TDR Targets

Basic information

Technical information

TDR Targets ID: 1446793
Name: 3-[[(4-ethoxyphenyl)methylamino]methyl]-1-[(4 -methoxyphenyl)methyl]indole-2-carboxylic aci d
MW: 444.522 | Formula: C27H28N2O4
H donors: 2 H acceptors: 2 LogP: 2.35 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)CNCc1c(C(=O)O)n(c2c1cccc2)Cc1ccc(cc1)OC
InChi: 1S/C27H28N2O4/c1-3-33-22-14-8-19(9-15-22)16-28-17-24-23-6-4-5-7-25(23)29(26(24)27(30)31)18-20-10-12-21(32-2)13-11-20/h4-15,28H,3,16-18H2,1-2H3,(H,30,31)
InChiKey: GMSYFIRKOLTJLX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[[(4-ethoxyphenyl)methylamino]methyl]-1-[(4-methoxyphenyl)methyl]-2-indolecarboxylic acid
3-[[(4-ethoxybenzyl)amino]methyl]-1-(4-methoxybenzyl)indole-2-carboxylic acid
NCGC00122323-01
E518-0279

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis		0.0062	0.0476	0.0849
Entamoeba histolytica	protein kinase domain containing protein	0.0393	0.4321	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0067	0.0538	0.0959
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0161	0.162	0.1746
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.0476	0.3796
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0538	0.095
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0538	0.095
Brugia malayi	F/Y-rich N-terminus family protein	0.0043	0.026	0.0463
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0196	0.0454
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0173	0.0309
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0189	0.1949	0.4511
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Loa Loa (eye worm)	cuticular endochitinase	0.0077	0.0646	0.1143
Brugia malayi	Pre-SET motif family protein	0.0036	0.0173	0.0309
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0385	0.0687
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0448	0.08
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.006	0.006
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0538	0.095
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0385	0.0891
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0385	0.0891
Echinococcus granulosus	tumor protein p63	0.0408	0.4495	0.802
Echinococcus multilocularis	tumor protein p63	0.0408	0.4495	0.802
Loa Loa (eye worm)	hypothetical protein	0.0122	0.117	0.2069
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.016	0.0286
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.1746	0.3115
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0091	0.0816	0.1443
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Schistosoma mansoni	protein phosphatase 2C	0.0042	0.0238	0.0425
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0173	0.0401
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0189	0.1949	0.4511
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0265	0.0612
Giardia lamblia	Kinase, CAMK CAMKL	0.0091	0.0816	0.1888
Trypanosoma brucei	glucosidase, putative	0.0038	0.0196	0.0454
Echinococcus multilocularis	dual specificity	0.0393	0.4321	0.7709
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0504	0.5604	1
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0042	0.0244	0.0565
Echinococcus multilocularis	peregrin	0.0129	0.1253	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0131	0.0303
Trichomonas vaginalis	CMGC family protein kinase	0.0091	0.0816	0.1888
Plasmodium vivax	SET domain protein, putative	0.0036	0.0173	0.1381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0127	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0185	0.1899	0.3357
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0196	0.0454
Brugia malayi	Carboxylesterase family protein	0.0399	0.439	0.7832
Schistosoma mansoni	chromobox protein	0.0078	0.0665	0.1186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0094	0.0218
Brugia malayi	PHD-finger family protein	0.0042	0.0244	0.0436
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Echinococcus granulosus	para nitrobenzyl esterase	0.0067	0.0538	0.0959
Toxoplasma gondii	histone lysine-specific demethylase	0.0062	0.0476	0.1101
Onchocerca volvulus		0.0122	0.117	0.3475
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0393	0.4321	1
Loa Loa (eye worm)	hypothetical protein	0.0399	0.439	0.7762
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0538	0.095
Brugia malayi	MH2 domain containing protein	0.0144	0.1429	0.255
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0256	0.0592
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0399	0.439	0.7762
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0171	0.1746	0.3087
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0223	0.0517
Mycobacterium ulcerans	dehydrogenase	0.0062	0.0476	0.0476
Echinococcus multilocularis	lysine specific demethylase 5A	0.0156	0.1569	0.2799
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1253	0.2216
Schistosoma mansoni	chromobox protein	0.0078	0.0665	0.1186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0095	0.0219
Trichomonas vaginalis	CMGC family protein kinase	0.0393	0.4321	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0385	0.0891
Entamoeba histolytica	protein kinase, putative	0.0189	0.1949	0.4511
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.026	0.278	0.4916
Plasmodium falciparum	protoporphyrinogen oxidase	0.0062	0.0476	0.3796
Leishmania major	hypothetical protein, conserved	0.0042	0.0238	0.0551
Loa Loa (eye worm)	hypothetical protein	0.006	0.0448	0.0793
