Detailed information for compound 1526675

Basic information

Technical information
  • TDR Targets ID: 1526675
  • Name: (5R)-1-(4-dimethylaminobut-2-ynyl)-5-methylpy rrolidin-2-one
  • MW: 194.273 | Formula: C11H18N2O
  • H donors: 0 H acceptors: 1 LogP: 0.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC#CCN1[C@H](C)CCC1=O)C
  • InChi: 1S/C11H18N2O/c1-10-6-7-11(14)13(10)9-5-4-8-12(2)3/h10H,6-9H2,1-3H3/t10-/m1/s1
  • InChiKey: YYUALTZHLJSXFR-SNVBAGLBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5R)-1-(4-dimethylaminobut-2-ynyl)-5-methyl-pyrrolidin-2-one
  • (5R)-1-(4-dimethylaminobut-2-ynyl)-5-methyl-2-pyrrolidinone
  • (5R)-1-(4-dimethylaminobut-2-ynyl)-5-methyl-2-pyrrolidone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni laminin gamma-3 chain 0.0151 0.0334 0.033
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0053 0.0058
Brugia malayi Cadherin domain containing protein 0.0151 0.0334 0.0677
Schistosoma mansoni hypothetical protein 0.0151 0.0334 0.033
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0053 0.0131
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.0231 0.0838
Giardia lamblia Replication factor C, subunit 1 0.002 0.0006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0184
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.0464 0.1239
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Echinococcus granulosus transmembrane protease serine 3 0.0248 0.058 0.1552
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0067 0.0123 0.0142
Echinococcus granulosus lamin 0.0028 0.0026 0.0056
Brugia malayi beta-lactamase family protein 0.0073 0.0138 0.0275
Echinococcus granulosus Mastin 0.0248 0.058 0.1552
Echinococcus multilocularis integrin beta 2 0.046 0.1113 0.1328
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0157 0.0349 0.0344
Echinococcus multilocularis fibropellin Ia 0.0151 0.0334 0.0395
Echinococcus granulosus caspase 8 0.0141 0.031 0.0824
Loa Loa (eye worm) hypothetical protein 0.009 0.0182 0.0242
Loa Loa (eye worm) hypothetical protein 0.0048 0.0076 0.0101
Toxoplasma gondii aspartyl protease ASP3 0.0329 0.0784 0.2567
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0052 0.0086 0.0097
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0053 0.0058
Plasmodium vivax metacaspase 1, putative 0.0141 0.031 0.1003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0166
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0304 0.072 0.2353
Echinococcus multilocularis protein jagged 2 0.0151 0.0334 0.0395
Schistosoma mansoni serine-type protease inhibitor 0.0437 0.1057 0.1052
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Toxoplasma gondii kringle domain-containing protein 0.0409 0.0985 0.3232
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0053 0.0058
Echinococcus granulosus lamin dm0 0.0028 0.0026 0.0056
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0035 0.0042 0.0142
Trypanosoma brucei beta tubulin 0.0028 0.0025 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni integrin alpha 0.1947 0.4859 0.4856
Loa Loa (eye worm) hypothetical protein 0.0056 0.0097 0.0129
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Plasmodium vivax cardiolipin synthetase, putative 0.0027 0.0022 0.0051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0305 0.0724 0.0963
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0056 0.0097 0.0302
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0138 0.0437
Schistosoma mansoni hypothetical protein 0.0151 0.0334 0.033
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0053 0.0058
Toxoplasma gondii calcium binding egf domain-containing protein 0.0395 0.095 0.3115
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0053 0.0049
Echinococcus granulosus tubulin beta 4A class IVa 0.0028 0.0025 0.0053
Onchocerca volvulus 0.0048 0.0076 0.0146
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0032
Schistosoma mansoni hypothetical protein 0.0021 0.0008 0.0003
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0053 0.0058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0223 0.0516 0.1052
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0053 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0259 0.081
Trichomonas vaginalis hypothetical protein 0.0463 0.112 0.4298
Brugia malayi Muscle positioning protein 4 0.0151 0.0334 0.0677
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.005 0.0081 0.0248
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0052 0.0086 0.0238
Loa Loa (eye worm) hypothetical protein 0.1074 0.266 0.354
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.1224 0.3039 1
Schistosoma mansoni amidase 0.0387 0.0929 0.0925
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0006 0.0002
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0126 0.0273 0.0857
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.0044 0.0146
Plasmodium vivax plasmepsin IV, putative 0.0284 0.067 0.219
Plasmodium falciparum cysteine repeat modular protein 1 0.0409 0.0985 0.3229
Treponema pallidum ATP-dependent RNA helicase 0.0056 0.0097 0.0299
Brugia malayi replication factor A 73 kDa subunit 0.0035 0.0042 0.0076
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0044 0.0039
Loa Loa (eye worm) aspartyl protease 6 0.0248 0.0579 0.0771
Onchocerca volvulus 0.0035 0.0044 0.008
Leishmania major eukaryotic initiation factor 4a, putative 0.0056 0.0097 0.0273
Echinococcus multilocularis apoptotic protease activating factor 1 0.0164 0.0368 0.0435
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Schistosoma mansoni hypothetical protein 0.0039 0.0053 0.0049
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0287 0.0677 0.1812
Schistosoma mansoni hypothetical protein 0.0223 0.0516 0.0512
Mycobacterium ulcerans hydrolase 0.0191 0.0435 0.1654
Loa Loa (eye worm) hypothetical protein 0.0108 0.0227 0.0302
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.017 0.0602
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0124 0.0166
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0099 0.0203 0.0759
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0056 0.0097 0.0353
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0053 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Trypanosoma cruzi oligopeptidase b 0.005 0.0081 0.0248
Trypanosoma cruzi oligopeptidase b 0.005 0.0081 0.0248
Brugia malayi nuclear receptor NHR-88 0.0021 0.0007 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0007 0.0002
Echinococcus granulosus tumor susceptibility gene 101 protein 0.095 0.2348 0.6316
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.0031
Loa Loa (eye worm) beta-tubulin 0.0028 0.0025 0.0033
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0053 0.01
Onchocerca volvulus 0.1702 0.4242 0.8713
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0056 0.0097 0.0299
Brugia malayi Integrin alpha pat-2 precursor 0.1947 0.4859 0.9981
Plasmodium falciparum plasmepsin VIII, putative 0.0248 0.0579 0.189
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0067 0.0123 0.0387
Echinococcus multilocularis fibrillin 1 0.0415 0.1 0.1193
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0138 0.0481
Brugia malayi putative amidase 0.0047 0.0072 0.0138
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0044 0.0129
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0011 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.031 0.1177
Brugia malayi RNA binding protein 0.013 0.0283 0.0571
Echinococcus multilocularis tumor protein p63 0.0349 0.0834 0.0993
Echinococcus granulosus phospholipase d3 0.0031 0.0033 0.0077
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0053 0.0058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0216 0.0498 0.1331
Giardia lamblia Beta tubulin 0.0028 0.0025 0.0451
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.007 0.0066
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0184 0.018
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0044 0.0125
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0194 0.0444 0.1692
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0076 0.0085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0248 0.058 0.0576
Brugia malayi Trypsin family protein 0.0248 0.058 0.1183
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0044 0.0099
Schistosoma mansoni hypothetical protein 0.0173 0.0391 0.0386
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.0203 0.073
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0044 0.0129
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0007 0.0002
Onchocerca volvulus 0.0248 0.0579 0.1181
Onchocerca volvulus 0.0039 0.0053 0.01
Schistosoma mansoni hypothetical protein 0.0024 0.0015 0.001
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0035 0.0042 0.0056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0006 0.0004
Brugia malayi EGF-like domain containing protein 0.0151 0.0334 0.0677
Mycobacterium ulcerans amidase 0.0047 0.0072 0.0255
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0259 0.0523
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Brugia malayi Amidase family protein 0.0047 0.0072 0.0138
Echinococcus multilocularis notch 0.0151 0.0334 0.0395
Echinococcus multilocularis integrin alpha ps 0.0873 0.2153 0.2574
Mycobacterium ulcerans amidase 0.0047 0.0072 0.0255
Loa Loa (eye worm) hypothetical protein 0.009 0.0182 0.0242
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.195 0.4868 0.4866
Onchocerca volvulus 0.0051 0.0083 0.0161
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0044 0.0125
Schistosoma mansoni cell polarity protein 0.0151 0.0334 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0603 0.2304
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0053 0.0049
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0014 0.0031
Brugia malayi beta-lactamase 0.0073 0.0138 0.0275
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0259 0.0976
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0194 0.0444 1
Echinococcus granulosus phospholipase D 0.0147 0.0324 0.0861
Echinococcus multilocularis Kelch repeat type 1 0.0469 0.1136 0.1354
Mycobacterium tuberculosis Conserved protein 0.0073 0.0138 0.0481
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0053 0.0058
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0257 0.0603 0.0802
Echinococcus granulosus tumor protein p63 0.0349 0.0834 0.2235
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0053 0.0049
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.0409 0.0985 0.1311
Loa Loa (eye worm) hypothetical protein 0.0223 0.0516 0.0687
Echinococcus granulosus protein jagged 2 0.0151 0.0334 0.0888
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0067 0.0123 0.0119
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0053 0.0049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0007 0.0002
