Detailed information for compound 1446587

Basic information

Technical information
  • TDR Targets ID: 1446587
  • Name: N-[(E)-1-phenyl-2-propylhex-2-enyl]-4-(triflu oromethyl)benzamide
  • MW: 389.454 | Formula: C23H26F3NO
  • H donors: 1 H acceptors: 1 LogP: 7.23 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC/C(=C\CCC)/C(c1ccccc1)NC(=O)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C23H26F3NO/c1-3-5-10-17(9-4-2)21(18-11-7-6-8-12-18)27-22(28)19-13-15-20(16-14-19)23(24,25)26/h6-8,10-16,21H,3-5,9H2,1-2H3,(H,27,28)/b17-10+
  • InChiKey: YKNPPNZBHNKTMT-LICLKQGHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(E)-1-phenyl-2-propyl-hex-2-enyl]-4-(trifluoromethyl)benzamide
  • SDCCGMLS-0090897.P001
  • NCGC00074367-01
  • UPCMLD01APSI001159A

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus caspase 0.0097 0.0941 0.0941
Echinococcus multilocularis para nitrobenzyl esterase 0.0156 0.1589 0.1589
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.011 0.0683
Echinococcus granulosus serine:threonine protein kinase haspin 0.0495 0.5307 0.5307
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0003
Brugia malayi Carboxylesterase family protein 0.0156 0.1589 0.1588
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0017
Trypanosoma cruzi metacaspase, putative 0.0026 0.0163 0.0317
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.011 0.0683
Brugia malayi Cell death protein 3 precursor 0.0026 0.0163 0.0162
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0003 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0149 0.1232
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.011 0.0488
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0297 0.0721
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.008
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0297 0.054
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.143 0.143
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0001
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0458 0.0457
Echinococcus granulosus para nitrobenzyl esterase 0.0156 0.1589 0.1589
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.008 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0495 0.5307 0.5307
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0056 0.0055
Brugia malayi steroid hormone receptor 0.0011 0.0003 0.0001
Mycobacterium tuberculosis Probable reductase 0.012 0.12 0.7498
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.011 0.0186
Schistosoma mansoni hypothetical protein 0.012 0.1198 0.1198
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0854 0.2077
Echinococcus granulosus caspase 2 0.0026 0.0163 0.0163
Onchocerca volvulus 0.0231 0.2414 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0156 0.1589 0.1589
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0034 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.011 0.0488
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0018 0.0018
Leishmania major cytochrome p450-like protein 0.0021 0.011 0.0186
Echinococcus multilocularis caspase 3 0.0071 0.0657 0.0657
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1347 0.8446
Entamoeba histolytica Ran family GTPase 0.0024 0.0139 0.0335
Schistosoma mansoni ran 0.0024 0.0139 0.0139
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0003 0.0001
Echinococcus multilocularis dual specificity 0.0386 0.4105 0.4105
Brugia malayi jmjC domain containing protein 0.0015 0.0047 0.0045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0168 0.0166
Onchocerca volvulus Putative endochitinase 0.0076 0.071 0.2936
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0163 0.0394
Loa Loa (eye worm) carboxylesterase 0.0923 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0015 0.0047 0.0045
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0508 0.0508
Loa Loa (eye worm) carboxylesterase 0.0156 0.1589 0.1588
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0028 0.0191 0.1008
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.008 0.0079
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0652 0.0652
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.008 0.0298
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0034 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0344 0.3649 0.3648
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0156 0.1589 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.011 0.0683
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0226 0.0471
Brugia malayi polk-prov protein 0.003 0.0212 0.021
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0191 0.1193
Trypanosoma brucei metacaspase MCA2 0.0026 0.0163 0.0317
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0458 0.2728
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.011 0.0683
Schistosoma mansoni ap endonuclease 0.0018 0.008 0.008
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0095 0.092 0.092
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0139 0.0147
Loa Loa (eye worm) hypothetical protein 0.012 0.1198 0.1196
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0149 0.1232
Plasmodium falciparum MO15-related protein kinase 0.0089 0.0854 0.7125
Schistosoma mansoni intermediate filament proteins 0.0026 0.0168 0.0168
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0089 0.0854 0.0854
Echinococcus granulosus BC026374 protein S09 family 0.0156 0.1589 0.1589
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0232 0.0457
Loa Loa (eye worm) hypothetical protein 0.0065 0.0587 0.0586
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.011 0.0683
Trypanosoma brucei Metacaspase-4 0.0026 0.0163 0.0317
Onchocerca volvulus 0.0156 0.1589 0.6582
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.008 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0652 0.4095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.011 0.0488
Leishmania major hypothetical protein, conserved 0.0015 0.0047 0.0032
Schistosoma mansoni hypothetical protein 0.0036 0.0277 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Schistosoma mansoni cytochrome P450 0.0021 0.011 0.011
Echinococcus granulosus mitogen activated protein kinase 15 0.0089 0.0854 0.0854
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0313
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0335 0.071
