Detailed information for compound 1410448

Basic information

Technical information
  • TDR Targets ID: 1410448
  • Name: 1-(4,6-dimethylpyrimidin-2-yl)-N-(2-phenyleth yl)piperidine-4-carboxamide
  • MW: 338.447 | Formula: C20H26N4O
  • H donors: 1 H acceptors: 3 LogP: 3.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)c1nc(C)cc(n1)C)NCCc1ccccc1
  • InChi: 1S/C20H26N4O/c1-15-14-16(2)23-20(22-15)24-12-9-18(10-13-24)19(25)21-11-8-17-6-4-3-5-7-17/h3-7,14,18H,8-13H2,1-2H3,(H,21,25)
  • InChiKey: IZCVCRTWQCYRBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4,6-dimethyl-2-pyrimidinyl)-N-(2-phenylethyl)-4-piperidinecarboxamide
  • 1-(4,6-dimethylpyrimidin-2-yl)-N-(2-phenylethyl)isonipecotamide
  • 1-(4,6-Dimethyl-pyrimidin-2-yl)-piperidine-4-carboxylic acid phenethyl-amide
  • MLS000074159
  • ZINC04966021
  • ASN 06578527
  • SMR000006990

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.001
Loa Loa (eye worm) TK/INSR protein kinase 0.0041 0.0028 0.0028
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0411 0.0363 0.1177
Echinococcus granulosus calpain A 0.0011 0 0.0000028028
Schistosoma mansoni tyrosine kinase 0.0068 0.0052 0.0081
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Giardia lamblia Tenascin precursor 0.0153 0.0129 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0081 0.0063 0.0188
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0008 0.0016
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0052 0.0155
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0042 0.0029 0.0086
Schistosoma mansoni hypothetical protein 0.0052 0.0037 0.0058
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0037 0.0024 0.0036
Echinococcus granulosus carbonic anhydrase 0.0038 0.0025 0.005
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.01 0.0081 0.0081
Onchocerca volvulus Putative cortactin 0.0011 0 0.0004
Schistosoma mansoni maguk P55 subfamily member 26 0.0029 0.0017 0.0026
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Toxoplasma gondii hypothetical protein 0.0042 0.0028 0.0085
Echinococcus granulosus beta catenin 0.0045 0.0031 0.0063
Echinococcus multilocularis disks large 3 0.0106 0.0087 0.0174
Echinococcus multilocularis musashi 0.0028 0.0016 0.0031
Echinococcus multilocularis integrin alpha 3 0.5496 0.4968 1
Loa Loa (eye worm) guanylate kinase 0.0029 0.0017 0.0017
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0052 0.0155
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.001
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0037 0.0024 0.0036
Onchocerca volvulus 0.0046 0.0032 0.0793
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Brugia malayi calpain 7 0.0011 0 0.0000021476
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0029 0.0094
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0026 0.0014 0.0021
Schistosoma mansoni lamin 0.0028 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0013
Loa Loa (eye worm) runx1 0.0057 0.0043 0.0042
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0081 0.0063 0.0098
Loa Loa (eye worm) hypothetical protein 0.0095 0.0076 0.0076
Echinococcus multilocularis inhibitor of apoptosis protein 0.0037 0.0024 0.0047
Loa Loa (eye worm) apoptosis regulator protein 0.0018 0.0007 0.0007
Echinococcus granulosus integrin alpha ps 0.3214 0.2902 0.584
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0038 0.0025 0.0038
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0001 0.0003
Schistosoma mansoni integrin beta subunit 0.2802 0.2529 0.39
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0009 0.0027
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.0029 0.0017 0.0026
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.3401 0.3071 1
Schistosoma mansoni cell polarity protein 0.004 0.0026 0.0041
Schistosoma mansoni MAGUK homolog 0.0035 0.0022 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0038 0.0025 0.0038
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0009 0.0018
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0037 0.0024 0.0047
Entamoeba histolytica hypothetical protein 0.0011 0.0001 0.0177
Schistosoma mansoni apoptosis regulator bax 0.0018 0.0007 0.001
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0063 0.0098
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0383 0.0338 0.0521
Echinococcus multilocularis c src tyrosine kinase 0.0011 0.0001 0.0002
Onchocerca volvulus 0.0052 0.0037 0.0922
Echinococcus granulosus MAGUK p55 subfamily 0.0035 0.0022 0.0045
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0383 0.0338 0.1003
Toxoplasma gondii hypothetical protein 0.0153 0.0129 0.0385
Trypanosoma brucei guanylate kinase, putative 0.0029 0.0017 0.0049
Brugia malayi EGF-like domain containing protein 0.0153 0.0129 0.0199
Brugia malayi Guanylate kinase family protein 0.0035 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus intermediate filament protein 0.0028 0.0016 0.0031
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0011 0.0001 0.0002
