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0104	0.1087	0.471
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1097	0.2551
Brugia malayi	Cathepsin L-like precursor	0.0129	0.1374	0.1374
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0502	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0502	0.0502
Trypanosoma cruzi	major cysteine proteinase, putative	0.0104	0.1082	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1095	0.1095
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.002	0.0111	0.0111
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.1097	0.1097
Brugia malayi	Cathepsin L-like precursor	0.018	0.1969	0.1969
Echinococcus granulosus	Regulator of G protein signaling 20	0.002	0.0111	0.0111
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0053	0.0053
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0054	0.0502	0.0502
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0502	0.0502
Brugia malayi	beta-lactamase	0.0043	0.0381	0.0381
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.0153	0.0153
Echinococcus multilocularis	solute carrier family 5	0.004	0.0345	0.0345
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0502	0.1013
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0381	0.1056
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0557	0.1469
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0853	0.9788	0.9788
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0153	0.0153
Trypanosoma brucei	trypanothione reductase	0.0046	0.0407	0.1026
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0054	0.0502	0.1129
Echinococcus multilocularis	RUN	0.0024	0.0153	0.0153
Giardia lamblia	Cathepsin L precursor	0.0054	0.0502	0.1129
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0036	0.0036
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0728	0.0728
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.0681	0.3413
Onchocerca volvulus	Cathepsin F homolog	0.018	0.1969	0.614
Plasmodium vivax	vivapain-3	0.0105	0.1097	0.5431
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0502	0.0502
Schistosoma mansoni	rab6-interacting	0.0024	0.0153	0.0153
Echinococcus multilocularis	expressed protein	0.0393	0.4439	0.4439
Schistosoma mansoni	rab6-interacting	0.0024	0.0153	0.0153
Giardia lamblia	Cathepsin B precursor	0.0054	0.0502	0.1129
Onchocerca volvulus		0.003	0.0227	0.071
Plasmodium falciparum	serine repeat antigen 4	0.0054	0.0502	0.2315
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0307	0.344	0.344
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0502	0.1129
Trypanosoma cruzi	cysteine peptidase, putative	0.0051	0.0471	0.0413
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.1087	0.3374
Echinococcus multilocularis	high affinity choline transporter 1	0.0366	0.4125	0.4125
Onchocerca volvulus		0.0037	0.0303	0.0944
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0381	0.1056
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0028	0.02	0.02
Giardia lamblia	Cathepsin B precursor	0.0054	0.0502	0.1129
Onchocerca volvulus		0.0043	0.0381	0.119
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0381	0.0381
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0111	0.0111
Plasmodium falciparum	serine repeat antigen 6	0.0054	0.0502	0.2315
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3102	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0366	0.4125	0.4125
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0502	0.0502
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Loa Loa (eye worm)	hypothetical protein	0.004	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0502	0.0502
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.3975	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0262	0.0262
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0407	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0381	0.0381
Onchocerca volvulus		0.0043	0.0381	0.119
Schistosoma mansoni	hypothetical protein	0.0033	0.0262	0.0262
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.006	0.5
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0067	0.0651	0.0651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1097	0.2647
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0502	0.0444
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0105	0.1097	0.1097
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0111	0.0111
Mycobacterium ulcerans	lipase LipD	0.0043	0.0381	0.1766
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0381	0.1056
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0381	0.082
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.018	0.1969	0.1969
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0502	0.0502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Giardia lamblia	Cathepsin L precursor	0.0054	0.0502	0.1129
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0111	0.0111
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.018	0.1969	0.1969
Echinococcus granulosus	intermediate filament protein	0.0028	0.0206	0.0206
Brugia malayi	CXXC zinc finger family protein	0.003	0.0227	0.0227
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0381	0.1683
Giardia lamblia	Cysteine protease	0.0054	0.0502	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0502	0.1129
Echinococcus granulosus	dnaJ subfamily B	0.043	0.4876	0.4876
Schistosoma mansoni	inositol transporter	0.004	0.0345	0.0345
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.004	0.0345	0.0345
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0395	0.0395
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1097	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0262	0.0262
Echinococcus granulosus	histone lysine methyltransferase setb	0.0037	0.0303	0.0303
Schistosoma mansoni	hypothetical protein	0.0072	0.0709	0.0709
Plasmodium falciparum	serine repeat antigen 7	0.0054	0.0502	0.2315
Leishmania major	cathepsin L-like protease	0.018	0.1969	0.5647
Echinococcus granulosus	beta-adrenergic receptor kinase	0.002	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0471	0.0471
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0407	0.114
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0179	0.1954	0.1906
Brugia malayi	cathepsin F-like cysteine proteinase	0.0051	0.0471	0.0471
Onchocerca volvulus		0.018	0.1969	0.614
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0502	0.1013
Toxoplasma gondii	cathepsin B	0.0307	0.344	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0395	0.0395