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0458 0.0458
Trypanosoma brucei protein kinase, putative 0.0089 0.0854 0.2013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Trypanosoma cruzi ion transport protein, putative 0.011 0.109 0.2594
Brugia malayi follicle stimulating hormone receptor 0.028 0.2945 0.2944
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0089 0.0854 0.2013
Brugia malayi intermediate filament protein 0.0026 0.0168 0.0166
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1692 0.412
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0089 0.0854 0.2013
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0226 0.0471
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Onchocerca volvulus 0.012 0.1198 0.4959
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0232 0.0231
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0508 0.0508
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0163 0.0317
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.011 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0056 0.0055
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0191 0.1193
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0198 0.0198
Trichomonas vaginalis spcc417.12 protein, putative 0.0156 0.1589 0.3869
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0854 0.0854
Schistosoma mansoni hypothetical protein 0.0086 0.0817 0.0817
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0047 0.0045
Onchocerca volvulus Putative endochitinase 0.0085 0.081 0.3351
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Echinococcus multilocularis GPCR, family 2 0.0018 0.008 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.011 0.0488
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.143 0.1429
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0003 0.0001
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0139 0.115
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.011 0.0155
Echinococcus multilocularis dna polymerase kappa 0.004 0.0318 0.0318
Schistosoma mansoni chitinase 0.0011 0.0001 0.0001
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Echinococcus multilocularis cyclin dependent kinase 9 0.0089 0.0854 0.0854
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.008 0.008
Echinococcus granulosus GPCR family 2 0.0018 0.008 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0277 0.0277
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0003 0.0003
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0163 0.0163
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.008 0.0079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0139 0.0258
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.008 0.066
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0198 0.0374
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0089 0.0854 0.7125
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.008 0.0112
Echinococcus multilocularis 0.0021 0.011 0.011
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0386 0.4105 1
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.008
Plasmodium falciparum thioredoxin reductase 0.0053 0.0458 0.3818
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0163 0.0317
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0026 0.0025
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.011 0.0683
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0139 0.0138
Giardia lamblia Kinase, CAMK CAMKL 0.0089 0.0854 0.1922
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0003 0.0003
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0047 0.0047
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.008 0.0191
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0458 0.1042
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0156 0.1589 0.1588
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0318 0.1997
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.143 0.143
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.011 0.0488
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.011 0.0683
Leishmania major trypanothione reductase 0.0053 0.0458 0.1042
Plasmodium vivax hypothetical protein, conserved 0.012 0.1198 1
Echinococcus granulosus serine:threonine protein kinase haspin 0.0495 0.5307 0.5307
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0191 0.0385
Leishmania major DNA polymerase kappa, putative 0.0021 0.0104 0.0173
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.4105 1
Onchocerca volvulus Putative endochitinase 0.0085 0.081 0.3351
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0277 0.0277
Echinococcus granulosus lamin dm0 0.0026 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0156 0.1589 0.1588
Brugia malayi Pre-SET motif family protein 0.0029 0.0198 0.0197
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0534 0.0534
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0163 0.0286
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.4105 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.011 0.0683
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0318 0.0773
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0534 0.3356
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Loa Loa (eye worm) hypothetical protein 0.0923 1 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0163 0.0163
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0018 0.0018
Echinococcus multilocularis neuroligin 0.0156 0.1589 0.1589
Brugia malayi jmjC domain containing protein 0.0057 0.0508 0.0507
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.2586 0.6268
Echinococcus granulosus dual specificity 0.0386 0.4105 0.4105
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0534 0.0534
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.12 0.7498
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.011 0.0488
Toxoplasma gondii exonuclease III APE 0.0018 0.008 0.0082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0534 0.3356
Loa Loa (eye worm) haspin protein kinase 0.0495 0.5307 0.5306
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0139 0.115
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.0854 0.2077
Loa Loa (eye worm) hypothetical protein 0.0058 0.0513 0.0512
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0047 0.0045