Plasmodium falciparum	conserved protein, unknown function	0.0122	0.117	0.9337
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0091	0.0816	0.1443
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0256	0.0592
Loa Loa (eye worm)	jmjC domain-containing protein	0.0266	0.285	0.5039
Echinococcus granulosus	peregrin	0.0129	0.1253	0.2236
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Echinococcus granulosus	jumonji domain containing protein	0.018	0.184	0.3284
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0129	0.1253	0.2236
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0223	0.0517
Onchocerca volvulus	Putative endochitinase	0.0077	0.0646	0.1683
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0129	0.1253	0.2236
Onchocerca volvulus	Putative endochitinase	0.0086	0.0754	0.2051
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0062	0.0476	0.0849
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0158	0.0281
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0042	0.0238	0.0425
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0091	0.0816	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Mycobacterium tuberculosis	Possible chitinase	0.0065	0.0515	0.0555
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Brugia malayi	jmjC domain containing protein	0.0042	0.0238	0.0425
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0042	0.0238	0.19
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1469	0.262
Echinococcus multilocularis	jumonji domain containing 1A	0.0042	0.0238	0.0425
Echinococcus granulosus	neuroligin	0.0067	0.0538	0.0959
Loa Loa (eye worm)	heterochromatin protein 1	0.0078	0.0665	0.1175
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0171	0.1746	0.3115
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0026	0.006	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.2674	0.4729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0095	0.0219
Plasmodium vivax	JmjC domain containing protein	0.0042	0.0238	0.19
Brugia malayi	Heterochromatin protein 1	0.0078	0.0665	0.1186
Onchocerca volvulus	Putative endochitinase	0.0086	0.0754	0.2051
Trichomonas vaginalis	serine/threonine kinase, putative	0.0091	0.0816	0.1888
Schistosoma mansoni	alpha glucosidase	0.0038	0.0196	0.035
Loa Loa (eye worm)	haspin protein kinase	0.0504	0.5604	0.991
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0256	0.0592
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0196	0.0454
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0091	0.0816	0.1888
Schistosoma mansoni	hypothetical protein	0.0129	0.1253	0.2236
Mycobacterium tuberculosis	Possible oxidoreductase	0.0062	0.0476	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0265	0.0468
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0385	0.068
Entamoeba histolytica	hypothetical protein	0.0035	0.016	0.0371
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0177	0.041
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0385	0.0687
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.0122	0.117	0.2088
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0385	0.0687
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.0816	0.1888
Brugia malayi	hypothetical protein	0.0504	0.5604	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0016	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0095	0.0219
Onchocerca volvulus		0.0067	0.0538	0.1311
Onchocerca volvulus		0.0067	0.0538	0.1311
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0385	0.0891
Echinococcus granulosus	acetylcholinesterase	0.0399	0.439	0.7832
Schistosoma mansoni	amine oxidase	0.0062	0.0476	0.0849
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0042	0.0244	0.1949
Loa Loa (eye worm)	haspin protein kinase	0.0504	0.5604	0.991
Giardia lamblia	Kinase, CAMK CAMKL	0.0091	0.0816	0.1888
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0196	0.0347
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0052	0.0121
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0067	0.0538	0.0959
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0238	0.0421
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0042	0.0238	0.0551
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0393	0.4321	0.7709
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0062	0.0476	0.3796
Echinococcus granulosus	dual specificity	0.0393	0.4321	0.7709
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0095	0.0219
Onchocerca volvulus		0.006	0.0448	0.1005
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0504	0.5604	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0156	0.1569	0.2774
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0196	0.0454
Brugia malayi	Carboxylesterase family protein	0.0399	0.439	0.7832
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0303	0.0702
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0131	0.0303
Brugia malayi	endochitinase	0.0086	0.0754	0.1345
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0223	0.0517
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0303	0.0702
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0385	0.0891
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0454	0.081
Echinococcus granulosus	chromobox protein 1	0.0078	0.0665	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0232	0.0411
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.0816	0.1888