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.1222	0.3818
Brugia malayi	Cathepsin L-like precursor	0.018	0.1969	0.1969
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0381	0.0323
Onchocerca volvulus	Cathepsin L homolog	0.018	0.1969	0.614
Plasmodium vivax	serine-repeat antigen (SERA)	0.0054	0.0502	0.2315
Leishmania major	cathepsin L-like protease	0.023	0.2549	0.7364
Brugia malayi	Cathepsin L-like precursor	0.018	0.1969	0.1969
Brugia malayi	intermediate filament protein	0.0028	0.0206	0.0206
Brugia malayi	PXA domain containing protein	0.002	0.0111	0.0111
Entamoeba histolytica	hypothetical protein	0.0054	0.0502	0.1013
Plasmodium vivax	unspecified product	0.0051	0.0471	0.2152
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Schistosoma mansoni	cathepsin C	0.0054	0.0502	0.0502
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0111	0.0129
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0111	0.0111
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0153	0.0153
Echinococcus granulosus	cathepsin l cysteine peptidase	0.018	0.1969	0.1969
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0381	0.1766
Schistosoma mansoni	polycystin 1-related	0.0024	0.0153	0.0153
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0395	0.0855
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0728	0.0728
Onchocerca volvulus		0.0159	0.1723	0.5375
Plasmodium falciparum	serine repeat antigen 1	0.0054	0.0502	0.2315
Loa Loa (eye worm)	cysteine protease	0.018	0.1969	0.1969
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0111	0.0111
Brugia malayi	Cathepsin L-like precursor	0.018	0.1969	0.1969
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0111	0.0111
Onchocerca volvulus		0.018	0.1969	0.614
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1095	0.1095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Onchocerca volvulus	Cathepsin L homolog	0.018	0.1969	0.614
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0502	0.1013
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0381	0.1056
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0111	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0502	0.1129
Plasmodium falciparum	serine repeat antigen 2	0.0054	0.0502	0.2315
Schistosoma mansoni	cathepsin F (C01 family)	0.018	0.1969	0.1969
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0105	0.1097	0.1043
Echinococcus granulosus	cysteine protease	0.0105	0.1097	0.1097
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0395	0.0395
Schistosoma mansoni	lipoxygenase	0.0024	0.0153	0.0153
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0037	0.0303	0.0718
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.004	0.0345	0.0345
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.1087	0.3374
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0414	0.0414
Schistosoma mansoni	cpg binding protein	0.0032	0.0247	0.0247
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1097	0.2551
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0395	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0111
Leishmania major	cathepsin L-like protease	0.018	0.1969	0.5647
Echinococcus granulosus	cpg binding protein	0.0032	0.0247	0.0247
Brugia malayi	Pre-SET motif family protein	0.0037	0.0303	0.0303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0037	0.0303	0.0303
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.002	0.0111	0.0129
Giardia lamblia	Cathepsin B precursor	0.0307	0.344	0.8632
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0153	0.0153
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0502	0.0502
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0395	0.0395
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0206	0.0206
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0054	0.0502	0.2315
Plasmodium falciparum	serine repeat antigen 8	0.0054	0.0502	0.2315
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.1222	0.3818
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Plasmodium falciparum	cysteine proteinase falcipain 3	0.018	0.1969	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0307	0.344	0.8632
Plasmodium vivax	serine-repeat antigen (SERA)	0.0054	0.0502	0.2315
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0502	0.1013
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.023	0.2549	0.7364
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.018	0.1969	0.4874
Giardia lamblia	Cathepsin L precursor	0.0054	0.0502	0.1129
Brugia malayi	Doublecortin family protein	0.0024	0.0153	0.0153
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0502	0.0502
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0395	0.0395
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0054	0.0502	0.2315
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0381	0.1056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1097	0.3067
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.018	0.1969	0.4874
Brugia malayi	A-kinase anchor protein 10, precursor	0.002	0.0111	0.0111
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0303	0.0303
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1095	0.1095
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0502	0.0502
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.028	0.028
Echinococcus granulosus	cathepsin l1	0.0129	0.1374	0.1374
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0471	0.0471
Echinococcus granulosus	lamin	0.0028	0.0206	0.0206
Brugia malayi	cathepsin F-like cysteine proteinase	0.0054	0.0502	0.0502
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0105	0.1097	0.1097
Giardia lamblia	Cysteine protease	0.0054	0.0502	0.1129
Entamoeba histolytica	cysteine protease, putative	0.018	0.1969	0.4808
Brugia malayi	regulator of G-protein signaling rgs-7	0.002	0.0111	0.0111
Brugia malayi	Thioredoxin reductase	0.0046	0.0407	0.0407
Schistosoma mansoni	cathepsin s	0.0051	0.0471	0.0471
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.3975	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3975	1
Echinococcus granulosus	GPCR family 2	0.0033	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1723	0.1723
Toxoplasma gondii	cathepsin CPL	0.018	0.1969	0.5647
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1095	0.1095

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 79.4328 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	84.9214 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1538471

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1396791