Echinococcus multilocularis hypothetical protein 0.0086 0.0817 0.0817
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.008 0.0497
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.011 0.0488
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.011 0.0488
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0047 0.0047
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.011 0.0186
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.008 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0003 0.0006
Plasmodium vivax JmjC domain containing protein 0.0015 0.0047 0.038
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0652 0.149
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.2642 0.6435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Mycobacterium ulcerans chitinase/cellulase 0.0065 0.0587 0.369
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.2642 0.2641
Mycobacterium ulcerans chitinase/cellulase 0.0065 0.0587 0.369
Brugia malayi Cytochrome P450 family protein 0.0067 0.0615 0.0614
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.008 0.0192
Trypanosoma cruzi ion transport protein, putative 0.011 0.109 0.2594
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0318 0.0773
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0318 0.1997
Plasmodium falciparum thioredoxin reductase 0.0018 0.008 0.0655
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0156 0.1589 0.1589
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0139 0.0138
Brugia malayi hypothetical protein 0.0016 0.0053 0.0052
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0534 0.0533
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0615 0.0614
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0652 0.4095
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.011 0.0488
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0198 0.0198
Schistosoma mansoni gliotactin 0.0156 0.1589 0.1589
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0513 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) hypothetical protein 0.0059 0.0523 0.0521
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0458 0.3818
Brugia malayi nuclear receptor NHR-88 0.0011 0.0003 0.0001
Echinococcus granulosus dna polymerase eta 0.0014 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0163 0.0317
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0508 0.0508
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0344 0.3649 0.3649
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Brugia malayi endochitinase 0.0076 0.071 0.0708
Brugia malayi Protein kinase domain containing protein 0.0089 0.0854 0.0852
Mycobacterium tuberculosis Conserved protein 0.0028 0.0191 0.1008
Brugia malayi Carboxylesterase family protein 0.0923 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2106 0.2105
Giardia lamblia Kinase, CAMK CAMKL 0.0089 0.0854 0.1922
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0047 0.0047
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.008 0.008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0165 0.04
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0386 0.4105 1
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.008 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0003 0.0001
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.008 0.0655
Loa Loa (eye worm) haspin protein kinase 0.0495 0.5307 0.5306
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0386 0.4105 0.4104
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0318 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0001
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0495 0.5307 0.5307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0163 0.0394
Schistosoma mansoni hypothetical protein 0.0131 0.131 0.131
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0508 0.0508
Echinococcus multilocularis caspase 2 0.0026 0.0163 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1692 0.412
Schistosoma mansoni voltage-gated potassium channel 0.0095 0.092 0.092
Trichomonas vaginalis ran, putative 0.0024 0.0139 0.0335
Giardia lamblia DINP protein human, muc B family 0.0021 0.0104 0.0062
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.008 0.0493
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0003 0.0006
Loa Loa (eye worm) chitinase I 0.0076 0.071 0.0708
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.008 0.0191
Echinococcus multilocularis snurportin 1 0.0344 0.3649 0.3649
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.011 0.0488
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0001
Leishmania major cytochrome p450-like protein 0.0021 0.011 0.0186
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0232 0.0487
Schistosoma mansoni hypothetical protein 0.0021 0.011 0.011
Echinococcus granulosus potassium voltage gated channel protein 0.0095 0.092 0.092
Echinococcus multilocularis BC026374 protein (S09 family) 0.0156 0.1589 0.1589
Trichomonas vaginalis protein kinase atmrk1, putative 0.0089 0.0854 0.2077
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0165 0.04
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0156 0.1589 0.1589
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.179 0.4358
Onchocerca volvulus 0.012 0.1198 0.4959
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0534 0.1229
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.008 0.0112
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.008 0.066
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.008 0.0081
Loa Loa (eye worm) acetylcholinesterase 1 0.0923 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0095 0.092 0.092
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0318 0.0699
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0089 0.0854 0.7125
Echinococcus multilocularis lamin dm0 0.0026 0.0168 0.0168
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0149 0.1232
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0149 0.0282
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.008 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0854 0.2077
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0003 0.0003