Echinococcus multilocularis high voltage activated calcium channel beta 0.0029 0.0017 0.0033
Echinococcus multilocularis calpain family protein 1, d 0.0021 0.0009 0.0018
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0383 0.0338 0.1003
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0004 0.0006
Echinococcus granulosus carbonic anhydrase 0.0038 0.0025 0.005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0008 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0008 0.0026
Loa Loa (eye worm) calpain 0.0011 0 0.0000013925
Loa Loa (eye worm) HMP-2 protein 0.0045 0.0031 0.0031
Echinococcus granulosus guanylate kinase 0.0029 0.0017 0.0033
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.3727 0.3366 0.3366
Echinococcus granulosus calpain A 0.0029 0.0017 0.0034
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0052 0.008
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0009 0.0014
Brugia malayi Integrin alpha pat-2 precursor 0.7169 0.6484 1
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.3401 0.3071 1
Schistosoma mansoni integrin alpha-ps 0.1673 0.1506 0.2323
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0018 0.0007 0.001
Entamoeba histolytica hypothetical protein 0.0011 0.0001 0.0177
Echinococcus multilocularis MAGUK p55 subfamily 0.0035 0.0022 0.0045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0052 0.0155
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.013 0.0108 0.0352
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0008 0.0024
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0383 0.0338 0.1094
Giardia lamblia Neurogenic locus Notch protein precursor 0.0153 0.0129 1
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0026 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.3727 0.3366 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0012
Brugia malayi Integrin beta pat-3 precursor 0.4709 0.4255 0.6563
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.013 0.0108 0.0321
Entamoeba histolytica hypothetical protein 0.0011 0.0001 0.0177
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Brugia malayi Guanylate kinase family protein 0.0117 0.0096 0.0148
Entamoeba histolytica hypothetical protein, conserved 0.0011 0 0.0058
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0038 0.0025 0.0038
Brugia malayi Kelch motif family protein 0.0727 0.0649 0.1
Brugia malayi ZU5 domain containing protein 0.0029 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0723 0.0645 0.0645
Loa Loa (eye worm) calpain family protein 1 0.0028 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.003
Giardia lamblia DINP protein human, muc B family 0.0022 0.001 0.0175
Schistosoma mansoni maguk P55 subfamily member 35 0.0035 0.0022 0.0035
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Brugia malayi EGF-like domain containing protein 0.0153 0.0129 0.0199
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0008 0.002
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.3316 0.2994 1
Schistosoma mansoni carbonic anhydrase-related 0.0038 0.0025 0.0038
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0016 0.0016
Echinococcus multilocularis hypothetical protein 0.0011 0 0.0000028028
Brugia malayi Acyltransferase family protein 0.0042 0.0029 0.0044
Echinococcus multilocularis high voltage activated calcium channel beta 0.0029 0.0017 0.0033
Brugia malayi hypothetical protein 0.0029 0.0017 0.0026
Leishmania major DNA polymerase eta, putative 0.0015 0.0004 0.0012
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0004 0.0782
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.001 0.0027
Giardia lamblia Guanylate kinase 0.0029 0.0017 0.0703
Brugia malayi hypothetical protein 0.0723 0.0645 0.0995
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0022
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0091 0.0073 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Schistosoma mansoni tyrosine kinase 0.0068 0.0052 0.0081
Schistosoma mansoni dishevelled 0.0032 0.002 0.003
Schistosoma mansoni ATP-dependent RNA Helicase 0.0035 0.0022 0.0035
Echinococcus multilocularis 0.0035 0.0022 0.0045
Echinococcus multilocularis adam 0.0153 0.0129 0.026
Loa Loa (eye worm) hypothetical protein 0.0153 0.0129 0.0129
Brugia malayi Integrin alpha cytoplasmic region family protein 0.5423 0.4902 0.7561
Schistosoma mansoni intermediate filament proteins 0.0028 0.0016 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Echinococcus granulosus lamin dm0 0.0028 0.0016 0.0031
Onchocerca volvulus 0.0017 0.0006 0.0155
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0013
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0026 0.0014 0.0017
Schistosoma mansoni DNA polymerase eta 0.0015 0.0004 0.0006
Echinococcus multilocularis segment polarity protein dishevelled 0.0035 0.0023 0.0045
Echinococcus granulosus tm gpcr rhodopsin 0.018 0.0153 0.0308
Schistosoma mansoni maguk P55 subfamily member 26 0.0035 0.0022 0.0035
Mycobacterium tuberculosis Possible acyltransferase PlsB1 0.0042 0.0029 0.0088