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0093	0.0841	0.15
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0538	0.095
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Onchocerca volvulus		0.0067	0.0538	0.1311
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2324	0.411
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0476	0.0841
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0062	0.0476	0.0849
Schistosoma mansoni	phosphatidylserine receptor	0.0042	0.0238	0.0425
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0196	0.0454
Schistosoma mansoni	hypothetical protein	0.0087	0.0765	0.1365
Brugia malayi	Carboxylesterase family protein	0.0067	0.0538	0.0959
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0223	0.0517
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0882	1	1
Echinococcus multilocularis	dual specificity	0.0189	0.1949	0.3478
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0067	0.0538	0.0579
Brugia malayi	Carboxylesterase family protein	0.0067	0.0538	0.0959
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0265	0.0612
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0091	0.0816	0.651
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0091	0.0816	0.1888
Plasmodium falciparum	MO15-related protein kinase	0.0091	0.0816	0.651
Onchocerca volvulus		0.0122	0.117	0.3475
Schistosoma mansoni	jumonji domain containing protein	0.0336	0.3655	0.6521
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0173	0.0309
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.006	0.0138
Echinococcus granulosus	carboxylesterase 5A	0.0399	0.439	0.7832
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0091	0.0816	0.651
Echinococcus granulosus	lysine specific demethylase 6a	0.0042	0.0238	0.0425
Schistosoma mansoni	hypothetical protein	0.0504	0.5604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0293	0.0677
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0091	0.0816	0.1888
Entamoeba histolytica	hypothetical protein	0.0035	0.016	0.0371
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Brugia malayi	PHD-finger family protein	0.0129	0.1253	0.2236
Entamoeba histolytica	hypothetical protein	0.0026	0.006	0.0138
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0454	0.0802
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0393	0.4321	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0196	0.0454
Entamoeba histolytica	hypothetical protein	0.0035	0.016	0.0371
Brugia malayi	jmjC domain containing protein	0.0042	0.0238	0.0425
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0189	0.1949	0.4511
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1429	0.2527
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0538	0.095
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0062	0.0476	0.0476
Onchocerca volvulus		0.0067	0.0538	0.1311
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0042	0.0244	0.0565
Echinococcus multilocularis	jumonji domain containing protein	0.018	0.184	0.3284
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0164	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0515	0.091
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.0122	0.117	0.2088
Echinococcus granulosus	JmjC domain containing protein 4	0.0042	0.0238	0.0425
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0093	0.0841	0.15
Trichomonas vaginalis	CMGC family protein kinase	0.0091	0.0816	0.1888
Echinococcus multilocularis	lysine specific demethylase 6a	0.0042	0.0238	0.0425
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0161	0.162	0.162
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0223	0.0517
Brugia malayi	chromobox protein homolog 3	0.0044	0.0265	0.0472
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0042	0.0244	0.0565
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.0196	0.0454
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0127	0.0295
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1469	0.262
Schistosoma mansoni	protein kinase	0.0091	0.0816	0.1456
Brugia malayi	GSG2	0.0504	0.5604	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.0816	0.1888
Echinococcus multilocularis	dual specificity	0.0393	0.4321	0.7709
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0256	0.0592
Toxoplasma gondii	hypothetical protein	0.0122	0.117	0.2708
Trichomonas vaginalis	CMGC family protein kinase	0.0091	0.0816	0.1888
Treponema pallidum	fructose-bisphosphate aldolase	0.0329	0.3573	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0238	0.0421
Echinococcus multilocularis	phd:f box containing protein	0.0042	0.0238	0.0425
Brugia malayi	endochitinase	0.0077	0.0646	0.1153
Echinococcus multilocularis	chromobox protein 1	0.0078	0.0665	0.1186
Trichomonas vaginalis	CMGC family protein kinase	0.0393	0.4321	1
Brugia malayi	Cell division protein kinase 2	0.0091	0.0816	0.1456
Onchocerca volvulus		0.0093	0.0841	0.2347
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.006	0.0064
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0816	0.1456
Brugia malayi	follicle stimulating hormone receptor	0.026	0.278	0.4961
Echinococcus multilocularis	neuroligin	0.0067	0.0538	0.0959
Giardia lamblia	Kinase, CAMK CAMKL	0.0091	0.0816	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0841	0.1486
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0504	0.5604	1
Brugia malayi	hypothetical protein	0.0035	0.016	0.0286
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0196	0.0454