Echinococcus granulosus phd:f box containing protein 0.0015 0.0047 0.0047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.008 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0198 0.0198
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0335 0.0335
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0212 0.0437
Loa Loa (eye worm) hypothetical protein 0.0156 0.1589 0.1588
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0163 0.0286
Brugia malayi Pre-SET motif family protein 0.0203 0.2106 0.2105
Entamoeba histolytica protein kinase, putative 0.0386 0.4105 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0198 0.0198
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0156 0.1589 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0508 0.0508
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.0672
Toxoplasma gondii thioredoxin reductase 0.0053 0.0458 0.1013
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.011 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0149 0.0282
Schistosoma mansoni hypothetical protein 0.0495 0.5307 0.5307
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.12 0.7498
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0854 0.2077
Trypanosoma brucei trypanothione reductase 0.0053 0.0458 0.1042
Plasmodium falciparum glutathione reductase 0.0018 0.008 0.0655
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0047 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0247 0.2586 0.6268
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0335 0.071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.008 0.0114
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0854 0.2077
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0047 0.0047
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0226 0.0471
Schistosoma mansoni protein kinase 0.0089 0.0854 0.0854
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0508 0.0508
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0386 0.4105 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1589 0.1588
Loa Loa (eye worm) hypothetical protein 0.0026 0.0168 0.0166
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.011 0.0488
Echinococcus multilocularis dual specificity 0.0386 0.4105 0.4105
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.012 0.1198 0.1196
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0226 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0001
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0386 0.4105 0.4104
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.008 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0534 0.3217
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0226 0.1413
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0191 0.0385
Brugia malayi Cytochrome P450 family protein 0.0032 0.0226 0.0224
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0097 0.0941 0.0941
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0104 0.0454
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.016 0.1635 0.1635
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.011 0.0683
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0652 0.3972
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0001
Brugia malayi glutathione reductase 0.0053 0.0458 0.0457
Echinococcus multilocularis musashi 0.0026 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.0161
Plasmodium falciparum metacaspase-like protein 0.0026 0.0163 0.1351
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0011 0.0001 0.0001
Loa Loa (eye worm) glutathione reductase 0.0053 0.0458 0.0457
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.011 0.0488
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1347 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.2642 0.6435
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.008 0.0295
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0003 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0452 0.045
Echinococcus multilocularis caspase 0.0097 0.0941 0.0941
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0187 0.0187
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.0941 0.0941
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0198 0.0198
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.011 0.0186
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.12 0.7498
Leishmania major metacaspase, putative 0.0026 0.0163 0.0317
Loa Loa (eye worm) hypothetical protein 0.0131 0.131 0.1309
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.008 0.0493
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0139 0.0258
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0047 0.0047
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0003 0.0006
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0028 0.0191 0.1193
Brugia malayi Cell division protein kinase 2 0.0089 0.0854 0.0852
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0089 0.0854 0.2013
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus multilocularis dual specificity 0.0386 0.4105 0.4105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.12 0.7498
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.008 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0034 0.0033
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0923 1 1
Toxoplasma gondii hypothetical protein 0.012 0.1198 0.2835
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Onchocerca volvulus Putative endochitinase 0.0076 0.071 0.2936
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1692 0.412
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.008 0.0078
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.008 0.008
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0163 0.0286
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0156 0.1589 0.3869
Echinococcus granulosus acetylcholinesterase 0.0923 1 1
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0854 0.2077
Brugia malayi Latrophilin receptor protein 2 0.0018 0.008 0.0078
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0047 0.0032
Echinococcus multilocularis caspase 8 0.0026 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0001
Echinococcus granulosus lamin 0.0026 0.0168 0.0168
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.011 0.0683
Brugia malayi RNA, U transporter 1 0.0092 0.0883 0.0882
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.011 0.0488