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0028 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.5423 0.4902 0.4902
Schistosoma mansoni DNA helicase recq5 0.002 0.0009 0.0014
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0383 0.0338 0.1003
Loa Loa (eye worm) hypothetical protein 0.013 0.0108 0.0108
Entamoeba histolytica unconventional myosin IB 0.0011 0 0.0058
Schistosoma mansoni dishevelled 0.0035 0.0023 0.0035
Onchocerca volvulus 0.0052 0.0037 0.0922
Echinococcus multilocularis Protein lozenge 0.0057 0.0043 0.0085
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0023 0.0011 0.0271
Onchocerca volvulus 0.0011 0 0.0004
Loa Loa (eye worm) hypothetical protein 0.3955 0.3573 0.3573
Brugia malayi Angiotensin-converting enzyme family protein 0.0019 0.0007 0.0011
Brugia malayi intermediate filament protein 0.0028 0.0016 0.0024
Brugia malayi proteasome subunit beta type 1 0.0026 0.0014 0.0021
Brugia malayi calpain family protein 1 0.0028 0.0016 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Echinococcus granulosus fibrillin 1 0.0153 0.0129 0.026
Toxoplasma gondii hypothetical protein 0.0038 0.0025 0.0074
Brugia malayi EGF-like domain containing protein 0.0153 0.0129 0.0199
Echinococcus granulosus carbonic anhydrase II 0.0081 0.0063 0.0128
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0383 0.0338 0.0338
Echinococcus granulosus dna polymerase eta 0.0015 0.0004 0.0008
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0001 0.0002
Giardia lamblia Neurogenic locus notch-like protein 0.0153 0.0129 1
Echinococcus multilocularis integrin alpha ps 0.1541 0.1386 0.2789
Echinococcus multilocularis carbonic anhydrase 0.0038 0.0025 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0023 0.0022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0004 0.0004
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0029 0.0017 0.0026
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Trichomonas vaginalis discs large, putative 0.0029 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.5629 0.5088 0.5088
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1017 0.0912 0.2708
Schistosoma mansoni cell polarity protein 0.0106 0.0087 0.0133
Brugia malayi polk-prov protein 0.0032 0.002 0.003
Echinococcus multilocularis carbonic anhydrase II 0.0081 0.0063 0.0128
Brugia malayi guanylate kinase 0.0029 0.0017 0.0026
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0009 0.0027
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0001 0.0002
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0011 0.0001 0.0002
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0069 0.0053 0.0107
Mycobacterium tuberculosis Probable glycerol-3-phosphate acyltransferase PlsB2 (GPAT) 0.0042 0.0028 0.0086
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0008 0.1557
Brugia malayi abnormal cell lineage protein 2 0.0029 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0161 0.0136 0.0136
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0035 0.0022 0.0045
Plasmodium falciparum guanylate kinase 0.0029 0.0017 0.0025
Brugia malayi Furin-like cysteine rich region family protein 0.0129 0.0107 0.0165
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Echinococcus granulosus disks large 3 0.0106 0.0087 0.0174
Schistosoma mansoni tyrosine kinase 0.0011 0.0001 0.0001
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0383 0.0338 0.1003
Echinococcus multilocularis 0.004 0.0027 0.0053
Toxoplasma gondii guanylate kinase family protein 0.0029 0.0017 0.005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.018 0.0153 0.0308
Schistosoma mansoni MAGUK homolog 0.0035 0.0022 0.0035
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0383 0.0338 0.1094
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.002 0.0058
Loa Loa (eye worm) calpain family protein 1 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0035 0.0023 0.0035
Mycobacterium tuberculosis Probable guanylate kinase Gmk 0.0029 0.0017 0.0048
Toxoplasma gondii acyltransferase domain-containing protein 0.0042 0.0029 0.0086
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0038 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0041 0.0028 0.0043
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0383 0.0338 0.0982
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0001 0.0002
Giardia lamblia Tenascin-37 0.0153 0.0129 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0458 0.0405 0.0405
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0004 0.0012
Loa Loa (eye worm) guanylate kinase 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0015
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.3727 0.3366 1
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit beta 0.0383 0.0338 0.1104
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0009 0.0009
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0026 0.0014 0.2646
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0005