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0044 0.0116
Loa Loa (eye worm) hypothetical protein 0.0284 0.067 0.0892
Onchocerca volvulus Matrilysin homolog 0.0347 0.083 0.1696
Brugia malayi Phospholipase D. Active site motif family protein 0.0058 0.01 0.0196
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0056 0.0097 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0126 0.0273 0.0364
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.105 0.26 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0007 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0121 0.0259 0.0345
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0007 0.0009
Brugia malayi Matrixin family protein 0.0157 0.0349 0.0708
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0053 0.0071
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Schistosoma mansoni hypothetical protein 0.0039 0.0053 0.0049
Plasmodium falciparum plasmepsin IV 0.0284 0.067 0.219
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0053 0.0058
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0052 0.0086 0.0219
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0052 0.0086 0.0264
Entamoeba histolytica tubulin family protein 0.0028 0.0025 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0007 0.0003
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0053 0.0058
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0053 0.0058
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.0203 0.073
Brugia malayi G-protein coupled receptor 0.0039 0.0053 0.01
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0025 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0063 0.0189
Loa Loa (eye worm) phospholipase D 0.0031 0.0033 0.0045
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0174 0.0394 0.1469
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0067 0.0123 0.0164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.009 0.0182 0.0679
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0304 0.072 0.2353
Loa Loa (eye worm) hypothetical protein 0.195 0.4868 0.6478
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0191 0.0435 0.0884
Loa Loa (eye worm) amidase 0.0047 0.0072 0.0096
Trypanosoma cruzi cardiolipin synthetase, putative 0.0058 0.01 0.0311
Echinococcus multilocularis tubulin subunit beta 0.0028 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0035 0.0042 0.0142
Brugia malayi Melatonin receptor type 1A 0.0039 0.0053 0.01
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.007 0.0066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Loa Loa (eye worm) hypothetical protein 0.0141 0.031 0.0413
Echinococcus multilocularis protein patched 0.0257 0.0603 0.0716
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni DNA ligase IV 0.002 0.0006 0.0001
Trichomonas vaginalis tubulin, putative 0.0028 0.0025 0.0076
Mycobacterium leprae conserved hypothetical protein 0.0169 0.0381 0.1446
Trypanosoma brucei prolyl endopeptidase 0.0126 0.0273 0.0881
Brugia malayi hypothetical protein 0.095 0.2348 0.4817
Mycobacterium ulcerans amidase 0.0047 0.0072 0.0255
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Schistosoma mansoni amine GPCR 0.0039 0.0053 0.0049
Brugia malayi Phospholipase D. Active site motif family protein 0.0031 0.0033 0.0059
Schistosoma mansoni tsg101-related 0.0791 0.1947 0.1943
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0006 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0053 0.0049
Entamoeba histolytica hypothetical protein 0.0159 0.0355 0.2213
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0007 0.0004
Trypanosoma cruzi amidase, putative 0.0047 0.0072 0.0218
Schistosoma mansoni tubulin subunit beta 0.0028 0.0025 0.002
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0006 0.0004
Brugia malayi mbt repeat family protein 0.0048 0.0076 0.0146
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0053 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.031 0.1177
Echinococcus multilocularis neurogenic locus notch protein 0.0151 0.0334 0.0395
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0138 0.0481
Plasmodium vivax RNA helicase-1, putative 0.0056 0.0097 0.0299
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.017 0.0602
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0025 0.0033
Trypanosoma brucei Metacaspase-4 0.0141 0.031 0.1003
Brugia malayi EGF-like domain containing protein 0.0151 0.0334 0.0677
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0138 0.0437
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.0011 0.0006
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.1224 0.3039 0.3635
Echinococcus granulosus neuropeptide receptor A26 0.0515 0.1251 0.336
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0047 0.0072 0.0218
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0053 0.0131
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0007 0.0003
Loa Loa (eye worm) Notch2 0.0151 0.0334 0.0445
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0023 0.0012 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.046 0.1113 0.1327
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.0273 0.0268
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0047 0.0072 0.0224
Chlamydia trachomatis transcriptional repressor NrdR 0.0174 0.0394 0.1278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0222 0.0514 0.0509
Loa Loa (eye worm) tubulin beta-2A chain 0.0028 0.0025 0.0033
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0014 0.0031
Entamoeba histolytica hypothetical protein 0.0159 0.0355 0.2213
Echinococcus granulosus notch 0.0151 0.0334 0.0888
Echinococcus multilocularis Mastin 0.0248 0.058 0.0689
Onchocerca volvulus 0.0039 0.0053 0.01
Trypanosoma cruzi cardiolipin synthetase, putative 0.0058 0.01 0.0311
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.1224 0.3039 1
Brugia malayi Protein K4 0.0027 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus multilocularis integrin alpha ps 0.0873 0.2153 0.2574
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.0464 0.0945
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.031 0.1177
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni lamin 0.0028 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0138 0.0437
Echinococcus multilocularis phospholipase D 0.0147 0.0324 0.0382
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0141 0.031 0.0628
Brugia malayi Cell death protein 3 precursor 0.0305 0.0724 0.1478
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0138 0.0481
Brugia malayi Kringle domain containing protein 0.0409 0.0985 0.2016
Schistosoma mansoni tar DNA-binding protein 0.013 0.0283 0.0278
Echinococcus multilocularis neurogenic locus notch protein 4 0.0151 0.0334 0.0395
Plasmodium falciparum plasmepsin II 0.0284 0.067 0.219
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0053 0.01
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.007 0.0066
Onchocerca volvulus 0.0028 0.0026 0.0042
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.0044 0.0146
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0056 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0646 0.1582 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0121 0.0259 0.0976
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0184
Brugia malayi Calcitonin receptor-like protein seb-1 0.0705 0.173 0.3548
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0035 0.0044 0.024
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.0203 0.073
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0053 0.0131
Brugia malayi mbt repeat family protein 0.0048 0.0076 0.0146
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0008 0.001
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.1224 0.3039 0.3036
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0053 0.01
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1224 0.3039 1
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0023 0.0012 0.0022
Brugia malayi larval opioid receptor 0.0039 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.0539 0.1313 0.1748
Loa Loa (eye worm) hypothetical protein 0.0045 0.0068 0.0091
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0007 0.0004
Brugia malayi Peripheral plasma membrane protein CASK 0.002 0.0005 0.0001
Plasmodium falciparum plasmepsin VI 0.0284 0.067 0.219
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0414 0.0998 0.327
Brugia malayi Bromodomain containing protein 0.0039 0.0053 0.0099
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.04 0.0962 0.128
Loa Loa (eye worm) hypothetical protein 0.0191 0.0435 0.0579
Loa Loa (eye worm) hypothetical protein 0.0248 0.058 0.0772
Loa Loa (eye worm) hypothetical protein 0.0418 0.1008 0.1342
Echinococcus multilocularis tubulin beta 1 chain 0.0028 0.0025 0.0024
Leishmania major hypothetical protein, conserved 0.0304 0.072 0.2333
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Schistosoma mansoni amine GPCR 0.0039 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.0248 0.0579 0.0771
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0053 0.0049
Schistosoma mansoni neuropeptide receptor 0.0039 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Brugia malayi Bromodomain containing protein 0.0077 0.0148 0.0293
Schistosoma mansoni hypothetical protein 0.0173 0.0391 0.0386
Echinococcus granulosus fibrillin 1 0.002 0.0005 0.0000010845
Entamoeba histolytica phospholipase D, putative 0.0166 0.0373 0.2328
Brugia malayi RE15519p 0.0039 0.0053 0.01
Echinococcus granulosus fmrfamide receptor 0.0039 0.0053 0.0131
Loa Loa (eye worm) hypothetical protein 0.0705 0.173 0.2303
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0076 0.0101
Mycobacterium ulcerans transcriptional regulator NrdR 0.0174 0.0394 0.1495
Entamoeba histolytica hypothetical protein, conserved 0.0169 0.0381 0.2379
Brugia malayi notch-like transmembrane receptor 0.0151 0.0334 0.0677
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.005 0.0081 0.026
Brugia malayi Calcium binding EGF domain containing protein 0.0395 0.095 0.1943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0184 0.0482
Trypanosoma cruzi metacaspase, putative 0.0141 0.031 0.1003
Schistosoma mansoni opsin-like receptor 0.0039 0.0053 0.0049
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.007 0.0066
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.113 0.4314
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0053 0.0049
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0139 0.0306 0.1903
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0034
Schistosoma mansoni amine GPCR 0.0039 0.0053 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.0482 0.1169 0.2393
Echinococcus granulosus tubulin beta 1 chain 0.0028 0.0025 0.0053
Schistosoma mansoni biogenic amine receptor 0.0039 0.0053 0.0049