Brugia malayi	hypothetical protein	0.0062	0.0476	0.0849
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.0816	0.1888
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0538	0.0959
Echinococcus granulosus	dual specificity	0.0189	0.1949	0.3478
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0476	0.0841
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0196	0.0454
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0062	0.0476	0.0849
Brugia malayi	jmjC domain containing protein	0.0042	0.0238	0.0425
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Schistosoma mansoni	hypothetical protein	0.0122	0.117	0.2088
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.0122	0.117	0.2088
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0173	0.0309
Toxoplasma gondii	PHD-finger domain-containing protein	0.0042	0.0244	0.0565
Echinococcus multilocularis	dual specificity	0.0393	0.4321	0.7709
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Plasmodium falciparum	phd finger protein, putative	0.0129	0.1253	1
Giardia lamblia	Kinase, CMGC DYRK	0.0393	0.4321	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0232	0.0415
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0256	0.0593
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0093	0.0841	0.15
Trichomonas vaginalis	CMGC family protein kinase	0.0393	0.4321	1
Brugia malayi	AF-10 protein	0.0042	0.0244	0.0436
Echinococcus multilocularis	JmjC domain containing protein 4	0.0042	0.0238	0.0425
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0256	0.0593
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trypanosoma brucei	protein kinase, putative	0.0091	0.0816	0.1888
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0067	0.0538	0.1244
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0062	0.0476	0.1101
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.006	0.0138
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0423	0.4664	0.8322
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0091	0.0816	0.1456
Plasmodium vivax	hypothetical protein, conserved	0.0122	0.117	0.9337
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0256	0.0592
Echinococcus multilocularis	acetylcholinesterase	0.0399	0.439	0.7832
Mycobacterium ulcerans	monoamine oxidase	0.0062	0.0476	0.0476
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0156	0.1569	0.2799
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0062	0.0476	0.3796
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0196	0.0454
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0094	0.0218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0385	0.0891
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0504	0.5604	1
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Brugia malayi	SWIRM domain containing protein	0.0062	0.0476	0.0849
Echinococcus granulosus	dual specificity	0.0393	0.4321	0.7709
Onchocerca volvulus		0.0286	0.3078	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0116	0.0267
Brugia malayi	amine oxidase, flavin-containing family protein	0.0062	0.0476	0.0849
Brugia malayi	Bromodomain containing protein	0.0129	0.1253	0.2236
Mycobacterium ulcerans	oxidoreductase	0.0062	0.0476	0.0476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0385	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0238	0.0421
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0026	0.006	0.0167
Echinococcus granulosus	cyclin dependent kinase 9	0.0091	0.0816	0.1456
Schistosoma mansoni	amine oxidase	0.0062	0.0476	0.0849
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0238	0.0421
Schistosoma mansoni	hypothetical protein	0.0042	0.0244	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0185	0.1899	0.3357
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0256	0.0593
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0223	0.0517
Echinococcus granulosus	lysosomal alpha glucosidase	0.0171	0.1746	0.3115
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0196	0.0454
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.3078	0.7123
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Mycobacterium ulcerans	carboxylesterase, LipT	0.0067	0.0538	0.0538
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1429	0.2527
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0154	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0122	0.117	0.2069
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0196	0.0454
Onchocerca volvulus		0.0062	0.0476	0.11
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0091	0.0816	0.1456
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Entamoeba histolytica	protein kinase, putative	0.0189	0.1949	0.4511
Entamoeba histolytica	cell division protein kinase 2, putative	0.0091	0.0816	0.1888
Loa Loa (eye worm)	acetylcholinesterase 1	0.0399	0.439	0.7762
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0067	0.0538	0.0579
Schistosoma mansoni	serine/threonine protein kinase	0.0393	0.4321	0.7709
Loa Loa (eye worm)	haspin protein kinase	0.0508	0.5655	1
Echinococcus granulosus	phd:f box containing protein	0.0042	0.0238	0.0425
Onchocerca volvulus		0.0067	0.0538	0.1311
Onchocerca volvulus	Putative endochitinase	0.0077	0.0646	0.1683
Giardia lamblia	Fructose-bisphosphate aldolase	0.0329	0.3573	0.8269
Schistosoma mansoni	serine/threonine kinase	0.0091	0.0816	0.1456
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0062	0.0476	0.0849