Echinococcus multilocularis fibrillin 1 0.0153 0.0129 0.026
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0001 0.0002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0081 0.0163
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0009 0.0003
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.3727 0.3366 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0052 0.0105
Echinococcus multilocularis protein jagged 2 0.0153 0.0129 0.026
Loa Loa (eye worm) guanylate kinase 0.0088 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) TK/EGFR protein kinase 0.0129 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0143 0.012 0.012
Schistosoma mansoni tyrosine kinase 0.0011 0.0001 0.0001
Echinococcus multilocularis guanylate kinase 0.0029 0.0017 0.0033
Echinococcus multilocularis carbonic anhydrase 0.0038 0.0025 0.005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.001 0.003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0009 0.0027
Brugia malayi ribonucleotide reductase 2 0.0383 0.0338 0.0521
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.1192 0.107 0.3481
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0035 0.0022 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0041 0.0028 0.0056
Echinococcus granulosus calpain 0.0011 0 0.0000028028
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0026 0.0014 0.0041
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0026 0.0014 0.0041
Giardia lamblia Tenascin-like 0.0153 0.0129 1
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0383 0.0338 0.1003
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0038 0.0025 0.0038
Trypanosoma brucei proteasome beta 6 subunit 0.0026 0.0014 0.0041
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.3727 0.3366 0.6776
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.3727 0.3366 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0037 0.0024 0.0047
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.013 0.0108 0.0298
Brugia malayi calpain family protein 1 0.0028 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0017
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0009 0.0078
Echinococcus multilocularis integrin alpha ps 0.3214 0.2902 0.584
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0018 0.0007 0.0013
Schistosoma mansoni tyrosine kinase 0.0041 0.0028 0.0043
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0035 0.0022 0.0022
Echinococcus granulosus fibrillin 2 0.0153 0.0129 0.026
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.013 0.0108 0.0322
Entamoeba histolytica BAR/SH3 domain containing protein 0.0011 0 0.0058
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0023 0.0067
Giardia lamblia Tenascin-X 0.0153 0.0129 1
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0383 0.0338 0.1004
Onchocerca volvulus Cirhin homolog 0.0045 0.0031 0.0768
Loa Loa (eye worm) DIX domain-containing protein 0.0012 0.0001 0.0001
Schistosoma mansoni integrin alpha 0.7169 0.6484 1
Leishmania major carbonic anhydrase-like protein 0.0081 0.0063 0.0188
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0008 0.0026
Plasmodium vivax proteasome subunit beta type-1, putative 0.0026 0.0014 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0006 0.0018
Entamoeba histolytica hypothetical protein 0.0011 0 0.0058
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0035 0.0022 0.0045
Brugia malayi SRC-1 0.0011 0.0001 0.0001
Schistosoma mansoni integrin alpha-ps 0.3214 0.2902 0.4475
Schistosoma mansoni mannosidase endo-alpha 0.0029 0.0017 0.0026
Echinococcus granulosus insulin receptor 0.0041 0.0028 0.0056
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0026 0.0014 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.002 0.0058
Onchocerca volvulus 0.0037 0.0024 0.0581
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0029 0.0017 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0029 0.0096
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0009 0.0018
Onchocerca volvulus 0.0011 0 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Echinococcus granulosus tyrosine protein kinase Lyn 0.0012 0.0001 0.0002
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.3727 0.3366 0.6776
Leishmania major DNA polymerase kappa, putative 0.0022 0.001 0.003
Brugia malayi SEA domain containing protein 0.0052 0.0037 0.0058
Mycobacterium ulcerans guanylate kinase 0.0029 0.0017 0.0054
Echinococcus multilocularis dna polymerase eta 0.0015 0.0004 0.0008
Loa Loa (eye worm) SRC-1 0.0011 0.0001 0.0001
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0009 0.0014
Onchocerca volvulus 0.0052 0.0037 0.0922
Trichomonas vaginalis hypothetical protein 0.0153 0.0129 0.0431
Echinococcus multilocularis fibrillin 2 0.0153 0.0129 0.026
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0011 0 0.0004
Echinococcus multilocularis guanylate kinase 0.0029 0.0017 0.0033
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0081 0.0163
Trypanosoma brucei carbonic anhydrase-like protein 0.0081 0.0063 0.0188