Brugia malayi Peptidase family M13 containing protein 0.0091 0.0184 0.0369
Trypanosoma brucei oligopeptidase b 0.005 0.0081 0.0248
Loa Loa (eye worm) proteasome subunit beta type 1 0.0052 0.0086 0.0115
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0322 0.0766 0.2506
Brugia malayi Tubulin beta-1 chain 0.0028 0.0025 0.0041
Brugia malayi peptidase family M13 containing protein 0.0022 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0047 0.0072 0.0192
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0007 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0138 0.016
Trypanosoma cruzi metacaspase 5, putative 0.0141 0.031 0.1003
Onchocerca volvulus Matrilysin homolog 0.0157 0.0349 0.0708
Brugia malayi hypothetical protein 0.0486 0.1179 0.2414
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0044 0.008
Loa Loa (eye worm) hypothetical protein 0.0387 0.0929 0.1237
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0053 0.0058
Onchocerca volvulus 0.0039 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0007
Echinococcus multilocularis GPCR, family 2 0.0223 0.0516 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0007 0.0003
Giardia lamblia High cysteine protein 0.0151 0.0334 0.7502
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0053 0.0049
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0027 0.0022 0.0017
Echinococcus multilocularis prolyl endopeptidase 0.0126 0.0273 0.0321
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0029
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0025 0.0053
Plasmodium falciparum plasmepsin III 0.0248 0.0579 0.189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0053 0.0058
Brugia malayi Trypsin-like protease protein 5 0.0248 0.058 0.1183
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0044 0.0058
Echinococcus multilocularis caspase 8 0.0141 0.031 0.0366
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0053 0.0131
Brugia malayi GnHR receptor homolog 0.0039 0.0053 0.01
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0053 0.0058
Brugia malayi EGF-like domain containing protein 0.0151 0.0335 0.0678
Leishmania major cardiolipin synthetase, putative 0.0027 0.0022 0.0025
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.0011 0.0014
Echinococcus granulosus g protein coupled receptor 0.0039 0.0053 0.0131
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0044 0.0146
Onchocerca volvulus 0.0039 0.0053 0.01
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0025 0.0076
Onchocerca volvulus 0.0039 0.0053 0.01
Schistosoma mansoni hypothetical protein 0.0039 0.0053 0.0049
Plasmodium vivax glutathione reductase, putative 0.0043 0.0063 0.0189
Echinococcus granulosus hypothetical protein 0.0039 0.0053 0.0131
Loa Loa (eye worm) TK/ROR protein kinase 0.0409 0.0985 0.1311
Echinococcus granulosus disks large 3 0.0047 0.0073 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0008
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0044 0.0116
Echinococcus granulosus neurogenic locus notch protein 0.0151 0.0334 0.0888
Brugia malayi Latrophilin receptor protein 2 0.0223 0.0516 0.1052
Echinococcus multilocularis neuropeptide s receptor 0.0515 0.1251 0.1493
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0151 0.0334 0.033
Loa Loa (eye worm) amidase 0.0047 0.0072 0.0096
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.0464 0.2908
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0044 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0184 0.0179
Echinococcus multilocularis somatostatin receptor 0.0039 0.0053 0.0058
Echinococcus multilocularis serotonin receptor 0.0039 0.0053 0.0058
Echinococcus granulosus kelch ECH associated protein 1 like 0.0467 0.1132 0.3039
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0006 0.0004
Brugia malayi Phospholipase d protein 1 0.0166 0.0373 0.0757
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0035 0.0044 0.0146
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0387 0.0929 0.1107
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0138 0.051
Echinococcus multilocularis neuropeptide receptor A26 0.0515 0.1251 0.1493
Trypanosoma cruzi metacaspase 5, putative 0.0141 0.031 0.1003
Echinococcus granulosus enteropeptidase 0.0248 0.058 0.1552
Brugia malayi G-protein coupled receptor 0.0039 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0166
Schistosoma mansoni tubulin subunit beta 0.0028 0.0025 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0259 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.031 0.1177
Mycobacterium ulcerans amidase 0.0047 0.0072 0.0255
Schistosoma mansoni bromodomain containing protein 0.0065 0.0117 0.0113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0047 0.0114
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0025 0.0076
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0053 0.0131
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0025 0.0024
Brugia malayi steroid hormone receptor 0.0021 0.0007 0.0003
Schistosoma mansoni integrin beta subunit 0.0366 0.0875 0.0871
Schistosoma mansoni phospholipase D 0.0166 0.0373 0.0368
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0007 0.0002
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0044 0.0125
Brugia malayi Trypsin family protein 0.0248 0.058 0.1183
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0052 0.0086 0.0081
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Onchocerca volvulus 0.0409 0.0985 0.2016
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0067 0.0123 0.0387
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0053 0.0131
Onchocerca volvulus 0.0039 0.0053 0.01
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0166 0.0435
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Brugia malayi Pepsin A precursor 0.0248 0.0579 0.1181
Brugia malayi proteasome subunit beta type 1 0.0052 0.0086 0.0167
Brugia malayi putative neuropeptide receptor 0.0039 0.0053 0.01
Schistosoma mansoni neuropeptide receptor 0.0039 0.0053 0.0049
Schistosoma mansoni tubulin subunit beta 0.0028 0.0025 0.002
Onchocerca volvulus Putative cubilin 0.0151 0.0334 0.0677
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0053 0.0058
Onchocerca volvulus 0.0039 0.0053 0.01
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.007 0.0066
Schistosoma mansoni coup transcription factor 0.0021 0.0007 0.0002
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0044 0.0116
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0381 0.1419
Schistosoma mansoni hypothetical protein 0.0223 0.0516 0.0512
Echinococcus granulosus eukaryotic initiation factor 4A 0.0056 0.0097 0.0247
Brugia malayi follicle stimulating hormone receptor 0.0274 0.0646 0.1318
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0142 0.0164
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0035 0.0042 0.0044
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0171
Echinococcus multilocularis tissue type plasminogen activator 0.0409 0.0985 0.1175
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Giardia lamblia Proteasome subunit beta type 1 0.0052 0.0086 0.1849
Echinococcus multilocularis musashi 0.0028 0.0026 0.0025
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0053 0.0131
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0124 0.0166
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.1224 0.3039 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0026 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0108 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0006 0.0004
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0047 0.0072 0.0224
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0053 0.01
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0053 0.0058
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0067 0.0123 0.0387
Onchocerca volvulus 0.002 0.0005 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0007 0.0004
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0044 0.0125
Echinococcus multilocularis lamin dm0 0.0028 0.0026 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0067 0.0123 0.0387
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0248 0.058 0.1183
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0053 0.0071
Onchocerca volvulus 0.0222 0.0514 0.1047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0007 0.0003
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0569 0.1389 0.1658
Loa Loa (eye worm) hypothetical protein 0.0395 0.095 0.1264
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0093 0.0181
Loa Loa (eye worm) hypothetical protein 0.0248 0.0579 0.0771
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0007 0.0003
Schistosoma mansoni caspase-7 (C14 family) 0.0305 0.0724 0.0719
Giardia lamblia Beta tubulin 0.0028 0.0025 0.0451
Onchocerca volvulus 0.0151 0.0334 0.0677
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0052 0.0086 0.0268
Loa Loa (eye worm) tubulin beta-4 chain 0.0028 0.0025 0.0033
Echinococcus granulosus delta-like protein 1 0.0151 0.0334 0.0888
Onchocerca volvulus 0.0035 0.0044 0.008
Schistosoma mansoni patched 1 0.0257 0.0603 0.0598
Brugia malayi DKFZp564C0469 protein 0.002 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0026
Onchocerca volvulus 0.0151 0.0334 0.0677
Schistosoma mansoni egf-like domain protein 0.0395 0.095 0.0946
Schistosoma mansoni topbp1 0.002 0.0006 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.0259 0.1606
Echinococcus granulosus fibropellin Ia 0.0151 0.0334 0.0888
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Plasmodium falciparum metacaspase 1 0.0141 0.031 0.1003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0083 0.0078
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0053 0.0131
Schistosoma mansoni hypothetical protein 0.0099 0.0204 0.0199
Schistosoma mansoni hypothetical protein 0.0024 0.0015 0.001
Echinococcus multilocularis caspase 2 0.0305 0.0724 0.0861
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.0203 0.073
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0023 0.0012 0.0019
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0053 0.0049
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0044 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0007
Trypanosoma cruzi prolyl endopeptidase 0.0126 0.0273 0.0881
Echinococcus granulosus kelch ECH associated protein 1 0.0467 0.1132 0.3039
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0053 0.0058
Echinococcus multilocularis integrin alpha ps 0.0418 0.1008 0.1202
Loa Loa (eye worm) hypothetical protein 0.0139 0.0306 0.0407
Brugia malayi Calcium binding EGF domain containing protein 0.0151 0.0334 0.0677
Brugia malayi topoisomerase 0.002 0.0006 0.0002
Brugia malayi Calcium binding EGF domain containing protein 0.0151 0.0334 0.0677
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni amine GPCR 0.0039 0.0053 0.0049