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.008 0.0655
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.008 0.0192
Plasmodium vivax SET domain protein, putative 0.0029 0.0198 0.1648
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2414 0.5878
Leishmania major cytochrome p450-like protein 0.0032 0.0226 0.0471
Entamoeba histolytica protein kinase domain containing protein 0.0386 0.4105 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0095 0.092 0.0919
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.2642 0.6435
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.012 0.1198 0.1198
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0047 0.0047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0034 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0047 0.0045
Entamoeba histolytica chitinase, putative 0.0076 0.071 0.1726
Echinococcus granulosus importin subunit beta 1 0.0032 0.0232 0.0232
Schistosoma mansoni lamin 0.0026 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0156 0.1589 0.1588
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0162
Echinococcus granulosus small conductance calcium activated potassium 0.0131 0.131 0.131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0513 0.0512
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0156 0.1589 0.6582
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0652 0.0652
Brugia malayi jmjC domain containing protein 0.0015 0.0047 0.0045
Brugia malayi jmjC domain containing protein 0.0057 0.0508 0.0507
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0001
Brugia malayi Cytochrome P450 family protein 0.0021 0.011 0.0108
Onchocerca volvulus 0.0029 0.0198 0.0817
Schistosoma mansoni coup transcription factor 0.0011 0.0003 0.0003
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0232 0.0487
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0047 0.038
Loa Loa (eye worm) hypothetical protein 0.0156 0.1589 0.1588
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0168 0.0166
Plasmodium falciparum conserved protein, unknown function 0.012 0.1198 1
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0089 0.0854 0.0852
Echinococcus multilocularis acetylcholinesterase 0.0923 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0277 0.0277
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0104 0.0173
Schistosoma mansoni caspase-3 (C14 family) 0.0097 0.0941 0.0941
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0854 0.2077
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0034 0.0034
Plasmodium falciparum metacaspase 1 0.0026 0.0163 0.1351
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0139 0.0258
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1386 0.1386
Echinococcus granulosus caspase 8 0.0026 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0149 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.2642 0.6435
Giardia lamblia Kinase, CMGC DYRK 0.0386 0.4105 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.011 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Mycobacterium ulcerans hypothetical protein 0.0028 0.0191 0.1193
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.011 0.0683
Schistosoma mansoni neuroligin 3 (S09 family) 0.0156 0.1589 0.1589
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.4105 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0163 0.0394
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0003 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Brugia malayi endochitinase 0.0085 0.081 0.0808
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0003
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.1692 0.7009
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.011 0.0683
Loa Loa (eye worm) hypothetical protein 0.0923 1 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0047 0.0047
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0047 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0198 0.0198
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0508 0.0507
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0335 0.279
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.008 0.0114
Echinococcus multilocularis lamin 0.0026 0.0168 0.0168
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0047 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.008 0.008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.008 0.0112
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.011 0.0186
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0047 0.0047
Schistosoma mansoni calcium-activated potassium channel 0.0131 0.131 0.131
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus granulosus caspase 3 0.0071 0.0657 0.0657
Loa Loa (eye worm) cytochrome P450 0.0021 0.011 0.0108
Brugia malayi Endochitinase 0.0085 0.081 0.0808
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0248 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.008 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0001
Brugia malayi cyclin-dependent kinase 7 homolog 0.0089 0.0854 0.0852
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.008 0.0493
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0089 0.0854 0.0854
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0001
Brugia malayi hypothetical protein 0.0036 0.0277 0.0276
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0297 0.2472
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.011 0.0683
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.008 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Onchocerca volvulus Putative endochitinase 0.0085 0.081 0.3351
Echinococcus granulosus serine:threonine protein kinase NLK 0.0089 0.0854 0.0854
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.0173
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0089 0.0854 0.2077
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.011 0.0488
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1692 0.412
Brugia malayi jmjC domain containing protein 0.0015 0.0047 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0652 0.0652
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.012 0.1198 0.1198
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0165 0.04
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.0672