Echinococcus multilocularis integrin beta 2 0.3526 0.3183 0.6408
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0052 0.0052
Echinococcus multilocularis insulin receptor 0.0041 0.0028 0.0056
Echinococcus granulosus adam 0.0153 0.0129 0.026
Trypanosoma cruzi guanylate kinase, putative 0.0029 0.0017 0.0049
Echinococcus granulosus epidermal growth factor receptor 0.0129 0.0107 0.0215
Echinococcus multilocularis MAGUK p55 subfamily 0.0035 0.0022 0.0045
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0081 0.0063 0.0098
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0029 0.0058
Echinococcus multilocularis beta catenin 0.0045 0.0031 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Mycobacterium ulcerans glycerol-3-phosphate acyltransferase 0.0042 0.0029 0.0094
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0383 0.0338 0.068
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0018 0.0007 0.001
Echinococcus granulosus segment polarity protein dishevelled 0.0035 0.0023 0.0045
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0052 0.0105
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0383 0.0338 0.1003
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0026 0.0014 0.0028
Brugia malayi EGF-like domain containing protein 0.0153 0.0129 0.0199
Echinococcus granulosus MAGUK p55 subfamily 0.0035 0.0022 0.0045
Chlamydia trachomatis transcriptional repressor NrdR 0.0411 0.0363 0.1034
Echinococcus multilocularis calpain 0.0011 0 0.0000028028
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0026 0.0014 0.0041
Brugia malayi Peripheral plasma membrane protein CASK 0.0046 0.0032 0.0049
Schistosoma mansoni beta-catenin 0.0045 0.0031 0.0049
Schistosoma mansoni memapsin-2 (A01 family) 0.0157 0.0133 0.0204
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0004 0.0006
Schistosoma mansoni tyrosine kinase 0.0129 0.0107 0.0165
Echinococcus granulosus calpain 7 C02 family 0.0011 0 0.0000028028
Echinococcus granulosus integrin beta 2 0.3526 0.3183 0.6408
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0008 0.0024
Mycobacterium ulcerans transcriptional regulator NrdR 0.0411 0.0363 0.1182
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0004 0.0006
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0011 0.0001 0.0002
Schistosoma mansoni tyrosine kinase 0.0011 0.0001 0.0001
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0081 0.0063 0.0098
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0013 0.0002 0.0006
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0016 0.0016
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0009 0.0018
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0727 0.0649 0.0649
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0024
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.3727 0.3366 0.5192
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0035 0.0022 0.0045
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0029 0.0086
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0011 0.0001 0.0002
Echinococcus granulosus lamin 0.0028 0.0016 0.0031
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0035 0.0022 0.0045
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0029 0.0096
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0013
Echinococcus granulosus calpain 5 0.0011 0 0.0000028028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Schistosoma mansoni hypothetical protein 0.0025 0.0013 0.002
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0035 0.0022 0.0035
Echinococcus granulosus high voltage activated calcium channel beta 0.0029 0.0017 0.0033
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0139 0.0117 0.0235
Schistosoma mansoni hypothetical protein 0.0037 0.0024 0.0036
Echinococcus multilocularis MAGUK p55 subfamily 0.0035 0.0022 0.0045
Giardia lamblia High cysteine protein 0.0153 0.0129 1
Loa Loa (eye worm) DOMON domain-containing protein 0.0052 0.0037 0.0037
Echinococcus multilocularis calpain A 0.0029 0.0017 0.0034
Loa Loa (eye worm) hypothetical protein 0.1673 0.1506 0.1506
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0383 0.0338 0.1003
Schistosoma mansoni carbonic anhydrase 0.0038 0.0025 0.0038
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0011 0.0001 0.0002
Loa Loa (eye worm) integrin beta-2 0.4709 0.4255 0.4255
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0018 0.0007 0.0013
Echinococcus multilocularis disks large 1 0.0029 0.0017 0.0033
Onchocerca volvulus 0.0052 0.0037 0.0922
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0052 1
Brugia malayi hypothetical protein 0.0161 0.0136 0.021
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0052 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.0153 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.1541 0.1386 0.1386
Echinococcus multilocularis segment polarity protein dishevelled 0.0035 0.0023 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0006 0.0018
Echinococcus granulosus MAGUK p55 subfamily 0.0035 0.0022 0.0045