Echinococcus granulosus sterol regulatory element binding protein 0.0257 0.0603 0.1612
Loa Loa (eye worm) hypothetical protein 0.0539 0.1313 0.1748
Toxoplasma gondii ABC1 family protein 0.0073 0.0138 0.044
Echinococcus granulosus fatty acid amide hydrolase 1 0.0387 0.0929 0.2492
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0165 0.0371 0.0366
Schistosoma mansoni hypothetical protein 0.0151 0.0334 0.033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0044 0.0116
Trypanosoma brucei proteasome beta 6 subunit 0.0052 0.0086 0.0264
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0053 0.0058
Echinococcus multilocularis disks large 3 0.0047 0.0073 0.0081
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0044 0.008
Echinococcus multilocularis phospholipase d3 0.0031 0.0033 0.0034
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0044 0.0116
Mycobacterium ulcerans hypothetical protein 0.0121 0.0259 0.0976
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0044 0.0105
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0053 0.01
Echinococcus granulosus neurogenic locus protein delta 0.0151 0.0334 0.0888
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0053 0.0131
Brugia malayi intermediate filament protein 0.0028 0.0026 0.0042
Entamoeba histolytica hypothetical protein 0.0024 0.0014 0.0051
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.105 0.26 1
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0053 0.0058
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0056 0.0097 0.0189
Brugia malayi glutathione reductase 0.0043 0.0063 0.012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0223 0.0516 0.0613
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0027 0.0022 0.0051
Schistosoma mansoni septate junction protein 0.0151 0.0334 0.033
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Echinococcus granulosus fatty acid amide hydrolase 1 0.0047 0.0072 0.0181
Echinococcus multilocularis protein dispatched 1 0.027 0.0634 0.0753
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0053 0.0058
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0044 0.0058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0184 0.0245
Schistosoma mansoni hypothetical protein 0.0084 0.0165 0.0161
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.04 0.0962 0.1968
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.0259 0.0948
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0006 0.0000018265
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.031 0.1177
Brugia malayi hypothetical protein 0.0248 0.0579 0.1181
Echinococcus granulosus beta tubulin 0.0028 0.0025 0.0053
Mycobacterium ulcerans hypothetical protein 0.0073 0.0138 0.051
Schistosoma mansoni tubulin subunit beta 0.0028 0.0025 0.002
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Schistosoma mansoni transcription factor LCR-F1 0.0216 0.0498 0.0494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0044 0.008
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0138 0.0481
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.0231 0.0838
Brugia malayi Hemopexin family protein 0.0222 0.0514 0.1047
Plasmodium falciparum thioredoxin reductase 0.0043 0.0063 0.0189
Loa Loa (eye worm) hypothetical protein 0.0157 0.0349 0.0464
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0007
Entamoeba histolytica phospholipase D, putative 0.0166 0.0373 0.2328
Mycobacterium tuberculosis Conserved protein 0.0169 0.0381 0.1419
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0053 0.0049
Brugia malayi prolyl oligopeptidase family protein 0.0126 0.0273 0.0552
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0023 0.0012 0.0019
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0138 0.0515
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0044 0.0116
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0044 0.0058
Schistosoma mansoni hypothetical protein 0.0024 0.0015 0.001
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0093 0.0088
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0025 0.0024
Onchocerca volvulus Prolyl endopeptidase homolog 0.0126 0.0273 0.0552
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0067 0.0123 0.0387
Echinococcus multilocularis caspase 0.0287 0.0677 0.0805
Loa Loa (eye worm) tubulin beta-1 chain 0.0028 0.0025 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0026 0.0034
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0284 0.067 0.0666
Schistosoma mansoni integrin alpha-ps 0.0454 0.1099 0.1095
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0006 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Onchocerca volvulus 0.0039 0.0053 0.01
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0026 0.0034
Schistosoma mansoni tsg101-related 0.0791 0.1947 0.1943
Toxoplasma gondii EGF family domain-containing protein 0.0151 0.0334 0.1086
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0053 0.0071
Entamoeba histolytica hypothetical protein 0.0216 0.0498 0.3124
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0141 0.031 0.0306
Echinococcus granulosus Tolloid protein 1 0.0395 0.095 0.2548
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0053 0.0131
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0056 0.0097 0.0247
Brugia malayi Trypsin family protein 0.195 0.4868 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0387 0.0929 0.0925
Brugia malayi hypothetical protein 0.0216 0.0498 0.1015
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0053 0.0058
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0011 0.0006
Mycobacterium ulcerans amidase 0.0047 0.0072 0.0255
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0053 0.0071
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0053 0.0071
Entamoeba histolytica hypothetical protein 0.0159 0.0355 0.2213
Brugia malayi EGF-like domain containing protein 0.0151 0.0334 0.0677
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Schistosoma mansoni amine GPCR 0.0039 0.0053 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0138 0.0515
Onchocerca volvulus 0.0248 0.058 0.1183
Loa Loa (eye worm) hypothetical protein 0.04 0.0962 0.128
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0007 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0053 0.0131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0248 0.058 0.0576
Brugia malayi hypothetical protein 0.0094 0.0192 0.0385
Echinococcus granulosus kelch ECH associated protein 1 like 0.0467 0.1132 0.3039
Schistosoma mansoni tubulin subunit beta 0.0028 0.0025 0.002
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0076 0.0192
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0006 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0053 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0138 0.0515
Loa Loa (eye worm) hypothetical protein 0.0055 0.0093 0.0123
Plasmodium vivax plasmepsin V, putative 0.0248 0.0579 0.189
Mycobacterium leprae PROBABLE HYDROLASE 0.0191 0.0435 0.1654
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0027 0.0022 0.0051
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0063 0.007
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.005 0.0081 0.0222
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0223 0.0516 0.1379
Echinococcus granulosus expressed conserved protein 0.019 0.0433 0.1155
Onchocerca volvulus 0.0039 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.009 0.0182 0.0242
Brugia malayi aspartic protease BmAsp-1, identical 0.0248 0.0579 0.1181
Onchocerca volvulus 0.0039 0.0053 0.01
Onchocerca volvulus 0.0151 0.0334 0.0677
Schistosoma mansoni hypothetical protein 0.0084 0.0165 0.0161
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0053 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0159 0.0355 0.115
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0486 0.1179 0.1569
Echinococcus granulosus caspase 2 0.0305 0.0724 0.1938
Chlamydia trachomatis phospholipase D superfamily protein 0.0027 0.0022 0.0051
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0283 0.0376
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0121 0.0259 0.0976
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0053 0.0058
Schistosoma mansoni survival motor neuron protein 0.0099 0.0204 0.0199
Schistosoma mansoni neuropeptide receptor 0.0039 0.0053 0.0049
Brugia malayi beta-lactamase family protein 0.0073 0.0138 0.0275
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0063 0.0191
Echinococcus granulosus allatostatin A receptor 0.0039 0.0053 0.0131
Echinococcus granulosus orexin receptor type 2 0.0039 0.0053 0.0131
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0044 0.0125
Entamoeba histolytica hypothetical protein 0.0216 0.0498 0.3124
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0414 0.0998 0.0994
Schistosoma mansoni topbp1 0.002 0.0006 0.0001
Echinococcus multilocularis glycoprotein Antigen 5 0.0248 0.058 0.0689
Schistosoma mansoni notch 0.0151 0.0334 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Mycobacterium tuberculosis Probable reductase 0.0099 0.0203 0.073
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0248 0.058 0.0576
Schistosoma mansoni tar DNA-binding protein 0.013 0.0283 0.0278
Loa Loa (eye worm) hypothetical protein 0.009 0.0182 0.0242
Schistosoma mansoni serine-type protease inhibitor 0.0437 0.1057 0.1052
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0091 0.0184 0.0245
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0047 0.0072 0.0218
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0025 0.0024
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0052 0.0086 0.0313
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0007 0.0002
Onchocerca volvulus 0.0084 0.0166 0.0332
Schistosoma mansoni caspase-7 (C14 family) 0.0287 0.0677 0.0673
Echinococcus multilocularis phospholipase D1 0.0166 0.0373 0.0441
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0007 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Trypanosoma brucei metacaspase 0.0141 0.031 0.1003
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0006 0.0002
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0067 0.0123 0.032
Schistosoma mansoni hypothetical protein 0.0482 0.1169 0.1164
Echinococcus multilocularis sex peptide receptor 0.0039 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0027 0.0022 0.0051
Echinococcus granulosus prolyl endopeptidase 0.0126 0.0273 0.0723
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0067 0.0123 0.0362
Brugia malayi TAR-binding protein 0.013 0.0283 0.0571
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0053 0.01
Echinococcus granulosus nibrin 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Brugia malayi Integrin beta pat-3 precursor 0.0621 0.1518 0.3112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0184 0.0179