Echinococcus granulosus serine:threonine protein kinase haspin 0.0495 0.5307 0.5307
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0003
Entamoeba histolytica cell division protein kinase 2, putative 0.0089 0.0854 0.2077
Onchocerca volvulus 0.0026 0.0168 0.0689
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0078
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0034 0.0079
Trypanosoma cruzi metacaspase, putative 0.0026 0.0163 0.0317
Brugia malayi hypothetical protein 0.0156 0.1589 0.1588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0034 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0318 0.0699
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0086 0.0817 0.0817
Schistosoma mansoni serine/threonine protein kinase 0.0386 0.4105 0.4105
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0335 0.0813
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Echinococcus multilocularis acetylcholinesterase 0.0923 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0163 0.0394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0198 0.0198
Echinococcus multilocularis carboxylesterase 5A 0.0923 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0139 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Entamoeba histolytica hypothetical protein 0.0026 0.0165 0.04
Loa Loa (eye worm) cuticular endochitinase 0.0076 0.071 0.0708
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.011 0.0488
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.2642 0.2641
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.4105 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0318 0.0699
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.011 0.0683
Brugia malayi hypothetical protein 0.0025 0.0149 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0318 0.0699
Echinococcus granulosus acetylcholinesterase 0.0923 1 1
Schistosoma mansoni ran 0.0024 0.0139 0.0139
Loa Loa (eye worm) microfilarial chitinase 0.0074 0.0687 0.0686
Echinococcus multilocularis potassium voltage gated channel protein 0.0095 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.003 0.0212 0.021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0198 0.0197
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0034 0.0034
Plasmodium vivax metacaspase 1, putative 0.0026 0.0163 0.1351
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0191 0.0385
Schistosoma mansoni ap endonuclease 0.0018 0.008 0.008
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.011 0.0683
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0534 0.0534
Brugia malayi Carboxylesterase family protein 0.0156 0.1589 0.1588
Leishmania major serine/threonine kinase-like protein, putative 0.0089 0.0854 0.2013
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0149 0.0251
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1692 0.412
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0311
Brugia malayi Cytochrome P450 family protein 0.0032 0.0226 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.011 0.0488
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1347 0.8446
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0163 0.1351
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0163 0.0162
Echinococcus granulosus dna polymerase kappa 0.004 0.0318 0.0318
Schistosoma mansoni calcium-activated potassium channel 0.0124 0.124 0.124
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0003
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0089 0.0854 0.2013
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0047 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis serine/threonine kinase, putative 0.0089 0.0854 0.2077
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0163 0.0394
Plasmodium vivax importin-beta 2, putative 0.0032 0.0232 0.1929
Echinococcus granulosus carboxylesterase 5A 0.0923 1 1
Schistosoma mansoni lamin 0.0026 0.0168 0.0168
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0513 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.008 0.0114
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0091 0.0875 0.0875
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0047 0.0047
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.008 0.008
Echinococcus granulosus intermediate filament protein 0.0026 0.0168 0.0168
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0191 0.0461
Giardia lamblia Kinase, CAMK CAMKL 0.0089 0.0854 0.1922
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.008 0.0078
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0212 0.0437
Mycobacterium ulcerans hypothetical protein 0.0028 0.0191 0.1193
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.011 0.0683
Onchocerca volvulus 0.0026 0.0168 0.0689
Onchocerca volvulus 0.0156 0.1589 0.6582
Loa Loa (eye worm) hypothetical protein 0.012 0.1198 0.1196
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Plasmodium falciparum importin beta, putative 0.0032 0.0232 0.1929
Onchocerca volvulus 0.0156 0.1589 0.6582
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.008 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.179 0.4358
Leishmania major GTP-binding protein, putative 0.0024 0.0139 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1692 0.412
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0003 0.0001
Brugia malayi cytochrome P450 0.0021 0.011 0.0108
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.011 0.0488
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0458 0.0458
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0191 0.0191
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0139 0.0139
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0163 0.067
Entamoeba histolytica hypothetical protein 0.0086 0.0817 0.1987
Mycobacterium tuberculosis Carboxylesterase LipT 0.0156 0.1589 1
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0335 0.0813
Leishmania major hypothetical protein, conserved 0.0247 0.2586 0.6268
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.008 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0045
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.008 1
Loa Loa (eye worm) carboxylesterase 0.0156 0.1589 0.1588
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0854 0.2077