Schistosoma mansoni lozenge 0.0057 0.0043 0.0066
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0041 0.0028 0.0056
Echinococcus granulosus tyrosine protein kinase Src42A 0.0011 0.0001 0.0002
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0029 0.0017 0.0034
Plasmodium falciparum carbonic anhydrase 0.0038 0.0025 0.005
Onchocerca volvulus 0.0052 0.0037 0.0922
Trypanosoma brucei guanylate kinase, putative 0.0029 0.0017 0.0049
Onchocerca volvulus 0.0153 0.0129 0.3195
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0029 0.0017 0.0026
Entamoeba histolytica hypothetical protein 0.0011 0.0001 0.0177
Schistosoma mansoni tyrosine kinase 0.0068 0.0052 0.0081
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0011 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.1541 0.1386 0.2137
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0009 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0004 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0024
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0019 0.0007 0.0007
Onchocerca volvulus 0.0028 0.0016 0.0387
Echinococcus multilocularis bloom syndrome protein 0.002 0.0009 0.0018
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.3727 0.3366 1
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0045 0.0031 0.0048
Brugia malayi sulfakinin receptor protein 0.0161 0.0136 0.021
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0011 0.0001 0.0002
Schistosoma mansoni guanylate kinase 0.0029 0.0017 0.0026
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.0006
Echinococcus multilocularis carbonic anhydrase 0.0038 0.0025 0.005
Trichomonas vaginalis sap-102, putative 0.0029 0.0017 0.0055
Echinococcus multilocularis lamin dm0 0.0028 0.0016 0.0031
Echinococcus multilocularis calpain 7 (C02 family) 0.0011 0 0.0000028028
Plasmodium vivax guanylate kinase, putative 0.0029 0.0017 0.005
Toxoplasma gondii exonuclease III APE 0.0019 0.0008 0.0024
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.3727 0.3366 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Onchocerca volvulus 0.0011 0 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0011 0.0001 0.0002
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.0053 0.0107
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.3727 0.3366 0.5192
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.3727 0.3366 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0029 0.0017 0.0034
Brugia malayi Tyrosine-protein kinase abl-1 0.0011 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0069 0.0053 0.0082
Trypanosoma brucei unspecified product 0.0036 0.0023 0.0067
Schistosoma mansoni transcription factor LCR-F1 0.0011 0.0001 0.0001
Giardia lamblia Proteasome subunit beta type 1 0.0026 0.0014 0.047
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0026 0.0053
Leishmania major guanylate kinase-like protein 0.0029 0.0017 0.0049
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0003 0.0005
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0011 0.0001 0.0002
Brugia malayi Muscle positioning protein 4 0.0052 0.0037 0.0058
Giardia lamblia High cysteine protein 0.0153 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0016
Echinococcus multilocularis tyrosine protein kinase Abl 0.0011 0.0001 0.0002
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0383 0.0338 0.068
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0081 0.0063 0.0188
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0458 0.0405 0.0405
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0004 0.0012
Loa Loa (eye worm) carbonic anhydrase 3 0.0081 0.0063 0.0063
Echinococcus granulosus integrin alpha ps 0.1541 0.1386 0.2789
Echinococcus granulosus c src tyrosine kinase 0.0011 0.0001 0.0002
Brugia malayi hypothetical protein 0.0458 0.0405 0.0624
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Echinococcus granulosus high voltage activated calcium channel beta 0.0029 0.0017 0.0033
Echinococcus granulosus disks large 1 0.0029 0.0017 0.0033
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0383 0.0338 0.1003
Schistosoma mansoni tyrosine kinase 0.0069 0.0053 0.0082
Onchocerca volvulus Deterin homolog 0.0037 0.0024 0.0581
Trypanosoma brucei dihydroxyacetone phosphate acyltransferase, putative 0.0042 0.0029 0.0086
Echinococcus granulosus dna polymerase kappa 0.0042 0.0029 0.0058
Echinococcus granulosus guanylate kinase 0.0029 0.0017 0.0033
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0011 0.0001 0.0002
Echinococcus granulosus carbonic anhydrase 0.0038 0.0025 0.005
Loa Loa (eye worm) hypothetical protein 0.0153 0.0129 0.0129
Mycobacterium leprae PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE PLSB2 (GPAT) 0.0042 0.0028 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0016 0.0024
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0081 0.0063 0.0063
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0029 0.0017 0.0026