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0028 0.0025 0.0024
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0044 0.0125
Onchocerca volvulus 0.0039 0.0053 0.01
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0047 0.0072 0.0218
Brugia malayi Matrixin family protein 0.0157 0.0349 0.0708
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0053 0.0131
Echinococcus multilocularis beta tubulin 0.0028 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0138 0.0184
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0053 0.0131
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0052 0.0086 0.0508
Onchocerca volvulus 0.0164 0.0368 0.0746
Onchocerca volvulus 0.0021 0.0007 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0138 0.0515
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0031 0.0033 0.0057
Brugia malayi nuclear hormone receptor 0.0021 0.0007 0.0003
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0047 0.0072 0.0255
Plasmodium falciparum plasmepsin IX 0.0329 0.0784 0.2564
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0248 0.058 0.0576
Schistosoma mansoni opsin-like receptor 0.0039 0.0053 0.0049
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0067 0.0123 0.0423
Echinococcus multilocularis caspase 3 0.0146 0.0321 0.0379
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.005 0.0081 0.0248
Entamoeba histolytica hypothetical protein 0.0216 0.0498 0.3124
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0433 0.1155
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0053 0.0131
Echinococcus granulosus phospholipase D1 0.0166 0.0373 0.0992
Toxoplasma gondii beta-tubulin, putative 0.0028 0.0025 0.0065
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0377 0.0906 0.3448
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Echinococcus multilocularis expressed conserved protein 0.019 0.0433 0.0513
Echinococcus granulosus laminin 0.0395 0.095 0.2548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0007 0.0004
Toxoplasma gondii peptidase family M13 protein 0.0091 0.0184 0.0591
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.1224 0.3039 0.4044
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Leishmania major trypanothione reductase 0.0043 0.0063 0.0163
Onchocerca volvulus 0.0028 0.0026 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0044 0.0116
Echinococcus granulosus neuropeptide s receptor 0.0515 0.1251 0.336
Echinococcus multilocularis kelch ECH associated protein 1 0.0467 0.1132 0.135
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) matrixin family protein 0.0347 0.083 0.1104
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0093 0.0105
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.1224 0.3039 0.6239
Schistosoma mansoni hypothetical protein 0.0024 0.0015 0.001
Echinococcus granulosus tissue type plasminogen activator 0.0409 0.0985 0.2643
Plasmodium falciparum glutathione reductase 0.0043 0.0063 0.0189
Onchocerca volvulus 0.0039 0.0053 0.01
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0044 0.015
Loa Loa (eye worm) hypothetical protein 0.0157 0.0349 0.0464
Echinococcus multilocularis survival motor neuron protein 1 0.0486 0.1179 0.1406
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0025 0.0076
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0121 0.0259 0.0976
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0008
Brugia malayi Protein kinase domain containing protein 0.0409 0.0985 0.2016
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1472 0.3664 0.7524
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0053 0.0131
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0067 0.0123 0.0362
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.0184 0.0369
Schistosoma mansoni hypothetical protein 0.0223 0.0516 0.0512
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0044 0.0099
Plasmodium falciparum acyl-CoA synthetase 0.009 0.0182 0.0581
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0138 0.051
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0044 0.0116
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0006 0.0004
Onchocerca volvulus Slit protein homolog 0.0151 0.0335 0.0678
Mycobacterium tuberculosis Probable peptidase 0.005 0.0081 0.026
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0027 0.0022 0.0051
Brugia malayi Matrixin family protein 0.0157 0.0349 0.0708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Echinococcus granulosus intermediate filament protein 0.0028 0.0026 0.0056
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0166 0.0332
Echinococcus granulosus tar DNA binding protein 0.013 0.0283 0.0749
Loa Loa (eye worm) hypothetical protein 0.0042 0.0059 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0014 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0184 0.0179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0705 0.173 0.2303
Onchocerca volvulus 0.0039 0.0053 0.01
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0011 0.0006
Schistosoma mansoni cathepsin D (A01 family) 0.0471 0.114 0.1136
Loa Loa (eye worm) hypothetical protein 0.0248 0.058 0.0772
Echinococcus multilocularis sterol regulatory element binding protein 0.0257 0.0603 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0355 0.1348
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0248 0.058 0.1552
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) RNA binding protein 0.013 0.0283 0.0376
Schistosoma mansoni hypothetical protein 0.0039 0.0053 0.0049
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.1224 0.3039 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0053 0.0049
Onchocerca volvulus 0.0039 0.0053 0.01
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.0259 0.0976
Plasmodium falciparum eukaryotic initiation factor 4A 0.0056 0.0097 0.0299
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0053 0.01
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Echinococcus granulosus integrin alpha ps 0.0418 0.1008 0.2705
Loa Loa (eye worm) hypothetical protein 0.1528 0.3805 0.5063
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0025 0.0053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0007 0.0003
Echinococcus multilocularis Tolloid protein 1 0.0395 0.095 0.1132
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0014 0.0026
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Echinococcus granulosus adam 0.002 0.0005 0.0000010845
Leishmania major metacaspase, putative 0.0141 0.031 0.098
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0259 0.0523
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0047 0.0072 0.0255
Brugia malayi Matrixin family protein 0.0379 0.0908 0.1858
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.095 0.2348 0.2807
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0053 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0248 0.058 0.0576
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0259 0.0976
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Echinococcus granulosus caspase 0.0287 0.0677 0.1812
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0151 0.0334 0.033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0248 0.058 0.0576
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0171
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0259 0.081
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.0031
Entamoeba histolytica hypothetical protein 0.0159 0.0355 0.2213
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3333 0.8353 1
Brugia malayi neuropeptide F receptor 0.0039 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.0248 0.058 0.0772
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) TAR-binding protein 0.013 0.0283 0.0376
Echinococcus granulosus replication factor c subunit 1 0.002 0.0006 0.0003
Brugia malayi Delta serrate ligand family protein 0.0151 0.0334 0.0677
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0007 0.0003
Toxoplasma gondii prolyl endopeptidase 0.0126 0.0273 0.0884
Chlamydia trachomatis phospholipase D superfamily protein 0.0027 0.0022 0.0051
Echinococcus granulosus serotonin receptor 0.0039 0.0053 0.0131
Plasmodium vivax proteasome subunit beta type-1, putative 0.0052 0.0086 0.0264
Trypanosoma cruzi amidase, putative 0.0047 0.0072 0.0218
Loa Loa (eye worm) oxidoreductase 0.0035 0.0044 0.0058
Schistosoma mansoni tar DNA-binding protein 0.013 0.0283 0.0278
Echinococcus granulosus neuropeptide receptor 0.0039 0.0053 0.0131
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0053 0.0049
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0056 0.0097 0.0319
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0053 0.0049
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0141 0.031 0.1007
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0025 0.0076
Entamoeba histolytica acyl-coA synthetase, putative 0.0121 0.0259 0.1606
Echinococcus granulosus sex peptide receptor 0.0039 0.0053 0.0131
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0053 0.0071
Trypanosoma brucei metacaspase MCA2 0.0141 0.031 0.1003
Loa Loa (eye worm) hypothetical protein 0.0414 0.0998 0.1328
Schistosoma mansoni hypothetical protein 0.0084 0.0165 0.0161
Schistosoma mansoni caspase-3 (C14 family) 0.0287 0.0677 0.0673
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0008
Schistosoma mansoni cathepsin D (A01 family) 0.0471 0.114 0.1136
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0395 0.095 0.1264
Toxoplasma gondii beta tubulin 0.0028 0.0025 0.0065
Mycobacterium ulcerans hypothetical protein 0.0248 0.058 0.2215
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0093 0.0237
Trypanosoma cruzi metacaspase, putative 0.0141 0.031 0.1003
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.195 0.4868 0.6478
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0044 0.0125
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0035 0.0044 0.0146
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0007 0.0002
Plasmodium falciparum plasmepsin VII 0.0248 0.0579 0.189
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0138 0.0481
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0141 0.031 0.1007
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0053 0.0131
Brugia malayi Dopamine receptor protein 2 0.0039 0.0053 0.01
Brugia malayi Fibulin-1 precursor 0.0395 0.095 0.1943
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0067 0.0123 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0006 0.0004
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0044 0.0129
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0007 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0007 0.0003
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0194 0.0444 0.1692
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0047 0.0072 0.0224
Loa Loa (eye worm) hypothetical protein 0.0091 0.0184 0.0245