Echinococcus granulosus	dual specificity	0.0393	0.4321	0.7709
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0091	0.0816	0.1456
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0393	0.4321	0.764
Echinococcus multilocularis	carboxylesterase 5A	0.0399	0.439	0.7832
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.0476	0.3796
Echinococcus multilocularis	acetylcholinesterase	0.0399	0.439	0.7832
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0223	0.0517
Mycobacterium ulcerans	chitinase/cellulase	0.0065	0.0515	0.0515
Echinococcus granulosus	mitogen activated protein kinase 15	0.0091	0.0816	0.1456
Schistosoma mansoni	gliotactin	0.0067	0.0538	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0538	0.095
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0454	0.081
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0385	0.0891
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.0816	0.1888
Entamoeba histolytica	hypothetical protein	0.0189	0.1949	0.4511
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.006	0.0138
Leishmania major	UDP-galactopyranose mutase	0.0062	0.0476	0.1101
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0303	0.051
Onchocerca volvulus	Putative endochitinase	0.0086	0.0754	0.2051
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.016	0.0286
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0042	0.0238	0.0551
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0189	0.1949	0.4511
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0476	0.0841
Mycobacterium ulcerans	chitinase/cellulase	0.0065	0.0515	0.0515
Brugia malayi	Endochitinase	0.0086	0.0754	0.1345
Leishmania major	serine/threonine kinase-like protein, putative	0.0091	0.0816	0.1888
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0062	0.0476	0.0849
Leishmania major	chitinase	0.0077	0.0646	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0538	0.095
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0067	0.0538	0.0959
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0067	0.0538	0.0959
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0538	0.0959
Echinococcus multilocularis	hypothetical protein	0.0087	0.0765	0.1365
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Trichomonas vaginalis	CMGC family protein kinase	0.0393	0.4321	1
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0062	0.0476	0.3796
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0131	0.0303
Brugia malayi	Carboxylesterase family protein	0.0067	0.0538	0.0959
Echinococcus granulosus	lysine specific demethylase 5A	0.0156	0.1569	0.2799
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0173	0.0309
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0504	0.5604	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0062	0.0476	0.0513
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.016	0.0286
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0067	0.0538	0.0579
Onchocerca volvulus		0.0049	0.0322	0.0574
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.1746	0.3115
Trichomonas vaginalis	CMGC family protein kinase	0.0393	0.4321	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0042	0.0238	0.0551
Echinococcus multilocularis	para nitrobenzyl esterase	0.0067	0.0538	0.0959
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0399	0.439	0.7832
Brugia malayi	Carboxylesterase family protein	0.0067	0.0538	0.0959
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0087	0.0765	0.1365
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.006	0.006
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Echinococcus granulosus	acetylcholinesterase	0.0399	0.439	0.7832
Echinococcus granulosus	L aminoadipate semialdehyde	0.0093	0.0841	0.15
Brugia malayi	hypothetical protein	0.0067	0.0538	0.0959
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0091	0.0816	0.1888
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0062	0.0476	0.1101
Trichomonas vaginalis	CMGC family protein kinase	0.0393	0.4321	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0196	0.0454
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.0816	0.1456
Echinococcus multilocularis	cyclin dependent kinase 9	0.0091	0.0816	0.1456
Giardia lamblia	GTOR	0.0054	0.0385	0.0891
Onchocerca volvulus	Alhambra homolog	0.0129	0.1253	0.376
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0476	0.0841
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0091	0.0816	0.1456
Brugia malayi	jmjC domain containing protein	0.0423	0.4664	0.8322
Schistosoma mansoni	jumonji domain containing protein	0.0042	0.0238	0.0425
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0062	0.0476	0.3796
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.1949	0.4511
Schistosoma mansoni	phd/f-box containing protein	0.0042	0.0238	0.0425
Loa Loa (eye worm)	hypothetical protein	0.006	0.0454	0.0802
Schistosoma mansoni	acetylcholinesterase	0.0067	0.0538	0.0959
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Loa Loa (eye worm)	microfilarial chitinase	0.0075	0.0622	0.1101
Brugia malayi	Protein kinase domain containing protein	0.0189	0.1949	0.3478
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0091	0.0816	0.1888
Echinococcus granulosus	PHD finger protein rhinoceros	0.0129	0.1253	0.2236
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0196	0.0454
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.006	0.0138