Giardia lamblia hypothetical protein 0.0153 0.0129 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0011 0.0001 0.0002
Schistosoma mansoni carbonic anhydrase-related 0.0038 0.0025 0.0038
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0037 0.0024 0.0047
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.3316 0.2994 1
Schistosoma mansoni tyrosine kinase 0.0011 0.0001 0.0001
Echinococcus granulosus segment polarity protein dishevelled 0.0035 0.0023 0.0045
Trichomonas vaginalis guanylate kinase, putative 0.0029 0.0017 0.0055
Mycobacterium leprae conserved hypothetical protein 0.0411 0.0363 0.1134
Echinococcus granulosus bloom syndrome protein 0.002 0.0009 0.0018
Leishmania major guanylate kinase, putative 0.0029 0.0017 0.0049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0001 0.0002
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.3727 0.3366 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0017
Entamoeba histolytica hypothetical protein, conserved 0.0011 0 0.0058
Onchocerca volvulus 0.0028 0.0016 0.0387
Schistosoma mansoni inhibitor of apoptosis protein 0.0037 0.0024 0.0036
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0038 0.0025 0.0038
Echinococcus multilocularis lamin 0.0028 0.0016 0.0031
Schistosoma mansoni carbonic anhydrase-related 0.0038 0.0025 0.0038
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0052 0.0081
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.013 0.0108 0.03
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0383 0.0338 0.0959
Entamoeba histolytica protein kinase, putative 0.0011 0 0.0058
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0017
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0004 0.0008
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0009 0.0029
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0383 0.0338 0.1004
Brugia malayi Guanylate kinase family protein 0.0029 0.0017 0.0026
Echinococcus multilocularis integrin alpha ps 0.3214 0.2902 0.584
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0026 0.0053
Echinococcus multilocularis calpain 5 0.0011 0 0.0000028028
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0026 0.0014 0.0041
Leishmania major dihydroxyacetonephosphate acyltransferase 0.0042 0.0029 0.0086
Trypanosoma brucei RNA helicase, putative 0.0025 0.0013 0.0038
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0008 0.0026
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0029 0.0017 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0029 0.0086
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0005
Schistosoma mansoni lamin 0.0028 0.0016 0.0024
Schistosoma mansoni hypothetical protein 0.0038 0.0025 0.0038
Echinococcus multilocularis epidermal growth factor receptor 0.0129 0.0107 0.0215
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0011 0.0001 0.0001
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0037 0.0024 0.0036
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0042 0.0029 0.0086
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0383 0.0338 0.0982
Entamoeba histolytica recQ family helicase, putative 0.002 0.0009 0.1738
Trypanosoma cruzi guanylate kinase, putative 0.0029 0.0017 0.0049
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.3401 0.3071 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Brugia malayi Protein kinase domain containing protein 0.0041 0.0028 0.0043
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0153 0.0129 0.0431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0153 0.0129 0.0129
Entamoeba histolytica BAR/SH3 domain containing protein 0.0011 0 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0086
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0009 0.0018
Entamoeba histolytica guanylate kinase, putative 0.0029 0.0017 0.3187
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.0053 0.0107
Onchocerca volvulus 0.0458 0.0405 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0011 0.0001 0.0002
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0009 0.0029
Loa Loa (eye worm) proteasome subunit beta type 1 0.0026 0.0014 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0001 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0008 0.0016
Schistosoma mansoni DNA helicase recq1 0.002 0.0009 0.0014
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0029 0.0094
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0011 0.0001 0.0002
Loa Loa (eye worm) RecQ helicase 0.002 0.0009 0.0009
Trichomonas vaginalis calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative 0.0029 0.0017 0.0055
Echinococcus granulosus integrin alpha 3 0.5496 0.4968 1
Wolbachia endosymbiont of Brugia malayi guanylate kinase 0.0029 0.0017 0.0029
Onchocerca volvulus 0.0011 0 0.0004
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0009 0.0029
Brugia malayi DIX domain containing protein 0.0012 0.0001 0.0002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0009 0.0014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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