Loa Loa (eye worm) acetyltransferase 0.0141 0.143 0.1429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.008 0.0112
Leishmania major ion transport protein-like protein 0.011 0.109 0.2594
Schistosoma mansoni importin beta-1 0.0032 0.0232 0.0232
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0156 0.1589 0.1589
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.4105 1
Echinococcus multilocularis dna polymerase eta 0.0014 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.2586 0.6268
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0162
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0652 0.0652
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.008 0.0655
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0156 0.1589 0.1589
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0313 0.0311
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.008 0.0114
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.008 0.0112
Brugia malayi Carboxylesterase family protein 0.0156 0.1589 0.1588
Onchocerca volvulus 0.0011 0.0003 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0508 0.0508
Echinococcus granulosus neuroligin 0.0156 0.1589 0.1589
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0003 0.0003
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0089 0.0854 0.0854
Leishmania major hypothetical protein, conserved 0.0025 0.0149 0.0282
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.011 0.011
Onchocerca volvulus 0.0156 0.1589 0.6582
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0386 0.4105 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.011 0.0683
Echinococcus granulosus dual specificity 0.0386 0.4105 0.4105
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0056 0.0055
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0089 0.0854 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0001
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0012
Brugia malayi nuclear hormone receptor 0.0011 0.0003 0.0001
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.011 0.0186
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0168 0.0166
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0033
Echinococcus multilocularis small conductance calcium activated potassium 0.0131 0.131 0.131
Echinococcus granulosus snurportin 1 0.0344 0.3649 0.3649
Brugia malayi ecdysteroid receptor 0.0011 0.0003 0.0001
Echinococcus granulosus dual specificity 0.0386 0.4105 0.4105
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0149 0.0282
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0226 0.0224
Mycobacterium tuberculosis Possible chitinase 0.0065 0.0587 0.3558
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0097 0.0941 0.0941
Plasmodium vivax glutathione reductase, putative 0.0053 0.0458 0.3818
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1692 0.412
Trypanosoma brucei metacaspase MCA3 0.0026 0.0163 0.0317
Trypanosoma brucei unspecified product 0.0034 0.0248 0.0525
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0165 0.0323
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0003 0.0003
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0232 0.0232
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.011 0.0683
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma cruzi metacaspase, putative 0.0026 0.0163 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0163 0.0394
Mycobacterium ulcerans carboxylesterase, LipT 0.0156 0.1589 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.008 0.0655
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1347 0.8446
Loa Loa (eye worm) haspin protein kinase 0.0498 0.5343 0.5343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0226 0.0224
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.011 0.0683
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.4105 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394
Loa Loa (eye worm) hypothetical protein 0.0095 0.092 0.0919
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0139 0.0227
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0652 0.1517
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.2642 0.6435
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0047 0.0047
Schistosoma mansoni serine/threonine kinase 0.0089 0.0854 0.0854
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0089 0.0854 0.2013
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0318 0.0699
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.12 0.7498
Trypanosoma cruzi metacaspase, putative 0.0026 0.0163 0.0317
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.12 0.8809
Trypanosoma brucei metacaspase 0.0026 0.0163 0.0317
Brugia malayi hypothetical protein 0.0495 0.5307 0.5306
Brugia malayi GSG2 0.0495 0.5307 0.5306
Echinococcus granulosus cyclin dependent kinase 9 0.0089 0.0854 0.0854
Schistosoma mansoni acetylcholinesterase 0.0156 0.1589 0.1589
Schistosoma mansoni DNA polymerase eta 0.0014 0.0034 0.0034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.0672
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0318 0.0699
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0047 0.0032
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.008 0.0112
Plasmodium falciparum glutathione reductase 0.0053 0.0458 0.3818
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0652 0.4095
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.011 0.0683
Loa Loa (eye worm) hypothetical protein 0.0065 0.0596 0.0595
Brugia malayi Importin beta-1 subunit 0.0032 0.0232 0.0231
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2945 0.2944
Leishmania major chitinase 0.0076 0.071 0.166
Brugia malayi Carboxylesterase family protein 0.0156 0.1589 0.1588
Brugia malayi Thioredoxin reductase 0.0053 0.0458 0.0457
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0045
Leishmania major importin beta-1 subunit, putative 0.0026 0.0165 0.0323
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0156 0.1589 0.1588
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.0854 0.2077
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.2642 0.6435
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0163 0.0394

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.16227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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