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.0816	0.1888
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0042	0.0238	0.0551
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0223	0.0517
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0049	0.0322	0.0575
Echinococcus multilocularis	chromobox protein 1	0.0078	0.0665	0.1186
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0062	0.0476	0.0849
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0385	0.0891
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0062	0.0476	0.1101
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Entamoeba histolytica	chitinase, putative	0.0077	0.0646	0.1496
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0393	0.4321	1
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Echinococcus granulosus	BC026374 protein S09 family	0.0067	0.0538	0.0959
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0265	0.0377
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0385	0.0687
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0062	0.0476	1
Schistosoma mansoni	hypothetical protein	0.0035	0.016	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0244	0.0432
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.0816	0.1888
Brugia malayi	jmjC domain containing protein	0.0042	0.0238	0.0425
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0042	0.0238	0.0425
Echinococcus granulosus	chromobox protein 1	0.0078	0.0665	0.1186
Brugia malayi	Pre-SET motif family protein	0.0251	0.2674	0.4772
Trichomonas vaginalis	chromobox protein, putative	0.0078	0.0665	0.1538
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0196	0.035
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0042	0.0238	0.0551
Trichomonas vaginalis	AGC family protein kinase	0.0091	0.0816	0.1888
Onchocerca volvulus		0.0099	0.0906	0.2572
Loa Loa (eye worm)	chitinase I	0.0077	0.0646	0.1143
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.006	0.0477
Trichomonas vaginalis	chromobox protein, putative	0.0078	0.0665	0.1538
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0196	0.035
Giardia lamblia	PHD finger protein 15	0.0129	0.1253	0.2901
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0244	0.1949
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0042	0.0238	0.0425
Echinococcus granulosus	jumonji domain containing 1A	0.0042	0.0238	0.0425
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0173	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0476	0.0841
Plasmodium vivax	hypothetical protein, conserved	0.0129	0.1253	1
Trichomonas vaginalis	CMGC family protein kinase	0.0091	0.0816	0.1888
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0091	0.0816	0.1456
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0173	0.0309
Loa Loa (eye worm)	PHD-finger family protein	0.0129	0.1253	0.2216
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0538	0.0959
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0043	0.026	0.0463
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.082	0.9278	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0232	0.0415
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0189	0.1949	0.3447
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0476	0.0841
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0091	0.0816	0.1888
Trichomonas vaginalis	spcc417.12 protein, putative	0.0067	0.0538	0.1244
Toxoplasma gondii	PHD-finger domain-containing protein	0.0129	0.1253	0.2901
Entamoeba histolytica	protein kinase, putative	0.0393	0.4321	1
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.006	0.0477
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0196	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0538	0.095
Schistosoma mansoni	BC026374 protein (S09 family)	0.0067	0.0538	0.0959
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0196	0.035
Entamoeba histolytica	hypothetical protein	0.0087	0.0765	0.1771
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0393	0.4321	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0238	0.0421
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0385	0.0891
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0385	0.0891
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0094	0.0218
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0156	0.1569	0.2799
Toxoplasma gondii	PHD-finger domain-containing protein	0.0129	0.1253	0.2901
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0062	0.0476	0.2667
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0161	0.162	1
Loa Loa (eye worm)	carboxylesterase	0.0399	0.439	0.7762
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.1949	0.3478
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0173	0.0306
Entamoeba histolytica	hypothetical protein	0.0035	0.016	0.0371
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0116	0.0267
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0329	0.3573	0.8269
Brugia malayi	jmjC domain containing protein	0.0156	0.1569	0.2799
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.0816	0.1888
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0423	0.4664	0.8322

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.631 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	18.4927 uM	PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	26.1216 uM	PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1592247

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1446793