Plasmodium falciparum metacaspase-like protein 0.0141 0.031 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.031 0.1177
Echinococcus multilocularis fat cadherin tumor suppressor 0.0151 0.0334 0.0395
Brugia malayi EGF-like domain containing protein 0.0151 0.0334 0.0677
Schistosoma mansoni biogenic amine receptor 0.0039 0.0053 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Echinococcus granulosus somatostatin receptor 0.0039 0.0053 0.0131
Echinococcus multilocularis protein jagged 2 0.002 0.0005 0.00000048189
Onchocerca volvulus 0.0248 0.058 0.1183
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0015 0.001
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0387 0.0929 0.1107
Schistosoma mansoni microtubule-associated protein tau 0.0592 0.1445 0.1441
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0248 0.0579 0.0771
Echinococcus granulosus fibrillin 2 0.002 0.0005 0.0000010845
Echinococcus multilocularis protein jagged 1 0.0151 0.0334 0.0395
Loa Loa (eye worm) hypothetical protein 0.0121 0.0259 0.0345
Trypanosoma brucei beta tubulin 0.0028 0.0025 0.0062
Loa Loa (eye worm) hypothetical protein 0.0139 0.0306 0.0407
Loa Loa (eye worm) trypsin family protein 0.0248 0.058 0.0772
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0414 0.0998 0.3252
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0044 0.0116
Schistosoma mansoni opsin-like receptor 0.0039 0.0053 0.0049
Mycobacterium tuberculosis Conserved protein 0.0073 0.0138 0.0481
Schistosoma mansoni cell polarity protein 0.0047 0.0073 0.0068
Echinococcus multilocularis laminin 0.0395 0.095 0.1132
Onchocerca volvulus 0.0039 0.0053 0.01
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0284 0.067 0.1794
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.0184 0.0659
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0067 0.0123 0.0387
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Brugia malayi Serotonin receptor 0.0039 0.0053 0.01
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0617 0.151 0.4961
Brugia malayi AKH receptor 0.0039 0.0053 0.01
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0053 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Echinococcus multilocularis neurogenic locus notch protein 0.0151 0.0334 0.0395
Brugia malayi hypothetical protein 0.0248 0.0579 0.1181
Onchocerca volvulus 0.0151 0.0334 0.0677
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0007 0.0003
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0053 0.0131
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0056 0.0097 0.0353
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0007 0.0002
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0031 0.0033 0.0064
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.105 0.26 1
Loa Loa (eye worm) glutathione reductase 0.0043 0.0063 0.0084
Brugia malayi aspartic protease BmAsp-2, identical 0.0248 0.0579 0.1181
Onchocerca volvulus Matrix metalloproteinase homolog 0.0347 0.083 0.1696
Loa Loa (eye worm) hypothetical protein 0.0084 0.0166 0.0221
Plasmodium vivax aspartyl proteinase, putative 0.0284 0.067 0.219
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0053 0.0131
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0027 0.0022 0.0051
Onchocerca volvulus 0.0035 0.0044 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.0259 0.1606
Onchocerca volvulus 0.0039 0.0053 0.01
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0093 0.0105
Brugia malayi PHD-finger family protein 0.0025 0.0019 0.0028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.0231 0.0866
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0121 0.0259 0.0948
Plasmodium falciparum plasmepsin V 0.0248 0.0579 0.189
Onchocerca volvulus Arrow homolog 0.04 0.0962 0.1968
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0283 0.0571
Loa Loa (eye worm) hypothetical protein 0.0164 0.0368 0.0489
Loa Loa (eye worm) hypothetical protein 0.0202 0.0464 0.0618
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.009 0.0182 0.0242
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Loa Loa (eye worm) MBCTL1 0.0055 0.0093 0.0123
Echinococcus granulosus microtubule associated protein 2 0.0592 0.1445 0.3884
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0053 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0141 0.031 0.1003
Toxoplasma gondii aspartyl protease ASP1 0.0284 0.067 0.2193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Leishmania major oligopeptidase b 0.005 0.0081 0.0222
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0027 0.0022 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.017 0.0602
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0076 0.0146
Brugia malayi ORL1-like opioid receptor 0.0039 0.0053 0.01
Plasmodium vivax aspartyl protease, putative 0.0248 0.0579 0.189
Loa Loa (eye worm) hypothetical protein 0.0121 0.0259 0.0345
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0035 0.0044 0.0146
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0044 0.0047
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0026 0.0042
Schistosoma mansoni hypothetical protein 0.0151 0.0334 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0355 0.1348
Loa Loa (eye worm) hypothetical protein 0.1472 0.3664 0.4876
Loa Loa (eye worm) matrix metalloproteinase 0.0157 0.0349 0.0464
Echinococcus granulosus glycoprotein Antigen 5 0.0248 0.058 0.1552
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0007 0.0002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0044 0.0058
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.005 0.0081 0.029
Schistosoma mansoni lamin 0.0028 0.0026 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0007 0.0002
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0044 0.0116
Onchocerca volvulus 0.195 0.4868 1
Mycobacterium ulcerans hypothetical protein 0.0169 0.0381 0.1446
Brugia malayi hypothetical protein 0.002 0.0006 0.0002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1955 0.488 0.4878
Loa Loa (eye worm) tubulin beta chain 0.0028 0.0025 0.0033
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Echinococcus multilocularis integrin alpha 3 0.1492 0.3714 0.4443
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0044 0.0116
Loa Loa (eye worm) hypothetical protein 0.0108 0.0227 0.0302
Echinococcus granulosus g protein coupled receptor 0.0039 0.0053 0.0131
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0007 0.0003
Echinococcus multilocularis adam 0.002 0.0005 0.00000048189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.017 0.0602
Brugia malayi Matrixin family protein 0.0157 0.0349 0.0708
Plasmodium vivax aspartyl protease, putative 0.0329 0.0784 0.2564
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0025 0.0053
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0076 0.0085
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0166 0.0161
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0414 0.0998 0.2677
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0053 0.0071
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0047 0.0072 0.008
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.005 0.0081 0.0248
Onchocerca volvulus Neurogenic locus notch homolog 0.0151 0.0335 0.0678
Echinococcus granulosus Protein patched homolog 1 0.0257 0.0603 0.1612
Onchocerca volvulus 0.0099 0.0204 0.041
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0008
Schistosoma mansoni tar DNA-binding protein 0.013 0.0283 0.0278
Brugia malayi hypothetical protein 0.0248 0.058 0.1183
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0053 0.0131
Leishmania major hypothetical protein, conserved 0.0073 0.0138 0.0411
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0052 0.0086 0.0264
Mycobacterium ulcerans lipase LipD 0.0073 0.0138 0.051
Brugia malayi hypothetical protein 0.0164 0.0368 0.0746
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0053 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0007 0.0009
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0053 0.01
Onchocerca volvulus 0.0157 0.0349 0.0708
Loa Loa (eye worm) hypothetical protein 0.04 0.0962 0.128
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.0203 0.073
Loa Loa (eye worm) hypothetical protein 0.095 0.2348 0.3124
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Loa Loa (eye worm) matrixin family protein 0.0379 0.0908 0.1209
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0053 0.0071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0248 0.058 0.0576
Schistosoma mansoni biogenic amine receptor 0.0039 0.0053 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Echinococcus granulosus neurogenic locus notch protein 0.0151 0.0334 0.0888
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0414 0.0998 0.327
Mycobacterium leprae conserved hypothetical protein 0.0174 0.0394 0.1495
Echinococcus granulosus fatty acid amide hydrolase 1 0.0387 0.0929 0.2492
Brugia malayi Eukaryotic aspartyl protease family protein 0.0248 0.0579 0.1181
Echinococcus granulosus neural cadherin 0.0151 0.0334 0.0888
Toxoplasma gondii thioredoxin reductase 0.0043 0.0063 0.0193
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0053 0.0131
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0047 0.0072 0.0224
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0184
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0414 0.0998 0.2042
Trypanosoma brucei metacaspase MCA3 0.0141 0.031 0.1003
Brugia malayi hypothetical protein 0.0027 0.0022 0.0034
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0067 0.0123 0.0391
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0284 0.067 0.0892
Schistosoma mansoni tar DNA-binding protein 0.013 0.0283 0.0278
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0053 0.0058
Onchocerca volvulus 0.0151 0.0334 0.0677
Onchocerca volvulus 0.0248 0.0579 0.1181
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0138 0.051
Onchocerca volvulus 0.0121 0.0259 0.0523
Echinococcus granulosus integrin beta 2 0.046 0.1113 0.2988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Schistosoma mansoni hypothetical protein 0.0151 0.0334 0.033
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0094 0.0192 0.0256
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0067 0.0123 0.0387
Loa Loa (eye worm) guanylate kinase 0.0039 0.0052 0.007
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit beta 0.0067 0.0123 0.0453
Brugia malayi Dopamine receptor protein 1 0.0039 0.0053 0.01
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0248 0.058 0.0576
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0184 0.0214
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0433 0.0513
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0035 0.0044 0.0146
Entamoeba histolytica tubulin family protein 0.0028 0.0025 0.0118
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0056 0.0097 0.011
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0025 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0138 0.0134
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0469 0.1136 0.1131
Echinococcus multilocularis tar DNA binding protein 0.013 0.0283 0.0333
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0569 0.1389 0.3731
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0044 0.008
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Loa Loa (eye worm) beta-lactamase 0.0073 0.0138 0.0184
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0067 0.0123 0.0387
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0007 0.0002
Brugia malayi hypothetical protein 0.002 0.0006 0.0002
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0007 0.0003
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0058 0.01 0.0315
Schistosoma mansoni notch 0.0151 0.0334 0.033
Loa Loa (eye worm) hypothetical protein 0.0151 0.0335 0.0445
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0284 0.067 0.2193
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0035 0.0044 0.0146
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0166
Brugia malayi ribonucleotide reductase 2 0.0067 0.0123 0.0244
Mycobacterium ulcerans hypothetical protein 0.0169 0.0381 0.1446
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0053 0.0131
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0052 0.0086 0.0264
Echinococcus granulosus integrin alpha 3 0.1492 0.3714 1
Brugia malayi Kelch motif family protein 0.0094 0.0192 0.0385
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0138 0.0481
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0007 0.0004
Brugia malayi Guanylate kinase family protein 0.0052 0.0085 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0705 0.173 0.3548
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Trypanosoma cruzi metacaspase, putative 0.0141 0.031 0.1003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.0182
Echinococcus granulosus neuropeptide receptor 0.0039 0.0053 0.0131
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.0646 0.0859
Trypanosoma brucei cardiolipin synthetase 0.0058 0.01 0.0311
Loa Loa (eye worm) integrin beta-2 0.0621 0.1518 0.2021
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0035 0.0042 0.0099
Echinococcus granulosus integrin alpha ps 0.0873 0.2153 0.5792
Entamoeba histolytica hypothetical protein 0.0216 0.0498 0.3124
Wolbachia endosymbiont of Brugia malayi cardiolipin synthase 0.0027 0.0022 0.006
Schistosoma mansoni replication factor A 1 rfa1 0.0035 0.0042 0.0037
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0395 0.095 0.1264
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0056 0.0097 0.0575
Echinococcus granulosus caspase 3 0.0146 0.0321 0.0853
Brugia malayi EGF-like domain containing protein 0.0151 0.0334 0.0677
Echinococcus granulosus protein jagged 1 0.0151 0.0334 0.0888
Loa Loa (eye worm) hypothetical protein 0.0395 0.095 0.1264
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0409 0.0985 0.3229
Schistosoma mansoni hypothetical protein 0.0151 0.0334 0.033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.0259 0.0976
Echinococcus granulosus protein jagged 1 0.0151 0.0334 0.0888
Trypanosoma brucei beta tubulin 0.0028 0.0025 0.0062
Loa Loa (eye worm) hypothetical protein 0.0094 0.0192 0.0256
Brugia malayi Cadherin domain containing protein 0.0151 0.0334 0.0677
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.105 0.26 1
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.1224 0.3039 1
Echinococcus multilocularis enteropeptidase 0.0248 0.058 0.0689
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0171
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0047 0.0072 0.0255
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0106 0.0223 0.0296
Schistosoma mansoni hypothetical protein 0.0024 0.0015 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0138 0.036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0047 0.0072 0.0067
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0093 0.0237
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0027 0.0022 0.0051
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0047 0.0072 0.0181
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0047 0.0072 0.0218
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0414 0.0998 0.3824
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0056 0.0097 0.0353
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0053 0.0131
Onchocerca volvulus 0.0073 0.0138 0.0275
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0053 0.0131
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0287 0.0677 0.0805
Echinococcus granulosus beta tubulin 0.0028 0.0025 0.0053
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Echinococcus multilocularis serotonin receptor 0.0039 0.0053 0.0058
Echinococcus multilocularis neural cadherin 0.0151 0.0334 0.0395
Brugia malayi beta-tubulin, identical 0.0028 0.0025 0.0041
Schistosoma mansoni tubulin subunit beta 0.0028 0.0025 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Echinococcus granulosus g protein coupled receptor 0.0039 0.0053 0.0131
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0395 0.095 0.0946
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0171
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.1224 0.3039 1
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Schistosoma mansoni hypothetical protein 0.0293 0.0693 0.0688
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0044 0.008
Toxoplasma gondii aspartyl protease 0.0248 0.0579 0.1893
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0047 0.0072 0.008
Onchocerca volvulus 0.0248 0.058 0.1183
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.0044 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0184 0.0482
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0414 0.0998 0.119
Loa Loa (eye worm) hypothetical protein 0.0091 0.0184 0.0245
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0376 0.0902 0.0897
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0151 0.0334 0.0677
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0007 0.0004
Brugia malayi GCC2 and GCC3 family protein 0.0151 0.0334 0.0677
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0231 0.0838
Echinococcus granulosus GPCR family 2 0.0223 0.0516 0.1379
Echinococcus multilocularis protein jagged 1 0.0151 0.0334 0.0395
Mycobacterium ulcerans acetyl-CoA synthetase 0.0035 0.0044 0.0146
Onchocerca volvulus 0.002 0.0006 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0007 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0063 0.0158
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0259 0.081
Leishmania major beta tubulin 0.0028 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.0184 0.0484
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0053 0.0131
Giardia lamblia Beta tubulin 0.0028 0.0025 0.0451
Schistosoma mansoni hypothetical protein 0.0024 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0083 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0053 0.0131
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0053 0.0131
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0067 0.0123 0.0387
Brugia malayi hypothetical protein 0.0039 0.0053 0.01
Echinococcus multilocularis neurogenic locus protein delta 0.0151 0.0334 0.0395
Brugia malayi Serotonin receptor 0.0039 0.0053 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0259 0.0976
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Schistosoma mansoni hypothetical protein 0.0418 0.1008 0.1004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0047 0.0072 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0007 0.0003
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0053 0.0058
Schistosoma mansoni neuropeptide receptor 0.0039 0.0053 0.0049
Echinococcus multilocularis transmembrane protease serine 3 0.0248 0.058 0.0689
Schistosoma mansoni histamine h1 receptor 0.0039 0.0053 0.0049
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0014 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0053 0.0131
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0056 0.0097 0.2089
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.0273 0.0268
Brugia malayi Calcium binding EGF domain containing protein 0.0151 0.0334 0.0677
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0223 0.0516 0.1379
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0216 0.0498 0.0591
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0047 0.0072 0.0218
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Onchocerca volvulus 0.0248 0.058 0.1183
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0248 0.058 0.1552
Echinococcus granulosus protein jagged 2 0.0151 0.0334 0.0888
Plasmodium vivax aspartyl protease, putative 0.0329 0.0784 0.2564
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0138 0.0481
Echinococcus granulosus geminin 0.0173 0.0391 0.104
Trypanosoma cruzi hypothetical protein, conserved 0.0159 0.0355 0.115
Trypanosoma brucei cardiolipin synthetase, putative 0.0058 0.01 0.0311
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0044 0.0099
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.009 0.0182 0.065
Onchocerca volvulus 0.0035 0.0044 0.008
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0053 0.0058
Mycobacterium ulcerans peptide amidase, GatA 0.0047 0.0072 0.0255
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0014 0.003
Plasmodium falciparum plasmepsin X 0.0329 0.0784 0.2564
Brugia malayi Thioredoxin reductase 0.0043 0.0063 0.012
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0047 0.0072 0.0255
Schistosoma mansoni integrin alpha-ps 0.0873 0.2153 0.2149
Brugia malayi G protein-coupled receptor 0.0039 0.0053 0.01
Brugia malayi Trypsin family protein 0.0248 0.058 0.1183
Schistosoma mansoni tsg101-related 0.0646 0.1582 0.1578
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0171
Plasmodium falciparum tubulin beta chain 0.0028 0.0025 0.0062
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Echinococcus granulosus apoptotic protease activating factor 1 0.0164 0.0368 0.0978
Onchocerca volvulus Putative phospholipase D 0.0031 0.0033 0.0059
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0056 0.0097 0.0092
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.0011 0.0006
Echinococcus granulosus neurogenic locus notch protein 4 0.0151 0.0334 0.0888
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0053 0.0058
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0053 0.0049
Brugia malayi Amidase family protein 0.0047 0.0072 0.0138
Onchocerca volvulus 0.0248 0.058 0.1183
Brugia malayi Dopamine receptor 0.0039 0.0053 0.01
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0067 0.0123 0.0387
Onchocerca volvulus 0.0073 0.0138 0.0275
Leishmania major hypothetical protein, conserved 0.0409 0.0985 0.3211
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0284 0.067 0.0797
Onchocerca volvulus 0.0073 0.0138 0.0275
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.0044 0.0146
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0007 0.0003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0053 0.0049
Onchocerca volvulus 0.0039 0.0053 0.01
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0007 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0138 0.0437
Schistosoma mansoni fatty-acid amide hydrolase 0.0047 0.0072 0.0067
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0151 0.0334 0.0677
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0414 0.0998 0.327
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0194 0.0444 0.1692
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0053 0.0058
Echinococcus multilocularis neurogenic locus protein delta 0.0151 0.0334 0.0395
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0076 0.0192
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.0184 0.0687
Loa Loa (eye worm) hypothetical protein 0.0257 0.0603 0.0802
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0047 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0076 0.0071
Plasmodium falciparum plasmepsin I 0.0284 0.067 0.219
Brugia malayi eukaryotic initiation factor 4A 0.0056 0.0097 0.0189
Schistosoma mansoni slit 0.0151 0.0335 0.033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0053 0.0131
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.105 0.26 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0007 0.0003
Trichomonas vaginalis esterase, putative 0.0073 0.0138 0.0515
Loa Loa (eye worm) hypothetical protein 0.0248 0.058 0.0772
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0248 0.058 0.0689
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0025 0.0024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0053 0.0049
Schistosoma mansoni hypothetical protein 0.0164 0.0368 0.0363
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0023 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0006 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0486 0.1179 0.3165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0007 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0053 0.0049
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0053 0.01
Trichomonas vaginalis tubulin alpha chain, putative 0.0028 0.0025 0.0076
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0013 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.0592 0.1445 0.1726
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0053 0.0131
Trypanosoma brucei metacaspase 5, putative 0.0141 0.031 0.1003
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.1224 0.3039 0.818
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0184
Toxoplasma gondii beta-1 tubulin, putative 0.0028 0.0025 0.0065
Schistosoma mansoni hypothetical protein 0.0223 0.0516 0.0512
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0248 0.0579 0.1893
Echinococcus multilocularis kelch ECH associated protein 1 0.0467 0.1132 0.135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0007 0.0009
Schistosoma mansoni notch 0.0151 0.0334 0.033
Onchocerca volvulus 0.0045 0.0068 0.0131
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0166 0.0193
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0053 0.0071
Plasmodium vivax aspartyl proteinase, putative 0.0248 0.0579 0.189
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0044 0.015
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0007 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0007 0.0003
Onchocerca volvulus Cell death protein 3 homolog 0.0305 0.0724 0.1478
Echinococcus multilocularis fibrillin 2 0.002 0.0005 0.00000048189
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0063 0.0084
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0171
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0044 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0157 0.0349 0.0464
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.005 0.0081 0.029
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0013 0.0008
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0142 0.037
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0056 0.0097 0.0299
Mycobacterium tuberculosis Conserved protein 0.0073 0.0138 0.0481
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.009 0.0182 0.0581
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0159 0.0355 0.115
Echinococcus multilocularis geminin 0.0173 0.0391 0.0462
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0035 0.0044 0.0146
Echinococcus granulosus slit 2 protein 0.0151 0.0335 0.0889
Mycobacterium leprae Probable lipase LipE 0.0073 0.0138 0.051
Loa Loa (eye worm) hypothetical protein 0.0248 0.058 0.0772
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0044 0.0146
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0056 0.0097 0.011
Echinococcus granulosus Niemann Pick C1 protein 0.046 0.1113 0.2987
Echinococcus multilocularis slit 2 protein 0.0151 0.0335 0.0395
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0053 0.0058
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.0184 0.0215
Loa Loa (eye worm) hypothetical protein 0.0482 0.1169 0.1555
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0184 0.0214
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0032 0.0068
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.1224 0.3039 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0056 0.0097 0.0273
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0248 0.058 0.0689
Brugia malayi amidase 0.0387 0.0929 0.1901
Loa Loa (eye worm) latrophilin receptor protein 2 0.0223 0.0516 0.0687
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0007 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0121 0.0259 0.0976
Brugia malayi neuropeptide F receptor 0.0039 0.0053 0.01
Schistosoma mansoni notch 0.0151 0.0334 0.033
Schistosoma mansoni hypothetical protein 0.0216 0.0498 0.0494
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Trypanosoma cruzi metacaspase, putative 0.0141 0.031 0.1003
Loa Loa (eye worm) hypothetical protein 0.0454 0.1099 0.1463
Loa Loa (eye worm) hypothetical protein 0.0151 0.0334 0.0445
Echinococcus multilocularis nibrin 0.002 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni neprilysin 0.0024 0.0015 0.001
Trypanosoma brucei trypanothione reductase 0.0043 0.0063 0.0189
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0409 0.0985 0.3229
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0223 0.0516 0.0613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0025 0.0053
Brugia malayi CHE-14 protein 0.0257 0.0603 0.123
Loa Loa (eye worm) hypothetical protein 0.0395 0.095 0.1264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0053 0.0049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0138 0.0275
Toxoplasma gondii calcium binding egf domain-containing protein 0.0395 0.095 0.3115
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0141 0.031 0.1007
Brugia malayi sulfakinin receptor protein 0.0039 0.0053 0.01
Plasmodium vivax acyl-CoA synthetase, putative 0.009 0.0182 0.0581
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0045
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0027 0.0022 0.0051
Schistosoma mansoni notch 0.0151 0.0334 0.033
Brugia malayi EGF-like domain containing protein 0.0151 0.0334 0.0677
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0248 0.0579 0.0575
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0191 0.0435 0.1628
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0108 0.0124
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0113 0.024 0.0873
Brugia malayi ecdysteroid receptor 0.0021 0.0007 0.0003
Loa Loa (eye worm) notch protein 0.0151 0.0334 0.0445
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Trypanosoma cruzi beta tubulin, putative 0.0028 0.0025 0.0062
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Loa Loa (eye worm) integrin alpha pat-2 0.3001 0.7515 1
Trypanosoma brucei beta tubulin 0.0028 0.0025 0.0062
Echinococcus granulosus tubulin subunit beta 0.0028 0.0025 0.0053
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0033 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0086
Trypanosoma brucei prolyl oligopeptidase, putative 0.005 0.0081 0.0248
Echinococcus multilocularis beta tubulin 0.0028 0.0025 0.0024
Echinococcus multilocularis lamin 0.0028 0.0026 0.0025
Schistosoma mansoni adenoreceptor 0.0039 0.0053 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0007 0.0004
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0063 0.0189
Plasmodium vivax tubulin beta chain, putative 0.0028 0.0025 0.0062
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0284 0.067 0.2564
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0184 0.0368
Schistosoma mansoni hypothetical protein 0.0084 0.0165 0.0161
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0204 0.041
Mycobacterium ulcerans beta-lactamase 0.0073 0.0138 0.051
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.0184 0.0687
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.0248 0.058 0.0576
Schistosoma mansoni hypothetical protein 0.0409 0.0985 0.0981
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0141 0.031 0.1177
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.0464 0.055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0007 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0138 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0007 0.0009
Schistosoma mansoni notch 0.0151 0.0335 0.033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0007 0.0002
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0076 0.0071
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0138 0.0515
Schistosoma mansoni myosin xvIII 0.0039 0.0053 0.0049

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2.4 uM kg-1 Tested for tremorolytic activity in mice, expressed as dose required to double the dose of oxotremorine inducing a predetermined (grade 2) tremor intensity. ChEMBL. 2933518
ED50 (functional) = 0.29 uM l-1 Tested for agonist activity at Muscarinic acetylcholine receptor in guinea pig ileum ChEMBL. 2933518
EPMR (functional) = 4.6 Tested for agonist activity at muscarinic receptor in guinea pig ileum, expressed as equipotent molar ratio relative to carbamylcholine. ChEMBL. 2933518
KA (functional) = 2.34 Tested for agonist activity at Muscarinic acetylcholine receptor in guinea pig ileum ChEMBL. 2933518
LD50 (ADMET) = 426 uM kg-1 Acute toxicity of the compound in mice ChEMBL. 2933518

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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